Intro-losses mentioned, pregnancies mentioned-can I post a PGD question here? — The Bump
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Intro-losses mentioned, pregnancies mentioned-can I post a PGD question here?

I hope I can post a question here about PGD testing.  I was recently posting on PAIF board, but sadly lost 2 babies in the last few weeks. (one at 10w2d yesterday and the other at 8 weeks).  Basically out of 6 5 day blasts, I had 3 pregnancies, of which 5 implanted and began to grow and 5 miscarried.  We are going to begin a new IVF cycle as soon as we can and are considering PGD testing.  Has anyone done this and would you be willing to share your experience?  If all the embryos are abnormal are they all just not used?  What about normal ones? Will those result in a successful pregnancy"  Any advice appreciated.

Re: Intro-losses mentioned, pregnancies mentioned-can I post a PGD question here?

  • I'm so sorry for your losses.  How heartbreaking for you.

    We just did PGD testing and found out today that none of our three embryos are viable.  Even though this is painful, I'm glad we did the testing because now we know these wouldn't have made it if they had transferred them and we have more info about the quality of the embryos so my dr can hopefully make appropriate adjustments to my protocol on the next round.

    If the embryos are abnormal they are not used.  If you get a normal one, they usually recommend only implanting one because the chances of a healthy pregnancy are 60% (I think - I'm not so good with numbers - but it's much higher than if they transfer without testing).

    Because you've had so many losses, it sounds like testing might be the right move for you.

    Good luck with all.
  • I'm so sorry for your losses.

    We did our first ER last November and had 6 5day blasts and we did do CCS or PGS. This tests the embies to see if they are chromosomally correct, PGD tests for a genetic disease so be sure to choose the right one. 

    It was devastating to get the results but after a lot of grieving we realize that it was good we did test or else we would have gone through losses ourselves. Our clinic does not use any embryos that test abnormal in CCS.

    The 2 reasons we chose to do CCS was that my husband is a Kidney patient and DNA in sperm can get affected by CKD & my mother had 6 miscarriages (all in the 2nd trimester) and I am her only live birth. Our RE looked through our history and still didn't think it was totally necessary but once she saw the results she said its good that we did do the CCS or it would have been heartache after heartache.

    I wish you all the best.

    DH :  36, has Chronic Kidney Disease, on dialysis & is waiting on the transplant list (average wait for B+ is 5 years)

    Me:   36, Hypothyroidism, PCOS, BMI 32, need to be done with "child bearing" ASAP so that I can be a Kidney donor (was fun realizing we didn't as much time as we thought :-/ )

    We're TTC#1

    IUI #1 : 5mcg Letrozole (CD 3-7) + Ovidrel Trigger + Had the one follicle = BFN  (March 2014)

    IUI #2 : 5mcg Letrozole (CD 3-7) + 150 iu Bravelle on CD9 (after much begging!) + Had the one follicle = BFN (April 2014)

    7th May 2014 - changed REs, this one seems to care (we think....)

    IUI #3 : 7mcg Letrozole (CD 3- 7) + 75 iu Bravelle (CD 8-12) + CD12 Scan 5/16 + Had 3 follicles (2 under 15mm) = BFN(May 2014)

    IUI #4 : 7mcg Letrozole (CD 3- 7) + 75 iu Bravelle (CD 8-12) + CD12 Scan 5/16 + Had 1 follicle + DH gave best sample so far = BFN(June 2014)

    IVF#1 -  ER Only Cycle Sept-Oct 2014, 17  eggs Retrieved, 14 mature, 10 fertilized, 6 made it to Blast & post PGS  5 were not viable due to chromosomal abnormalities
    Not sure where we go from here...

    We're parents to two very adorable, bratty, affectionate & goofy Bernese Mountain Dog pups who would very much like a 2 legged baby brother or sister of their own!

  • @Roeni ;
    I'm so sorry to hear about your losses. I have lost 2 pregnancies (1 single and 1 twin pg). We are considering PGS testing due to our recurrent loss as well, so I'll be following and reading any future replies. I just wanted you to know I'm thinking of you, and you're not alone. ((HUGS))

    Me (33) | DH (33)
    Married in Oct 2005

    TTC #1 Sept 2007.  Dx PCOS w/ IR, no ovulation, 6 cycles of Clomid failed. First cycle of Femara gave us our first miracle in May 2011
    TTC #2. 10+ cycles of Femara w/ TI, Femara w/ IUI, Starting IVF #1 in January 2015
    My Blog

  • We are doing pgs for gender selection as i carry an x linked disorder.
  • Hopeful_momHopeful_mom
    2500 Comments 500 Love Its Third Anniversary Name Dropper
    edited April 2017
    I'm so very sorry for your losses it's truly heartbreaking!! I know ur pain too well, I MC both twins as well and wish my body could've held on to one, it's been a while since ur post so hopefully u've had success.  Were you able to get any testing done after the fact.  I was able to test baby B as that was the one I delivered 2nd and she came back normal.  I'll spare you the details but I went from my dr appt to both of them sounding and looking perfect to loosing them hours later. I really didn't want to do PGS testing as I wanted to do a 3dt again and become pregnant ASAP BUT because my MC was so bad my RE and OH think I should do the testing.  
    So because of my age I wanted to bank in hopes of more then one child and now I have to pray I can get the one.  My last cycle gave me 3 blasts and they all came back abnormal there's a lot more hurt and tears that go with the testing process.  Yes it's better to know so u don't have another MC but to not even get one normie is devastating too.  Just did another round and was very lucky to be able to get 6 sent for testing.  So at the moment I have hope that I have normies in this batch!!
    Getting the normal is another hurdle checked off as the next step is the transfer.  I hear it's 50% the egg and 50% on ur body.  So besides testing my embryos it's also making sure we didn't miss anything and there's no blood clotting issue or anything on my end.  So far there isn't which makes the MC worse.  U want to kno what is wrong so u can fix it.  And if it's PGD (genetic testing) you need if it wasn't recommended from the beginning after ur original blood work then it's probably PGS testing you would do.
    best of luck and hope we'll be back over to the paif board soon!!! I kno it's never soon enough, it has been some time for you so I hope so!!
    History of TTC in spoiler box
    TTC since 2014
    Unexplained Infertility - but I am 40...Low AMH .30
    7 - IUI (50mg-150mg Clomid) Feb - August 2016 all BFN 
    IVF#1 August 2016 (Antagonist protocol 4/5 eggs) Cancelled cycle :( RE thought I would get at least 10.
    IVF#2 Sept 2016 (microdose luporn pro - disappearing follies, ONLY ONE, convert to IUI) BFN
    IVF#3 November 2016 (4 ER, 3 F,  3DT)-BFP  with TWINS // MC both at almost 10wks  :'( 
    IVF#4 March 2017 //EPP  (10 ER (1 wonky so 9 ER) 7F, 3B (5AB, (2)5BB) PGS tested- ALL abnormal  :'( 
    IVF#5 April 2017 // EPP (7 ER, 7F yes! 6B) 2/5 day 4/6 day - 2 PGS normal! yes!! :)
    IVF#6 May 2017 // Antagonist didn't have time for Estrogen Priming...(4 ER, 3 F, 3B) (5AB, (2) 5BB) 2 PGS normal, yes!! :)
    IVF#7 June 2017 // EPP praying this is it and then on to an FET!

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