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PCOS/Metformin users

Lindsey7348Lindsey7348 member
in Pregnant after IF
Hi ladies!

I am 7w3d pregnant with twins and have been taking my metformin for 6 months now. At my RE appt yesterday, he graduated me to my OB/GYN. I told him I was to run out of metformin soon (today) and he said well have your OB check your glucose levels to determine if you need to continue on it or not. I do not have an appt there until next Wednesday and am nervous about stopping the medicine, even just for a week. He said I would be fine to discontinue use of it anyway.

My question I guess is, if any of you were on Metformin, did you stop taking it once you got pregnant? Before end of first tri?

TIA!!
Me: 31 DH: 31
TTC#1 since Sept. 2011
March 2012-June 2012 - IUI's- BFN

Sept 2012= IVF #1- 14 eggs, 9 fert, no frosties. 2 blasts 5dt=BFN
Oct/Nov 2012= IVF #2- 20 eggs, 14 fert, no frosties. 2 blasts transferred despite mild OHSS=BFN
Nov 2012= hubby got transferred, moving to new state, time for a break until summer!
Feb 2013= Natural BFP!! Valentine's day surprise! 
Mar 2013= m/c @ 7.5 weeks :(

*New RE*
July 2013= ER for a freeze all cycle. 21 eggs, 9 fert, freeze all day 1.
Lab is closed in August! (Of course!) 
Sept 2013= FET #1 - transferred 3 not so great quality day 3 embies=BFN
Oct 2013= FET #2- transferred 4! 3 good, 1 poor= BFP! On hubby's birthday :)
Started bleeding at 5w5d. ER trip confirms one gest sac, one yolk sac, no fetal pole. 6w u/s showed nothing. Levels drop from 4,500 to 250. 
Nov.2013=meet with RE to discuss where to go from here.
       *Tests showed PCOS-ish. High testosterone. Start Metformin 1500 mg.
February 2014- CLomid, IUI, Trigger. 4 juicy and ripe follies (24,25, 28 and 34!) 111 million post wash sperm count. BFFN!!!! WTH?
March 2014- Over my RE. Year of fun for us and looking into RMANJ.
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Re: PCOS/Metformin users

  • poohnikipoohniki member
    I'm on metformin but also on prednisone which raises glucose levels. I am 10w and no signs on me stopping anytime soon.
    ***WARNING***

    TTC Since 12/2008;  DH: 32, Azoospermia     me: 33, DX during IVF #4: Low AMH (Normal FSH) / SER due 
    to IVF Meds (causing failure to fertilize) Recent DX: Hashimoto's, Lupus Anticoagulant, White Blood Cell Disorder 
    High ANA, ATA, & APA, PAI-1 Heterozygous= blood clotting disorder; connective tissue disorder 
    IVF w/ ICSI #1 2/2011     IVF w/ ICSI #2 5/2011    IVF w/ ICSI #3 12/2012   *New RE* IVF w/ ICSI #4  5/2013
    IVF w/ ICSI #5 8/2013 (Natural Cycle- No drugs)- One follicle->one blast. CCS normal. FET 9/10- 6BB blast. m/c @ 5w
    IUI #1 12/23- BFN  IUI #2 Cancelled (ovulated during AF)  Prep:CoQ10 (300 mg); DHEA (25 mg); Melatonin (3 mg), Folgard 2.2, Metformin 500 2x, Levothyroxine 50mcg, Aspirin 81mg w/ calcium, B12,  Vit. D 4000 & Prenate Elite Daily; Cabergoline 1/2 pill 2x week-  Cycling: Estrace Priming; Prednisone 10mg, Lovenox 40mg 2x,  Femera & Menopur   
    IUI #2.1 6/30 & 7/1. 1st Beta: 90 (7/15); 2nd Beta: 226 (7/17); 3rd Beta: 766   EDD: 3/23/2015

       **ALL WELCOME**                                    My Blog 
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  • Aeml1985Aeml1985 member
    I was in metformin, but am/was non insulin resistant PCOS (always normal sugars) so it was ok for me to stop taking it once I was pregnant.
    Andrea (31), married Aaron (36) September 2012
    Parents to fur babies Tiki and Gizzmo and 2yr old Georgia
    IF veterans; #1 conceived on second clomid+HCG+IUI, #2 conceived on 1st Letrozole+HCG+IUI
    EDD: Feb 5, 2018


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  • happygirl1013happygirl1013 member
    I am 26 weeks and I continue to take metaformin.  My OB said it can help reduce miscarriage changes in the first tri, and because I have insulin resistance, it helps prevent gestational diabetes throughout the rest of my pregnancy.  Good luck!

    IVF #1 Oct 2013- cancelled 
    IVF #2 Mar 2014- success.... baby girl born 11/28/14
    FET #1 Mar 2016- baby boy due 12/16/16


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  • ktupiakktupiak member
    I also have insulin resistance with PCOS. I am 13 weeks right now but when I first found out I was pregnant I forgot to ask my doctor if it was okay to keep taking the metformin so I stopped it for about a week. I went crazy, I could feel the changes so quickly even without eating sugar it was not a smart decision for me. I did some research and talked to my doc fin ally and like PP said it does reduce your chance of early miscarriage as well as help with gestational diabetes. I myself am on the lowest dose 500mg) and it doesnt seem to be working anymore so tomorrow at my appt I am talking to my doc about possibly allowing me to take more, I really dont want to develop the gestational diabetes sp I wantto get this under control now. with this medicine the rewards greatly outway the riks.
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  • Lindsey7348Lindsey7348 member
    Thanks so much ladies!! I called my pharmacy and they approved another RX so I am going to continue it until I speak with my dr next week. I'm nervous bc i have only seen her twice which is during my annuals. I see my RE for all things fertility/pregnancy related so I feel she wont know what to do/say.
    Sigh. I just want to rest easy.
    Thanks again!
    Me: 31 DH: 31
    TTC#1 since Sept. 2011
    March 2012-June 2012 - IUI's- BFN

    Sept 2012= IVF #1- 14 eggs, 9 fert, no frosties. 2 blasts 5dt=BFN
    Oct/Nov 2012= IVF #2- 20 eggs, 14 fert, no frosties. 2 blasts transferred despite mild OHSS=BFN
    Nov 2012= hubby got transferred, moving to new state, time for a break until summer!
    Feb 2013= Natural BFP!! Valentine's day surprise! 
    Mar 2013= m/c @ 7.5 weeks :(

    *New RE*
    July 2013= ER for a freeze all cycle. 21 eggs, 9 fert, freeze all day 1.
    Lab is closed in August! (Of course!) 
    Sept 2013= FET #1 - transferred 3 not so great quality day 3 embies=BFN
    Oct 2013= FET #2- transferred 4! 3 good, 1 poor= BFP! On hubby's birthday :)
    Started bleeding at 5w5d. ER trip confirms one gest sac, one yolk sac, no fetal pole. 6w u/s showed nothing. Levels drop from 4,500 to 250. 
    Nov.2013=meet with RE to discuss where to go from here.
           *Tests showed PCOS-ish. High testosterone. Start Metformin 1500 mg.
    February 2014- CLomid, IUI, Trigger. 4 juicy and ripe follies (24,25, 28 and 34!) 111 million post wash sperm count. BFFN!!!! WTH?
    March 2014- Over my RE. Year of fun for us and looking into RMANJ.
    Report Reply
  • orange1414orange1414 member
    I stopped my Met at 12 weeks. My MFM wanted me to have an early glucose test, which I did at 14 weeks, and passed easily. I'll do the normal gestational diabetes test later on. It was so great to get off the Met and away from the GI issues!
    Trying to grow our family with both fertility treatments and adoption since March 2009 
    IUIs#1-4 = BFN, IVF#1 = c/p, IVF#2 = OHSS, FET#1=BFP
    BabyFruit Ticker
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