Infertility

November IVF

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Re: November IVF

  • @emmasemm- Happy to hear you got the clearance to trigger with ER on Friday as planned.  And 3 mature eggs would be such a huge improvement over last time, I'm so excited for you.  Would they consider a 5 day transfer if they are growing well at 3-4 days, or do they prefer 3/4 day transfers at your clinic?  I wonder if perhaps waiting a little farther into the cycle as someone else on here does (is it you @dragonette505?) may help you since you did several days of stims before anything even started growing?  I know someone mentioned, sorry I forget who it was, that the first few days of stims may be a waste for some people until their body starts naturally producing some hormones, so I wonder if you wait until CD5 or 6 to start stims if it might help you have to stim for less days and expose the follicles to a shorter period of the medications?  

    @dragonette505 Congrats on the wonderful ER and 8 mature and all fertilized, that is a great percentage of fertilization.  Do you get a day 3 report or have to wait until day 5 or 6 for final outcome?  Hopefully this septum won't be a delay, but if they do need to remove it, at least it's better to get it done before the transfer.  

    @mac627 Don't worry too much about the ER, did they give you follicle measurements or an estimate of expected retrieval numbers?  There are many factors that go into recovery after the ER, but the procedure is usually very straightforward and if using general anesthesia or conscious sedation you shouldn't feel a thing.  The worst part for me has always been waking up after and developing worsening pressure/cramps the next 3-6 hours, but this is because my ovaries are HUGE by the time we get to ER and the trauma of egg retrieval causes me to feel very uncomfortable.  Some ibuprofen, rest and increased sodium and fluid intake usually has me feeling better within about 24 hours though.  

    @baseballhoney Good luck in your 2WW.  Hopefully the progesterone continues to cause you little side effects so you can feel well during this period before going for beta.  What day is your beta scheduled and will you test at home prior?

    AFM, had my first monitoring today and boy was I more nervous than ever before.  Since day one of my higher dose stims this cycle I have felt twinges, heaviness in my ovaries as well as increased bloating daily.  Then last night, I started to get sharper pains on each side and got so nervous that I may be ovulating early.  I'm not sure if my body is just more sensitive to these medications after 3 cycles, but am guessing after my ultrasound this morning that it is more likely a quicker response.  I have about 25-35 follicles on each side, about 15 total are already 10-12, there is one that is already a 13.  Then there is a very large group between 8-10, so hopefully some of them will continue to grow with a few more days of medications.  Luckily, there are many growing together for now and no lead follicle as I had previous rounds, but with this many developing, my ovaries are already "huge and quite bloated" as the ultrasound tech put it.  She said there is very little ovarian tissue that is not developing into follicles, and I also have some free fluid, she kept asking if I was in a lot of pain (back and abdomen), which luckily I am not yet..  Previously, I would have 3-5 that would take off and about 10 that would then lag a few mm behind, but never anything quite like this.  I am getting nervous that with a few more days of meds I am going to be even more uncomfortable, as how I feel now is typically how I feel towards the end (after 8-10 days of stims).  Also, I have had mild OHSS before, and am nervous about moderate to severe.  But at the same time, it is nice to feel more secure and comfortable with my RE and his protocol this time around.  I know he reviews the results every step of the way and prescribes the new orders himself.  We will see what the bloodwork shows and next steps later today.  Most likely I will have monitoring again on Friday and start cetrotide either today or tomorrow, based on my calendar.  Hoping that I am on track for possible triggering this weekend with ER Monday or Tuesday (it would be after only 7-8 days of stims) as I am already anxious to get this phase over with so we can prep for FET.  While, we are tentatively still scheduled for a 5 day fresh transfer, it is looking more likely that it will be an FET with risk of OHSS and my progesterone usually rises by the end of stims.  

    Sorry for always writing novels, but I really appreciate how supportive this group is and it's so nice to be able to talk to others who truly understand. While I am not happy that any of us have to be here, I am so grateful to be able to share this experience with such strong and wonderful women!
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  • @adc0417 I have only done a day 5 transfer... the theory is any good embryo will make a baby so day 3 or 5 will not matter if the embie is destined to keep growing. The reason day 5's are preferred is because you have more info about the quality of the embryo. At day 3 they can all look promising, but by day 5 in some cases, half of the embryos may have arrested. At the stage of day 3, theres no way of knowing which ones will keep growing and which will arrest. 
  • @bethann1022 I find I always get achy twingy ovaries the first few days (especially coming off of estrogen priming) I'm always happy to know my girls are awake and doing their business! You've got a ton in there so you are definitely going to feel them more the whole time! Its possible if you get enough mature you will go early....
    I am the gal who my doc makes me wait till CD 6 or 7 before beginning to stim (but that is after coming off priming) and while it makes the whole cycle longer, the active phase is not very long. This past cycle I only stimmed 10 days (which is great for me!) My doc says basically the antral follies are not able to respond to the meds till they reach a certain size so she holds me up till I get there. Although I wonder if the priming makes it all a bit slower, but still since it gives a chance for more follies to pop up it makes sense.

  • @dragonette505 I’m glad you aren’t stuck waiting forever for the MRI, I hope you are able to get the all clear. 

    @mac627 they didn’t give me an estimate but I’m guess I’ll trigger on Saturday night and retrieve on Monday.  I’m basing this on the fact that I have a new employee starting on Monday so it would actually be a horrible day for me to miss work.  Poor girl, I actually missed her second interview too because I was sick that day.  I’m really not winning any boss of the year awards lately.  Congrats on your trigger and good luck at your retrieval tomorrow.  I know I was a mess before my first retrieval.  When I got in the room I actually started ugly crying because I felt like there was so much riding on it and just so many emotions.  I promise you will be ok no matter what happens.  There is so much joy and disappointment on this rollercoaster you WILL be ok!  Trust in your strength and trust in yourself.  Baby dust to you my friend.

    @emmasemm I have definitely found out the less I know the better this process goes for me.  It would have never worked with my old clinic where I trusted no-one though.  I think I’m the only person in the history of PGS testing where I told everyone who would listen you can’t tell me genders DON’T TELL me.  I made them white it out before they scanned it into my mychart.  I can get a little obsessive and the less things I have to google the better it is for everyone involved.  YAY for your trigger tonight and good luck at your retrieval tomorrow I’ll keep my fingers crossed for you

    @adc0417 I’ve never done a day 3 transfer.  My clinics have seemed to only do them if there are only 1-2 eggs still dividing on day3.  They have always said there is much better luck with a day 5 but I don’t really know stats on this.

    @bethann1022 wow that is a quick and big response!  I would be worried about OHSS too I’m glad you RE is keeping a close eye on you.  I will probably doing my ER around the same time you do.  We can be buddies




    Me:38 DW:33 
    TTC History in Spoiler ***Trigger Warning*** Losses/Child Mentioned 
    Dx: My wife has no sperm  :D and apparently my embryos aren't as good as they look
    2016

     * April IUI#1 - BFN
     * June IUI#2 - BFN
     * July IUI#3 - CP  :'(
     * Sept IVF#1 - 4 Retrieved & Mature, 4 Blasts.  Fresh Transfer 1  - CP  :'(
     * November FET #1 - Transferred 1 Blast - CP  :'(
    2017 Switched REs - Recurrent loss testing for me - all normal, remaining 2 frosties sent for PGS - both abnormal
     * April/May IVF#2:  9 retrieved, 8 mature, 7 fertilized, 7 blasts!  Sent for testing - 2PGS Normals (0 remaining)
     * November IVF #3 12R, 8M, 6F, 4 blasts! - All 4 PGS normal!
     * November FET# 2 (Transfer a PGS normal from IVF#2) - BFP!!!
    2018 DD born 8/20/18
    2019 5PGS frosties ( 4 remaining)
      * September FET#3 (1PGS normal) - Beta#1: 139.7  Beta#2: 322.6

  • @2MomsHoping HA! I am the same way.. I know when I will need the day off based on if there are new employee trainings coming up. Also, I can almost always guarantee my boss or my assistant will take the day off at crucial moments in my IVF cycle.... almost without fail! 
  • @bethann1022 Sounds like your follicles are doing great! My RE does 2 betas for some reason so they will be on the 28th and 30th. I am going to try not to test at home, but we will see if I can actually hold off! 

    I got the call call this morning that 2 of our remaining 10 had made it to freezing. I know it's great that we have some to freeze and not everyone gets there, but I can't help but feeling a bit disappointed. 
  • @baseballhoney trust me, I understand how you feel! We want as many embies as possible because who knows which one with be the take home babies. But you’ve got some in you as well and hopefully they are snuggling in real good and those two can be siblings!
  • Received my bloodwork results, E2 already at 610 after only four days of stims, but RE states this is a good number for the number of follicles I have developing, dosing stays the same.  Tomorrow, repeat bloodwork only and most likely starting cetrotide.  Expect my next ultrasound will be Friday or Saturday based on tomorrow's labs.  

    @2MomsHoping it does sound like we are on very similar schedules, we will see what the next few days hold for each of us, but hoping we can trigger this weekend to prevent a holiday retrieval at least.  It's nice to have a buddy going through these steps at the same time!  How are you feeling?
  • Thanks @dragonette505! It's nice to know I'm not alone in my feelings. 
  • bethann1022bethann1022 member
    edited November 2017
    @baseballhoney I also can empathize with your feelings of gratitude and concurrent disappointment as this is how I felt both of my first two cycles.  But remember, you are currently PUPO and hopefully already have your first take-home baby (ies?) growing inside you.    

    Edited for autocorrect errors
  • @dragonette505 Congrats on 8.  I think that is a great number!  I love how much information you have for all of us.

    @bethann1022 that is a whole bunch of follies! 

    @baseballhoney it's a good sign that you have Frosties it means you have good embies.

    @2momshoping i haven't even thought about them revealing the gender before implantation.... Yikes. Do they ask you which one you want?

    @laurad75. Your gift is so thoughtful.  I know an egg donor and she decided to never have children of her own but she helped out another family when she was young.  I know she is very proud of her decision.  

    AFM my first blood draw and sono is tomorrow.  I am sore already- it hurts to sit up and i am curious if I am being a wimp, or i am just crazy bloated for some other reason.  The nurse said it is too early to have stretch pain.  I am 40 years old with good AMH and FSH and on 300 GonalF and 75 Menopur- i feel like my dosage is rather high.  He said I was on 225 10 years ago/ no menopur for my last cycle.
  • @adc0417 my RE does 5 day transfer ideally and only does 3 day if they have to because the embies aren’t looking good for day 5. 

    @bethann1022 wow that’s a lot of follies!! Sounds uncomfortable. Hope you’re able to quickly move to trigger and that you don’t have to deal with OHSS!

    @baseballhoney it’s great that you have some to freeze!! I’m sorry it’s not as many as you were hoping for- it’s hard to have 10 in your mind and then have that cut to 2. Still awesome though!

    @emmasemm so glad you had good growth!! Good luck with the trigger tonight (maybe you already did it because you’re ahead)! If you do a 4 day transfer on Tuesday we would potentially have transfers on the same day! :smile:

    @2MomsHoping man I’m so with you when it comes to needing to take off on the most inconvenient days!! My first IUI was my first day of the very first day of the school year (I’m a teacher) and my potential transfer is next Tuesday- which is parent teacher conferences. Ps. I have off the rest of the week for thanksgiving break! So of course I KNEW it would be Tuesday. :smile: I just keep reminding myself that it’s worth the added stress. I’d rather have something to transfer on Tuesday and have to deal with the inconvenience than have nothing to transfer and be able to go to conferences. Still annoying though!


    Thank you so much for all the reassurance about ER!! I’m feeling better about it I think. I’ve done progesterone suppositories for my IUI cycles but not the PIO, which I imagine is much more intense symptoms. I’ve now transferred my nervousness to the PIO- haven’t had to do an IM shot yet, my hubs is NOT into needles, so I’ve done all the shots so far. Bought him a present today- oranges to practice on.
    TTC #1
    dx: DOR
    8 cycles Clomid (1 BFP & MC)
    3 failed IUIs (Follistim & Trigger)
    IVF #1
  • The bump cut me off! So here’s the rest of my update:

    I’m trying not to invest too much into my numbers because I know the result can be drastically different from my expectations. Trying not to get my hopes up basically. I think I had 4 that were 18+, 6 in the 14-17 range and a few other smaller ones. Hoping some of those become my embies!! 
    TTC #1
    dx: DOR
    8 cycles Clomid (1 BFP & MC)
    3 failed IUIs (Follistim & Trigger)
    IVF #1
  • @bethann1022 I’ve been feeling pretty good.  I’m lucky in that I generally don’t have many side effects with the drugs.  I’m kinda  poor responder so I think they just don’t effect me as much.  

    @baseballhoney I relate.  Anytime I see a number go down it stings.  I think its totally normal to waffle between happy for what you do have and and wishing all those little embryos made it.  Its hard to go through this process with a little bit of grief along the way.

    @sunnyinatx each clinic is different but if you have a bunch PGS normals at my clinic they typically share the gender and you get to choose which one to put in.  Actually the only thing I ever wanted out of a pregnancy was to NOT know the gender and its still one of the very few things I have control over.  This drives my partner mad and actually shocks me because I’m quite the planner, but there is just something romantic about meeting you son/daughter in the delivery room and keeping that mystery that I can’t shake.  ***Begin TW also to be honest since my losses I am very scared of positive tests and I think knowing the gender would make it even harder on me if we have another loss.  End TW***

    @mac627 with the PIO having a little ice pack for the spot and warming the oil in the hand really helped me.  I do all my sims myself but I’m just not limber enough for the PIO..lol I don’t know how people do it themselves.  You follicle counts sound good!  Are you triggering soon?

    Going back in for monitoring tomorrow and I'm going to see what they say, I might have to refill some meds depending on what they say...boo

    Me:38 DW:33 
    TTC History in Spoiler ***Trigger Warning*** Losses/Child Mentioned 
    Dx: My wife has no sperm  :D and apparently my embryos aren't as good as they look
    2016

     * April IUI#1 - BFN
     * June IUI#2 - BFN
     * July IUI#3 - CP  :'(
     * Sept IVF#1 - 4 Retrieved & Mature, 4 Blasts.  Fresh Transfer 1  - CP  :'(
     * November FET #1 - Transferred 1 Blast - CP  :'(
    2017 Switched REs - Recurrent loss testing for me - all normal, remaining 2 frosties sent for PGS - both abnormal
     * April/May IVF#2:  9 retrieved, 8 mature, 7 fertilized, 7 blasts!  Sent for testing - 2PGS Normals (0 remaining)
     * November IVF #3 12R, 8M, 6F, 4 blasts! - All 4 PGS normal!
     * November FET# 2 (Transfer a PGS normal from IVF#2) - BFP!!!
    2018 DD born 8/20/18
    2019 5PGS frosties ( 4 remaining)
      * September FET#3 (1PGS normal) - Beta#1: 139.7  Beta#2: 322.6

  • @2MomsHoping I triggered last night and ER is tomorrow morning! Good luck with monitoring tomorrow. Hope you don’t have to reorder meds- that’s so annoying!
    TTC #1
    dx: DOR
    8 cycles Clomid (1 BFP & MC)
    3 failed IUIs (Follistim & Trigger)
    IVF #1
  • Good luck tomorrow @mac627!
    Me:38 DW:33 
    TTC History in Spoiler ***Trigger Warning*** Losses/Child Mentioned 
    Dx: My wife has no sperm  :D and apparently my embryos aren't as good as they look
    2016

     * April IUI#1 - BFN
     * June IUI#2 - BFN
     * July IUI#3 - CP  :'(
     * Sept IVF#1 - 4 Retrieved & Mature, 4 Blasts.  Fresh Transfer 1  - CP  :'(
     * November FET #1 - Transferred 1 Blast - CP  :'(
    2017 Switched REs - Recurrent loss testing for me - all normal, remaining 2 frosties sent for PGS - both abnormal
     * April/May IVF#2:  9 retrieved, 8 mature, 7 fertilized, 7 blasts!  Sent for testing - 2PGS Normals (0 remaining)
     * November IVF #3 12R, 8M, 6F, 4 blasts! - All 4 PGS normal!
     * November FET# 2 (Transfer a PGS normal from IVF#2) - BFP!!!
    2018 DD born 8/20/18
    2019 5PGS frosties ( 4 remaining)
      * September FET#3 (1PGS normal) - Beta#1: 139.7  Beta#2: 322.6

  • GL today @mac627!

    @2MomsHoping, I'm with you. Not wanting to know the sex is also the one thing I'm clinging to in this process.

    AFM, I'm still stimming away here. Last night was day 8 and my Dr tells me my labs look good, but my estradiol is still lower than they'd like. It looks like I'll be stimming for at least 12 days. 
  • GL today @mac627!

    I'm having a mental crises regarding the PIO shots.  So far in this process I have done all the injections myself with no problem.  I know its ideal that H help me with the IM shots but he travels a lot so I can't count on him being around each night.  I figured I would just have to figure out how to do it myself but when I shared that with my acupuncturist she looked at me like I was crazy and made me feel like it was going to be more difficult than I imagined.  Can I do it myself?  I'm going to start the research right now but if anyone has helpful links or videos that would be great.  I dreamt about this all night.   
    History and blog link in spoiler
    2016 - dx with super low ovarian reserve; failed cycle with clomid, failed IUI, 
    2017 - egg retrieval #1 - 3 eggs, 0 embryos appropriate for transfer; ER #2 2 eggs, 0 embryos on day 3; ER #3 1 egg 0 embryos
    moved to donor egg in summer 2017; 35 eggs retrieved; 19 fertilized; 9 total embryos
    Fresh transfer Dec 2017= BFP!  baby boy born 8/22/18

    May 2019 - surprise natural pregnancy ended in MC
    Nov 2019 FET; MC at 9 weeks
    May 2020 FET; BFN
    July 2020 FET; CP treated with methotrexate
    Oct 2020 BFP! 

    Take a look at my blog


  • @laurad75, one of the women in my RESOLVE group does all of her IM shots herself. Apparently she sits on a stool in front of a mirror so she can see what she's doing back there. So, it is possible!
  • @laurad75 there are quite a few women who do PIO themselves, but for me it was pretty difficult.  I am an RN and prefer to give myself the injections, also my DH works 1-2 evenings a week so isn't always available when I need them done. My first FET in January, I tried to do the first two in my thighs and honestly could not walk without pain for weeks after, do not try this unless your RE allows it and possibly gives you a short 1in needle (I know a couple women who were able to do that).  So I then switched to Crinone for next 2 cycles, but after an ERA showed that I was pre-receptive, my RE strongly suggested I switch to only PIO.  I did 6 injections of PIO for the next round, I was so stuck on not having my DH do them that I did 5 in the right and tried one on the left (failed miserably so had to have DH do in the middle of the cycle).  Well when I started my last FET and knew I would have to do a minimum of 16 injections, I just had my DH do them from the beginning, we drew circles on the target areas and honestly, he did a MUCH better job than I did with these specific injections.  I did have to do two nights myself while he was at work, so I just made sure to reserve the right side for these particular nights and honestly, it was much easier than expected.  

    Hope this helps, I guess my point is, if you can share some of the responsibility for these, it may take the stress off you and also may be easier than you expect.  
  • Hey guys! There has been so much activity the past week I can't keep up! I just got back from a vacation in Morocco (baby moon #3 ...third times the charm, right?) and started estrogen priming today!! I picked up a bunch of my meds today- looks like I will be on 300 Follistim and Menopur (can't remember the dose). Im SO EXCITED!
  • @bethann1022 That is helpful.  I am planning for H to do the injections whenever he can but want to make sure I won't be panicking the nights he isn't around. Thank you.  
    History and blog link in spoiler
    2016 - dx with super low ovarian reserve; failed cycle with clomid, failed IUI, 
    2017 - egg retrieval #1 - 3 eggs, 0 embryos appropriate for transfer; ER #2 2 eggs, 0 embryos on day 3; ER #3 1 egg 0 embryos
    moved to donor egg in summer 2017; 35 eggs retrieved; 19 fertilized; 9 total embryos
    Fresh transfer Dec 2017= BFP!  baby boy born 8/22/18

    May 2019 - surprise natural pregnancy ended in MC
    Nov 2019 FET; MC at 9 weeks
    May 2020 FET; BFN
    July 2020 FET; CP treated with methotrexate
    Oct 2020 BFP! 

    Take a look at my blog


  • @steph8986 I am so sorry none of your made it. So many hugs.
    @dragonette505 yay for 8! FX you get some frosts!
    @baseballhoney so glad your transfer went well. Thinking good thoughts for you!
    @mac627 good luck today!
    @sunnyinatx I am 30 and am going to be on 300 follistim and (I think its 75) menopir- my AMH is 2.08, so I am also nervous about the higher dose

  • @laurad75 when i had to do the PIO, I did it myself.  It takes balls iam not gonna lie but it's easy when the motivation is so good.  With poi think warm, a warm room a warm towel and the meds body temp ish.    I did mine in my upper hip/butt area. I sat on the toilet in reverse and used the toilet tank as the area to set stuff.  You twist and give yourself the shot.  you can also put one hand on the tank to help with the twist.  it bleeds and plan to use a heating pad or sit in your car with the seat warmers on to help disperse the oil.
  • WHOA! SO much to catch up on. I swear I take a few days off the boards and there's about 3 pages to catch up on!

    Congrats to all who went through ER, those who are now PUPO and those about to trigger. I am about to be part of the party (I hope.... if AF shows in the next day or so...)

    I stopped BCP Tuesday (14th) and am waiting for AF today/tomorrow. Meds *should* be arriving today! If I don't see AF I still go in day 3/4 for baseline and they will start me on my new protocol....

    Anyone else in here do microdose this cycle? It is my first time and not sure what to expect (other than the additional shots). Previously I was on priming and 300 gonal, 40amps meno and cetrotide the last 4 days. I always triggered mainly with Lupron and now I get to do a full hCG shot. YAY for IMs :/
  • Hi everyone! I'm sorry I have been MIA. Lots of stuff going on personally this past week and work has also been complete chaos, hence I was on a bit of a forced bump break. I have been keeping up with reading everyone's updates, just haven't been able to respond. I will have to do a thorough response to everyone's updates when I'm on a desktop. 

    Quick update on me: I went for a progesterone test on Monday which was 3 DPO. Came back at 18 so I started Estrace on Tuesday. Had my injection class yesterday. I'll be on 200 units of Puregon and 75 of menopur. CD 1 still on track to be Nov 22nd-ish. Starting to slightly freak out about the process. I have a lot of health anxiety so this process will not be easy on my mental health. 
    Me: 35 I DH: 38
    *TW loss and children mentioned*
    DD:2006 | Dx: Unexplained Secondary Infertility | DS: 2011

    TFAS since 2012

    Oct 16: Spontaneous BFP | m/c @ 9w1d (massive SCH) | D&C
    Apr 17: IUI #1 = BFN
    May 17: IUI #2 = BFN
    Jun 17: IUI #3 = Late BFP (18 DPO) | NMC 17Jul17 @ ~6w
    Aug 17: IUI #4 = Cancelled due to premature ovulation | TI = BFN
    Sep 17: IUI #5 = Cancelled due to overstimulation (10+ follies)
    Nov 17: IVF #1 = Cancelled due to non-IF related health issue | TI = BFN
    Dec 17: IVF #1 = Puregon 200, Menopur 75, Orgalutran, Suprefact trigger due to OHSS risk | 22R, 18M, 16F, 10B frozen  
    Feb 18: FET #1 (medicated) = BFN
    Mar 18: FET #2 (natural cycle) = CP (beta 1: 54; beta 2: 0)
    Apr 18: FET #3 (natural cycle) = cancelled due to missed ovulation
    Apr 18: FET #3 (natural cycle) = BFP! Beta 1: 201  Beta 2: 585 Beta 3: 3254 Beta 4: 9715 U/S 19May - one bean measuring on track with a HB of 125!
    EDD: 07Jan2019 Team Green
    My Rainbow Baby Boy born 03Jan2019 <3 

  • @cmiller73 Ive done two MDL cycles and I definitely got great yields. You do one Lupron shot in the AM and another in the PM (exactly 12 hrs apart, so if you do AM shots at 7 AM the evenings will be 7 PM...make sure you can be somewhere to do these). You will likely not be using the same amounts or doses of the others (and you wont need ganerelix or cetrotide at all as the Lupron will keep you from ovulating). And yes you'll have to trigger with HCG because you will be using Lupron throughout the cycle. You should feel about the same... my current doc has me do AM and PM shots with an antagonist cycle, so it isn't so odd...
  • @tosh24 so glad you are gearing up to start!
  • @sunnyinatx That's good advice.  I like the toilet strategy.  Thank you. 

    @dragonette505 Great news about your sleeper emby but sorry your feeling so shitty.  Take it easy!
    History and blog link in spoiler
    2016 - dx with super low ovarian reserve; failed cycle with clomid, failed IUI, 
    2017 - egg retrieval #1 - 3 eggs, 0 embryos appropriate for transfer; ER #2 2 eggs, 0 embryos on day 3; ER #3 1 egg 0 embryos
    moved to donor egg in summer 2017; 35 eggs retrieved; 19 fertilized; 9 total embryos
    Fresh transfer Dec 2017= BFP!  baby boy born 8/22/18

    May 2019 - surprise natural pregnancy ended in MC
    Nov 2019 FET; MC at 9 weeks
    May 2020 FET; BFN
    July 2020 FET; CP treated with methotrexate
    Oct 2020 BFP! 

    Take a look at my blog


  • laurad75 said:
    @sunnyinatx That's good advice.  I like the toilet strategy.  Thank you. 

    @dragonette505 Great news about your sleeper emby but sorry your feeling so shitty.  Take it easy!
    I cracked up over the sleeper emby
    if it becomes a baby it’s gonna be a ninja!

  • Hi All, Glad things are going well for everyone. There's been a LOT of activity on here! 
    I have my WTF appt coming up this Monday morning. I've started a list of questions. The only thing my 
    Dr. mentioned was that she for sure wanted to do karyotype testing on us. Do any here have other suggestions or things to request from experience? I'm nervous and emotional. From what I gather karyotype testing can tell if there's a chromosome issue, of which they can't "fix" you. If I had my preference for what went wrong, I'd rather it be an issue with my body maturing the eggs properly instead of "all eggs are screwed from the start". But before trying to pay out of pocket AGAIN, I would want testing and reasonable confidence that they know what is wrong and how to fix it. My numbers across the board have always been PERFECT, this includes E2, FSH, AMH, LH, TSH, and Prolactin. They found severe Endometriosis this summer during my Lap, and THAT was my reasonable explanation. Having a problem with the eggs was 100% unexpected (for those that didn't see, I had 6 fertilize, and none grow from there. all were 1 and 2 cells on days 3 and 5). 
    Any ideas or questions I should add to my list? 
    -Steph

    Me:28-Severe Endometriosis  DH:30 -Excellent

    Spring 2008-Started TTC
    Fall 2011"Unexplained Infertiltiy"-3 IUI's with Clomid-All BFN
    Spring 2013-Divorce
    Feb 2017-RE Consult "unexplained Infertiltiy"
    Mar, Apr, May 2017-Letrozole/Ovidrel/IUI-BFN's
    July 2017-Laproscopy/Hysteroscopy-"Severe Endometriosis with Bowel Lesion not removed"
    November 2017-IVF-14-Retrieved, 7 Mature, 6 Fertilized(ICSI) 0 embryos. Fertilized did not divide.
    New d(x)-Egg problem

  • @laurad75 I’m having the same concerns about pio- I’ve done all my shots so far but DH is gonna do this one. We have to start Friday morning. But he won’t always be able to do it- he’ll be away on Sunday for instance so either I have to find someone else to do it or I’m gonna have to do it myself! Asked the nurse this morning and she said not to do the thigh. To sit sideways in front of a long mirror so you can sit the spot, cross your legs and then it should be easier. She said to ice before and to put heat on after. Not looking forward to it!

    @steph8986 glad your appt is coming up! I hope you can get some answers and a plan you feel good about. I don’t know anything about karyotype testing, so I’m sorry I can’t be of much help! I’m wishing you luck with the appointment!

    @tosh24 glad you’ll be starting next week! 

    @cmiller73 I did hcg microdose this cycle each night along with follistim twice a day and ganirelix in the morning. It wasn’t bad- just lots of shots! The ganirelix was the worst one for me! I also did a dual trigger with lupron and hcg - both of those were fine as well but mine were all subcutaneous. I haven’t had to do any IM at all yet (until now for the pio). 

    @kiwi2628 welcome back from Morocco! That sounds lovely. Glad you’re starting soon! 

    @dragonette505 that’s nuts that they got an immature one to fertilize!! Never heard of that being a thing. Wonder how that works! But it’s great that you have 9 now! 

    AFM had the ER today and you guys were right- it wasn’t bad. Just sleepy and a little crampy but a heating pad is my best friend right now. We got 14 eggs so I’m happy with that. Just waiting for the fert report tomorrow! 

    TTC #1
    dx: DOR
    8 cycles Clomid (1 BFP & MC)
    3 failed IUIs (Follistim & Trigger)
    IVF #1
  • @steph8986 I'm guessing they will suggest that it was an egg quality issue, but if your DH hasn't already done so, I'd get an SA done. Karyotyping is pretty basic, my DH and I had that done a couple years ago just to rule out any problems. In most cases, even if they find one or both partners have an issue that doesn't mean it is why all of your embies didn't progress. I'm guessing karyotyping will be able to let you know if you have a mitochondrial disease (which is not super common but could mess with embryo growth). The main think I see if that endo is possibly your main issue as it can wreck egg quality... the main thing I would ask is about what you can do to improve egg quality or if there are any procedures to help with your endo. So sorry none of this sounds good... from what I've heard, the main reasons for embies to arrest so early are:
    genetic abnormalities
    mitochondrial dysfunction
    bad lab practices (which I would look into, because I'm shocked ALL of your embies arrested so early)
    that's all I can think of (but will do some research)
    testing I would want is the karyotyping
    sperm analysis
    not sure if your clinic looks at inflammation markers, but its something to think about
  • @mac627 14 is lucky this month!!! get some rest and drink fluids!
  • *Lurking*

    @laurad75 my husband works shift work so I had a similar situation where he wasn't always available. I did all my stims myself with no trouble but had a mental block on the PIO. There was 2 nights he was working the late shift, 1 of them I drove 2 hours for him to give it to me (which was miserable) so I decided to do it myself the next night. My nurse had given me 1 inch needles to do it in my leg and I trusted myself more there. My advice would be not to do the leg, it bled so so much and was incredibly painful to walk for a few days after (felt like I'd pulled the main muscle for about a week). It's tough but if I had to I'd do it in the hip like some others suggest!  Good luck!
    Me & DH: 28  |  TTC since May 2016  |  DH: Morphology 0%  |  2 IUI's with Clomid - BFN  |  IVF ICSI Sept. 2017
  • Thank you @mac627 and @loverin - I'm not doing it in the thigh.  Not happening.  

    @mac627 Congrats on the 14 and I'm glad you are feeling okay.  

    I'm going to continue watching youtube videos!
    History and blog link in spoiler
    2016 - dx with super low ovarian reserve; failed cycle with clomid, failed IUI, 
    2017 - egg retrieval #1 - 3 eggs, 0 embryos appropriate for transfer; ER #2 2 eggs, 0 embryos on day 3; ER #3 1 egg 0 embryos
    moved to donor egg in summer 2017; 35 eggs retrieved; 19 fertilized; 9 total embryos
    Fresh transfer Dec 2017= BFP!  baby boy born 8/22/18

    May 2019 - surprise natural pregnancy ended in MC
    Nov 2019 FET; MC at 9 weeks
    May 2020 FET; BFN
    July 2020 FET; CP treated with methotrexate
    Oct 2020 BFP! 

    Take a look at my blog


  • @mac627 congrats on 14!!!
  • @mac627 Congratulations on the 14!! And I'm glad everything went well for you. 
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