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IF Testing and Treatment Week of 11/18-11/25/19

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Re: IF Testing and Treatment Week of 11/18-11/25/19

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    Yayyyy @kpearse99 go follies go!! Most women alternate sides when ovulating, which is why a blocked tube can be an issue if the egg has nowhere to go. Sounds like the letrozole is doing its thing and you're ready to rock and roll! As for HIO, I would also go for the 2-day hold, that being said, when we didn't get our -3 in and I was stressing I reminded myself that if there was an issue with sperm meeting egg because of CM or them getting lost all up in there, the IUI itself gives us a better chance anyway. 

    TTC History:

    Me: 36  MH: 39, TTC since Dec 2017

    Aug '18: PCOS dx

    Nov '18: MH SA - 19mil

    Dec '18-Mar '19: Letrozole + TI - all BFN

    Apr '19: Letrozole + TI, - BFN.  Repeat SA (27mil) & DNA fragmentation test (17%)

    Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)

    Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil) 

    Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.

    Mar '20: FET #1, perfect 5AA blast transferred. BFN.

    Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w                                                  

    Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d. 

    May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN. 

    June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between. 


    Sept '21: RPL, immune testing normal

    Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic

    Dec '21: Positive for endometritis, RX Flagyl & Keflex

    Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP

    Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN

    Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin. 

    Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal. 

    June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.

    July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN. 

    Sep '22: Taking a break

    Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed. 

    Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23


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    @kiki047 thanks, friend!! We got the -3 in last night so we'll be going with the 2 day hold for sure. I remind myself of that all the time too, that the IUI bypasses all of those other things that could get in the way and that's the timing that really matters the most. So thanks for the extra reminder on that :) It's always helpful!

    @inthewoods23 right? The funny quirky comments are the best... and for some reason they do the trick for me  :D I'm also always turning everything he says to me into some sort of dirty version haha something is wrong with my brain! 
    Our TTC Journey
    TTC #1: May 2011
    BFP: 10/27/2011 |  EDD: 6/30/12
    DS born 6/28/12 via C/S 3 

    TTC #2: September 2018
    Me: 36 | DH: 39
    Mirena removed 9/13/2018 after 6 years
    BFP 11/11/2018 | MC @ 5.5 weeks on Thanksgiving
    July 2019 - Diagnosed with Secondary Unexplained IF
    August 2019 - 2.5 mg of Letrozole = Never Ovulated so Trigger and IUI were cancelled
    9/30/2019 - IUI #1 (5 mg of Letrozole + Trigger) =  BFP but Betas showed CP @ 4 weeks
    10/28/2019 - IUI #2 (7.5mg of Letrozole + Trigger) = BFN
    11/25/2019 - IUI #3 (7.5mg of Letrozole, Trigger + Crinone after IUI) = BFN
    12/24/2019 - IUI #4 (7.5mg of Letrozole + Crinone after IUI) = BFN
    1/24/2020 - IUI #5 (50mg of Clomid + Trigger + Crinone after IUI) = BFN and an Ovarian Cyst
    3/2/2020 - Taking a break to reset/NTNP
    11/1/2020 - At peace with where things are in life and are no long actively TTC. Whatever happens will happen and it will all be okay. <3

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    Oh my gosh @mvt2003 I’m so sorry you are facing another obstacle. When will they redo the prolactin?
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    @bows22 Thanks friend. The order is already in, we just have to go to the lab. We'll probably do it Tuesday since we have our physicals anyway. 
    me: 35 / so: 34 | ttc #1 since 9/2018
    DX: MFI
    IVF Cycle #1 February 2020 4 embryos frozen, 1 fresh transfer = CP 
    FET #1 Natural Cycle March 2020 CXL'd due to Covid-19 :( 
    FET #1 Natural Cycle June 2020 - CP #2
    FET #2 Natural Cycle July 2020 - BFP!!!!!! Beta #1 = 273


    June Signature Challenge - Favorite TV Quotes


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    @kpearse99 another reason why we're friends - I also twist everything MH says into something dirty and he just rolls his eyes at me. 
    @mvt2003 oh friend, I hope you guys can catch a break soon. FX they can get the prescription sorted out. I've heard of guys being put on clomid before for this but I think you'll be the first person I "know" who will have tried it so I'm curious how it goes for YH! FX FX!

    TTC History:

    Me: 36  MH: 39, TTC since Dec 2017

    Aug '18: PCOS dx

    Nov '18: MH SA - 19mil

    Dec '18-Mar '19: Letrozole + TI - all BFN

    Apr '19: Letrozole + TI, - BFN.  Repeat SA (27mil) & DNA fragmentation test (17%)

    Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)

    Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil) 

    Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.

    Mar '20: FET #1, perfect 5AA blast transferred. BFN.

    Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w                                                  

    Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d. 

    May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN. 

    June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between. 


    Sept '21: RPL, immune testing normal

    Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic

    Dec '21: Positive for endometritis, RX Flagyl & Keflex

    Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP

    Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN

    Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin. 

    Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal. 

    June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.

    July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN. 

    Sep '22: Taking a break

    Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed. 

    Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23


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    @kiki047 yup!!! The eye roll and I get a "what's wrong with you" chuckle quite often haha I love it!!

    @mvt2003 wow - I am so sorry, my dear friend, for that news. I hope everything gets worked out for the prescription so that gets crossed off of your worry list. How is YH doing with all of this news? My heart is starting to break for him, as I know it's not easy to get news about yourself that you were not expecting. I'm hoping so hard it was just a fluke. <3
    Our TTC Journey
    TTC #1: May 2011
    BFP: 10/27/2011 |  EDD: 6/30/12
    DS born 6/28/12 via C/S 3 

    TTC #2: September 2018
    Me: 36 | DH: 39
    Mirena removed 9/13/2018 after 6 years
    BFP 11/11/2018 | MC @ 5.5 weeks on Thanksgiving
    July 2019 - Diagnosed with Secondary Unexplained IF
    August 2019 - 2.5 mg of Letrozole = Never Ovulated so Trigger and IUI were cancelled
    9/30/2019 - IUI #1 (5 mg of Letrozole + Trigger) =  BFP but Betas showed CP @ 4 weeks
    10/28/2019 - IUI #2 (7.5mg of Letrozole + Trigger) = BFN
    11/25/2019 - IUI #3 (7.5mg of Letrozole, Trigger + Crinone after IUI) = BFN
    12/24/2019 - IUI #4 (7.5mg of Letrozole + Crinone after IUI) = BFN
    1/24/2020 - IUI #5 (50mg of Clomid + Trigger + Crinone after IUI) = BFN and an Ovarian Cyst
    3/2/2020 - Taking a break to reset/NTNP
    11/1/2020 - At peace with where things are in life and are no long actively TTC. Whatever happens will happen and it will all be okay. <3

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    @NYTino24 so glad your consult went well.

    @kpearse99 FX so hard for you, friend!!

    @mvt2003 I'm so sorry for that discouraging news. I hope it was just a fluke. 💙

    AFM, I got the expected BFN this morning and AF should be here any minute. I have a call in to the RE to renew my letrozole RX. TBH I think one more failed IUI is going to be the end of the road for us. DH and I had a huge discussion last night about how I am tired of putting EVERYTHING in our life on hold for children that may never arrive. 
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    @emeraldduchess so many hugs, friend. I am so very sorry. I'm keeping you in my thoughts. 
    me: 35 / so: 34 | ttc #1 since 9/2018
    DX: MFI
    IVF Cycle #1 February 2020 4 embryos frozen, 1 fresh transfer = CP 
    FET #1 Natural Cycle March 2020 CXL'd due to Covid-19 :( 
    FET #1 Natural Cycle June 2020 - CP #2
    FET #2 Natural Cycle July 2020 - BFP!!!!!! Beta #1 = 273


    June Signature Challenge - Favorite TV Quotes


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    @mvt2003 Oh dear. I'm sorry. At least you won't have to wait too long for an update. Fx!

    @emeraldduchess I don't know what to say. I am so sorry and am sending all the love and support the internet will allow <3
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    @keikilove Thank you, friend. I am so grateful for the support. I'm trying very hard to keep it together for MH, but in private I'm having a hard time. I'm trying to keep your good example of finding gratitude in my life, was literally thinking of you this morning as I drove in to work and cried, and kept telling myself things I am grateful for. <3 Thank you. 
    me: 35 / so: 34 | ttc #1 since 9/2018
    DX: MFI
    IVF Cycle #1 February 2020 4 embryos frozen, 1 fresh transfer = CP 
    FET #1 Natural Cycle March 2020 CXL'd due to Covid-19 :( 
    FET #1 Natural Cycle June 2020 - CP #2
    FET #2 Natural Cycle July 2020 - BFP!!!!!! Beta #1 = 273


    June Signature Challenge - Favorite TV Quotes


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    @emeraldduchess will you still be taking progesterone after O then?
    Our TTC Journey
    TTC #1: May 2011
    BFP: 10/27/2011 |  EDD: 6/30/12
    DS born 6/28/12 via C/S 3 

    TTC #2: September 2018
    Me: 36 | DH: 39
    Mirena removed 9/13/2018 after 6 years
    BFP 11/11/2018 | MC @ 5.5 weeks on Thanksgiving
    July 2019 - Diagnosed with Secondary Unexplained IF
    August 2019 - 2.5 mg of Letrozole = Never Ovulated so Trigger and IUI were cancelled
    9/30/2019 - IUI #1 (5 mg of Letrozole + Trigger) =  BFP but Betas showed CP @ 4 weeks
    10/28/2019 - IUI #2 (7.5mg of Letrozole + Trigger) = BFN
    11/25/2019 - IUI #3 (7.5mg of Letrozole, Trigger + Crinone after IUI) = BFN
    12/24/2019 - IUI #4 (7.5mg of Letrozole + Crinone after IUI) = BFN
    1/24/2020 - IUI #5 (50mg of Clomid + Trigger + Crinone after IUI) = BFN and an Ovarian Cyst
    3/2/2020 - Taking a break to reset/NTNP
    11/1/2020 - At peace with where things are in life and are no long actively TTC. Whatever happens will happen and it will all be okay. <3

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    edited November 2019
    @kpearse99 I plan to, though I hope I can get in touch with my RE early next week. They said Letrozole has to be taken CD3-7 but maybe there is wiggle room since I tend to O around CD2O? We'll see what they say. It's tough to not have to play phone tag, though. I can't leave my classroom to take a call and they don't answer or return phone calls after 2:45. Which is exactly when school gets out. SMH. Oh well. Maybe there is something we can do this cycle besides TI and progesterone. 
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    @emeraldduchess I hope they will give you wiggle room. My RE has me take it CD 4-8 and I know other people take it on days 5-9... 
    Our TTC Journey
    TTC #1: May 2011
    BFP: 10/27/2011 |  EDD: 6/30/12
    DS born 6/28/12 via C/S 3 

    TTC #2: September 2018
    Me: 36 | DH: 39
    Mirena removed 9/13/2018 after 6 years
    BFP 11/11/2018 | MC @ 5.5 weeks on Thanksgiving
    July 2019 - Diagnosed with Secondary Unexplained IF
    August 2019 - 2.5 mg of Letrozole = Never Ovulated so Trigger and IUI were cancelled
    9/30/2019 - IUI #1 (5 mg of Letrozole + Trigger) =  BFP but Betas showed CP @ 4 weeks
    10/28/2019 - IUI #2 (7.5mg of Letrozole + Trigger) = BFN
    11/25/2019 - IUI #3 (7.5mg of Letrozole, Trigger + Crinone after IUI) = BFN
    12/24/2019 - IUI #4 (7.5mg of Letrozole + Crinone after IUI) = BFN
    1/24/2020 - IUI #5 (50mg of Clomid + Trigger + Crinone after IUI) = BFN and an Ovarian Cyst
    3/2/2020 - Taking a break to reset/NTNP
    11/1/2020 - At peace with where things are in life and are no long actively TTC. Whatever happens will happen and it will all be okay. <3

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    @emeraldduchess I've had letrozole for CD3-7 twice and one cycle it was CD4-8. I don't see why it couldn't be 5-9? Hopefully you can!
    *TW* History:
    Me: 34 DH: 36 | Together since 2007 | Married July 2016

    TTC #1 since 7.2017
    Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies

    IUI #1-3 all BFN
    IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
    FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
    RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
    FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
    2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
    Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
    TTCAL naturally | starting 11.22.20

    Initial consultation with Reproductive Immunologist | 9.14.21
    Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
    Saline sono | 10.15.21 | normal
    Bloodwork | 10.21.21 high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
    BFP! | 11.3.21 | EDD 7.14.22 B) | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
    DS born 7.19.22 after induction


    TTC #2 begins 6.2023
    Consultation with RI | 6.6.23
    Saline sono, endometritis biopsy, skin & eye check | all normal
    Labs | high TSH, Factor XIII mutation, high %CD56
    Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
    Repeat labs after 3 weeks on meds
    Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
    Repeat labs in 8 weeks
    Follow up | 1.16.24 | Green light continues
    TTC put on pause
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    @emeraldduchess I hope they allow you to take it from 5-9! I have seen people starting medication on CD 3,4,5. Seems to me it varies from doctors to doctors 😆 
    TTC #1
    *TW*
    Me: 28 DH: 30
    Married: 09/16
    TTC #1 08/18

    ~2019~
    IUI #1 #2 #3 with letrozole cancelled 
    Natural cycle IUI #4 10/19 BFN
    First RE visit 11/19
    Clomid 50mg + IUI#5 11/19 BFN
    Elevated prolactin dx confirmed 11/19
    Clomid 50mg + IUI#6 cancelled

    ~2020~
    IVF #1 ICSI+PGT-A 02/20
    32R 19M 14F 7B 7 PGT-A normal
    Hysteroscopy to remove polyps 3/20
    FET 05/20 BFP! beta #1 9dp6dt 443.8; beta #2 11dp6dt 1212
    Baby has a heartbeat! 6w5d HB 128


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    @kpearse99 @inthewoods23 that's what I thought, too, it can't be like a non-negotiable thing. TBH I am not sure if it really had any effect last cycle since my LH levels went up, stalled, then fell before the trigger shot. 
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    Woohoo, @kpearse99!!!
    It's funny how it's the little things in life that mean the most...not where you live, or what you drive, or the price tag on your clothes... There's no dollar sign on a piece of mind, this I've come to know! *ZBB*

    Me: 36 DH 35 
    TTC  9/2016     BFP 12/9/16    EDD 8/21/17    NMC 1/8/16 at 7w6d
    TTC  2/2017  BFP 3/6/17   EDD 11/17/17   DS born 11/25/17 via ECS
    TTC 12/2018   BFP 6/2/19   EDD 2/12/20  NMC / BO at 7 weeks, low progesterone
    TTC 7/2019   BFP 8/21/19 EDD 4/22/20 CP at 5 weeks
    TTC 8/19    IUI #1 w/ Clomid + Ovidrel + progesterone  BFN, IUI 2 and 3 w/ Letrozole + Ovidrel + progesterone,
    IUI 4 Follistim + Ovidrel + progesterone BFP 1/9/20 EDD 9/18/20

    AMA, ITP in pregnancy, vWD type II - low Factor VIII, unexplained RPL and secondary infertility
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    @emeraldduchess I’ve taken Letrozole CD5-9 when I couldn’t get it in time to take CD3-7. Hopefully you can still take it this cycle.
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    Just did the Ovidrel.... I have a burning sensation now at the injection site... is this normal? I didn’t have it the last two times, but I also only let it sit outside of the fridge for 15 minutes instead of 30 this time. 
    Our TTC Journey
    TTC #1: May 2011
    BFP: 10/27/2011 |  EDD: 6/30/12
    DS born 6/28/12 via C/S 3 

    TTC #2: September 2018
    Me: 36 | DH: 39
    Mirena removed 9/13/2018 after 6 years
    BFP 11/11/2018 | MC @ 5.5 weeks on Thanksgiving
    July 2019 - Diagnosed with Secondary Unexplained IF
    August 2019 - 2.5 mg of Letrozole = Never Ovulated so Trigger and IUI were cancelled
    9/30/2019 - IUI #1 (5 mg of Letrozole + Trigger) =  BFP but Betas showed CP @ 4 weeks
    10/28/2019 - IUI #2 (7.5mg of Letrozole + Trigger) = BFN
    11/25/2019 - IUI #3 (7.5mg of Letrozole, Trigger + Crinone after IUI) = BFN
    12/24/2019 - IUI #4 (7.5mg of Letrozole + Crinone after IUI) = BFN
    1/24/2020 - IUI #5 (50mg of Clomid + Trigger + Crinone after IUI) = BFN and an Ovarian Cyst
    3/2/2020 - Taking a break to reset/NTNP
    11/1/2020 - At peace with where things are in life and are no long actively TTC. Whatever happens will happen and it will all be okay. <3

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    @misshelen86 I wish I could give you a hug IRL. Sending internet (((hugs))) instead. I’m so sorry the mall visit left you feeling so down. It’s completely understandable that you feel this way, I just feel terrible you’re going through this. I hope you’re feeling better after letting it out.❤️
    As for the U/S, my most recent one went exactly like yours. I asked the tech if there was a reason she was asking all those questions, was she seeing something I should be concerned about. She said those are the standard questions they ask everyone. I hope this helps you feel better! 
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    @mishelen86 I am so, so sorry, friend. This is such a triggering time of year. We get bombarded by images of happy families and LOs from EVERY direction. I had a similar meltdown in a store when I saw all the "My First Christmas" outfits. After my BFN this week I came very close to asking people NOT to send us Christmas cards because I was SO determined not to celebrate the holiday. IF is so freakin' cruel and it really does feel like the universe kicks us in the gut repeatedly. I hope that you feel better today. Please be good to yourself. <3 All the internet hugs. 
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    @misshelen86 I am so sorry you’re feeling all if these emotions right now. My heart is right there with you and I’m sending you so many creepy stranger hugs. I hope you were able to do something for yourself this weekend. ♥️
    Our TTC Journey
    TTC #1: May 2011
    BFP: 10/27/2011 |  EDD: 6/30/12
    DS born 6/28/12 via C/S 3 

    TTC #2: September 2018
    Me: 36 | DH: 39
    Mirena removed 9/13/2018 after 6 years
    BFP 11/11/2018 | MC @ 5.5 weeks on Thanksgiving
    July 2019 - Diagnosed with Secondary Unexplained IF
    August 2019 - 2.5 mg of Letrozole = Never Ovulated so Trigger and IUI were cancelled
    9/30/2019 - IUI #1 (5 mg of Letrozole + Trigger) =  BFP but Betas showed CP @ 4 weeks
    10/28/2019 - IUI #2 (7.5mg of Letrozole + Trigger) = BFN
    11/25/2019 - IUI #3 (7.5mg of Letrozole, Trigger + Crinone after IUI) = BFN
    12/24/2019 - IUI #4 (7.5mg of Letrozole + Crinone after IUI) = BFN
    1/24/2020 - IUI #5 (50mg of Clomid + Trigger + Crinone after IUI) = BFN and an Ovarian Cyst
    3/2/2020 - Taking a break to reset/NTNP
    11/1/2020 - At peace with where things are in life and are no long actively TTC. Whatever happens will happen and it will all be okay. <3

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    @misshelen86 I’m so sorry for all the feelings you are dealing with right now! It’s so hard to see happy little families when that is all we want! I turn bitter sometimes and think that they probably take for granted what they have...but in reality, I don’t know that because they could have easily had struggles too! But that doesn’t really help me in the moment! I hope you were able to do something that makes you happy this weekend! Sending you so many hugs right now though! 💜
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