I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
Began TTC in Aug '18 @ age 35
5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
Mar-Jun '19 IUIs, all BFN
Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
May '19 HSG shows open tube, but ultrasound suggests fibroids
MRI in June '19 confirms two large fibroids, one growing through wall of uterus
In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
April '20 --> June '20, natural IUIs, all BFN.
July? saline ultrasound and bubble test demonstrate open tube
July '20 clomid cycle cancelled for thin lining
Aug-Oct, 3 femara cycles, all BFN
RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
May '21, first IVF round cancelled due to cyst.
July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal.
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
Re: IF Weekly Testing & Treatment w/o 2/7
Also, that cervix wash thing sounds uncomfortable and weird. Thank god I've never had that done because usually it takes everything in my power not to pee in my RE's face when he's digging around in there. Most I've had is a swab to disinfect my cervix. Glad the transfer itself went well though! I hear you on the testing dilemma - take it from me who has only tested early once and been disappointed... my rule has always been never to test any sooner than 8-10dp5dt. So I can be sure that I could trust the results without question.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
I know timing for a medicated FET really doesn't matter that much because they're controlling all the parameters but do you think it makes any difference that a 5 day transfer on CD14 is like, unnaturally early even for early ovulators, and that maybe a transfer on CD21 is more likely to follow a more natural cycle timeline and therefore more likely to be successful? I'm a chronically late ovulator to begin with (when I'm not medicated), my normal is anywhere between CD16-19. I'm grasping at straws here, but my early transfer last cycle felt rushed even though my lining and everything else was more than sufficient.
Second Q, this is really more for @keikilove, did I read it correctly that your RE really thought that running was drawing blood flow away from your uterus? I thought exercise in general would be good to get blood flowing and raise your endorphins, etc, but should I not do things like cycling because it draws blood to my other major muscle masses and away from my core? I do both usually, a 20 min cycle and then a 5-10 min core class plus 10-15 mins of stretching or yoga, but where do you draw the line here?
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
Diagnosis (if you've been): AMA, Hashimoto's, and a slew of other things apparently... maybe even PCOS?; also sperm that doesn't ask for directions
How are things going?: Hey ladies! I'm coming out from under my rock to give you a bit of an update, mostly because today I received my Pregune report (Reproductive Immunology report) and it's interesting. I'm going to spoiler a bunch of screenshots for your consumption below.
Otherwise, I'm on Day 5 of mid-cycle bleeding (see my update in TWW if you'd like) and my acupuncturist tells me that the herbs I'm taking aren't known to cause mid-cycle bleeding (I'm 4DPO today and it started on O day). But maybe my body is just extra.
Screenshots... it's a LONG READ/SCROLL:
And then here's MH's and mine compatibility summary:
^^ a few things to note here:
- Anti HY Immunity means that we'll be transferring our female embryos first, since if I generate an immune response against HY antigens would mean significantly lowered chances of subsequent live births.
- Anti-HLA Antibodies... apparently I have them and apparently they're associated with early MCs, obstetrical complications and secondary infertility. Basically, it means that my immune system can go on the fritz against paternally derived antigens. So, I would potentially need to take immune modulators for this.
Then we get to our individual profiles. Of course, MH is a picture of perfect health (semen analysis wasn't part of this report btw; we already had both the DNA sperm frag test done separately and his semen analyses have varied, but have mostly been good since taking all the vitamins.
^^ And like, of course MH is the one that had epilepsy as a child, and also had a Pulmonary Embolism in 2015, meanwhile, I basically have been healthy as a horse until starting TTC.
More on HY immunity and / HLA antibodies.
Now things start to get more interesting: thrombophilia
^^ So I'm guessing Lovenox is in my future.
More fun stuff I'm high risk for:
Now, let's revisit that PCOS diagnosis I had back in 2009, but then was disproven by subsequent labs. Apparently, it might be a thing? Of course, some of this info cannot be relied on because I was taking DHEA in prep for my retrievals because my androgens have traditionally have been VERY LOW. Like my testosterone had been at 5 in October 2020. And also given the not-so-great response in my 1st / 2nd IVF cycles, I chose to add DHEA to my protocol without getting my T, DHEA, SHBG tested. I stopped taking DHEA in mid-Dec, but unfortunately this was after my blood draws. But also, what's up with AMH of 5.55?
And now let's talk about Leptin. WTF is it? Because both MH and I have elevated levels. Now, in December, when we did our testing, I was flirting with a BMI of ~25, and MH was solidly in the "overweight" range.
^^ Perhaps this is why his semen analysis have varied so?
TTC History
TTC#2
Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
Apr/May 2024 | required testing & waiting for a protocol
May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered
Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing
Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025
May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
As for your results, whew, that's a LOT to unpack. I'm no expert on the immune side of things but from what little I have picked up -
- re: Thrombophilia/PAI-1 4G/4G, yup sounds like lovenox and BA are the gold standard for that
I will admit, I went cross-eyed when I skimmed this study but it was shared in the RI group and thought you would find it interesting/relevant
- re: Leptin, never heard of this before but a preliminary google search has come up with some interesting articles. I have no comment on it, other than a "hmm" and a good dose of curiosity
- re: HLA match, I think this is where @keikilove's extensive knowledge is needed.
- curious about the PCOS coming up again. I would think you're right on about the DHEA being correlated with the fact that you were supplementing at the time. As for the AMH level, I got nothin' but we know AMH levels can fluctuate, didn't @optimistgardener have some wide variations too? What was your AMH before? High AMH is also correlated with PCOS, for example mine is very high (9.4ng/ml)
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
@kiki047 my AMH has been consistently in the 2-3 range previously.
Mar 2020: 2.30
Jun 2020: 2.38
Dec 2020: 2.68
Dec 2021: 5.55
Really effing strange.
TTC History
TTC#2
Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
Apr/May 2024 | required testing & waiting for a protocol
May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered
Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing
Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025
May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
@optimistgardener @kiki047 @keikilove
So I asked in Oct about exercise I am a heavy 6-7 day a week worker outer, running, biking, lifting and boxing. My OB said as long as the avg heart rate over the entire time is below 145 it is ok. I spike to 190 sometimes doing hills, as long as it is not consistent and your body has been used to the same routine for awhile prior you will be OK. The heart at higher rates will pump only to wear its needed, lungs, brain, but not uterus. That's all.
TTC Journey
AMA and poor sperm motility/count/morp
5% chance of IUI success
10/26/2021 - MC#1
Zoey Catherine
She fought DIPG (brain cancer) for 2 years
#LETTHELIGHTSHINE
http://zoeyslight.org/
https://www.instagram.com/casey_steinv2.0/
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
TTC Journey
AMA and poor sperm motility/count/morp
5% chance of IUI success
10/26/2021 - MC#1
Zoey Catherine
She fought DIPG (brain cancer) for 2 years
#LETTHELIGHTSHINE
http://zoeyslight.org/
https://www.instagram.com/casey_steinv2.0/
Can I pop in here and ask a question? If you'd rather I didn't, feel free to just ignore. I'm over 35 and been trying longer than 6 months so I think I technically might qualify for some intervention at this point *TW* although with a loss and CP so I'm not sure how that counting works. *End TW* I'm scheduling an appointment with my midwife to go over some next steps, but I'm not exactly sure what to ask/advocate for. I'm not sure I would be moving onto an RE (yet), so is there anything I can ask my midwife for or to do in the meantime? I'm requesting additional thyroid testing because my TSH was a little high, but other than that I'm kind of at a loss for what to be expecting.
TTC Journey
AMA and poor sperm motility/count/morp
5% chance of IUI success
10/26/2021 - MC#1
Zoey Catherine
She fought DIPG (brain cancer) for 2 years
#LETTHELIGHTSHINE
http://zoeyslight.org/
https://www.instagram.com/casey_steinv2.0/
Question: what has you hesitating about consulting with an RE now? Also, technically, with a loss and a CP, you could be considered an RPL case.
TTC History
TTC#2
Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
Apr/May 2024 | required testing & waiting for a protocol
May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered
Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing
Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025
May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
@kiki047 can you elaborate more about cycling? i've never heard that tbh. my OB has always been in the camp of "if it's what your body is used to, keep at it!" and kind of like now is not the time to suddenly decide to become an olympic weightlifter if that's not what you've been doing, but picking up new gentler things (yoga, walking, etc) is always a good idea.
@acleverusername i am a data nerd in all things, so while i don't know if i fully understand half of that report i think it's amazing to get that kind of knowledge about your body.
@optimistgardener thanks for pulling sources! from what i understand the 140 HR rule is one of those old, and not really backed by scientific data rules (of which there are many in the land of pregnancy, i could get on a soap box about the fear mongering that i think happens). also, for what it's worth i def vote treat yourself on the bday cake.
@caseys02 thanks for chiming in with what sounds like a similar mentality from your OB
@acleverusername i will say my OB doesn't consider a CP and MC a RPL scenario, BUT they support going to a RE after 6 mos once you hit 32 which is younger than a lot of OBs. she was happy to support me looking to a RE back in july if i wanted to.
that being said, i guess i am ripping the bandaid off here. we've hit our $5000 insurance deductible already (gah, that's so depressing) so i reached out to BCBS and confirmed that since we've hit our deductible we've got 90% coverage for fertility diagnostic services, and IVF with 4 retrievals. as long as i'm reading it all right. i filled out a contact form for shady grove fertility which has a good reputation from other people i've known to down this route, and actually missed a call from them already this morning. i'm not sure if i'm putting the cart before the horse as we await chromosomal testing
eta: ugh false, apparently they only comply with mandated IVF in Arkansas, Illinois and Massachusetts. Even tho my state also has mandated IVF coverage, so I’m pushing back.
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
TTC History
TTC#2
Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
Apr/May 2024 | required testing & waiting for a protocol
May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered
Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing
Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025
May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
@acleverusername ah yes, optimist is right, it was @bumblebee0210 that I was thinking of. She has a point about the discrepancy between the labs/testing measures. I had my AMH done by my old RE in April but the new RE wanted to re-do it in his own lab in August so that he'd have a true baseline to go by. Yours is still a pretty huge leap but honestly, if you're not doing any more ERs at this point AMH isn't really much of an indicator of anything else so it certainly doesn't seem like something to be majorly concerned about.
@abjm0325 I know there's a concurrent discussion going on over in the Randoms thread about this but yes, by all means, please feel free to pop in and out to ask questions. I agree with what PPs have said about CD3 testing which would typically include a thyroid panel as well, and a semen analysis for YH. My OB also ordered a saline sonohysterogram, otherwise known as an SHG, which includes a pelvic ultrasound. Others have done an HSG instead, it really seems to just depend on the doctor.
@anniemarie887 I'm sorry you're finding yourself starting to go down the IF path, but I can assure you that you're in good company here. FWIW, I know a few people who used Shady Grove, MH and his ex-wife included, who had good things to say about them.
As for the activity question - @bows22 and I have been talking about this too, and @optimistgardener @anniemarie887 we're right there with you in the camp of just don't overdo it/no heavy lifting or taking up some wild new HIIT workout post-transfer but otherwise carry on, keep your HR below 140, and don't let yourself overheat. *TW* I had pretty significant bleeding because I had an SCH after my 2nd FET which ultimately resulted in a MMC, so I was on modified bed rest for 3 weeks. After that I just got it in my head that I had to do next to nothing during the TWW but I've been gradually letting myself let go of that notion because clearly that wasn't the key to a successful transfer after all *end TW*
My old clinic had a whole list of Dos and Don'ts following an embryo transfer like no baths, no hot tubs/saunas, no sex (I'll admit, we've disregarded this one once we had a BFP because I think it originally had to do with not wanting to introduce foreign bacteria close to the cervix after a procedure but 10dpt always felt safe), no activity more than a short walk, no heavy lifting, etc. My new clinic just said no hot tubs/saunas or anything that will raise my body temperature. Otherwise no discharge instructions whatsoever. We feel like common sense prevails here and just don't do anything too wild.
@keikilove thinking about you today and sending you happy, loving, abundantly fertile thoughts for your transfer!
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
@kiki047 @acleverusername. I did have wild fluctuation in AMH-- from 0.4 in January to 1.39 in August of the same year. Same lab, same doctors. I did supplement, but I don't know what changed. Weirdly, I had my best cycle right after that reading, so I wonder if even if it's random fluctuations, if those fluctuations are correlated with actual egg quantity/quality? Also-- doesn't TEW call it "always meandering hormone"? I mean 5.5 is high maybe it's the DHEA. (I was also taking DHEA when mine went up)
@optimistgardener. Why am I associated with the butt-hanging method? I feel like you told me to do that. PIO was actually the one shot I made my husband do, but I did really try to relax my leg... Also-- not to freak anyone out, but I *still* have weird tenderness from PIO shots, and I stopped them like 2 months ago.
BFP 11/30/2017 | MMC 12/31/2017
BFP 6/22/2018 | CP 6/27/2018
BFP 10/5/2018 | EDD 6/14/2019
Baby girl born 6/19/19
TTC #2 May 2020-November 2021
BFP 7/18/2020 | MonoDi Twins | MMC 9/10/2020
BFP 11/7/2020 | CP 11/9/2020
RE Consult January 2021 | Dx "borderline DOR"/RPL
IVF with PGT:
Standard Antagonist:
ER #1 3/27/2021 7R | 5M | 3F | 2B | 1 PGT-A Normal, 1 low-level mosaic
ER #2 4/22/2021 10R | 7M | 3F | 2B | 0 normal, 2 aneuploid
ER #3 5/19/2021 2R | 1M | 0F
Estrogen Priming Antagonist:
ER #4 7/10/2021 5R | 4M | 3F | 1B | 1 PGT-A Normal
Duostim (Standard Antagonist):
ER #5 9/22/2021 13R | 11M | 8F | 5B | 2 PGT-A Normal, 1 low-level mosaic, 2 aneuploid
ER #6 10/9/2021 9R | 6M | 4 F | 1B | 1 aneuploid
FET #1 11/5/2021 | EDD 7/24/2022
Baby boy born 7/19/22
TTC #3 since May 2023 (ntnp)
IVF Started Fall 2023 (Standard Antagonist)
ER #7 10/6/2023 | 9R | 6M | 5F | 3B | 2 aneuploid, 1 high-level mosaic
ER #8 10/31/2023 | 5R | 4M | 3F | 1B | 1 PGT-A Normal
FET #2 11/27/23 | CP (bHCG = 8)
FET #3 planned Jan 2024
@acleverusername I don't have any IF coverage with my insurance, so I suppose I'm reluctant to pull the trigger to move to an RE. I know that is probably what I should start pursuing though as it may be a bit of a wait.
I did also question whether AMH could be correlated with egg quantity, since we know that AFC can fluctuate wildly from cycle to cycle, so might AMH temporarily do the same if @acleverusername had a ton of follicles at that time?
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
@acleverusername I have no input on your report but I love that you got it done and find all the data in it to fascinating!
@optimistgardener I am sorry I missed popping in last week to wish you luck. SS is a dangerous rabbit hole, perhaps take up a new hobby for this TWW and when the Google urge arises, pick up your cross stitch (for example) instead!
@abjm0325 I agree with the others to at least get started with bloodwork and SA if possible through your current doctor. Also getting on the schedule for an RE (or 2) to have a consult and get to know them for the future isn't a bad idea as sometimes the wait can be long to get an appointment.
Diagnosis (if you've been): AMA, DOR, procrastination, block headed sperm, unruly thyroid
@optimistgardener @kiki047 @bumblebee0210 well, PubMed to the rescue. Apparently DHEA supplementation can greatly affect AMH levels.So there. Also, yes TEW calls AMH "always meandering hormone", but generally she says that when ppl say "my AMH in June was 1.47 and now it's 1.08."
@anniemarie887 while Shady Grove is a large and well known clinic, they also tend to be a bit of a "factory", preferring doing the same thing over and over again, even when results don't justify repetition. I recently had a friend who did 2 ER cycles there, got good amount of eggs (12-14 mature each retrieval), but 2-3 blasts that all ended up abnormal. When she tried to get her RE to make change, her RE categorically refused telling her that she just needs to do more cycles. They also don't use HGH (Omnitrope) for egg quality in older patients. My friend then went and consulted with CCRM and the treatment there was like night and day... so she got away from SGH as fast as she could. Moral of the story: don't just consult with 1 doctor/clinic. And don't forget to ask questions not just about the treatment you'll get from the doc, but also the treatment you'll get from the clinic.
TTC History
TTC#2
Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
Apr/May 2024 | required testing & waiting for a protocol
May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered
Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing
Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025
May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
@shortstack930 did you have any more lining checks leading up to your transfer tomorrow?
TTC History
TTC#2
Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
Apr/May 2024 | required testing & waiting for a protocol
May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered
Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing
Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025
May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
@acleverusername wow that report is so detailed! Do you have an appointment with the RI to discuss everything and make a plan? No more lining checks for me but I've been chugging pomegranate juice!
@optimistgardener it is hard not to SS after a FET because with the progesterone it makes you have all the symptoms!!
@abjm0325 I agree with everyone else that you should qualify to see an RE or at least get some testing at the OB. And I second what Clever said about possibly having an RPL diagnosis.
@anniemarie887 definitely use that insurance if you can!! I'm sorry you're here, but you are very welcome!
@walkawaynee I'm so glad you're having such a better experience with this new RE office and I'm excited for your IVF cycle to begin!
@keikilove I hope your transfer went well for you yesterday!!!
Married 07/2012
DD born 07/2014
DD2 born 10/2018
DS born 10/2022
IF history:
TTC #2 since January 2016
June-Aug 2017: 3 IUIs w/Clomid = BFN
Sept 2017: Dx w/Endometriosis
Oct 2017: IUI w/Letrozole = BFN
Nov 2017: IUI w/Letrozole = BFN
Dec 2017: pre-IVF testing
Jan-Feb 2018: IVF--17 eggs retrieved, 13 fertilized, 9 frozen and 1 transferred on 2/10 = BFP on 2/19!!! EDD 10/29/2018
FET Oct 2021: BFP on 10/31! MC at 5 weeks
FET Feb 2022: BFP on 2/15! EDD 10/29/22
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
TTC History
TTC#2
Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
Apr/May 2024 | required testing & waiting for a protocol
May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered
Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing
Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025
May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
@acleverusername yup and she knows about *TW* the MC we had after our FET in October *end TW* so she's just an asshole and doesn't care. I can't wait to hear what TEW says about your results!
Married 07/2012
DD born 07/2014
DD2 born 10/2018
DS born 10/2022
IF history:
TTC #2 since January 2016
June-Aug 2017: 3 IUIs w/Clomid = BFN
Sept 2017: Dx w/Endometriosis
Oct 2017: IUI w/Letrozole = BFN
Nov 2017: IUI w/Letrozole = BFN
Dec 2017: pre-IVF testing
Jan-Feb 2018: IVF--17 eggs retrieved, 13 fertilized, 9 frozen and 1 transferred on 2/10 = BFP on 2/19!!! EDD 10/29/2018
FET Oct 2021: BFP on 10/31! MC at 5 weeks
FET Feb 2022: BFP on 2/15! EDD 10/29/22
@acleverusername thanks for sharing that, good info to know. i know a few women here in maryland who started with johns hopkins and switch to shady grove with more success. ccrm has a location in northern va, but with traffic it can take 2 hours each way for a 40 mile drive.
@optimistgardener they are suppsoed to have an answer for me tomorrow, can you send me some of your optimism my way? bc i am not feeling it for this
@Shortstack06 it's also like 10x worse that YH boss is a woman, she sounds like a total troll. also its none of her business why he needs time off, that's intrusive. eta: GOOD LUCK today!!!
eta: i did wind up making an appt w/shady grove, it's mid march. i've got my OB f/u next week, so i can always cancel the SG appt if i want to. went this morning and had 6 vials of blood taken: A1C, thyroid, lupus, and a bunch of clotting disorder stuff. posting more over on ttcal to try and keep the mess i'm living in relevant.
TTC History
TTC#2
Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
Apr/May 2024 | required testing & waiting for a protocol
May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered
Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing
Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025
May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
Diagnosis (if you've been): post vasectomy and RPL
Pink Champagne is my favorite.
April 2009 - 8+ week MC
January 2012 - BFP - DS Born 10/21/2012
May 2013 - BFP - Twins MMC @ 13 weeks D&C
Oct 2013 - BFP MC @ 6 weeks
Dec 2013 - BFP DD Born 8/16/14 - Cholestasis at 36+5
Nov 2016 - BFP MC @ 6 weeks
Dec 2016 - BFP DD Born 6/19/17 @ 28+4 Severe Pre-E, IUGR, Cholestasis
Nov 2017 - BFP MC @ 6 weeks
Jan 2017 - BFP MC @ 6 weeks
Jan 2019 - BFP MC @ 6 weeks
DH Vasectomy Aug 2019
Feb 2022 - TTC #4 with IVF - RPL testing
Protein C and S Deficiency - Blood Thinners for Treatment - Maybe we don't know!
June 2022 - IVF - 2 embryos - 1 transferred 6/22/22 - Transfer Failed
July 2022 - FET - cancelled
Dec 2022 - Vasectomy reversal
June 2023 - DH diagnosed with Brain Tumor - TTC put on indefinite hold
January 2025 - Surprise BFP! Due 9/13/2025 - CP
January 2025 - Trying Again
TTC History
TTC#2
Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
Apr/May 2024 | required testing & waiting for a protocol
May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered
Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing
Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025
May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
TTC History
TTC#2
Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
Apr/May 2024 | required testing & waiting for a protocol
May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered
Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing
Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025
May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023