Hi ladies, I feel compelled to share my experience with you because I think it has so many ethical and emotional implications. Of course, it is ONLY my experience and it may not extrapolate, but I still think it is very relevant. I had a bunch of blastocysts and did PGS because I wanted to avoid m/c or Down's (over 35). Only a couple returned normal, but the results had a few things that puzzled me, and since the alternative was to discard the embryos, I decided to retest instead, with a different lab (after also reading articles about abnormal embryos being implanted in Europe and developing normally or retested with different results). Guess what?? More returned normal, PLUS the rest of abnormal ones had totally different abnormality profiles.
So I'm sitting here thinking, how many normal embryos are killed each day after PGS results? How many women who can only produce one embryo that turns out abnormal end up unsuccessful just because of throwing away the embryo? This technology is only experimental, the labs either make awful mistakes OR the embryos are mosaic and good cells may exist that can then lead to self-correction in the embryos. Playing God is awful and heartbreaking. I still don't know what to do with my "abnormal" embryos in this case because I definitely don't trust the results anymore..
@liljoy - thank you for posting - this is great advice, and thought-provoking.
I'm also sorry you're in this position. The second lab, even though more were returned normal, did it confirm the normalcy of the ones that had been deemed normal with the first round of testing? I guess I'd start with those, and then (if they didn't take) work my way through all the "abnormal" ones.
The other day, I was reading about Louise Brown and the team who developed IVF (Roberts and Steptoe). Apparently, they tried 100 times before she was born. I think often about couples trying to conceive 40 or 50 years ago - before they new how to isolate an ovum, before the IVF technology was developed. Reading about them, I thought about the women who volunteered to give Roberts and Steptoe their eggs, in the hopes of conceiving, who never managed to conceive. I am so grateful to those women for their sacrifices, and so grateful that we live in a time where we can turn to IVF.
That said, with PGS, we are not so different than those women, 50 years ago - with a lot of IF, actually. It's crazy to think how little they know, and how much there is to learn, and that we are actively paying for (largely) experimental treatments.
This is very interesting to me. Now that we have had one round of IVF and it was somewhat of a success (**TW no heartbeat has been detected and I'm 8.5 weeks tomorrow, d&c scheduled for friday**end TW), my doctor has been heavily suggesting pgs testing for our next cycle. I'm only 33 and my AMH is normal, so my husband and I have been trying to decide if we really need it. We will be doing chromosomes *TW on the d&c **end TW, so I guess that will also play a factor in our decision.
But this is something I will definitely look into more. It makes me wonder how precise these tests are....especially for how expensive they are. Thank you for sharing this.
Me: 34
TTC: 40 months Me: endometrial polyps and most recently diagnosed with polypoid endometrium. Mild endometriosis. AMH 4.5. FSH 9.2. TSH 8.5 (recently started synthroid) Everything else normal. DH: now an exDH. lol. JUST MEEEEE! IVF #1: ER 3/11/17 (5 fertilized) ET 3/16/17 BFP (B#1-113, B#2-534, B#3-3190) MC @ 8 weeks TTC with just donor soon!
@Ash_SE The bad results that turned good were trisomies (with 96% certitude). Other differences were monosomies instead of trisomies, etc. Very different. Both labs are top notch and in-network with insurance, one on West Coast and one on the East Coast..
@liljoy I asked my RE about this as we had two cycles of ivf with my own eggs and had no normal embryos with PGS. The mosaics and self correction are from embryos tested in day 3 when there are very few cells...in theory (per my RE) once you get to a 5 day blastocyst (when our embryos were tested) the cells are what they are and there won't be any autocorrection. That being said, most tests are not 100% accurate so there is definitely a chance that sampling could produce false positive or false negative results with PGS at 5 days too
What did your RE say about the discrepancy between the two labs?
******TW***** Me 39 DH44
Married 8/2/14
TTC 9/14
Dx: PCOS, blocked L fallopian tube, suspect poor egg quality
MFI (low #, poor morphology)
IVF #1 9/15 Failed
IVF #2 12/15 Failed 1st DE FET 5/16-BFN 2nd DE FET 7/18-BFP 8/17 Baby HR 140/min EDD 4/6/17
I think it is good to factor this in before deciding whether to do PGS for others doing ivf , but sorry that you now have to deal with the confusing results @liljoy ... nothing can just be straight forward in this process!
******TW***** Me 39 DH44
Married 8/2/14
TTC 9/14
Dx: PCOS, blocked L fallopian tube, suspect poor egg quality
MFI (low #, poor morphology)
IVF #1 9/15 Failed
IVF #2 12/15 Failed 1st DE FET 5/16-BFN 2nd DE FET 7/18-BFP 8/17 Baby HR 140/min EDD 4/6/17
CP #1- due April 2017 lost 5.5 weeks cp #2- due May 2017 lost at 4.5 weeks iUI #1- BFN IUI #2-BFN IVF#1- transfer 2- BFP! Due October 2017 c/p#3 lost at 3.5 weeks
I was wondering about the same thing. Very interesting to hear about your differing results, and fx for better things to come! It also may empower me to do that too (i.e. retesting with a different lab), depending on our hypothetical results. :) so thank you!
liljoy this has got me thinking alot thanks for sharing!!! I actually called my DR to make sure they didn't discard my abnormal embryos just yet. I'm not saying they were all wrong but apart of me still thinks one was normal. I've always been torn on PGS and this makes it more so. I wonder about the blasts that make it to blast but not the stage that it can be frozen. Since I'm doing the testing am I losing normal embabies.
I'm wondering if part of the problem is that my embryos do better in the womb then outside. For example, if I wanted to do a transfer with an embryo that couldn't make it to the necessary stage needed to be frozen, could that embryo make for a viable pregnancy. Some things I've read say that the blastocyst has to get to a later stage to be frozen because an early stage blastocyst won't freeze. Am I losing normal embryos that might be able to thrive if placed in my uterus and just aren't strong enough to freeze. I had a normal embryo before so its frustrating to think I cant get one again!
QsMadd so very sorry to hear of your loss!! Hoping you can get some answers. Wishing your heart, body and soul heal quickly.
History of TTC in spoiler box
TTC since 2014 Unexplained Infertility - but I am 40...Low AMH .30 7 - IUI (50mg-150mg Clomid) Feb - August 2016 all BFN IVF#1 August 2016 (Antagonist protocol 4/5 eggs) Cancelled cycle RE thought I would get at least 10. IVF#2 Sept 2016 (microdose luporn pro - disappearing follies, ONLY ONE, convert to IUI) BFN IVF#3 November 2016 (4 ER, 3 F, 3DT)-BFP with TWINS // MC both at almost 10wks IVF#4 March 2017 //EPP (10 ER (1 wonky so 9 ER) 7F, 3B (5AB, (2)5BB) PGS tested- ALL abnormal IVF#5 April 2017 // EPP (7 ER, 7F yes! 6B) 2/5 day 4/6 day - 2 PGS normal! yes!! IVF#6 May 2017 // Antagonist didn't have time for Estrogen Priming...(4 ER, 3 F, 3B) (5AB, (2) 5BB) 2 PGS normal, yes!! IVF#7 June 2017 // EPP praying this is it and then on to an FET!
@Hopeful_mom The day 2/3 vs day 5 is another separate question, and I also know from experience RE's opinions differ on this too....So, it's still up in the air and probably impossible to get a definitive answer. Unlike the PGS testing, which in time I'm sure will perfect. But now, it seems to be too experimental to fully trust it. I think the reasonable compromise, at least in some cases, is to still PGS test and then decide what to do. This way, you can avoid clearly risky embryos such as Down's and Edwards'. It also depends on the reason one opts for PGS. Is it to try to rule out m/c (in which case avoiding anything abnormal makes sense)? Is it to rule out Down's? Is it because one has too many embryos and wants to decide on the best? Etc.
I am considering retesting and was wondering if you could share specifically which test(s) you used and if the re-testing was using the same test only different equipment? We used NGS through reprogenetics and I'm just trying to discern what would be a good second choice. Thank you for sharing your experience, is is very helpful.
Hi ladies, I feel compelled to share my experience with you because I think it has so many ethical and emotional implications. Of course, it is ONLY my experience and it may not extrapolate, but I still think it is very relevant. I had a bunch of blastocysts and did PGS because I wanted to avoid m/c or Down's (over 35). Only a couple returned normal, but the results had a few things that puzzled me, and since the alternative was to discard the embryos, I decided to retest instead, with a different lab (after also reading articles about abnormal embryos being implanted in Europe and developing normally or retested with different results). Guess what?? More returned normal, PLUS the rest of abnormal ones had totally different abnormality profiles.
So I'm sitting here thinking, how many normal embryos are killed each day after PGS results? How many women who can only produce one embryo that turns out abnormal end up unsuccessful just because of throwing away the embryo? This technology is only experimental, the labs either make awful mistakes OR the embryos are mosaic and good cells may exist that can then lead to self-correction in the embryos. Playing God is awful and heartbreaking. I still don't know what to do with my "abnormal" embryos in this case because I definitely don't trust the results anymore..
@dragonette505 Yep, that's very wise and important. See, we are our own advocates and sometimes it pays off. My RE said she "learnt something new" with my experience. I'll give all my 3 "normal" embryos a chance one way or the other, but won't want to discard the "abnormal" ones either. I think I might want to keep them just in case in the future the science will clarify their status. I'd rather donate them than throw them away.
All of this is why I declined PGS testing. With my DOR we were not expecting many eggs already and I couldn’t bear the idea of throwing any away if the science behind it is questionable. My RE pushed for it initially then when I told him my concerns he agreed with me that we did not need to do it. This is one of the articles I saved on it. https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-017-0318-3
Would you mind sharing who the other lab was. We had our testing through cooper genomics. Only one "normal" embryo which turned into a blighted ovum pregnancy (genetic abnormality). So I am now really questioning the results. I am waiting to hear if my other embryos have been discarded. The more I'm reading the more I am thinking this is all psuedoscience. If they haven't been discarded, I'm not sure if I should retest or just see if we can give them a try.
I'm bringing this thread back to life because of what I am going through right now. I think it is important for women who are being told to do this test should be informed. I am NOT saying that my results are wrong, as at my age, likely most if not all my eggs aren't great....but I truly thought I would have at least 1 good one. I am hoping my indeterminate one is, but I am just not willing to risk it by retesting (thaw, rebiopsy, refreeze, thaw, fet).
I will take my chances this time around. If I do another IVF, I will do PGS again just because of my age, but I won't be as one-sided in the results.
Me: 45yo, DH: 47yo 3 Daughters (singleton @27yo, ID Di/Di Twins @34yo) Protein S Deficiency (Blood Clotting Disorder), MTHFR & VIT D issue 5 MC's: Blighted Ovum-D&C @ 9wks; Natural MC @ 7wks; Blighted Ovum-D&C @ 9wks; MC boy-D&C @ 9wks & Chem PG in 2019 Tubes were tied after my Twins (and now I am old). Remarried and want to give my DH a baby!
IVF#1 OE June 2019 - ER 6/15/19, 24R, 21M, 20F, 7 6DBlasts Frozen for PGS Testing, RESULTS of PGS 4 abnormal girls, 2 abnormal boys, 1 indeterminate girl FET#1 OE August 23, 2019 (transferring 1 indeterminate girl & 1 abnormal boy) - BFN IVF#2 November 15, 2019 - ER 9R, 9M, 6F, 2 5dBlasts (fresh transfer) and 1 6DBlast frozen for PGS Testing, FRESH Transfer: November 20, 2019, 2 5-day blasts transferred!! BFP 8dp5dt on 11/27 - 12/2 on FRER, BETA #1 12/2 - 11.93. BETA #2 12/4: 4.41 ~CHEMICAL PG ******************Starting Donor Process June 2020: Egg Donor Cycle and Fresh Transfer of 1 embryo in Czech Republic - CANCELLED DUE TO COVID19 October 2020. Split Cycle at UFC with a friend (Andrea) I met on the Bump who was also supposed to go to Prague too DE Retrieval9/26/2020, 26R, 24M, 12 split Cycle, 9 Fertilized + 1 "questionable", PRAYING FOR AT LEAST 5 BLASTS 10/1/2020: 4 5DBlasts (AA, BB, BC, BC), 10/2/2020: 3 6DBlasts (BB, BB, BC) FOR A TOTAL OF: 7 BLASTS!! THANK YOU GOD!! PGS RESULTS: 5 NORMALS! DAY 5: AA BOY, BB GIRL, BC BOY / DAY 6: BB GIRL, BC GIRL DE FETOctober 29, 2020 - CANCELED DUE TO FLUID IN LINING DE FET November 16th, 2020 (transferring an PGS normal Hatching AA Boy)
@sarahroses - yes! I just did that in my last round. My doctor agreed after I had genetic counseling, so I put in one abnormal one (Trisomy 11) and one indeterminate one. Unfortunately, neither stuck, but it was worth a shot out of 7 embryos tested, not 1 was "normal"...
Me: 45yo, DH: 47yo 3 Daughters (singleton @27yo, ID Di/Di Twins @34yo) Protein S Deficiency (Blood Clotting Disorder), MTHFR & VIT D issue 5 MC's: Blighted Ovum-D&C @ 9wks; Natural MC @ 7wks; Blighted Ovum-D&C @ 9wks; MC boy-D&C @ 9wks & Chem PG in 2019 Tubes were tied after my Twins (and now I am old). Remarried and want to give my DH a baby!
IVF#1 OE June 2019 - ER 6/15/19, 24R, 21M, 20F, 7 6DBlasts Frozen for PGS Testing, RESULTS of PGS 4 abnormal girls, 2 abnormal boys, 1 indeterminate girl FET#1 OE August 23, 2019 (transferring 1 indeterminate girl & 1 abnormal boy) - BFN IVF#2 November 15, 2019 - ER 9R, 9M, 6F, 2 5dBlasts (fresh transfer) and 1 6DBlast frozen for PGS Testing, FRESH Transfer: November 20, 2019, 2 5-day blasts transferred!! BFP 8dp5dt on 11/27 - 12/2 on FRER, BETA #1 12/2 - 11.93. BETA #2 12/4: 4.41 ~CHEMICAL PG ******************Starting Donor Process June 2020: Egg Donor Cycle and Fresh Transfer of 1 embryo in Czech Republic - CANCELLED DUE TO COVID19 October 2020. Split Cycle at UFC with a friend (Andrea) I met on the Bump who was also supposed to go to Prague too DE Retrieval9/26/2020, 26R, 24M, 12 split Cycle, 9 Fertilized + 1 "questionable", PRAYING FOR AT LEAST 5 BLASTS 10/1/2020: 4 5DBlasts (AA, BB, BC, BC), 10/2/2020: 3 6DBlasts (BB, BB, BC) FOR A TOTAL OF: 7 BLASTS!! THANK YOU GOD!! PGS RESULTS: 5 NORMALS! DAY 5: AA BOY, BB GIRL, BC BOY / DAY 6: BB GIRL, BC GIRL DE FETOctober 29, 2020 - CANCELED DUE TO FLUID IN LINING DE FET November 16th, 2020 (transferring an PGS normal Hatching AA Boy)
Chiming in here... all of our 7 embies tested aneuploid by CG in October 2018. I chose the first A grade from the list and transferred on 11/30. He was tested as XYY. We have a healthy 12 week old who is thriving. Some could argue he only had an extra sex chromosome. Okay but thousands of people would’ve made the decision to discard him and my story amazed the shit out of a leading fertility specialist.
Someone inboxed me here awhile ago to ask about it but I missed it not logging in here in quite some time. She asked if I tested again during pregnancy. I did not because I knew it would not change my mind or change the course of my decision making in pregnancy. He passed the AS with flying colors.
Next time, I will choose the next grade A from the list (mosaic trisomy 13) and transfer without abandon. The thing I most want to impress upon you ladies is that PGS testing is not pseudoscience. What they are doing is biopsying a few cells out of hundreds and from the part that only becomes the placenta. They cannot biopsy from any part that becomes the actual baby and even if they could, abnormalities can still correct themselves in utero.
For 30 years, we’ve know that we can place the placenta under a microscope and find islands of chromosome abnormalities having nothing to do with the baby that was just born. And so it makes sense that different labs result differently.
It was an extremely difficult decision and caused great anxiety for us. I will never regret making it even if it had not worked, but at the same time, I know that I wouldn’t be saying the same thing had it not worked. My heart goes out to anyone in the same shoes.
People think we become mothers when we give birth but the truth is we become mothers the moment we start calling our babies to us in our thoughts, dreams and prayers. Some paths are short and some are so long that you can easily forget where you were headed.
How I feel all of the time. My 7 Year Journey ***Tw in spoiler***
IVF IVF #1 - September 2018; Follistim, Menopur, Cetrotide & Lupron/HCG combo trigger; PGS; ICSI Back on Levothyroxine FET #1 - October 2018; cancelled, all PGS aneuploid FET #1 - November 30th, transferred anyway Wondfo BFP 5dp5dt, CB Digi 6dpt, 1st Beta on 7dpt 93 2nd Beta on 10dpt 510!
TTC #1 since 2011. Tried for 5 years before we knew there was a one year rule. Diag w/MS 2016; w/PCOS & IF 2017 New RE 2018; PCOS diagnosis taken away, IF due to ovary adhesions, but prev. RE insists PCOS IF
IUI IUI #1 July 2017 w/100mg Clo+trigger; BFN; benched w/big cysts IUI #2 October 2017 w/50mg Clo+trigger; BFN; benched w/big cysts IUI #3 February 2018 w/5mg Femara+trigger; low P BFP February; mc March; Subclinical hypothyroid started Levothyroxine IUI #4 March 2018 w/7.5mg Femara+trigger; BFN Medicated cycle & TI April 2018 w/7.5mg Femara+trigger; BFN Tried several cycles on our own; all BFN
People think we become mothers when we give birth but the truth is we become mothers the moment we start calling our babies to us in our thoughts, dreams and prayers. Some paths are short and some are so long that you can easily forget where you were headed.
How I feel all of the time. My 7 Year Journey ***Tw in spoiler***
IVF IVF #1 - September 2018; Follistim, Menopur, Cetrotide & Lupron/HCG combo trigger; PGS; ICSI Back on Levothyroxine FET #1 - October 2018; cancelled, all PGS aneuploid FET #1 - November 30th, transferred anyway Wondfo BFP 5dp5dt, CB Digi 6dpt, 1st Beta on 7dpt 93 2nd Beta on 10dpt 510!
TTC #1 since 2011. Tried for 5 years before we knew there was a one year rule. Diag w/MS 2016; w/PCOS & IF 2017 New RE 2018; PCOS diagnosis taken away, IF due to ovary adhesions, but prev. RE insists PCOS IF
IUI IUI #1 July 2017 w/100mg Clo+trigger; BFN; benched w/big cysts IUI #2 October 2017 w/50mg Clo+trigger; BFN; benched w/big cysts IUI #3 February 2018 w/5mg Femara+trigger; low P BFP February; mc March; Subclinical hypothyroid started Levothyroxine IUI #4 March 2018 w/7.5mg Femara+trigger; BFN Medicated cycle & TI April 2018 w/7.5mg Femara+trigger; BFN Tried several cycles on our own; all BFN
Re: PGS results are not reliable, word of caution (own experience+literature)
I'm also sorry you're in this position. The second lab, even though more were returned normal, did it confirm the normalcy of the ones that had been deemed normal with the first round of testing? I guess I'd start with those, and then (if they didn't take) work my way through all the "abnormal" ones.
The other day, I was reading about Louise Brown and the team who developed IVF (Roberts and Steptoe). Apparently, they tried 100 times before she was born. I think often about couples trying to conceive 40 or 50 years ago - before they new how to isolate an ovum, before the IVF technology was developed. Reading about them, I thought about the women who volunteered to give Roberts and Steptoe their eggs, in the hopes of conceiving, who never managed to conceive. I am so grateful to those women for their sacrifices, and so grateful that we live in a time where we can turn to IVF.
That said, with PGS, we are not so different than those women, 50 years ago - with a lot of IF, actually. It's crazy to think how little they know, and how much there is to learn, and that we are actively paying for (largely) experimental treatments.
But this is something I will definitely look into more. It makes me wonder how precise these tests are....especially for how expensive they are. Thank you for sharing this.
TTC: 40 months
Me: endometrial polyps and most recently diagnosed with polypoid endometrium. Mild endometriosis. AMH 4.5. FSH 9.2. TSH 8.5 (recently started synthroid) Everything else normal.
DH: now an exDH. lol. JUST MEEEEE!
IVF #1: ER 3/11/17 (5 fertilized) ET 3/16/17 BFP (B#1-113, B#2-534, B#3-3190) MC @ 8 weeks
TTC with just donor soon!
What did your RE say about the discrepancy between the two labs?
Me 39 DH44
1st DE FET 5/16-BFN
2nd DE FET 7/18-BFP
8/17 Baby HR 140/min EDD 4/6/17
Some REs still believe day 5 can be mosaic (interesting to also read his replies in the comments):
https://drgeoffreysherivf.com/pgs-in-ivf-are-some-chromosomally-abnormal-embryos-capable-of-resulting-in-normal-babies-and-being-wrongly-discarded/
This paper also insists day 5 biopsies are not relevant because cells are from what will develop into the placenta (thus the exterior), and abnormal cells at the exterior don't count: https://www.centerforhumanreprod.com/fertility/possibility-selectively-transferring-embryos-preimplantation-genetic-diagnosis-pgdpgs-determined-chromosomally-abnormal/
This also supports the same argument ("Dr. Vidali (and his wife), personally, experienced an IVF cycle in which all embryos were declared aneuploid, only to learn upon repeat analysis that 40% were found to be chromosomally normal (euploid)." https://www.24-7pressrelease.com/press-release/transferring-allegedly-chromosomally-abnormal-embryos-comments-on-todays-article-in-the-new-york-times-by-kira-peikoff-422079.php
Here are cases about successful abnormal embryos (more cases are from Europe and Israel in the above link) : https://www.preventmiscarriage.com/documents/Live-births-of-3-normal-neonates.pdf
Either way, it is clear mine were either mosaic or the labs made mistakes.
Me 39 DH44
1st DE FET 5/16-BFN
2nd DE FET 7/18-BFP
8/17 Baby HR 140/min EDD 4/6/17
CP #1- due April 2017 lost 5.5 weeks
cp #2- due May 2017 lost at 4.5 weeks
iUI #1- BFN
IUI #2-BFN
IVF#1- transfer 2- BFP! Due October 2017 c/p#3 lost at 3.5 weeks
I'm wondering if part of the problem is that my embryos do better in the womb then outside. For example, if I wanted to do a transfer with an embryo that couldn't make it to the necessary stage needed to be frozen, could that embryo make for a viable pregnancy. Some things I've read say that the blastocyst has to get to a later stage to be frozen because an early stage blastocyst won't freeze. Am I losing normal embryos that might be able to thrive if placed in my uterus and just aren't strong enough to freeze. I had a normal embryo before so its frustrating to think I cant get one again!
QsMadd so very sorry to hear of your loss!! Hoping you can get some answers. Wishing your heart, body and soul heal quickly.
Unexplained Infertility - but I am 40...Low AMH .30
7 - IUI (50mg-150mg Clomid) Feb - August 2016 all BFN
IVF#1 August 2016 (Antagonist protocol 4/5 eggs) Cancelled cycle RE thought I would get at least 10.
IVF#2 Sept 2016 (microdose luporn pro - disappearing follies, ONLY ONE, convert to IUI) BFN
IVF#3 November 2016 (4 ER, 3 F, 3DT)-BFP with TWINS // MC both at almost 10wks
IVF#4 March 2017 //EPP (10 ER (1 wonky so 9 ER) 7F, 3B (5AB, (2)5BB) PGS tested- ALL abnormal
IVF#5 April 2017 // EPP (7 ER, 7F yes! 6B) 2/5 day 4/6 day - 2 PGS normal! yes!!
IVF#6 May 2017 // Antagonist didn't have time for Estrogen Priming...(4 ER, 3 F, 3B) (5AB, (2) 5BB) 2 PGS normal, yes!!
IVF#7 June 2017 // EPP praying this is it and then on to an FET!
It also depends on the reason one opts for PGS. Is it to try to rule out m/c (in which case avoiding anything abnormal makes sense)? Is it to rule out Down's? Is it because one has too many embryos and wants to decide on the best? Etc.
https://www.endonews.com/efa.mc.2017.the-abnormal-embryos-that-arenttens-of-thousands-of-women-thought-they-couldnt-have-babies-but-what-if-they-could.dr.-norbert-gleicher-dr.-monica-halem?utm_content=bufferfe87d&utm_medium=social&utm_source=facebook.com&utm_campaign=buffer
This sort of thing is one of the reasons Ive decided to take my chances... I posted these articles on my infertility insta because I feel like its important for people to know who is the appropriate group for testing: IE If you have a TON of embies, you are better off testing...even if you get some false negatives, you will likely have sufficient positives. But with women with fewer embies, we could be chucking out our only chances for a baby with your own eggs...I know it may still not work for me, but I'm giving my eggs a chance
https://www.thecut.com/2017/09/ivf-abnormal-embryos-new-last-chance.html
https://www.centerforhumanreprod.com/fertility/transferring-supposedly-chromosomally-abnormal-embryos-ivf-cycle/
https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-017-0318-3
I will take my chances this time around. If I do another IVF, I will do PGS again just because of my age, but I won't be as one-sided in the results.
3 Daughters (singleton @27yo, ID Di/Di Twins @34yo)
Protein S Deficiency (Blood Clotting Disorder), MTHFR & VIT D issue
5 MC's: Blighted Ovum-D&C @ 9wks; Natural MC @ 7wks; Blighted Ovum-D&C @ 9wks; MC boy-D&C @ 9wks & Chem PG in 2019
Tubes were tied after my Twins (and now I am old). Remarried and want to give my DH a baby!
IVF#1 OE June 2019 - ER 6/15/19, 24R, 21M, 20F, 7 6DBlasts Frozen for PGS Testing,
RESULTS of PGS 4 abnormal girls, 2 abnormal boys, 1 indeterminate girl
FET#1 OE August 23, 2019 (transferring 1 indeterminate girl & 1 abnormal boy) - BFN
IVF#2 November 15, 2019 - ER 9R, 9M, 6F, 2 5dBlasts (fresh transfer) and 1 6DBlast frozen for PGS Testing,
FRESH Transfer: November 20, 2019, 2 5-day blasts transferred!!
BFP 8dp5dt on 11/27 - 12/2 on FRER, BETA #1 12/2 - 11.93. BETA #2 12/4: 4.41 ~CHEMICAL PG
******************Starting Donor Process
June 2020: Egg Donor Cycle and Fresh Transfer of 1 embryo in Czech Republic - CANCELLED DUE TO COVID19
October 2020. Split Cycle at UFC with a friend (Andrea) I met on the Bump who was also supposed to go to Prague too
DE Retrieval 9/26/2020, 26R, 24M, 12 split Cycle, 9 Fertilized + 1 "questionable", PRAYING FOR AT LEAST 5 BLASTS
10/1/2020: 4 5DBlasts (AA, BB, BC, BC), 10/2/2020: 3 6DBlasts (BB, BB, BC) FOR A TOTAL OF: 7 BLASTS!! THANK YOU GOD!!
PGS RESULTS: 5 NORMALS! DAY 5: AA BOY, BB GIRL, BC BOY / DAY 6: BB GIRL, BC GIRL
DE FET October 29, 2020 - CANCELED DUE TO FLUID IN LINING
DE FET November 16th, 2020 (transferring an PGS normal Hatching AA Boy)
3 Daughters (singleton @27yo, ID Di/Di Twins @34yo)
Protein S Deficiency (Blood Clotting Disorder), MTHFR & VIT D issue
5 MC's: Blighted Ovum-D&C @ 9wks; Natural MC @ 7wks; Blighted Ovum-D&C @ 9wks; MC boy-D&C @ 9wks & Chem PG in 2019
Tubes were tied after my Twins (and now I am old). Remarried and want to give my DH a baby!
IVF#1 OE June 2019 - ER 6/15/19, 24R, 21M, 20F, 7 6DBlasts Frozen for PGS Testing,
RESULTS of PGS 4 abnormal girls, 2 abnormal boys, 1 indeterminate girl
FET#1 OE August 23, 2019 (transferring 1 indeterminate girl & 1 abnormal boy) - BFN
IVF#2 November 15, 2019 - ER 9R, 9M, 6F, 2 5dBlasts (fresh transfer) and 1 6DBlast frozen for PGS Testing,
FRESH Transfer: November 20, 2019, 2 5-day blasts transferred!!
BFP 8dp5dt on 11/27 - 12/2 on FRER, BETA #1 12/2 - 11.93. BETA #2 12/4: 4.41 ~CHEMICAL PG
******************Starting Donor Process
June 2020: Egg Donor Cycle and Fresh Transfer of 1 embryo in Czech Republic - CANCELLED DUE TO COVID19
October 2020. Split Cycle at UFC with a friend (Andrea) I met on the Bump who was also supposed to go to Prague too
DE Retrieval 9/26/2020, 26R, 24M, 12 split Cycle, 9 Fertilized + 1 "questionable", PRAYING FOR AT LEAST 5 BLASTS
10/1/2020: 4 5DBlasts (AA, BB, BC, BC), 10/2/2020: 3 6DBlasts (BB, BB, BC) FOR A TOTAL OF: 7 BLASTS!! THANK YOU GOD!!
PGS RESULTS: 5 NORMALS! DAY 5: AA BOY, BB GIRL, BC BOY / DAY 6: BB GIRL, BC GIRL
DE FET October 29, 2020 - CANCELED DUE TO FLUID IN LINING
DE FET November 16th, 2020 (transferring an PGS normal Hatching AA Boy)
Someone inboxed me here awhile ago to ask about it but I missed it not logging in here in quite some time. She asked if I tested again during pregnancy. I did not because I knew it would not change my mind or change the course of my decision making in pregnancy. He passed the AS with flying colors.
Next time, I will choose the next grade A from the list (mosaic trisomy 13) and transfer without abandon. The thing I most want to impress upon you ladies is that PGS testing is not pseudoscience. What they are doing is biopsying a few cells out of hundreds and from the part that only becomes the placenta. They cannot biopsy from any part that becomes the actual baby and even if they could, abnormalities can still correct themselves in utero.
For 30 years, we’ve know that we can place the placenta under a microscope and find islands of chromosome abnormalities having nothing to do with the baby that was just born. And so it makes sense that different labs result differently.
It was an extremely difficult decision and caused great anxiety for us. I will never regret making it even if it had not worked, but at the same time, I know that I wouldn’t be saying the same thing had it not worked. My heart goes out to anyone in the same shoes.
My 7 Year Journey ***Tw in spoiler***
IVF #1 - September 2018; Follistim, Menopur, Cetrotide & Lupron/HCG combo trigger; PGS; ICSI
Back on Levothyroxine
FET #1 - October 2018; cancelled, all PGS aneuploid
FET #1 - November 30th, transferred anyway
Wondfo BFP 5dp5dt, CB Digi 6dpt,
1st Beta on 7dpt 93
2nd Beta on 10dpt 510!
TTC #1 since 2011. Tried for 5 years before we knew there was a one year rule.
Diag w/MS 2016; w/PCOS & IF 2017
New RE 2018; PCOS diagnosis taken away, IF due to ovary adhesions, but prev. RE insists PCOS IF
IUI
IUI #1 July 2017 w/100mg Clo+trigger; BFN; benched w/big cysts
IUI #2 October 2017 w/50mg Clo+trigger; BFN; benched w/big cysts
IUI #3 February 2018 w/5mg Femara+trigger; low P
BFP February; mc March; Subclinical hypothyroid started Levothyroxine
IUI #4 March 2018 w/7.5mg Femara+trigger; BFN
Medicated cycle & TI April 2018 w/7.5mg Femara+trigger; BFN
Tried several cycles on our own; all BFN
My 7 Year Journey ***Tw in spoiler***
IVF #1 - September 2018; Follistim, Menopur, Cetrotide & Lupron/HCG combo trigger; PGS; ICSI
Back on Levothyroxine
FET #1 - October 2018; cancelled, all PGS aneuploid
FET #1 - November 30th, transferred anyway
Wondfo BFP 5dp5dt, CB Digi 6dpt,
1st Beta on 7dpt 93
2nd Beta on 10dpt 510!
TTC #1 since 2011. Tried for 5 years before we knew there was a one year rule.
Diag w/MS 2016; w/PCOS & IF 2017
New RE 2018; PCOS diagnosis taken away, IF due to ovary adhesions, but prev. RE insists PCOS IF
IUI
IUI #1 July 2017 w/100mg Clo+trigger; BFN; benched w/big cysts
IUI #2 October 2017 w/50mg Clo+trigger; BFN; benched w/big cysts
IUI #3 February 2018 w/5mg Femara+trigger; low P
BFP February; mc March; Subclinical hypothyroid started Levothyroxine
IUI #4 March 2018 w/7.5mg Femara+trigger; BFN
Medicated cycle & TI April 2018 w/7.5mg Femara+trigger; BFN
Tried several cycles on our own; all BFN