i am 12 weeks. Have horrible nausea and vomiting. I've tried Diclegis and phergan suppositories. Not much luck with either. My Dr gave me Zofran as a last resort. I'm an OB and work 12 hour night shifts. Some nights are horrible. I'm just leery of the Zofran. Not to mention it gives me an awful headache and constipation. Wondering what your experiences with zofran have been. Did your dr recommend it?