Infertility

Low AMH Level

18384868889167

Re: Low AMH Level

  • Just spoke to my RE and he wouldn’t put me on Provera to induce my period as my estrogen is low which means my lining is thin.  He can put me on birth control but is afraid it’ll suppress my ovarian response for the cycle.  So, recommends repeating the blood test in 2 weeks and seeing where I’m at then. Ughhhhhh :s
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  • @adc0417 oh jeez:-/ I’m sorry lady! That is so frustrating! It is so hard to walk around in these bodies that simply won’t do what we want them to do!   

    AFM finally got a positive OPK.  Exactly when I expected! CD 25.  Insane.  Thanks IVF!  Anyway at least I was able to schedule the EFT.  Still awaiting alllll the blood work from the different labs for the autoimmune panel and the blood clot panel!  RE is on vacation so I expect them early next week.  Although she is of course checking email because she responded to me at 8am this morning (I emailed at 7am) and coordinated setting up my EFT  and sent me the plan.  I don’t think she’s ever really on vacation. 
    Me: Hashimoto Autoimune Disease
    Homozygous MTHFR Cr677
    DOR - AMH  .27 High FSH (don't even know how high)
    2 iui's to start - BFN 
    IVF 1 -3 made it do day 5!    2 5AA 1 6BB  PGS results =  all abnormal :(
    IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty.  Nothing made it to day 5
    IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
    IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
    IVF 5 - Canceled -  looked like 1 follicle and we were afraid it was empty
    IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS

    Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!!  1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.

    FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
    Chemical pregnancy
    FET#2 - PGS normal boy - BFN
    Natural pregnancy - cycle following the FET2????   Miscarriage at 8 weeks.  viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal :(

    DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
    1st transfer - chemical pregnancy
    2nd transfer - success, May 17 2020 due date!
  • @adc0417- I am so sorry for the further delay. I was in limbo for 2.5 months last winter and they some of my hardest times during this journey ever. Thinking of you.

    @hopefuljj- yay for getting things scheduled! that is great your RE is so responsive! It really is amazing when our REs go above and beyond like that.

    @ilky- congrats on your report! I hope day 5 is just as good! Keep us posted!


    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
  • @ilky-  great report indeed - grow embabies grow!!  looking forward to the next one!!

    @adc0417 sorry for the delay it sux but we all want things to be as perfect as can be during this process!!

    @hopefuljj yea for ovulation u really know your body girl ;)  Try and catch up on some sleep!  I actually taped the remainder of the olympics the last few nights as bode millers boring tone just kills me...there's just no excitement in his voice at all...he was putting me to sleep!  I felt terrible for Von...she literally just had to get down the mountain, poor thing!!  I was so looking forward to the female skaters and I just felt terrible for USA!  Who knew the highlight was going to be the team event...at least they all looked lovely  :D  I missed Apollo in these games though...so speed skating wasn't as much fun too watch...but regardless I still had them on.

    @emmasemm not sure if i missed an update from you...you're probably busy with your thesis....
    History of TTC in spoiler box
    TTC since 2014
    Unexplained Infertility - but I am 40...Low AMH .30
    7 - IUI (50mg-150mg Clomid) Feb - August 2016 all BFN 
    IVF#1 August 2016 (Antagonist protocol 4/5 eggs) Cancelled cycle :( RE thought I would get at least 10.
    IVF#2 Sept 2016 (microdose luporn pro - disappearing follies, ONLY ONE, convert to IUI) BFN
    IVF#3 November 2016 (4 ER, 3 F,  3DT)-BFP  with TWINS // MC both at almost 10wks  :'( 
    IVF#4 March 2017 //EPP  (10 ER (1 wonky so 9 ER) 7F, 3B (5AB, (2)5BB) PGS tested- ALL abnormal  :'( 
    IVF#5 April 2017 // EPP (7 ER, 7F yes! 6B) 2/5 day 4/6 day - 2 PGS normal! yes!! :)
    IVF#6 May 2017 // Antagonist didn't have time for Estrogen Priming...(4 ER, 3 F, 3B) (5AB, (2) 5BB) 2 PGS normal, yes!! :)
    IVF#7 June 2017 // EPP praying this is it and then on to an FET!

  • Sorry for being a bit awol this week. Crazy busy days.

    @ilky Great embie development!

    @adc0417 oh I hope you’re not waiting too much longer

    @hopefuljj oh that’s so good you Od and can get moving!

    @jamieh2000 my suggestion would be do a bunch of things you can’t do KU or that will be more difficult after - spur of the moment weekend breaks, getting tipsy in a fancy bar, go up an indoor climbing wall, go in one of those indoor skydiving centers... 

    @hopeful_mom thanks for asking, no I was quieter this week, but love titting as much as I could

    Though today was a good day.
    I had my appointment with the haematologist and she did a crazy amount of blood work and I go back in just under two weeks for the results. She took me very seriously and said we were absolutely right to go to her to get everything else checked. And she said regardless of whether it helps TTC, if anyone plans multiple injectibles cycles they should be on baby aspirin as a prophylactic to heavily reduce the risk of thrombosis from abnormally high estrogen levels over a prolonged period of time.
    I also finally found a great place to do local monitoring! It seems to be “the” place for all the lesbian couples to go to for their IUIs so they’re used to measuring follicles and linings etc. And I can get US whenever I want, just drop in first thing in the morning, easy peasy. 45 Euro a Time. Blood work same day no problem at all. And they’ll even email the report in English to my new RE before 4pm every day (I’m in Germany so I was expecting to have to act as intermediate translator. I could have kissed the nurse when she explained it all to me after I’d seen the doctor!
    And finally I got written confirmation we can do the karotyping here in country. Just need to call for the appointment date/time on Monday. 
    In other news, I’m at the end of CD30, think I Od between CD17 and CD21, so am now waiting to see when AF shows up. I’m pleased this cycle has been a bit longer as it hopefully lines up end of March to start the first IVF cycle with the new RE.
    You know me, I need a plan ;-)
    And yes, also trying to write my thesis in the middle of all this and work. Six weeks and I hope I am finished. Only six weeks seems not enough time, but I am determined not to take the extension as I just want it done now.
    But for tonight it’s time for bed after a nice dinner out with DH :-)
    Me 43 DH 45
    Married 12/2016
    TTC #1 since 04/2015
    AMA, DOR (AMH 0.65, AFC 2-4) and autoimmune issues (RA, APS), low TSH, adenomyosis
    7 retrievals, 3 transfers
    Jun19 FET BFP, due date 7th March 2020, DD born Feb20
    Sep17 IVF1 - 1ER, 1F, 1ET, BFN
    Nov17 IVF2 - 1ER, 0F
    Jan18 IVF3 - 3ER, 1F, 1ET, BFN
    Feb18 - second opinion and additional testing
    Apr18 IVF4 - cancelled (E2 too high)
    May/Jun18 IVF4 - 4ER, 0M, 1F, 1 frozen day 3 (not best quality)
    Jun/Jul18 IVF5 - 5 ER, 3M, 2F, 2 frozen day 3 (not best quality)
    Jul/Aug18 IVF6 - 4ER, 3M, 2F, 2 frozen day 3 (good quality)
    Aug/Sep18 IVF7 - cancelled (cyst)
    Sep/Oct18 IVF7 - 3ER, 3M, 2F, 2 frozen Day 3 (excellent quality)
    Oct18 IVF8 - Cancelled (cyst and too low TSH)
    Oct18-Jan19 bringing TSH under control
    Feb19 ERA and hysteroscopy
    Mar19 Investigation for fibroid and adenomyosis
    Apr19 adenomyosis confirmed, polyps removed
    Jun19 FET after 2 months Lupron, autoimmune protocol, transferred two day 3 frozen embryos
    Sep17 - Pergoveris 10-17 Sep, Orgalutran 15-18 Sep, Ovitrelle 18 Sep, ER 20 Sep for 2 follies, 1 mature egg, fertilized, ET 1x 2d 4-cell embryo 22/09, 05/10 BFN
    Nov17 IVF2 - Pergoveris 2-14 Nov, Orgalutran 5-14 Nov, Ovitrelle 15 Nov, ER 17 Nov for 3 follies, 1 mature egg, did not fertilize
    Jan18 IVF3 - Pergoveris 30 Dec - 8 Jan, Orgalutran 5-8 Jan, Ovitrelle 9 Jan, ER 11 Jan 3 eggs, 2 mature, 1 fertilized, ET 1x 4d 12-cell embryo 15/01, 24/01 BFN
    May/Jun18 IVF4 - Rekovelle 25-29 May, Menogon 30May - 2Jun, Zomacton 25 27 29 31 May and 2Jun, Cetrotide 30May - 3Jun, Gonasi 3Jun, ER 5Jun 4 eggs, none mature, two matured overnight, 1 fertilized with ICSI, Frozen day 3 but not good quality
    Jun/Jul18 IVF5 - Rekovelle 21-24 June, Menogon 25Jun-3Jul, Puregon 4-5Jul, Zomacton 21 23 25 27 29 Jun, Cetrotide 25Jun-5Jul, Gonasi 6Jul, ER 8Jul 5 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 but not good quality
    Jul/Aug18 IVF6 - Rekovelle 26-29 Jul, Menogon 30Jul-7Aug, Buserelin 26Jul-7Aug, Zomacton 26 28 30 Jul 1 3 Aug, Gonasi 7Aug, ER 9Aug 4 eggs, 3 mature, 2 fertilized (normal IVF), 2 frozen day 3 good quality
    Sep/Oct18 IVF7 - Menogon 19-30Sep, Buserelin 19-30Sep, Zomacton 19 21 23 25 27 Sep, Ovitrelle 1 Oct, ER 3 eggs, 3 mature, 2 fertilized with ICSI, 2 frozen day 3 excellent quality 

    Fav Quote: The greatest thing you'll ever learn is just to love and be loved in return

  • @Ilky wonderful update lady!!!! Grow embabies grow!! Next update is Sunday?

    @Hopeful_mom thank goodness the Olympics are over Saturday! I can not keep up with this insane sleep schedule! I feel like a zombie when I get to work the next day! Speed skating was crazy last night because Korea ended up not dominating!  And poor us ladies for figure skating:( but my god those Russians are amazing!!  

    @emmasemm that is so great about the clinic for local monitoring!! I’m so excited that things are all coming together for you!  I bet/hope/pray your March cycle will exceed your expectations:). Good luck with the thesis writing! I hear you on not wanting to extend it, just get it done so that it is in the past:)
    Me: Hashimoto Autoimune Disease
    Homozygous MTHFR Cr677
    DOR - AMH  .27 High FSH (don't even know how high)
    2 iui's to start - BFN 
    IVF 1 -3 made it do day 5!    2 5AA 1 6BB  PGS results =  all abnormal :(
    IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty.  Nothing made it to day 5
    IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
    IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
    IVF 5 - Canceled -  looked like 1 follicle and we were afraid it was empty
    IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS

    Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!!  1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.

    FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
    Chemical pregnancy
    FET#2 - PGS normal boy - BFN
    Natural pregnancy - cycle following the FET2????   Miscarriage at 8 weeks.  viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal :(

    DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
    1st transfer - chemical pregnancy
    2nd transfer - success, May 17 2020 due date!
  • @emmasemm- YAY! so happy you found a place for local monitoring. What a relief! Sounds like things are coming together and timing may line up. Let's get this party started!!

    @ilky- any update on your embabies?! you are doing PGS right?

    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
  • @JamieH2000 yes, we got the call yesterday. I was so down yesterday :( 3 embryos didn’t make it to day 6. 4 biopsied and 1 will be checked today. Dr will call me today on the fate of the last one. Then they will be off to pgs testing. I guess I wasn’t expecting 50% of loss, which seems about average. I’m just concerned and worried about the pgs results. I’d love to have at least 2-3 good quality embryos since we don’t even know if the first try will work. I don’t know how I will make it another week to get results... trying to not lose hope and pray, but with all the raging hormones not helping right now :)
  • @ilky- I totally get it, I would feel the same. I know its not much comfort, but I actually think 4/8 is above average! When I had 6 at day 3 my RE said she only expected to have 1-3 left at day 5/6. So hopefully they are good quality and with your age, 50% or more should be normal, so I am crossing everything that at least 2-3 come back normal! that is such a great result with low AMH! Hope the rest results come ASAP since I know the wondering is just the worst!
    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
  • @JamieH2000 Thank you darling! I know, I should be grateful considering I didnt have any for the first 3 IVF tries. I really do think the things that I did in between the IVF #3 and IVF #4 helped tremendously. I was surprised of the # of eggs, embryos I got too!
  • Ilky  Thats great news!  I know its sad when all our embabies don't make it through, lets hope your golden eggs are this batch!  Each step of this process is not easy, hoping this week goes by super fast!  Hang on there! 

    @emmasemm yay for finding a good spot for monitoring!  I'm feeling great for this next round!  I hate that you have so much going on but you thrive through it all!  Hope you will find some time to relax while stemming and let those follies grow!!!

    @hopefuljj Thrilled hockey finally got gold, didn't realize how long its gone on for.  The Russians were great indeed...I still even they weren't judged fairly, the older girl deserved the extra point for her free skate, can you tell I paid attention  :D  Its crazy that they are both so young and yet they may not be at the following Olympics.  Glad you can get your beauty sleep back ;)
    History of TTC in spoiler box
    TTC since 2014
    Unexplained Infertility - but I am 40...Low AMH .30
    7 - IUI (50mg-150mg Clomid) Feb - August 2016 all BFN 
    IVF#1 August 2016 (Antagonist protocol 4/5 eggs) Cancelled cycle :( RE thought I would get at least 10.
    IVF#2 Sept 2016 (microdose luporn pro - disappearing follies, ONLY ONE, convert to IUI) BFN
    IVF#3 November 2016 (4 ER, 3 F,  3DT)-BFP  with TWINS // MC both at almost 10wks  :'( 
    IVF#4 March 2017 //EPP  (10 ER (1 wonky so 9 ER) 7F, 3B (5AB, (2)5BB) PGS tested- ALL abnormal  :'( 
    IVF#5 April 2017 // EPP (7 ER, 7F yes! 6B) 2/5 day 4/6 day - 2 PGS normal! yes!! :)
    IVF#6 May 2017 // Antagonist didn't have time for Estrogen Priming...(4 ER, 3 F, 3B) (5AB, (2) 5BB) 2 PGS normal, yes!! :)
    IVF#7 June 2017 // EPP praying this is it and then on to an FET!

  • moly416moly416 member
    edited February 2018
    Hi all,
    Just wanted to introduce myself and share my story - I've been browsing this thread for a while and find all of you very inspiring! I've posted in a different thread before about my first IVF cycle which yielded zero embryos. It was a bit of a conundrum as I had a significant number of follicles, more than a dozen, but only ended up with 4 eggs collected during ER. Only 2 were mature and end up being fertilized - we opted for PGS/FET - and none had made it to the blastocyst stage. 
    At my WTF appt, the doctors suggested that I had started with too low of a dose of stimulants and recommended to start with the maximum dosage in the next IVF cycle. It seemed reasonable to me. We re-did some blood work and lo and behold, a few days later, I find out that my AMH had dropped to 0.6 ng/mL. It was at 2.8 about a year ago. This could very well explain the results of my first cycle. My RE is still very positive because my AFC is ~15 from last November. Has anyone experienced this drastic change in AMH? I've been taking folic acid and vitamin D the past few months, too! I guess a year really matters in fertility. Because of this result, I decided to do a fresh transfer just in case we don't get more embryos next time around. 
    History in Spoiler
    Me: 34 DH: 31
    Dx: PCOS with history of endometrial cancer (under control with hormone therapy)
    RE advised IVF as fastest way to get pregnant before hysterectomy
    IVF #1, Jan 2018: Tons of follies, only 2 eggs, zero blasts :(
    IVF #2, April 2018: 22 eggs-> 16 mature -> 9 fertilized -> 3 5-day blasts -> 2 PGS normal
    FET#1 June 2018


  • @moly416 Welcome!! So sorry to hear about your first IVF cycle being unsuccessful and such a drastic drop in your AMH.  Can I ask you how old you are?  I haven’t heard about such a significant drop in AMH in one year, but I think the age can impact that.  You should also look into CoQ10 and DHEA.
  • @adc0417 I just turned 34 in december. I really should work on my signature. They did just advise me on the coq10 and dhea.
    History in Spoiler
    Me: 34 DH: 31
    Dx: PCOS with history of endometrial cancer (under control with hormone therapy)
    RE advised IVF as fastest way to get pregnant before hysterectomy
    IVF #1, Jan 2018: Tons of follies, only 2 eggs, zero blasts :(
    IVF #2, April 2018: 22 eggs-> 16 mature -> 9 fertilized -> 3 5-day blasts -> 2 PGS normal
    FET#1 June 2018


  • @moly416 sorry you are having difficulties. Just popped by to suggest also taking vitamin D. If your level is low, it can artificially lower your amh level, from what I’ve read. Good luck!
    Me:32 DH:36
    Me: DOR, poor egg quality, MTHFR
    DH: MFI
    TTC since 3/2014
    2015: 3 IUI's-BFN
    12/2015: 1st IVF cycle-(9 follicles retrieved, 5 mature, 3 fertilized w/ICSI, transferred 1 excellent and 1 good embryo on day 3)-chemical pregnancy
    3/2016: 2nd IVF cycle- canceled (3 follicles retrieved, 3 mature, all fertilized w/ICSI, 1 fragmented, 2 arrested) 
    3/2016: RE suggested donor eggs- taking an ivf break and to supplement 
    9/2016: 3rd ivf cycle-cancelled due to early ovulation
    Oct./Nov 2016: 4th ivf cycle- EPP-AFC:5, retrieved 10, 10 mature, 8 fertilized with ICSI, 6 blastocysts biopsied and frozen. 3 CCS normal embryos
    1/9/17: transferred 1 embryo-BFP 1/16
    1/18/17: beta #1-104
    1/20/17: beta #2-174
    2/2/17: first u/s, heartbeat of 107 at 6w1d
    7/20/17: baby boy born at 30+3 via emergency c-section 


  • @moly416- I believe that follcile count is much more important than the AMH number and usually much more indicative of IVF success. I believe they didn't give you the right protocol or triggered you too early. They should be able to get more mature eggs. I think it makes sense to start with max stims next time. Unfortunately sometimes it takes more than 1 cycle to figure out the best protocol. Were you on birth control before your cycle? That ruined my first one. My second one wasn't better with micro dose lupron. The third time we did estrogen priming with antagonist and that was the ticket for me to get more eggs (see my siggy details). Best wishes and keep us posted!
    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
  • Thank you so much ladies for the advice! 

    @Kp214 I had been taking Vitamin D but this winter has been dreary and the sun hasn't really shown itself the past months. Maybe it wasn't enough Vitamin D. I was taking 2,000 units daily.

    @JamieH2000 I was on Mirena IUD which shouldn't really have anything to do with the ovaries. They also did say they wanted to do a dual trigger this time ~ lupron and Ovidrel. 
    History in Spoiler
    Me: 34 DH: 31
    Dx: PCOS with history of endometrial cancer (under control with hormone therapy)
    RE advised IVF as fastest way to get pregnant before hysterectomy
    IVF #1, Jan 2018: Tons of follies, only 2 eggs, zero blasts :(
    IVF #2, April 2018: 22 eggs-> 16 mature -> 9 fertilized -> 3 5-day blasts -> 2 PGS normal
    FET#1 June 2018


  • @moly416 You might consider increasing that dose. 
    Me:32 DH:36
    Me: DOR, poor egg quality, MTHFR
    DH: MFI
    TTC since 3/2014
    2015: 3 IUI's-BFN
    12/2015: 1st IVF cycle-(9 follicles retrieved, 5 mature, 3 fertilized w/ICSI, transferred 1 excellent and 1 good embryo on day 3)-chemical pregnancy
    3/2016: 2nd IVF cycle- canceled (3 follicles retrieved, 3 mature, all fertilized w/ICSI, 1 fragmented, 2 arrested) 
    3/2016: RE suggested donor eggs- taking an ivf break and to supplement 
    9/2016: 3rd ivf cycle-cancelled due to early ovulation
    Oct./Nov 2016: 4th ivf cycle- EPP-AFC:5, retrieved 10, 10 mature, 8 fertilized with ICSI, 6 blastocysts biopsied and frozen. 3 CCS normal embryos
    1/9/17: transferred 1 embryo-BFP 1/16
    1/18/17: beta #1-104
    1/20/17: beta #2-174
    2/2/17: first u/s, heartbeat of 107 at 6w1d
    7/20/17: baby boy born at 30+3 via emergency c-section 


  • @hopeful_mom I’m so with you about Medvedeva!!!  They were both amazing but I did want her to get gold:). 

    @ilky I totally understand how you feel:( your results were really great though! Above average for sure! I would be thrilled with those results!  It’s so wonderful that you were able to have such great results after the previous cycles, everything you did really paid off! You should be proud of your body:). I’m crossing absolutely everything for you and can’t wait to celebrate when you get great PGS results!!!!  Hope this wait goes by fast for you:) you are strong and patient, you’ve got this!!

    @moly416 I echo everything these ladies already said.  I would be less worried about the amh and focus on afc.  And for sure take vitamin D if it is low.  Here is my question... my amh is .27 (or so it was a year ago, god knows what it is now...). Sometimes I produce an ok amount of follicles, like 6-7 (ok amount for DOR) but then most are empty:(. Is this what happened when they only retrieved 4 from the cycle you had more than a dozen follicles?  
    I read an insane amount on issues with trigger causing empty follicles vs empty follicles for other reasons etc.  In my case, I do fear it was an egg quality issue (I just turned 37, did all my retrieval’s at age 36) and I suspect quality issues were likely from my Hashimoto autoimmune disease or from endometriosis which I have no symptoms of by my RE suspects.   I’m curious what your clinic said to you in regards to what you retrieved?  I very highly recommend taking HGH (human growth hormone, aka omnitrope) which is as far as I know always out of pocket, but might help with egg quality.  It really is all such a mystery to be honest in regards to what works and what doesn’t. I basically did the same protocol except on my canceled cycles where I tried to up my dose by a lot and had a dominant follicle alone in a ghost town both times, and had wildly different outcomes each round.  I have not done the DHEA because with my thyroid issue it could be problematic but I very highly recommend a high dose of COQ10 for a couple months to assist with egg quality and 200 mg  vitamin E twice a day. 
    Good luck!!

    AFM - doing my weird Yale EFT receptivity test Monday! My sister is picking me up with my as of today  6month old niece!!!! I can’t brlieve she is 6 months old!!!!!  She’s going to drive me up to Westchester and spend the day with me and I’m so excited about it:) I got all my insane blood work results and mostly they were good, the active killer cells (which I know is basically bullshit) are quite elevated so she is actually recommending  I to do intralipid therapy and take low dose prednisone for transfer! Which I had begged for and she said no.   I’m happy because based on everything I have read, with the Hashi, I am more likely to have high levels of uterine killer cells than not, so if I can’t get that tested for I would rather do all the weird shit because it took me 1 year to get myself here with 2 embryos for transfer.  So the girl who got allergy shots for a year (and now for 3.5 yrs) before getting pregnant just so she wouldn’t even have to take a Zyrtec while pregnant (I’m allergic to my cat...my baby girl) is like GIVE ME ALL THE DRUGS!  I’ll take anything!    Oh how things change on this journey and expectations get reset constantly.  The only thing hanging over my head is that I never went to Jersey to find a doctor to do an ERA.....
    Jaime!  If the first transfer doesn’t work, I might have to book me a flight to Chicago)!!!!!!!!!  
     
    Me: Hashimoto Autoimune Disease
    Homozygous MTHFR Cr677
    DOR - AMH  .27 High FSH (don't even know how high)
    2 iui's to start - BFN 
    IVF 1 -3 made it do day 5!    2 5AA 1 6BB  PGS results =  all abnormal :(
    IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty.  Nothing made it to day 5
    IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
    IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
    IVF 5 - Canceled -  looked like 1 follicle and we were afraid it was empty
    IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS

    Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!!  1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.

    FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
    Chemical pregnancy
    FET#2 - PGS normal boy - BFN
    Natural pregnancy - cycle following the FET2????   Miscarriage at 8 weeks.  viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal :(

    DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
    1st transfer - chemical pregnancy
    2nd transfer - success, May 17 2020 due date!
  • IlkyIlky member
    I got my PGS results!!! We have 3 normal embryos! Yay! I'm so happy, although a little sad for the ones didnt make. I cant wait to have my period now lol. It's been 11 days I hope it will come soon. If everything goes well (pray to God) then my transfer will be around the 3rd week of March smiley

  • @hopefuljj- wow I am so glad you did that bloodwork and that your RE is willing to add in the drugs you wanted! Now I am wondering if I should insist on the same testing! For the intralipids, I feel like I have heard thats not covered by insurance and really expensive? I hope thats not the case for you, but curious if it would be covered for me even. My thyroid antibodies were elevated, but only slightly over the range, so I may have some very mild Hashi too. My mom had Graves (opposite of Hashi) so thyroid issues are in my family too. I think there is def a correlation between some of this autoimmune stuff and DOR/quality issues. I really hope science figures this all out soon! I am not sure if I posted, but I will be adding in doxy (antibiotic) and Medrol (steroid) this time, per my request. My RE said its an older school protocol, but it can't hurt so I figured why not. I wonder how different predisone and medrol are? Anyways, yay for getting the EFT done and seeing your niece! So glad you are going to get to transfer soon :) probably April?

    @ilky- congrats girl, that is a great result for you I think! How exciting!! Are you doing an a natural FET or medicated FET? 
    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
  • IlkyIlky member
    @JamieH2000 thank you! We will be doing a medicated one. I dont think my doctor even considers a natural one. We didnt discuss that option and a few people I know who went to him they all did medicated cycles. Fingers crossed! 
  • edited March 2018
    @Ilky What did you do differently between ivf #3 and #4? I'm finally able to join the convo now. I've had 4 failed IUIs and am proceeding to IVF. Just got my protocol for estrogen primed antagonist protocol. Found out that this protocol requires 2 months just to get to retrieval, then one month off, then transfer month. So a total of 4 months to find out if the IVF worked. My acupuncturist recommended me to take a month off from stims to just do acupuncture and herbs to prime for IVF. I'm on the fence about it because i've been going to another lady for acupuncture since November and have never stopped my sessions. My AMH was tested september 2017 to be 0.898. I don't want to waste any more time but off course, want to give this IVF the best possible chance of success since it is such an expensive investment. My RE doesn't want me on herbs while we are cycling, so i can't do them together. What do you ladies recommend?
    ***** child/loss TW *****
    Age: 32 DH: 35
    natural pregnancy DD 2012 TTC #2 since 2014
    9/2015 chemical pregnancy
    Initial workup: 
         AMH: 0.898 ng/ml
         Antral Follicle Count: 5
         FSH day 3: 6.56 mIU/ml
         LH day 3: 5.24 mIU/ml
         Estradiol day 3: 46.75 pg/ml

    IUI 1-4 BFN

    IVF #1 After ovulation was confirmed with progesterone levels on CD19. Cetrotide ½ dose X4 doses and minivelle was started CD 20 to continue through stim. Upon AF, started follistim 150 bid and menopur 75 bid on CD3. Started cetrotide 1 dose when biggest follicle reached 13mm. Retrieved 4 eggs out of 12 follicles, 2 PGS normal, FET #1 9/14/18 BFP beta#1 10dp6dt 369, 12dp6dt 1210 
  • IlkyIlky member
    @babyhopeful442 I'm sorry you need to go through this whole process, but I definitely understand why you dont want wait any longer and get on with it. 
    I took two months of between the #3rd and the #4th IVFs. As you can see from my siggy, 3rd one got cancelled even before it started due to low AFC and high FSH (my AMH is 0.56). I did so many different things in that time so I dont know which one worked but I feel like its a combination of some or all. Here is the list. Feel free to ask if you need any details on any of them.
    - 400mg Uniquinol (200 x2)
    - onion tea (boiled onion water drink 2x for 3 weeks)
    - acupuncture 2x week
    - mayan abdominal massage therapy once every week (except during menses)

    The above are just the new things I started. I had already been doing natural prenatals, B12+folate (I have mthfr), b complex, vitamin d, selenium and magnesium. I'm also gluten, and dairy free. I dont eat sugar (including naturally sweet fruits like peaches) and I eat very limited carbs. In addition to all supplements above I believe taking liver supporting milk thistle and free radical remover alpha lipoic acid during the stims helped tremendously. 

    Good luck! I know its hard and I am still in the game but keep positive (although its normal to feel crap for a time) and pray! We are here for you!
  • @Ilky what was your AFC for this last round? and do you remember for the previous rounds? 
    ***** child/loss TW *****
    Age: 32 DH: 35
    natural pregnancy DD 2012 TTC #2 since 2014
    9/2015 chemical pregnancy
    Initial workup: 
         AMH: 0.898 ng/ml
         Antral Follicle Count: 5
         FSH day 3: 6.56 mIU/ml
         LH day 3: 5.24 mIU/ml
         Estradiol day 3: 46.75 pg/ml

    IUI 1-4 BFN

    IVF #1 After ovulation was confirmed with progesterone levels on CD19. Cetrotide ½ dose X4 doses and minivelle was started CD 20 to continue through stim. Upon AF, started follistim 150 bid and menopur 75 bid on CD3. Started cetrotide 1 dose when biggest follicle reached 13mm. Retrieved 4 eggs out of 12 follicles, 2 PGS normal, FET #1 9/14/18 BFP beta#1 10dp6dt 369, 12dp6dt 1210 
  • IlkyIlky member
    @babyhopeful442 #1:7 cancelled #2:11 only 3 grew cancelled and converted to IUI, #3:7 cancelled and #4:7 they got 9 mature eggs
  • Ilky woohoo thats so AMAZING!!!  huge congrats to you!!!  You better be on cloud nine, you got everything back!!  Thats not easy to do!  All of your fighters made it through thats wonderful news!!

    @jamieh2000 @hopefuljj I know i'm 1/2 way through here but still freak out, especially as my mom has hasi so I"m always concerned about the thyroid BUT so far so good.  Hoping all will continue well and I'll have to go to her specialist after and really double check.  Of course this dr isn't covered by insurance probably why I put it off all these years!  I think its great you keep making the recommendations to your RE.  I did that with mine after my acupuncturist looked over my blood work go figure ;)  And you weigh everything!  They were very against lovenox so I obviously let them habe that one as it has a mess of things that can go along with it too.

    @babyhopeful442 I just wanted to add try to not fill discouraged many woman do quite a few IUIs and they dont work.  Usually REs will do 6 for woman before moving on to IVF....and your low amh isn't too bad right now so have some hope!!  If you've been doing acupuncture this whole time you may not need to take more time off.  Are you doing bcp?  I did EPP too but no BCP so I didn't have time off in between cycles but I was also banking and did cycles back to back.
    History of TTC in spoiler box
    TTC since 2014
    Unexplained Infertility - but I am 40...Low AMH .30
    7 - IUI (50mg-150mg Clomid) Feb - August 2016 all BFN 
    IVF#1 August 2016 (Antagonist protocol 4/5 eggs) Cancelled cycle :( RE thought I would get at least 10.
    IVF#2 Sept 2016 (microdose luporn pro - disappearing follies, ONLY ONE, convert to IUI) BFN
    IVF#3 November 2016 (4 ER, 3 F,  3DT)-BFP  with TWINS // MC both at almost 10wks  :'( 
    IVF#4 March 2017 //EPP  (10 ER (1 wonky so 9 ER) 7F, 3B (5AB, (2)5BB) PGS tested- ALL abnormal  :'( 
    IVF#5 April 2017 // EPP (7 ER, 7F yes! 6B) 2/5 day 4/6 day - 2 PGS normal! yes!! :)
    IVF#6 May 2017 // Antagonist didn't have time for Estrogen Priming...(4 ER, 3 F, 3B) (5AB, (2) 5BB) 2 PGS normal, yes!! :)
    IVF#7 June 2017 // EPP praying this is it and then on to an FET!

  • @ilky woooooow!!!! What an incredible outcome!!!! How wonderful!!!!!  

    @jamieH2000 Hey lady! Intralipids are not going to be covered...I’m actually terrified becaue I haven’t talked cost yet:/  the autoimmune blood panel I just did wasn’t covered and neither will this EFT receptivity test.  I just tacked on a few thousand dollars worth of tests and procedures because I think I’m a bloody doctor!!  I reallly need to chill back on all of this!  I love that you are adding doxy and medrol! I still see ladies who have much success when doing that!!  It’s interesting that your mom has Graves and that your antibodies are slightly raised but you don’t have an actual Hashi diagnosis.  Have you checked all your thyroid #’s recently  just to make sure? It’s so crazy how many issues there are for us to wonder and worry about, it feels endless....I just hope this works for both of us and we can stop thinking for just a little while!!
    Me: Hashimoto Autoimune Disease
    Homozygous MTHFR Cr677
    DOR - AMH  .27 High FSH (don't even know how high)
    2 iui's to start - BFN 
    IVF 1 -3 made it do day 5!    2 5AA 1 6BB  PGS results =  all abnormal :(
    IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty.  Nothing made it to day 5
    IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
    IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
    IVF 5 - Canceled -  looked like 1 follicle and we were afraid it was empty
    IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS

    Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!!  1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.

    FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
    Chemical pregnancy
    FET#2 - PGS normal boy - BFN
    Natural pregnancy - cycle following the FET2????   Miscarriage at 8 weeks.  viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal :(

    DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
    1st transfer - chemical pregnancy
    2nd transfer - success, May 17 2020 due date!
  • @hopefuljj- I have my thyroid checked annually and its always been fine, so I think thats why I don't have a hashi diagnosis. My thyroid antibodies were like 36 and the normal range was like 0-34, so they were hardly outside of normal. My RE said that we would just check my TSH once I become pregnant since it can spike during pregnancy because of the antibodies.

    @emmasemm- that is so frustrating to have to fly to another country for testing, but I understand just wanting to get it done and get some answers. Its always a catch 22- we don't want to have things wrong but we also want answers for the issues! 
    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
  • @JamieH2000 that’s good about your thyroid:) the IVF meds (mostly estrogen) mess with the TSH levels so it’s always stressful and you have to get them checked all the time so I’m glad you aren’t dealing with it.   My TSH has been all over the place even when I’m so strict with my meds because of all the estrogen:(.  Right now it’s good but I never fully trust it because at the previous  check it was very elevated.   
    @hopeful_mom I wouldn’t worry too much about your mom having Hashi. It’s good for all women to get their thyroid checked before, during and after pregnancy but you likely aren’t going to develop Hashi during your pregnancy, and If you did it takes a while for the antibodies to do enough damage to your thyroid that your TSH levels are affected, so if you didn’t have high antibodies when you last checked prior to pregnancy you are likely in the clear:) .  Now hypothyroidism without the autoimmune aspect is another story.  That I know can come on for women after pregnancy but as long as you have your TSH tested throughout you will be fine! 

    I’m trying to sort out all the meds I’m ordering for FET....thought it would be a natural cycle.  Lol’ing about that as I try to navigate this calendar of  meds insanity over here!!!   Awaiting biopsy results for infection and other things as well as the receptivity test...which I’ve decided is BS and wish I had gotten an ERA but it is what it is at this point.  I have tried to do all the things...can’t wait for my intralipid therapy, it will officially be the most insane thing I have done this far on this journey:) weeeee! And I’m officially already dreaming the f out about having to do PIO shots.  I’ve done SO many shots at this point but never PIO.....so...scared!!!!! 
    Hope all you ladies are doing great!

    Me: Hashimoto Autoimune Disease
    Homozygous MTHFR Cr677
    DOR - AMH  .27 High FSH (don't even know how high)
    2 iui's to start - BFN 
    IVF 1 -3 made it do day 5!    2 5AA 1 6BB  PGS results =  all abnormal :(
    IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty.  Nothing made it to day 5
    IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
    IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
    IVF 5 - Canceled -  looked like 1 follicle and we were afraid it was empty
    IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS

    Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!!  1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.

    FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
    Chemical pregnancy
    FET#2 - PGS normal boy - BFN
    Natural pregnancy - cycle following the FET2????   Miscarriage at 8 weeks.  viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal :(

    DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
    1st transfer - chemical pregnancy
    2nd transfer - success, May 17 2020 due date!
  • Hi ladies! IF any of you have read the whole thread then you already know who I am. If any of you do not have insurance for IVF meds please inbox me. I know a great way to save money, basically free just pay shipping but only for crinone, ganirelix and endometrim.
     *****Trigger Warning, Loss and Pregnancy Mentioned*****

    Married my best friend in 2013 (I was 33), After 1.5yrs of TTC got my first BFP naturally on 2/7/15 but ended in DNC on 4/14/15, not viable. In 2015 I was 35...Found out I had only one working ovary, which was DOR, with scar tissue and I ovulated at 7 days, with a small cervix opening and a tilted uterus... Needing an RE was a must.....IUI#1 Sept 2015,,, BFN IUI#2 Oct 2015,,,BFN IUI#3 Dec 2015,,BFN IVF#1 2/1/16- BFN IVF# on 3/29/16 retrieval only - 1 healthy chromosome tested embryo. IVF#3 retrieval 4/23/16- 0 healthy embryos. IVF#4 retrieval 6/17/16- 1 healthy embryo. FET#1-Transferred Both Healthy Embryos on 9/6/16 BFP!! 9/15/16 Beta 22.3, 9/17/16 Beta 60.5 & 9/19/16 Beta 195! 1st US on 9/23/16, only 1 Gast Sac & Yolk Sac found, US 9/30/16 US 6wk 1day saw and heard Heartbeat 120bpm!! EDD 5/25/2017 Had a healthy baby girl via CSection on 5/18/17 8lbs 15oz. Then four months later got pregnant naturally and had a healthy baby boy on 6/13/18 7lbs 6oz (at age 38). Needless to say, anything is possible! I'm keeping my signature open so it gives someone out there hope that anything is possible. Message me if you ever have any questions or just need someone to talk to. DON'T GIVE UP!

  • @hopefuljj- I'm confused- what do you feel the EFT is BS? I know you still wanted an ERA, but I think the EFT should check alot of good things still? As for PIO, the first one is the worst! Make sure to warm up the oil first in your hand/bra/etc and then rub good after and sit with a heating pad. Any idea on timing yet? so excited for you!!
    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
  • @hopefuljj what she said ^^ ;)  I would put the syringe with the pio in between my legs to heat it up, use these thick thighs for something  :D  Its not cute, is DH giving them to you< I couldn't manage that one on my own and had my sister give them to me!  Just remember to switch sides...it doesn't tickle and some days are better the others for whatever reason...
    Can't wait for your time line!!

    @JamieH2000 how are you looking?
    History of TTC in spoiler box
    TTC since 2014
    Unexplained Infertility - but I am 40...Low AMH .30
    7 - IUI (50mg-150mg Clomid) Feb - August 2016 all BFN 
    IVF#1 August 2016 (Antagonist protocol 4/5 eggs) Cancelled cycle :( RE thought I would get at least 10.
    IVF#2 Sept 2016 (microdose luporn pro - disappearing follies, ONLY ONE, convert to IUI) BFN
    IVF#3 November 2016 (4 ER, 3 F,  3DT)-BFP  with TWINS // MC both at almost 10wks  :'( 
    IVF#4 March 2017 //EPP  (10 ER (1 wonky so 9 ER) 7F, 3B (5AB, (2)5BB) PGS tested- ALL abnormal  :'( 
    IVF#5 April 2017 // EPP (7 ER, 7F yes! 6B) 2/5 day 4/6 day - 2 PGS normal! yes!! :)
    IVF#6 May 2017 // Antagonist didn't have time for Estrogen Priming...(4 ER, 3 F, 3B) (5AB, (2) 5BB) 2 PGS normal, yes!! :)
    IVF#7 June 2017 // EPP praying this is it and then on to an FET!

  • Thanks for the PIO tips @JamieH2000 and @Hopeful_mom!!!!! Much appreciated!
    transfer is scheduled around April 16th.  I have been putting all the dates to remember to take different things into my callendar so there are gonna be alarms going off like crazy until then! 

    @jamieH2000 I only think EFT is crap because it’s not an ERA! But yes it testable for a bunch of stuff and I’m still super glad I got it, I just wish it would test for receptivity on a specific timeline like ERA:-/

    it it feels so weird to be taking birth control...it’s  been SO long!  I’m totally not worried about the Lupron but super nervous about the PIO still and there’s also this vaginal stuff?!!!! It’s for Inflamation and I’m not sure why I’m taking it during this FET.  It’s  not even on my calendar yet, or maybe it didn’t fit with all the other meds;).  If anyone did baby aspirin for a transfer, when are you supposed to start that???
    Me: Hashimoto Autoimune Disease
    Homozygous MTHFR Cr677
    DOR - AMH  .27 High FSH (don't even know how high)
    2 iui's to start - BFN 
    IVF 1 -3 made it do day 5!    2 5AA 1 6BB  PGS results =  all abnormal :(
    IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty.  Nothing made it to day 5
    IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
    IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
    IVF 5 - Canceled -  looked like 1 follicle and we were afraid it was empty
    IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS

    Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!!  1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.

    FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
    Chemical pregnancy
    FET#2 - PGS normal boy - BFN
    Natural pregnancy - cycle following the FET2????   Miscarriage at 8 weeks.  viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal :(

    DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
    1st transfer - chemical pregnancy
    2nd transfer - success, May 17 2020 due date!
  • @hopefuljj- wow, only 1 month until transfer for you! So exciting!  I take aspirin during my FET cycle. I start when I start the estrogen. I think it helps thin the blood and lowers stroke risk because of the increased estrogen. Is the vaginal stuff crinone? Some people do both PIO and crinone for progesterone. 
    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
  • @JamieH2000 transfer is actually April 11th! I keep thinking it’s later... thanks for the info on baby Asprin!  The vaginal stuff is Metronidazole.   So confused about it...  I picked no up the PIO plus needles today.  I’m horrified.  The needles are basically the same size as the scary one you usually just use to mix meds!!!! How in the world would I do injections with a needle that size daily?!!!! 
    @Hopeful_mom I wish I could have my sister do the PIO shots for me! I’m gonna have to let DH do them or figure out how to do them in my own.  I wish I still lived in BK so I was closer to her!
    Me: Hashimoto Autoimune Disease
    Homozygous MTHFR Cr677
    DOR - AMH  .27 High FSH (don't even know how high)
    2 iui's to start - BFN 
    IVF 1 -3 made it do day 5!    2 5AA 1 6BB  PGS results =  all abnormal :(
    IVF 2 - stimmed for 19 days. insanity. Had 5 follicles that looked mature but only 2 contained mature eggs the others were empty.  Nothing made it to day 5
    IVF 3 - added in HGH - 4 mature follicles (had some empties again) 3 made it to day 5/6 for PGS (held for testing with next retrieval
    IVF 4 - Upped my dosage for the first time - Canceled 11 days into sims - looked like 1 follicle and we were afraid it was empty
    IVF 5 - Canceled -  looked like 1 follicle and we were afraid it was empty
    IVF 6 - 3 mature, 2 fertalized 1 made it to day 5 and sent for PGS

    Sent in IVF round 3 and 6 (4 embryos) for PGS testing and got 2 normal embryos!!!  1Boy and 1Girl. Took a little over a year to get those two embryos so demanded all sorts of test prior to attempting transfer. Did EFT, ERA and NK Cells testing.

    FET#1 - Intralipid drips, Prednisone, and did a depot lupron shot before starting the FET protocol
    Chemical pregnancy
    FET#2 - PGS normal boy - BFN
    Natural pregnancy - cycle following the FET2????   Miscarriage at 8 weeks.  viability scan had shown an enlarged yolk sac so I had been warned that it was likely not chromosonally normal :(

    DEIVF cycle - picked a donor who is willing to be open! Her cycle resulted in in 4 PGS Normal embryos
    1st transfer - chemical pregnancy
    2nd transfer - success, May 17 2020 due date!
  • @hopefuljj Like others have said, you will have good PIO days & not so good PIO days lol. DH chickened out on giving me my trigger shot (exactly 2 years ago today actually). So I had to man up and do it myself since time was of the essence. After that, I ended up doing all my PIO injections myself too. I basically had my back turned to my bathroom mirror and looked over my shoulder in the mirror. Don't let the needle scare you too much. Yes, it's bigger than most, but you will appreciate it bc it will inject much quicker than a smaller needle would. Oh, and it helps that you have a good amount of meat back there lol. 
    ****Siggy TW****
    natural pregnancy: 2008 
    Me: 28 (Hypothyroid), DH: 35
    Together since: 2010
    Married: 2013
    TTC: 2013
    Infertility: severe MFI, low AMH (0.5)
    Met RE: January 2016
    ER: 3/14 (4 follies, 6 eggs retrieved, 2 fertilized)
    fresh 3dt of 2 embryos= BFP (1 implanted)
    EDD w/ baby boy= 12/6/16
  • @hopefuljj woohoo the countdown is on awesome!!! If u were in Bk I could help u too  :) some girls r rockstars and do it themselves.  I did them all on my own as my sister got the very first round wrong and it hurt.  I prepared the PIO and she became a pro!! Can DH not help? I kno the needles I scary BUT they do have some junk in the truck to go through, at least for me  :D.  If you have to do them on ur own there's a bunch of utube videos that could help too.  Once u get through the first you'll see it's not so bad....there will be sensitive days where you'll need to sleep on the other side and wonder what hurts....then bam oh it's the pio.  But considering what the crinone did to me I'm all about the PIO!!! 
    History of TTC in spoiler box
    TTC since 2014
    Unexplained Infertility - but I am 40...Low AMH .30
    7 - IUI (50mg-150mg Clomid) Feb - August 2016 all BFN 
    IVF#1 August 2016 (Antagonist protocol 4/5 eggs) Cancelled cycle :( RE thought I would get at least 10.
    IVF#2 Sept 2016 (microdose luporn pro - disappearing follies, ONLY ONE, convert to IUI) BFN
    IVF#3 November 2016 (4 ER, 3 F,  3DT)-BFP  with TWINS // MC both at almost 10wks  :'( 
    IVF#4 March 2017 //EPP  (10 ER (1 wonky so 9 ER) 7F, 3B (5AB, (2)5BB) PGS tested- ALL abnormal  :'( 
    IVF#5 April 2017 // EPP (7 ER, 7F yes! 6B) 2/5 day 4/6 day - 2 PGS normal! yes!! :)
    IVF#6 May 2017 // Antagonist didn't have time for Estrogen Priming...(4 ER, 3 F, 3B) (5AB, (2) 5BB) 2 PGS normal, yes!! :)
    IVF#7 June 2017 // EPP praying this is it and then on to an FET!

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