Annnd the bloodwork came back disappointing too, my body isn’t responding as she’d hoped. Trying not to count myself out yet but I did leave work and come home to watch baseball and try to marshal myself up
I’m sorry @lucyb1954 :-/ I have never done a mini-stim, I always did low dose of menopur and follistim. What was your blood work? Did they give you your estrogen levels? Ugh, I’m sorry, I know how stressful and hard this is. Every cycle is different, so you never know if it’s just not a great month for you. I did cancel on 2 cycles for lack of response when I was doing IVF. Did they tell you to just keep on for now and come back for bloodwork and ultrasound? Thinking of you. Hope you can do some relaxing and enjoy the baseball.
Me: Hashimoto Autoimune Disease Homozygous MTHFR Cr677 DOR - AMH .27 High FSH (don't even know how high) 2 iui's to start - BFN IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5 IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol Chemical pregnancy FET#2 - PGS normal boy - BFN Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos 1st transfer - chemical pregnancy 2nd transfer - success, May 17 2020 due date!
Awww thanks 🙏 my follicles were still small on the ultrasound and my estradiol hadn’t budged from 45. Working from home today so I can be here to get the follistim shipment and take it immediately. I go in for another ultrasound and bloodwork tomorrow so I’ll find out more then.
@lucyb1954 sorry you’re having a rough start I would also not call 225 a low dose - it’s pretty much a normal dose. Hope the change in meds prompts a change - How many days have you been stimming now?
AFM AF has arrived, baseline looks all quiet, now to just continue the Lupron until the next check in a week
Me 43 DH 45 Married 12/2016 TTC #1 since 04/2015 AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis 7 retrievals, 3 transfers
Jun19 FET BFP, due date 7th March 2020, DD born Feb20
Sep17 IVF1 - 1ER, 1F, 1ET, BFN Nov17 IVF2 - 1ER, 0F Jan18 IVF3 - 3ER, 1F, 1ET, BFN Feb18 - second opinion and additional testing Apr18 IVF4 - cancelled (E2 too high) May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality) Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality) Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality) Aug/Sep18 IVF7 - cancelled (cyst) Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality) Oct18 IVF8 - Cancelled (cyst and too low TSH) Oct18-Jan19 bringing TSH under control Feb19 ERA and hysteroscopy Mar19 Investigation for fibroid and adenomyosis Apr19 adenomyosis confirmed, polyps removed Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Sep17 - Pergoveris 10-17 Sep, Orgalutran 15-18 Sep, Ovitrelle 18 Sep, ER 20 Sep for 2 follies, 1 mature egg, fertilized, ET 1x 2d 4-cell embryo 22/09, 05/10 BFN Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
Hi 👋🏼 @emmasemm glad to see you’re progressing well. I had started on 150 of the menopur and then she upped me to 225 after a couple of days. I’m currently on my 7th day of stims and just added follistim today after the crappy results yesterday. How long do people normally stim for? I have an appointment with the RE to discuss tomorrow. My guess is that she’ll want to discuss whether I want to cancel. I’m thinking maybe I’ll keep stimming to Saturday and see what happens. Ugh I knew this would hit me hard I just didn’t know how hard.
@lucyb1954 Can you write exactly which meds you did at which does on which days so far? And what cycle day did you do your baseline and start your meds? If I remember you had baseline labs for E2 and FSH? Can you remind me what they were? On your last scan, how many follicles on each side and how big were they? You should have the two dimensional measurements for each follicle. Also the two dimensional measurements of both ovaries would be helpful to try to give you some more hints of what to ask tomorrow.
Me 43 DH 45 Married 12/2016 TTC #1 since 04/2015 AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis 7 retrievals, 3 transfers
Jun19 FET BFP, due date 7th March 2020, DD born Feb20
Sep17 IVF1 - 1ER, 1F, 1ET, BFN Nov17 IVF2 - 1ER, 0F Jan18 IVF3 - 3ER, 1F, 1ET, BFN Feb18 - second opinion and additional testing Apr18 IVF4 - cancelled (E2 too high) May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality) Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality) Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality) Aug/Sep18 IVF7 - cancelled (cyst) Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality) Oct18 IVF8 - Cancelled (cyst and too low TSH) Oct18-Jan19 bringing TSH under control Feb19 ERA and hysteroscopy Mar19 Investigation for fibroid and adenomyosis Apr19 adenomyosis confirmed, polyps removed Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Sep17 - Pergoveris 10-17 Sep, Orgalutran 15-18 Sep, Ovitrelle 18 Sep, ER 20 Sep for 2 follies, 1 mature egg, fertilized, ET 1x 2d 4-cell embryo 22/09, 05/10 BFN Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
@emmasemm I don’t know all the answers to your questions but I can ask tomorrow. Here’s what I know:
stim days 1-5: clomid 150 stim days 1-2: menopur 150 (with the clomid) stim days 3-7: 225 menopur stim day 7: 150 follistim
i was on estrace for approx. a month before starting stims and started stims on CD21. The day before I started stims I had an ultrasound and the nurse saw 8 follies on the right and four on the left. I don’t know how big my ovaries are. I know they’re small but I don’t know the measurements.
My ultrasound on stim day 6 showed 6 follies on my right and 2-3 on my left, none above 10mm but I don’t know how big each one was.
My last lab before starting estrace was in late February. My FSH was 8 and my E2 was 97. I had more labs done after starting estrace and had e2 of 210.
I think the labs labs from February were done on CD15.
Whew I realize I need much more info. @emmasemm you really need to switch professions and be a doctor!
@lucyb1954 estrace for a month? Hmmm. At you’re appointment I would ask if it is possible that you were over suppresses from the long estrace priming protocol. My stim protocol was always aproximatey 10 days of estrace and then 75 menopur and 225 follistim . Since your doctor is doing clomid and had not intended to introduce follistim until there was not a great response, and was doing 150 menopur, that is a pretty classic mini IVF protocol... Stim days are supposedly still 9-10 days for a mini IVF cycle which is what a regular IVF cycle usually is too. I once stunned for a horrific 18 days on a regular IVF low dose cycle. Some doctors will let’s you continue to stim if there is no response at all for a few days and basically say that the first X days didn’t count because nothing was happening but that is so taxing, I feel like sometimes it’s just better to cancel the cycle and try another month, in your case possibly with less suppression with the down regulating. (Meaning less days of estrace before you stimulate the ovaries. You down rev to quiet the ovaries and hope to get the follicles to grow uniformly)
Good luck tomorrow lady. Hopefully you get some good news!
Me: Hashimoto Autoimune Disease Homozygous MTHFR Cr677 DOR - AMH .27 High FSH (don't even know how high) 2 iui's to start - BFN IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5 IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol Chemical pregnancy FET#2 - PGS normal boy - BFN Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos 1st transfer - chemical pregnancy 2nd transfer - success, May 17 2020 due date!
Ok so I agree with @hopefuljj that your estrogen priming was waaaaaaay too long. 10-12 days max is what you want. You want to try to bring the follicles in line but not shut everything into a deep sleep. It should be started around 2-3 days after you ovulate in a normal cycle.
You should then get a bleed at the normal time for you - if you don’t have regular 28-30 day cycles they should have you on a progesterone such as provera to induce a bleed at the right time. But means you stop the estrogen just before you get your bleed.
On day 1 or 2 of bleeding you go for baseline. Baseline only works in the first days of the cycle - any other time is nonsense. You should just ignore your CD15 numbers. At baseline you want to see as many very small antral follicles (2-5mm) on each ovary as possible - though I never saw more than 2 each side as my DOR is really very diminished. They should still measure those follicles in a DOR patient. You should have E2 and FSH blood tests. E2 should be below 50 and FSH as low as possible under 10. If either is higher you should skip the cycle. If all is good you start stims that night.
If they really saw 12 follicles total then that’s not typical DOR - but is fitting with your fragile X finding. But without blood work who knows if they are antral follicles or not.
Not everyone responds to clomid well, so next time maybe just go traditional and use follistim etc from the start with the Menopur. You don’t need crazy doses. My best rounds were equivalent to 300 combined. Not mini but not maxi either. The main thing is to get the fsh injections started before your own natural fsh production has kicked in. Otherwise you’re just wasting meds and see little effect.
See what you get at this next appointment but don’t be afraid to cancel sooner rather than later in this case. Ask for all the reports they have so far for this round, get them used to providing the reports after each appointment to you. I think with a 10 day estrogen priming normal stim cycle you could see a different result. Ask them now about microdose Lupron instead of cetrotide too next round - the other fragilex ladies I know did better with MDL (Not started luteal, started same day as stims). But also fine to try once with cetrotide first if you will have multiple tries.
Good luck!
Me 43 DH 45 Married 12/2016 TTC #1 since 04/2015 AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis 7 retrievals, 3 transfers
Jun19 FET BFP, due date 7th March 2020, DD born Feb20
Sep17 IVF1 - 1ER, 1F, 1ET, BFN Nov17 IVF2 - 1ER, 0F Jan18 IVF3 - 3ER, 1F, 1ET, BFN Feb18 - second opinion and additional testing Apr18 IVF4 - cancelled (E2 too high) May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality) Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality) Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality) Aug/Sep18 IVF7 - cancelled (cyst) Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality) Oct18 IVF8 - Cancelled (cyst and too low TSH) Oct18-Jan19 bringing TSH under control Feb19 ERA and hysteroscopy Mar19 Investigation for fibroid and adenomyosis Apr19 adenomyosis confirmed, polyps removed Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Sep17 - Pergoveris 10-17 Sep, Orgalutran 15-18 Sep, Ovitrelle 18 Sep, ER 20 Sep for 2 follies, 1 mature egg, fertilized, ET 1x 2d 4-cell embryo 22/09, 05/10 BFN Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
I decided to go ahead and cancel the cycle because absolutely nothing was budging. I spoke briefly with my RE and told her that it seems like we oversuppressed with the estrace. We are going to regroup next week but she did mention doing a no suppression lead in and just going in line with my natural cycle.
I’m going to also request full stims, MDL, and skipping the Clomid. @emmasemm with a cycle of IVF in line with my own cycle is there a chance my natural FSH will kick in too fast before I start the Stims? And I was curious how the AFC number doesn’t fit with DOR but does with Fragile X...how does that work?
@lucyb1954 I’m sorry lady:( I know what that feels like to cancel. As for the chance of your FSH kicking into gear too soon, it is a possibility. I don’t think estrogen priming to bring down FSH and align follicle growth is bad, but a month of it is just too much. I always did IVF with my natural cycle start date so I’m not sure why you can’t do both. You have to go in for monitoring to check for ovulation and once you have ovulated you count back (10 days or less) from when day 3 should be (Cycle day 3) and that is when you start the estrogen. So you start the estrogen on that day and then go in for baseline on cycle day 3 to see if you are cleared for stims. I know some women have done it without priming and I’d you don’t need it great.
Me: Hashimoto Autoimune Disease Homozygous MTHFR Cr677 DOR - AMH .27 High FSH (don't even know how high) 2 iui's to start - BFN IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5 IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol Chemical pregnancy FET#2 - PGS normal boy - BFN Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos 1st transfer - chemical pregnancy 2nd transfer - success, May 17 2020 due date!
@lucyb1954 oh I’m sorry - but I hope you get a much better start next time. But well done for taking the decision. I know it’s hard.
I agree with @hopefuljj that estrogen priming when used in the normal way should be ok, but for some people that can still be a bit suppressive... I would suggest to discuss what she suggested and a natural start with your RE.
Ask her about doing a baseline even on cycle day 2. If you can get in that short notice, I’ve even done it on CD1! The key thing is to start the stims (Menopur or Follistim or whatever you’re using) already before that FSH rises. My best cycles (with 7-10 days estrogen priming before) were with an FSH of only 3-4. Of course this is not my natural level!
What I’ve seen with a few other fragilex ladies is the number of follicles and eggs can be on the low end of normal, even if AMH is very very low. And I’ve seen this “difficult to get the follicles to grow” phenomenon before. It seems to be linked to the way the fragile x affects the ovaries and their response to the hormones.
Me 43 DH 45 Married 12/2016 TTC #1 since 04/2015 AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis 7 retrievals, 3 transfers
Jun19 FET BFP, due date 7th March 2020, DD born Feb20
Sep17 IVF1 - 1ER, 1F, 1ET, BFN Nov17 IVF2 - 1ER, 0F Jan18 IVF3 - 3ER, 1F, 1ET, BFN Feb18 - second opinion and additional testing Apr18 IVF4 - cancelled (E2 too high) May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality) Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality) Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality) Aug/Sep18 IVF7 - cancelled (cyst) Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality) Oct18 IVF8 - Cancelled (cyst and too low TSH) Oct18-Jan19 bringing TSH under control Feb19 ERA and hysteroscopy Mar19 Investigation for fibroid and adenomyosis Apr19 adenomyosis confirmed, polyps removed Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Sep17 - Pergoveris 10-17 Sep, Orgalutran 15-18 Sep, Ovitrelle 18 Sep, ER 20 Sep for 2 follies, 1 mature egg, fertilized, ET 1x 2d 4-cell embryo 22/09, 05/10 BFN Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
@lucyb1954 I'm sorry you had to cancel It can be so frustrating, but the first cycle is often almost an experiment. I always did estrogen patch priming for a few days, and stared my stims really early. My follicle count was never more than 3 or 4, but my two last cycles, they got 5 eggs. We found that the dual trigger was really good for me. Wishing you all the luck in your next cycle.
Hi @bakerstreetboys! How are YOU!!! I’m waiting to hear confirmation tomorrow that my donor has started stims! Time to crawl into my cave and hide until this part is over possibly. Eeeeeeek!
Me: Hashimoto Autoimune Disease Homozygous MTHFR Cr677 DOR - AMH .27 High FSH (don't even know how high) 2 iui's to start - BFN IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5 IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol Chemical pregnancy FET#2 - PGS normal boy - BFN Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos 1st transfer - chemical pregnancy 2nd transfer - success, May 17 2020 due date!
@hopefuljj Eek that is so exciting! Will she be keeping in pretty close contact with you to let you know how it's going? I think I'd have to give my phone away so I wouldn't stalk her
I'm doing ok, thanks Just trying to keep calm and stay positive!
@hopefuljj yay!!!! 😀😀😀 I’m excited for you. And for you @bakerstreetboys! I’m thinking and praying for everyone. I’m not a religious person but I’m putting it out there for everyone.
@emmasemm interesting about the Fragile X stuff. So maybe I have some good eggs still left in there but they’re just not responding. When’s your transfer slated for?
Thanks everyone one for the advice. I’m going to a conference and then a vacation mid June and the doctor mentioned we could use progesterone to delay CD1 until I get back although it probably should happen around that time anyway. Will that affect anything for my next cycle?
And has has anyone had luck with HGH? My RE mentioned it at one of our initial meetings but didn’t want to jump to it on our first cycle. And I’m kinda scared I’ll grow a new appendage with it or something 🤪
@lucyb1954 you won’t grow a new appendage 😂😂😂. I took it a few rounds and it seemed helpful in shortening my stim time but not sure what else it helped with if anything. From what I’ve heard it is supposed to be beneficial for women over 40? But some doctors say there is not enough research to say that for sure. I fought to get it and use it! My RE was finally like, ok fine.
Me: Hashimoto Autoimune Disease Homozygous MTHFR Cr677 DOR - AMH .27 High FSH (don't even know how high) 2 iui's to start - BFN IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5 IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol Chemical pregnancy FET#2 - PGS normal boy - BFN Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos 1st transfer - chemical pregnancy 2nd transfer - success, May 17 2020 due date!
@hopefuljj 😂 thanks! Just want a baby, no new appendages thank you very much!
hows your donor egg lady doing? How are you doing? Are you doing a fresh transfer?
i went in for a follow up with my RE today. We will be doing the HGH as well as MDL. I’ll go in for a baseline on CD3 for bloodwork and ultrasound, probably June 24th or so. Then we’ll start the stims if everything looks okay, Gonal F at 300 and menopur 150. She offered me to do either an estrace lead in for 10-12 days or without. I’m a little divided on it... I’m scared it will oversuppress me again but it also keeps the FSH in check. Any thoughts hive mind? 🐝
she did do do an ultrasound and found I had 2 good size follies. I don’t know if it’s bad that she didn’t see more 🤷♀️
Its up to you on the estrogen priming. I think 10 days would be worth to try- but you could also try to baseline one month without it. Just be prepared to skip that cycle if your FSH and/or E2 is tool high. If it is too high then you do the 10 days Estrogen priming at the end of that cycle, re- baseline and if ok start stims next time. Also i still recommend to try getting baseline on CD2 if you can. Just to get one step ahead of your body...
AFM suffering extreme tiredness from the estrogen patches. So much that I changed my work schedule next week so I don’t have any long drives as it’s not safe. Funny how I had zero effects from the Lupron but estrogen kills me each time!
Me 43 DH 45 Married 12/2016 TTC #1 since 04/2015 AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis 7 retrievals, 3 transfers
Jun19 FET BFP, due date 7th March 2020, DD born Feb20
Sep17 IVF1 - 1ER, 1F, 1ET, BFN Nov17 IVF2 - 1ER, 0F Jan18 IVF3 - 3ER, 1F, 1ET, BFN Feb18 - second opinion and additional testing Apr18 IVF4 - cancelled (E2 too high) May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality) Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality) Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality) Aug/Sep18 IVF7 - cancelled (cyst) Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality) Oct18 IVF8 - Cancelled (cyst and too low TSH) Oct18-Jan19 bringing TSH under control Feb19 ERA and hysteroscopy Mar19 Investigation for fibroid and adenomyosis Apr19 adenomyosis confirmed, polyps removed Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Sep17 - Pergoveris 10-17 Sep, Orgalutran 15-18 Sep, Ovitrelle 18 Sep, ER 20 Sep for 2 follies, 1 mature egg, fertilized, ET 1x 2d 4-cell embryo 22/09, 05/10 BFN Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
@emmasemm that’s interesting about the estrogen. It pretty much just made me cry every morning and then I would feel okay 🤷♀️ I had another question for you...it strikes me that I don’t really know what an antral follicle is versus other follicles. You mentioned that the follicles seen on a CD15 ultrasound may not be antral...so what are they? Getting my calendar today 🤓 hopefully I will be able to get in on CD2 for an ultrasound but going to be out of town so it may have to be CD3. Anyway when are you scheduled for transfer?
@Imajin99 I hope your break is good and helps you reset. Srsly the mental game required for all of this is nuts!
@hopefuljj been thinking about you! I’m reading up more in DE to make me feel less stressed about our next cycle. I hope everything is going well!
@emmasemm hope the estrogen isn’t making you too crazy in the brain 🤪 are you close to transfer day?
I’m up in Victoria BC for a workshop this week and of course my computers motherboard went kaput and it’s my work computer so I can’t have folks other than my in house IT folks fix it. It’s probably my fault... I spilled some coffee on it but then it worked fine for the rest of the day until I tried to live-stream baseball.
And I’ve been waiting to ovulate so I can start the next batch of estrace and progesterone... when I saw the RE on Thursday I had one follies on each ovary measuring 15mm or so and she said she thought I would ovulate in the next 3 days. Well so far no surge... if it doesn’t happen tomorrow AM I have to find somewhere to get a blood test to make sure we didn’t miss it.
What a day 🙄 anyone else had this issue with ovulation? I’m crampy and definitely feel it should be happening but no 🎲 so far.
@lucyb1954 If you started and stopped meds last cycle it can throw out your ovulation a bit the next cycle. This is particularly common with DOR patients. Keep testing and get the blood test worse case.
You can give antral follicles a Google as some of the RE websites describe them - so the info is reputable. But basically these are the follicles that have been “recruited” for a cycle, but which have not yet started to be exposed to the higher levels of FSH, so have not really started to grow. They should be big enough to be seen and with today’s ultrasound equipment if you have DOR they should be able to measure them quite easily. Under 5mm but typically 1-3mm range at baseline. However measuring is not really accurate as it differs per machine and person to person doing it, so that’s why they should check your E2 and FSH on the same day just to make sure that the bloodwork confirms they didn’t start to develop into “norma growing phase” follicles. Follicles as they grow cause estrogen to rise (not sure if they directly produce it or produce something else which makes other cells produce it...). So that’s why it’s important to check E2 as it tells you if what you see on the screen are really antral follicles (which don’t cause estrogen to rise) or already growing ones. By recruited I mean, each month your body pre selects (some say could be 2-4 weeks before your AF starts) the follicles for the next cycle. These are the ones it chooses to become antral follicles - so the number you could max get is somehow already set in a natural cycle. This is where the estrogen priming works - to stop your ovaries moving onto the stage which causes the selected follicles to become antral in a desynchronized way and allow it to hopefully recruit a few more in that same month. The whole feedback loop between hypothalamus, pituitary, ovaries, follicles and endometrial lining is a very finely balanced system. I find it pretty miraculous to be honest.
AFM well my lining Tuesday morning was 11.1mm and trilaminar. Which is record speed even for me after only 6 days of estrogen! I’m nervous it will get too thick and my cause a cancellation. Or something is growing that shouldn’t... let’s see... next US is Friday and we will also do bloods to make sure they are in line with what we see. Wednesday evening I had my first intralipids of this cycle - once again at home, on the sofa in my winter garden in the evening after work - definitely the lowest stress part of the process for me! I’m really hoping on Friday they say we can start progesterone etc on Friday or Saturday evening for a Monday or Tuesday afternoon transfer!
Me 43 DH 45 Married 12/2016 TTC #1 since 04/2015 AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis 7 retrievals, 3 transfers
Jun19 FET BFP, due date 7th March 2020, DD born Feb20
Sep17 IVF1 - 1ER, 1F, 1ET, BFN Nov17 IVF2 - 1ER, 0F Jan18 IVF3 - 3ER, 1F, 1ET, BFN Feb18 - second opinion and additional testing Apr18 IVF4 - cancelled (E2 too high) May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality) Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality) Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality) Aug/Sep18 IVF7 - cancelled (cyst) Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality) Oct18 IVF8 - Cancelled (cyst and too low TSH) Oct18-Jan19 bringing TSH under control Feb19 ERA and hysteroscopy Mar19 Investigation for fibroid and adenomyosis Apr19 adenomyosis confirmed, polyps removed Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Sep17 - Pergoveris 10-17 Sep, Orgalutran 15-18 Sep, Ovitrelle 18 Sep, ER 20 Sep for 2 follies, 1 mature egg, fertilized, ET 1x 2d 4-cell embryo 22/09, 05/10 BFN Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
@emmasemm woot!!! 🌈 that’s awesome! I hope lining grows just right.
You’re again a font of information. I didn’t realize that’s why they measure your E2 on CD2-3. I tried to get a blood test here in Canada but they told me I needed a Canadian doctors order. But still no surge levels even though my follies were at 15mm a week ago. My RE told me yesterday to just keep testing so I’m going to call her again tomorrow and see what she wants to do. I wonder if we missed it even though I’ve been testing for a week 🤷♀️
Well - we have a transfer booked for Tuesday!!!!!!!
Went for my ultrasound this morning, and you won’t believe it but due to a storm the entire doctors surgery had no power! No power means no ultrasound! I almost freaked out. But then my lovely obgyn called her friend who has a practice the other side of the city and we drove over there together and the two doctors did my scan in her friends practice. Phew! I guess having see her almost every week for over a year makes me a special patient! Ultrasound looked good - quiet ovaries, 12mm trilaminar lining... Bloods came back with no progesterone as we wanted - but my estrogen is low. It’s weird as my lining is great... so now I’m upping the patches plus taking progynova three times a day.
All my other meds start tomorrow - then just need to book our flights and off we go!
Me 43 DH 45 Married 12/2016 TTC #1 since 04/2015 AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis 7 retrievals, 3 transfers
Jun19 FET BFP, due date 7th March 2020, DD born Feb20
Sep17 IVF1 - 1ER, 1F, 1ET, BFN Nov17 IVF2 - 1ER, 0F Jan18 IVF3 - 3ER, 1F, 1ET, BFN Feb18 - second opinion and additional testing Apr18 IVF4 - cancelled (E2 too high) May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality) Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality) Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality) Aug/Sep18 IVF7 - cancelled (cyst) Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality) Oct18 IVF8 - Cancelled (cyst and too low TSH) Oct18-Jan19 bringing TSH under control Feb19 ERA and hysteroscopy Mar19 Investigation for fibroid and adenomyosis Apr19 adenomyosis confirmed, polyps removed Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Sep17 - Pergoveris 10-17 Sep, Orgalutran 15-18 Sep, Ovitrelle 18 Sep, ER 20 Sep for 2 follies, 1 mature egg, fertilized, ET 1x 2d 4-cell embryo 22/09, 05/10 BFN Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
@hopefuljj. My meds are exactly the same as yours and I start my meds on June 29th! It will be my first cycle!
39 years old DH 41. Sperm looks great. We live in San Diego Me: ****TW loss mentioned*** MTHFR Homozygous 677TT (dx 2016) hypothyroid 8/2018 Off birth control 11/29/2018 CP 2/10/2019. CP 3/8/2019 Saw fertility doctor, AFC 5, labs drawn 3/14/2019 Pregnant 4/18/2019 9 week ultrasound MM , stopped growing at 6 weeks, no HB. D&C 5/2/2019 Return to fertility doctor, labs show AMH 0.27. Diminished Ovarian Reserve 1st of 3 Egg retrievals planned tentatively for July 6/29/2019 started Antagonist Protocol 7/12/2019 First egg retrieval, only retrieved one egg and fell apart immediately, poor quality. 8/7/2019. Second cycle (follicular antagonist) canceled on day 5 of stims when a very large lead follicle grew out of nowhere. 11/8/2019. Second Egg retrieval with Lupron Flare Protocol. 2 eggs retrieved, fertilized with ICSI but no reaction occurred at all. Told I will never have my own babies with my eggs. 12/20/2019 ERA - pre-receptive. Needed 24 hours more of progesterone 2/2020 CP 3/2/2020 Egg donor cycle in Prague at Unica Clinic, 2 AA embryos, 1 transfer, 1 on ice. BFN. Due to pandemic, we could not return to Prague and will abandon our remaining embryo. 4/20/2020. BFP trying on our own! 06/04/2020 After HBs at 7 and 9 weeks, MM at 10 weeks 3 days. D&C, Hemorrhaged out 1 liter of blood from uterine artery rupture during procedure. Spent 1 night in the hospital with a balloon tamponade in my uterus. Baby was mosaic Trisomy 21. 8/2020. Moving forward with Donor Egg cycle at Utah Fertility Center and sharing a cycle with ladypOtter (Gina) I met on the Bump who was also supposed to go to Prague but couldn't. 9/26/2020 Donor retrieval of 26 eggs, 24 mature. Split cycle so I have 12 eggs with all 12 fertilizing. 6 PGS normal 3 boys, 3 girls 10/29/2020 Transfer day of girl donor egg embryo. BFP! First HCG 92.9. Then inappropriate rise, plateau and falling. Possibly ectopic pregnancy. ER visit with diagnosis of "pregnancy location unknown". CP 1/19/2021 Embryos shipped from Utah to my local clinic, starting prednisone for anti-histamine protocol. 2/26/2021 FET girl embryo BFP. Betas 62, 139, 386! HB at 6 weeks, then baby stopped growing at 8 week check up with weak HB measuring 6 weeks 4 days. MM at 9 weeks. D&C 4/15/21 7/13/2021 FET boy and girl embryos. First beta 10dp5dt 177, 14dp5dt 1631, 16dp5dt 6809. Pregnant with Identical triplets. At 9 weeks, Baby C no longer had a heart beat. Identical Twin Girls. Pregnancy complicated by TRAP Sequence with baby C an Acardiac fetus still receiving blood flow being pumped to it by other girls. Referred to UCSF at 18 weeks for consultation. No intervention needed at this time 2/18/22 After a failed NST, at 34 weeks 1 day, Charlotte born 4lb 4oz and Lily born 4lbs 10 oz. Our hearts are complete. Baby girls in NICU to grow and learn to eat.
@emmasemm omg! It’s finally here!!!! What a story having to drive with your doctor to another office?!? That’s bananas! And somehow so perfectly fitting for all the twists and turns you have already faced. This is so exciting! Sending all my sticky vibes your way:)
@andreamm31 good luck with your first cycle!!! June 29th will be here in no time!
@lucyb1954 for whatever reason after IVF retrievals I started having extremely delayed ovulation! Like I would ovulate on CD 28!!! And end up with 38-39 day cycles every month! It drove me mad when cycling cuz I had this extra 10+ days of waiting always, to start the next cycle. It has since gone back to my norm which is ovulation around CD 18 and AF about 11 days later but it was messed up for a long time.
Me: Hashimoto Autoimune Disease Homozygous MTHFR Cr677 DOR - AMH .27 High FSH (don't even know how high) 2 iui's to start - BFN IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5 IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol Chemical pregnancy FET#2 - PGS normal boy - BFN Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos 1st transfer - chemical pregnancy 2nd transfer - success, May 17 2020 due date!
@emmasemm all I can say is we will have a best seller after allnis said and done what an experience! I’m so glad you got the extra attention you deserved it’s never a dull moment!! Gkad you were also able to change your work schedule! Hoping you’ll be stress free for transfer and able to relax!! How many are you planning on transferring? So excited for you! Sending extra sticky vibes your way!!!
@hopefuljj how is your donor doing? Looking for an update not sure if I missed it! Hoping she has an amazing cycle for you with plenty of healthy embabies! Are you doing pgs? A fresh transfer? So very excited for u!!
@bakerstreetboys how r u feeling? How far long are you now? Hoping all is moving along well for u!
@Imajin99 hoping your vacay and break will do u good resulting in a great cycle for u in the summer!
@lucyb1954 these ivf riad is hard and cancelling sucks so bad but it’s great you get to try again a and have so much extra knowledge of what’s going on to help. Hopefully hgh will help, I hear it does work well when used, my RE for some reason didn’t allow it so it’s great that you have the option!!!
*****trigger**** thinking of you all and hoping for the best. Since it’s June I Wanted to share that my miracle love was actually from my June ivf cycle. Hoping this month will be successful for all!!!
History of TTC in spoiler box
TTC since 2014 Unexplained Infertility - but I am 40...Low AMH .30 7 - IUI (50mg-150mg Clomid) Feb - August 2016 all BFN IVF#1 August 2016 (Antagonist protocol 4/5 eggs) Cancelled cycle RE thought I would get at least 10. IVF#2 Sept 2016 (microdose luporn pro - disappearing follies, ONLY ONE, convert to IUI) BFN IVF#3 November 2016 (4 ER, 3 F, 3DT)-BFP with TWINS // MC both at almost 10wks IVF#4 March 2017 //EPP (10 ER (1 wonky so 9 ER) 7F, 3B (5AB, (2)5BB) PGS tested- ALL abnormal IVF#5 April 2017 // EPP (7 ER, 7F yes! 6B) 2/5 day 4/6 day - 2 PGS normal! yes!! IVF#6 May 2017 // Antagonist didn't have time for Estrogen Priming...(4 ER, 3 F, 3B) (5AB, (2) 5BB) 2 PGS normal, yes!! IVF#7 June 2017 // EPP praying this is it and then on to an FET!
@emmasemm I’m thinking about ya! Yay sticky wishes. Wait that sounds weird but you get what I mean. @hopefuljj I’m thinking about you too, hope your donors cycle went well! Glad I’m not the only one with an effed up cycle after this. Plus I was on the estrace for so long I think it just kind of messed with things and since I haven’t been able to get bloodwork up here in Canada we have no idea what’s going on. I’m slated to just go in for a baseline/cycle check on Monday (depending on what bloodwork indicates) and we’ll go from there.
@emmasemm You're a few hours ahead, so I will say GOOD LUCK tonight for tomorrow's transfer! Sending you all the good vibes. @lucyb1954 I think I missed something; why can't you get a blood test in Canada?
@bakerstreetboys I’m up here for a conference and I’ve been told I can’t get anything done without a Canadian doctors order. We’re headed back down to the US via ferry today but we haven’t quite decided our road trip plan... going from Victoria BC back to Utah. So it’s hard to predict what doctors we’ll be passing on our way. We had been thinking about a cycle with no suppression as well so if my ovaries look alright we might do that.
@emmasemm- I had to come back and check in on you!!! So excited to hear about your transfer!! So long in the making and enjoy every second of being PUPo!
History in Spoiler
Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015 Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive) March-May 2016: 1 TI and 2 IUIs- BFN June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary. August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze ), BFN May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid Nov 2017- Hysterscopy to remove polyp Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone Apr 2018- DE FET cancelled for lining issues Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin Baby Born born early @ 33.5 weeks due to Pre-e Back for # 2!
@emmasemm you must be PUPU by now!!! Yaaaaaaaaay!!!!!!!!!!!!!!!!
Me: Hashimoto Autoimune Disease Homozygous MTHFR Cr677 DOR - AMH .27 High FSH (don't even know how high) 2 iui's to start - BFN IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5 IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol Chemical pregnancy FET#2 - PGS normal boy - BFN Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos 1st transfer - chemical pregnancy 2nd transfer - success, May 17 2020 due date!
@lucyb1954 I also needed to travel during stims etc sometimes and it takes planning for multiple scenarios and dogged determination to get what you need done. I mostly had backups of backups ready to go and never used them, but backups make me feel comfortable. Or you have to accept skipping a cycle every now and again. Depends if all the planning for something you might never need is more stressful than skipping for you. We’re all different. Hope you enjoy your trip home - some awesome scenery along the way!
AFM Sorry I didn’t update yesterday (Tuesday) as we were so late home we just crashed straight to sleep. Short version - transfer went super smoothly and we now have two great quality day 3 embryos on board!
Longer version in spoiler ;-)
So after all my “doomsday planning” in the end it wasn’t needed - but I felt much better for it, you know, that little bit of control in a process where we have so little control! This transfer was such a different experience to my previous two when I just went in on my lunch break and it was very clinical in comparison.
We got up at 4am to go and catch our flight. DH can sleep anywhere so must have recovered about 4 me hours during the day - me, I was wide awake the whole time! The flight landed on time (a rare occurrence in itself!), the journey by train into London was smooth and we dropped into the clinic to sign the final paperwork so they could thaw our embryos. Now, *maybe* we all had a giggle over how well known my instructions were on which embryos to thaw in which order and under which circumstances... as in even the receptionist knew!
When we went to buy our London Underground tickets I paid with my card, but when I fished the tickets out someone had left a penny - which we took as a good luck sign. It’s safely tucked in a special part of my wallet. Having been ALL about the science for the last two years, I’m now willing to throw any kind of magic into the mix too - so quite happy when someone told me it’s a full moon and this Friday is the summer solstice! Plus it’s the anniversary of our first date this week!
In between we went for breakfast and DH had a coffee, then back for transfer. It was going to be delayed as they’d had a more complex retrieval in the morning, and the girl before me for transfer was super stressed about it. In the end we got to go in on time ahead of them because she emptied her bladder by mistake...
There were lots of hugs all round with the staff before we even started, everyone was really quite emotional. More than me! I wore my special socks and kept my sunglasses on underneath the hair net which just added a touch of glamour to the proceedings! They were so lovely in explaining everything as we went along to DH - as he’s not quite as familiar with my uterus as I am! Catheter placement was straightforward and the embryos came out of their catheter first time. We could clearly see where the little bit of fluid with the embryos in ended it and how it came to rest over the next minutes. Text book placement! Both the embryos we selected thawed perfectly - they even had already continued dividing by the last check before they went into the catheter which is very encouraging and the embryologist upgraded them to their best grade for day 3s! Some of you may know there is a rumor that laughter is good for implantation... well I’m not sure laughing during transfer is indicated, but they were playing some music in the background and at the moment the Cather came in the room with the embryos it switched over to Sade “Smooth operator” which had us all in stitches! DH proceeded to do a mock slow dance to it and so I was giggling the whole time. They also let him take all the photos he wanted of the screens and catheter etc.
Afterwards we went to a really nice Argentinian steak restaurant and had a “date” together with really great food using only bio ingredients and a completely plastic free environment. After that we took a taxi to a different airport to fly home - but with a few hours to spare where DH made a presentation for work and I just watched the world go by. Flight home was delayed for take off - but we had a good tailwind and landed pretty much on time - so home just after 11pm last night and pretty much fell straight asleep!
Today is the start of my “TWW retreat” - well it’s more a staycation. Previously I worked as normal - but this time I’ve taken the whole time to beta off and have lined up some relaxing gentle activities to keep me busy but hopefully also keep me relaxed. We all know normal stress levels have nothing to do with success or failure, but my job can be a bit higher stress sometimes and as we’ve spent a crazy amount of money and time we don’t want to look back and wonder “what if I’d take then time off”. DH is still working and next week is away on a course, so hoping I don’t go too stir crazy!
Once again thanks so much for all thinking of us - it really does mean a lot.
Me 43 DH 45 Married 12/2016 TTC #1 since 04/2015 AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis 7 retrievals, 3 transfers
Jun19 FET BFP, due date 7th March 2020, DD born Feb20
Sep17 IVF1 - 1ER, 1F, 1ET, BFN Nov17 IVF2 - 1ER, 0F Jan18 IVF3 - 3ER, 1F, 1ET, BFN Feb18 - second opinion and additional testing Apr18 IVF4 - cancelled (E2 too high) May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality) Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality) Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality) Aug/Sep18 IVF7 - cancelled (cyst) Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality) Oct18 IVF8 - Cancelled (cyst and too low TSH) Oct18-Jan19 bringing TSH under control Feb19 ERA and hysteroscopy Mar19 Investigation for fibroid and adenomyosis Apr19 adenomyosis confirmed, polyps removed Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Sep17 - Pergoveris 10-17 Sep, Orgalutran 15-18 Sep, Ovitrelle 18 Sep, ER 20 Sep for 2 follies, 1 mature egg, fertilized, ET 1x 2d 4-cell embryo 22/09, 05/10 BFN Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
@emmasemm omg the long version of your FET is just so so lovely!!!! So glad you took time off to just chill and good to stay somewhat busy:)
AFM: i know a few few people have asked for updates, I’m sorry I’ve been so quiet, I’m waiting on the report of what we have biopsied for PGS and frozen. I find out Friday. We had 12 growing the day after fertilization. (20 eggs, 16 mature, 12 fertilized and growing the next day). Feeling pretty nervous and panicked so staying sorta quiet about it all. Thanks for thinking of me ladies:)
Me: Hashimoto Autoimune Disease Homozygous MTHFR Cr677 DOR - AMH .27 High FSH (don't even know how high) 2 iui's to start - BFN IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5 IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol Chemical pregnancy FET#2 - PGS normal boy - BFN Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos 1st transfer - chemical pregnancy 2nd transfer - success, May 17 2020 due date!
@hopefuljj oh I am crossing everything for great results on Friday. This “one week wait” for freeze results is so tough, especially after multiple traumatic weeks like this with OE. Thiugh looking at the numbers so far it seems your clinic has tried to balance the quality and quantity with the donor. Come on embryos!!!
Me 43 DH 45 Married 12/2016 TTC #1 since 04/2015 AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis 7 retrievals, 3 transfers
Jun19 FET BFP, due date 7th March 2020, DD born Feb20
Sep17 IVF1 - 1ER, 1F, 1ET, BFN Nov17 IVF2 - 1ER, 0F Jan18 IVF3 - 3ER, 1F, 1ET, BFN Feb18 - second opinion and additional testing Apr18 IVF4 - cancelled (E2 too high) May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality) Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality) Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality) Aug/Sep18 IVF7 - cancelled (cyst) Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality) Oct18 IVF8 - Cancelled (cyst and too low TSH) Oct18-Jan19 bringing TSH under control Feb19 ERA and hysteroscopy Mar19 Investigation for fibroid and adenomyosis Apr19 adenomyosis confirmed, polyps removed Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Sep17 - Pergoveris 10-17 Sep, Orgalutran 15-18 Sep, Ovitrelle 18 Sep, ER 20 Sep for 2 follies, 1 mature egg, fertilized, ET 1x 2d 4-cell embryo 22/09, 05/10 BFN Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
@hopefuljj Thanks for updating us! I’m keeping everything crossed that you get a bunch of PGS normals! @emmasemm I love your transfer day story! Enjoy your TWW off work and keep busy! I’m looking forward to updates from you ladies!
AFM, nothing new or exciting to report. I will push to get the anatomy scan done as early as possible, so hopefully in another three weeks or so. Until then, I’ll just hope that little boy keeps growing in there!
Your Low AMH levels can be due to either premature ovarian insufficiency or age-related dimished ovarian reserve. It can be caused by either autoimmunity or an age-related decline in DHEA levels. Your absolute next step should be to order the book It Starts with the Egg. It will tell you everything and what you can do. The best part about it is she only looks at clinical trials - so you know these things have been proven to work on a large scale of women. The author talks about DHEA levels declining over time, so if you AMH levels are low, this could be an answer. The books was so helpful for us in IVF. The author herself had diminished ovarian reserve and ended up with 19 fertilized after following the protocols from the research.
Re: Low AMH Level
Homozygous MTHFR Cr677
DOR - AMH .27 High FSH (don't even know how high)
2 iui's to start - BFN
IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal
IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5
IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty
IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
Chemical pregnancy
FET#2 - PGS normal boy - BFN
Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
1st transfer - chemical pregnancy
2nd transfer - success, May 17 2020 due date!
I would also not call 225 a low dose - it’s pretty much a normal dose.
Hope the change in meds prompts a change - How many days have you been stimming now?
AFM AF has arrived, baseline looks all quiet, now to just continue the Lupron until the next check in a week
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
Can you write exactly which meds you did at which does on which days so far?
And what cycle day did you do your baseline and start your meds?
If I remember you had baseline labs for E2 and FSH? Can you remind me what they were?
On your last scan, how many follicles on each side and how big were they? You should have the two dimensional measurements for each follicle. Also the two dimensional measurements of both ovaries would be helpful to try to give you some more hints of what to ask tomorrow.
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
stim days 1-5: clomid 150
stim days 1-2: menopur 150 (with the clomid)
stim days 3-7: 225 menopur
stim day 7: 150 follistim
i was on estrace for approx. a month before starting stims and started stims on CD21. The day before I started stims I had an ultrasound and the nurse saw 8 follies on the right and four on the left. I don’t know how big my ovaries are. I know they’re small but I don’t know the measurements.
My ultrasound on stim day 6 showed 6 follies on my right and 2-3 on my left, none above 10mm but I don’t know how big each one was.
My last lab before starting estrace was in late February. My FSH was 8 and my E2 was 97. I had more labs done after starting estrace and had e2 of 210.
I think the labs labs from February were done on CD15.
Whew I realize I need much more info. @emmasemm you really need to switch professions and be a doctor!
At you’re appointment I would ask if it is possible that you were over suppresses from the long estrace priming protocol.
My stim protocol was always aproximatey 10 days of estrace and then 75 menopur and 225 follistim . Since your doctor is doing clomid and had not intended to introduce follistim until there was not a great response, and was doing 150 menopur, that is a pretty classic mini IVF protocol...
Stim days are supposedly still 9-10 days for a mini IVF cycle which is what a regular IVF cycle usually is too. I once stunned for a horrific 18 days on a regular IVF low dose cycle. Some doctors will let’s you continue to stim if there is no response at all for a few days and basically say that the first X days didn’t count because nothing was happening but that is so taxing, I feel like sometimes it’s just better to cancel the cycle and try another month, in your case possibly with less suppression with the down regulating. (Meaning less days of estrace before you stimulate the ovaries. You down rev to quiet the ovaries and hope to get the follicles to grow uniformly)
Good luck tomorrow lady. Hopefully you get some good news!
Homozygous MTHFR Cr677
DOR - AMH .27 High FSH (don't even know how high)
2 iui's to start - BFN
IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal
IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5
IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty
IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
Chemical pregnancy
FET#2 - PGS normal boy - BFN
Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
1st transfer - chemical pregnancy
2nd transfer - success, May 17 2020 due date!
Ok so I agree with @hopefuljj that your estrogen priming was waaaaaaay too long. 10-12 days max is what you want. You want to try to bring the follicles in line but not shut everything into a deep sleep. It should be started around 2-3 days after you ovulate in a normal cycle.
You should then get a bleed at the normal time for you - if you don’t have regular 28-30 day cycles they should have you on a progesterone such as provera to induce a bleed at the right time. But means you stop the estrogen just before you get your bleed.
On day 1 or 2 of bleeding you go for baseline. Baseline only works in the first days of the cycle - any other time is nonsense. You should just ignore your CD15 numbers.
At baseline you want to see as many very small antral follicles (2-5mm) on each ovary as possible - though I never saw more than 2 each side as my DOR is really very diminished. They should still measure those follicles in a DOR patient.
You should have E2 and FSH blood tests. E2 should be below 50 and FSH as low as possible under 10.
If either is higher you should skip the cycle.
If all is good you start stims that night.
If they really saw 12 follicles total then that’s not typical DOR - but is fitting with your fragile X finding. But without blood work who knows if they are antral follicles or not.
Not everyone responds to clomid well, so next time maybe just go traditional and use follistim etc from the start with the Menopur. You don’t need crazy doses. My best rounds were equivalent to 300 combined. Not mini but not maxi either.
The main thing is to get the fsh injections started before your own natural fsh production has kicked in. Otherwise you’re just wasting meds and see little effect.
See what you get at this next appointment but don’t be afraid to cancel sooner rather than later in this case. Ask for all the reports they have so far for this round, get them used to providing the reports after each appointment to you.
I think with a 10 day estrogen priming normal stim cycle you could see a different result. Ask them now about microdose Lupron instead of cetrotide too next round - the other fragilex ladies I know did better with MDL (Not started luteal, started same day as stims). But also fine to try once with cetrotide first if you will have multiple tries.
Good luck!
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
SD6
endo thickness = 5.8
left ovary= follies at 4.2, 5.6, 5.6
right ovary= follies at 4.0, 4.3, 5.4, 5.4, 6.3
SD8
endo thickness = 6.5
left ovary= 3.4, 3.4, 5.6
right ovary= 2.9, 3.6, 3.9, 4.2, 4.7, 5.1
left ovary size = 21.8 x 15.4
right ovary size = 14.9 x 14.7
they didn’t measure my ovary sizes on SD 6. And somehow the follies are shrinking???
I’ll get my E2 results back later today. I’m holding onto a ray of hope tenuously because there are follies there. But I did cry hard at first.
I’m going to also request full stims, MDL, and skipping the Clomid. @emmasemm with a cycle of IVF in line with my own cycle is there a chance my natural FSH will kick in too fast before I start the Stims? And I was curious how the AFC number doesn’t fit with DOR but does with Fragile X...how does that work?
anyway I hope everyone else’s stuff is humming along nicely! Thinking good thoughts for y’all @emmasemm @hopefuljj @bakerstreetboys @Imajin99 and everyone else ❤️
(Cycle day 3) and that is when you start the estrogen. So you start the estrogen on that day and then go in for baseline on cycle day 3 to see if you are cleared for stims. I know some women have done it without priming and I’d you don’t need it great.
Homozygous MTHFR Cr677
DOR - AMH .27 High FSH (don't even know how high)
2 iui's to start - BFN
IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal
IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5
IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty
IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
Chemical pregnancy
FET#2 - PGS normal boy - BFN
Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
1st transfer - chemical pregnancy
2nd transfer - success, May 17 2020 due date!
I agree with @hopefuljj that estrogen priming when used in the normal way should be ok, but for some people that can still be a bit suppressive... I would suggest to discuss what she suggested and a natural start with your RE.
Ask her about doing a baseline even on cycle day 2. If you can get in that short notice, I’ve even done it on CD1! The key thing is to start the stims (Menopur or Follistim or whatever you’re using) already before that FSH rises. My best cycles (with 7-10 days estrogen priming before) were with an FSH of only 3-4. Of course this is not my natural level!
What I’ve seen with a few other fragilex ladies is the number of follicles and eggs can be on the low end of normal, even if AMH is very very low. And I’ve seen this “difficult to get the follicles to grow” phenomenon before. It seems to be linked to the way the fragile x affects the ovaries and their response to the hormones.
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
How's everyone else doing?
I’m waiting to hear confirmation tomorrow that my donor has started stims! Time to crawl into my cave and hide until this part is over possibly. Eeeeeeek!
Homozygous MTHFR Cr677
DOR - AMH .27 High FSH (don't even know how high)
2 iui's to start - BFN
IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal
IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5
IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty
IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
Chemical pregnancy
FET#2 - PGS normal boy - BFN
Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
1st transfer - chemical pregnancy
2nd transfer - success, May 17 2020 due date!
@hopefuljj Eek that is so exciting! Will she be keeping in pretty close contact with you to let you know how it's going? I think I'd have to give my phone away so I wouldn't stalk her
I'm doing ok, thanks Just trying to keep calm and stay positive!
@emmasemm interesting about the Fragile X stuff. So maybe I have some good eggs still left in there but they’re just not responding. When’s your transfer slated for?
Thanks everyone one for the advice. I’m going to a conference and then a vacation mid June and the doctor mentioned we could use progesterone to delay CD1 until I get back although it probably should happen around that time anyway. Will that affect anything for my next cycle?
And has has anyone had luck with HGH? My RE mentioned it at one of our initial meetings but didn’t want to jump to it on our first cycle. And I’m kinda scared I’ll grow a new appendage with it or something 🤪
Homozygous MTHFR Cr677
DOR - AMH .27 High FSH (don't even know how high)
2 iui's to start - BFN
IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal
IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5
IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty
IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
Chemical pregnancy
FET#2 - PGS normal boy - BFN
Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
1st transfer - chemical pregnancy
2nd transfer - success, May 17 2020 due date!
hows your donor egg lady doing? How are you doing? Are you doing a fresh transfer?
i went in for a follow up with my RE today. We will be doing the HGH as well as MDL. I’ll go in for a baseline on CD3 for bloodwork and ultrasound, probably June 24th or so. Then we’ll start the stims if everything looks okay, Gonal F at 300 and menopur 150. She offered me to do either an estrace lead in for 10-12 days or without. I’m a little divided on it... I’m scared it will oversuppress me again but it also keeps the FSH in check. Any thoughts hive mind? 🐝
she did do do an ultrasound and found I had 2 good size follies. I don’t know if it’s bad that she didn’t see more 🤷♀️
hope everyone else else is plugging along!
Its up to you on the estrogen priming. I think 10 days would be worth to try- but you could also try to baseline one month without it. Just be prepared to skip that cycle if your FSH and/or E2 is tool high. If it is too high then you do the 10 days Estrogen priming at the end of that cycle, re- baseline and if ok start stims next time.
Also i still recommend to try getting baseline on CD2 if you can. Just to get one step ahead of your body...
AFM suffering extreme tiredness from the estrogen patches. So much that I changed my work schedule next week so I don’t have any long drives as it’s not safe. Funny how I had zero effects from the Lupron but estrogen kills me each time!
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
@lucyb1954 Sorry to hear about the cycle being cancelled however it looks like you have a good plan in place for the next cycle!
@emmasemm How you feeling? Did the tiredness let up? I am sure your transfer is coming up and that will be exciting!
bakerstreetboys How you feeling? Hoping its all been smooth.
@hopefuljj Happy to hear that all is working out with the donor cycle, any estimate on when the transfer will be?
AFM: Just hanging in there while I take this break. Travelling in July and then going to cycle in August!
@hopefuljj been thinking about you! I’m reading up more in DE to make me feel less stressed about our next cycle. I hope everything is going well!
@emmasemm hope the estrogen isn’t making you too crazy in the brain 🤪 are you close to transfer day?
I’m up in Victoria BC for a workshop this week and of course my computers motherboard went kaput and it’s my work computer so I can’t have folks other than my in house IT folks fix it. It’s probably my fault... I spilled some coffee on it but then it worked fine for the rest of the day until I tried to live-stream baseball.
And I’ve been waiting to ovulate so I can start the next batch of estrace and progesterone... when I saw the RE on Thursday I had one follies on each ovary measuring 15mm or so and she said she thought I would ovulate in the next 3 days. Well so far no surge... if it doesn’t happen tomorrow AM I have to find somewhere to get a blood test to make sure we didn’t miss it.
What a day 🙄 anyone else had this issue with ovulation? I’m crampy and definitely feel it should be happening but no 🎲 so far.
If you started and stopped meds last cycle it can throw out your ovulation a bit the next cycle. This is particularly common with DOR patients. Keep testing and get the blood test worse case.
You can give antral follicles a Google as some of the RE websites describe them - so the info is reputable.
But basically these are the follicles that have been “recruited” for a cycle, but which have not yet started to be exposed to the higher levels of FSH, so have not really started to grow. They should be big enough to be seen and with today’s ultrasound equipment if you have DOR they should be able to measure them quite easily. Under 5mm but typically 1-3mm range at baseline. However measuring is not really accurate as it differs per machine and person to person doing it, so that’s why they should check your E2 and FSH on the same day just to make sure that the bloodwork confirms they didn’t start to develop into “norma growing phase” follicles. Follicles as they grow cause estrogen to rise (not sure if they directly produce it or produce something else which makes other cells produce it...). So that’s why it’s important to check E2 as it tells you if what you see on the screen are really antral follicles (which don’t cause estrogen to rise) or already growing ones.
By recruited I mean, each month your body pre selects (some say could be 2-4 weeks before your AF starts) the follicles for the next cycle. These are the ones it chooses to become antral follicles - so the number you could max get is somehow already set in a natural cycle. This is where the estrogen priming works - to stop your ovaries moving onto the stage which causes the selected follicles to become antral in a desynchronized way and allow it to hopefully recruit a few more in that same month.
The whole feedback loop between hypothalamus, pituitary, ovaries, follicles and endometrial lining is a very finely balanced system. I find it pretty miraculous to be honest.
AFM well my lining Tuesday morning was 11.1mm and trilaminar. Which is record speed even for me after only 6 days of estrogen! I’m nervous it will get too thick and my cause a cancellation. Or something is growing that shouldn’t... let’s see... next US is Friday and we will also do bloods to make sure they are in line with what we see. Wednesday evening I had my first intralipids of this cycle - once again at home, on the sofa in my winter garden in the evening after work - definitely the lowest stress part of the process for me! I’m really hoping on Friday they say we can start progesterone etc on Friday or Saturday evening for a Monday or Tuesday afternoon transfer!
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
You’re again a font of information. I didn’t realize that’s why they measure your E2 on CD2-3. I tried to get a blood test here in Canada but they told me I needed a Canadian doctors order. But still no surge levels even though my follies were at 15mm a week ago. My RE told me yesterday to just keep testing so I’m going to call her again tomorrow and see what she wants to do. I wonder if we missed it even though I’ve been testing for a week 🤷♀️
Went for my ultrasound this morning, and you won’t believe it but due to a storm the entire doctors surgery had no power! No power means no ultrasound! I almost freaked out.
But then my lovely obgyn called her friend who has a practice the other side of the city and we drove over there together and the two doctors did my scan in her friends practice. Phew! I guess having see her almost every week for over a year makes me a special patient!
Ultrasound looked good - quiet ovaries, 12mm trilaminar lining...
Bloods came back with no progesterone as we wanted - but my estrogen is low. It’s weird as my lining is great... so now I’m upping the patches plus taking progynova three times a day.
All my other meds start tomorrow - then just need to book our flights and off we go!
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
39 years old DH 41. Sperm looks great. We live in San Diego
Me: ****TW loss mentioned***
MTHFR Homozygous 677TT (dx 2016)
hypothyroid
8/2018 Off birth control
11/29/2018 CP
2/10/2019. CP
3/8/2019 Saw fertility doctor, AFC 5, labs drawn
3/14/2019 Pregnant
4/18/2019 9 week ultrasound MM , stopped growing at 6 weeks, no HB. D&C
5/2/2019 Return to fertility doctor, labs show AMH 0.27. Diminished Ovarian Reserve
1st of 3 Egg retrievals planned tentatively for July
6/29/2019 started Antagonist Protocol
7/12/2019 First egg retrieval, only retrieved one egg and fell apart immediately, poor quality.
8/7/2019. Second cycle (follicular antagonist) canceled on day 5 of stims when a very large lead follicle grew out of nowhere.
11/8/2019. Second Egg retrieval with Lupron Flare Protocol. 2 eggs retrieved, fertilized with ICSI but no reaction occurred at all. Told I will never have my own babies with my eggs.
12/20/2019 ERA - pre-receptive. Needed 24 hours more of progesterone
2/2020 CP
3/2/2020 Egg donor cycle in Prague at Unica Clinic, 2 AA embryos, 1 transfer, 1 on ice. BFN. Due to pandemic, we could not return to Prague and will abandon our remaining embryo.
4/20/2020. BFP trying on our own!
06/04/2020 After HBs at 7 and 9 weeks, MM at 10 weeks 3 days. D&C, Hemorrhaged out 1 liter of blood from uterine artery rupture during procedure. Spent 1 night in the hospital with a balloon tamponade in my uterus. Baby was mosaic Trisomy 21.
8/2020. Moving forward with Donor Egg cycle at Utah Fertility Center and sharing a cycle with ladypOtter (Gina) I met on the Bump who was also supposed to go to Prague but couldn't.
9/26/2020 Donor retrieval of 26 eggs, 24 mature. Split cycle so I have 12 eggs with all 12 fertilizing. 6 PGS normal 3 boys, 3 girls
10/29/2020 Transfer day of girl donor egg embryo. BFP! First HCG 92.9. Then inappropriate rise, plateau and falling. Possibly ectopic pregnancy. ER visit with diagnosis of "pregnancy location unknown". CP
1/19/2021 Embryos shipped from Utah to my local clinic, starting prednisone for anti-histamine protocol.
2/26/2021 FET girl embryo BFP. Betas 62, 139, 386! HB at 6 weeks, then baby stopped growing at 8 week check up with weak HB measuring 6 weeks 4 days. MM at 9 weeks. D&C 4/15/21
7/13/2021 FET boy and girl embryos. First beta 10dp5dt 177, 14dp5dt 1631, 16dp5dt 6809. Pregnant with Identical triplets. At 9 weeks, Baby C no longer had a heart beat. Identical Twin Girls. Pregnancy complicated by TRAP Sequence with baby C an Acardiac fetus still receiving blood flow being pumped to it by other girls. Referred to UCSF at 18 weeks for consultation. No intervention needed at this time
2/18/22 After a failed NST, at 34 weeks 1 day, Charlotte born 4lb 4oz and Lily born 4lbs 10 oz. Our hearts are complete. Baby girls in NICU to grow and learn to eat.
@andreamm31 good luck with your first cycle!!! June 29th will be here in no time!
@lucyb1954 for whatever reason after IVF retrievals I started having extremely delayed ovulation! Like I would ovulate on CD 28!!! And end up with 38-39 day cycles every month! It drove me mad when cycling cuz I had this extra 10+ days of waiting always, to start the next cycle. It has since gone back to my norm which is ovulation around CD 18 and AF about 11 days later but it was messed up for a long time.
Homozygous MTHFR Cr677
DOR - AMH .27 High FSH (don't even know how high)
2 iui's to start - BFN
IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal
IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5
IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty
IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
Chemical pregnancy
FET#2 - PGS normal boy - BFN
Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
1st transfer - chemical pregnancy
2nd transfer - success, May 17 2020 due date!
Gkad you were also able to change your work schedule! Hoping you’ll be stress free for transfer and able to relax!! How many are you planning on transferring? So excited for you! Sending extra sticky vibes your way!!!
@hopefuljj how is your donor doing? Looking for an update not sure if I missed it! Hoping she has an amazing cycle for you with plenty of healthy embabies! Are you doing pgs? A fresh transfer? So very excited for u!!
@bakerstreetboys how r u feeling? How far long are you now? Hoping all is moving along well for u!
@Imajin99 hoping your vacay and break will do u good resulting in a great cycle for u in the summer!
@lucyb1954 these ivf riad is hard and cancelling sucks so bad but it’s great you get to try again a and have so much extra knowledge of what’s going on to help. Hopefully hgh will help, I hear it does work well when used, my RE for some reason didn’t allow it so it’s great that you have the option!!!
*****trigger****
thinking of you all and hoping for the best. Since it’s June I Wanted to share that my miracle love was actually from my June ivf cycle. Hoping this month will be successful for all!!!
Unexplained Infertility - but I am 40...Low AMH .30
7 - IUI (50mg-150mg Clomid) Feb - August 2016 all BFN
IVF#1 August 2016 (Antagonist protocol 4/5 eggs) Cancelled cycle RE thought I would get at least 10.
IVF#2 Sept 2016 (microdose luporn pro - disappearing follies, ONLY ONE, convert to IUI) BFN
IVF#3 November 2016 (4 ER, 3 F, 3DT)-BFP with TWINS // MC both at almost 10wks
IVF#4 March 2017 //EPP (10 ER (1 wonky so 9 ER) 7F, 3B (5AB, (2)5BB) PGS tested- ALL abnormal
IVF#5 April 2017 // EPP (7 ER, 7F yes! 6B) 2/5 day 4/6 day - 2 PGS normal! yes!!
IVF#6 May 2017 // Antagonist didn't have time for Estrogen Priming...(4 ER, 3 F, 3B) (5AB, (2) 5BB) 2 PGS normal, yes!!
IVF#7 June 2017 // EPP praying this is it and then on to an FET!
@lucyb1954 I think I missed something; why can't you get a blood test in Canada?
Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
March-May 2016: 1 TI and 2 IUIs- BFN
June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze ), BFN
May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline
Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid
Nov 2017- Hysterscopy to remove polyp
Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
Apr 2018- DE FET cancelled for lining issues
Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
Baby Born born early @ 33.5 weeks due to Pre-e
Back for # 2!
Homozygous MTHFR Cr677
DOR - AMH .27 High FSH (don't even know how high)
2 iui's to start - BFN
IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal
IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5
IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty
IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
Chemical pregnancy
FET#2 - PGS normal boy - BFN
Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
1st transfer - chemical pregnancy
2nd transfer - success, May 17 2020 due date!
@jamieh2000 just love the latest photos of your little man. His character really shines through!
@hopeful_mom it’s going to be a comedy movie for sure at the end
@hopefuljj hoping for some good news from your donor
@bakerstreetboys I guess your anatomy scan must be soon?
@lucyb1954 I also needed to travel during stims etc sometimes and it takes planning for multiple scenarios and dogged determination to get what you need done. I mostly had backups of backups ready to go and never used them, but backups make me feel comfortable. Or you have to accept skipping a cycle every now and again. Depends if all the planning for something you might never need is more stressful than skipping for you. We’re all different. Hope you enjoy your trip home - some awesome scenery along the way!
AFM
Sorry I didn’t update yesterday (Tuesday) as we were so late home we just crashed straight to sleep.
Short version - transfer went super smoothly and we now have two great quality day 3 embryos on board!
Longer version in spoiler ;-)
This transfer was such a different experience to my previous two when I just went in on my lunch break and it was very clinical in comparison.
We got up at 4am to go and catch our flight. DH can sleep anywhere so must have recovered about 4 me hours during the day - me, I was wide awake the whole time! The flight landed on time (a rare occurrence in itself!), the journey by train into London was smooth and we dropped into the clinic to sign the final paperwork so they could thaw our embryos. Now, *maybe* we all had a giggle over how well known my instructions were on which embryos to thaw in which order and under which circumstances... as in even the receptionist knew!
When we went to buy our London Underground tickets I paid with my card, but when I fished the tickets out someone had left a penny - which we took as a good luck sign. It’s safely tucked in a special part of my wallet.
Having been ALL about the science for the last two years, I’m now willing to throw any kind of magic into the mix too - so quite happy when someone told me it’s a full moon and this Friday is the summer solstice! Plus it’s the anniversary of our first date this week!
In between we went for breakfast and DH had a coffee, then back for transfer. It was going to be delayed as they’d had a more complex retrieval in the morning, and the girl before me for transfer was super stressed about it. In the end we got to go in on time ahead of them because she emptied her bladder by mistake...
There were lots of hugs all round with the staff before we even started, everyone was really quite emotional. More than me! I wore my special socks and kept my sunglasses on underneath the hair net which just added a touch of glamour to the proceedings!
They were so lovely in explaining everything as we went along to DH - as he’s not quite as familiar with my uterus as I am! Catheter placement was straightforward and the embryos came out of their catheter first time. We could clearly see where the little bit of fluid with the embryos in ended it and how it came to rest over the next minutes. Text book placement!
Both the embryos we selected thawed perfectly - they even had already continued dividing by the last check before they went into the catheter which is very encouraging and the embryologist upgraded them to their best grade for day 3s!
Some of you may know there is a rumor that laughter is good for implantation... well I’m not sure laughing during transfer is indicated, but they were playing some music in the background and at the moment the Cather came in the room with the embryos it switched over to Sade “Smooth operator” which had us all in stitches! DH proceeded to do a mock slow dance to it and so I was giggling the whole time.
They also let him take all the photos he wanted of the screens and catheter etc.
Afterwards we went to a really nice Argentinian steak restaurant and had a “date” together with really great food using only bio ingredients and a completely plastic free environment.
After that we took a taxi to a different airport to fly home - but with a few hours to spare where DH made a presentation for work and I just watched the world go by.
Flight home was delayed for take off - but we had a good tailwind and landed pretty much on time - so home just after 11pm last night and pretty much fell straight asleep!
Today is the start of my “TWW retreat” - well it’s more a staycation. Previously I worked as normal - but this time I’ve taken the whole time to beta off and have lined up some relaxing gentle activities to keep me busy but hopefully also keep me relaxed. We all know normal stress levels have nothing to do with success or failure, but my job can be a bit higher stress sometimes and as we’ve spent a crazy amount of money and time we don’t want to look back and wonder “what if I’d take then time off”. DH is still working and next week is away on a course, so hoping I don’t go too stir crazy!
Once again thanks so much for all thinking of us - it really does mean a lot.
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
AFM: i know a few few people have asked for updates, I’m sorry I’ve been so quiet, I’m waiting on the report of what we have biopsied for PGS and frozen. I find out Friday. We had 12 growing the day after fertilization. (20 eggs, 16 mature, 12 fertilized and growing the next day). Feeling pretty nervous and panicked so staying sorta quiet about it all. Thanks for thinking of me ladies:)
Homozygous MTHFR Cr677
DOR - AMH .27 High FSH (don't even know how high)
2 iui's to start - BFN
IVF 1 -3 made it do day 5! 2 5AA 1 6BB PGS results = all abnormal
IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty. Nothing made it to day 5
IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
IVF 5 - Canceled - looked like 1 follicle and we were afraid it was empty
IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS
Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!! 1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.
FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
Chemical pregnancy
FET#2 - PGS normal boy - BFN
Natural pregnancy - cycle following the FET2???? Miscarriage at 8 weeks. viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal
DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
1st transfer - chemical pregnancy
2nd transfer - success, May 17 2020 due date!
Thiugh looking at the numbers so far it seems your clinic has tried to balance the quality and quantity with the donor. Come on embryos!!!
Married 12/2016
TTC #1 since 04/2015
AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
7 retrievals, 3 transfers
Nov17 IVF2 - 1ER, 0F
Jan18 IVF3 - 3ER, 1F, 1ET, BFN
Feb18 - second opinion and additional testing
Apr18 IVF4 - cancelled (E2 too high)
May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
Aug/Sep18 IVF7 - cancelled (cyst)
Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
Oct18 IVF8 - Cancelled (cyst and too low TSH)
Oct18-Jan19 bringing TSH under control
Feb19 ERA and hysteroscopy
Mar19 Investigation for fibroid and adenomyosis
Apr19 adenomyosis confirmed, polyps removed
Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality
Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return
@emmasemm I love your transfer day story! Enjoy your TWW off work and keep busy!
I’m looking forward to updates from you ladies!
AFM, nothing new or exciting to report. I will push to get the anatomy scan done as early as possible, so hopefully in another three weeks or so. Until then, I’ll just hope that little boy keeps growing in there!