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suppression or no suppression

zeynsomzeynsom member
in Infertility Veterans
Hi all,
I have DOR. My first IVF cycle we used BCP for three weeks and then microdose flare protocol (Lupron 20 and Follistim 300 am and pm). I produced five eggs, 4F, three 3dt, one frozen on 6th day, none stuck. For my next cycle my RE does not want to use BCP because she thinks that it suppressed me too much. But we are still doing microdose lupron flare. I have heard from a few people that these natural cycles without BCP (or even estrace) are the worst. Eggs can be all over the place with their sizes and some people produced even less. Has anyone had a similar experience? Can you please share your experiences? Should I force my RE to change my protocol? If you used both BCP and estrace, which one worked better for you if you are DOR?

---- Siggy warning ------

Me 34 y/o  DH 35 y/o

IVF#1 (ICSI)-- April 2014-- MDL with BCP, 5R, 4 ICSID, 3dt with three embryos, 1 six-day freeze (2BA grade)-- BFN

IVF#2.1 (ICSI)-- August 2014: MDL without BCP-- cancelled

Natural IUI on 11/8 -- BFN

IVF#2.2 (ICSI)--Nov/Dec 2014: MDL without BCP, 5R, 1 ICSID, frozen on day 6 (grade 2BB)

FET #1: transferred two 5 (or 6?)day embryos on January 27. Beta #1 (2/4): 158, Beta #2 (2/6): 391 Beta #3(2/9): 1187 BFP! 

First u/s at 5w1d showed one gestational sac and yolk sac. Second u/s at 6w showed heartbeat at 102. Third u/s at 7w heart rate 145. EDD 10/15/2015


image

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Re: suppression or no suppression

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    mm29mm29 member
    For the future please note general questions will be best answered over on the Infertility  page.  This page is for those who have been posting on the IF board for 6+ months.  

    But to answer your question, BCP suppression can be bad for those of us who have DOR. Estrogen priming with medications such as estrace will actually prevent you from having lead follicles. From what I have seen with my own cycles and others who post on these boards, the REs who like to use BCPs is mostly for timing reasons. It is also my understanding that most women with DOR do not do well with Lupron. EPP, Antagonist protocols high stim and low stim are popular protocols for those who have DOR. I wish you luck!!
    ::: Married June 2003:::
    TTC #1 since: Aug. 2008
    Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo
    DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA
    Tx History: IUI 1&2= BFN
    IVF# 1 W/ICSI= BFN
    IVF# 2: cancelled d/t no response
    IVF# 3= 1 egg retrieved=immature/not viable
    IVF# 4= c/p
    ***CCRM ODWU***
    Found DHs BT and Me-decreased blood flow to uterus
    Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally
    ***New RE***
    DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture. 
    IVF# 6: (OE/DS) cancelled
    IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5
    Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015

    http://icanhazbabyz.blogspot.com/
    imageimage image 
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    J&D2007J&D2007 member
    Your question as pp indicates, should be posted over on IF, but let me address your question. I don't really think there is a need in your case for OCP's. I would definitely think about discussing other options other than MD Flare protocol. Yes, it's more difficult to get even egg growth but some say using an EPP protocol would help that. Has your RE discussed doing an EPP protocol with antagon instead? From personal experience, I had 5 retrieved with my MD flare protocol and 13 retrieved with a natural start antagon protocol. HTH.
    Me: 37, DH: 38: ttc 7 years, dx: unknown
    10/11: after 2 years, saw a RE, FSH 5.4
    11/11: BFP! (surprise after thyroid & normal hsg),
    12/11: missed m/c after 7 week u/s, 1/12: D&C
    6/12 IUI#1-IUI #3: clomid = BFP!, C/P
    IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
    IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
    IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
    IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
    10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
    Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
    Baby Will born 8/18. He's perfect.
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    zeynsomzeynsom member
    @mm29 and @J&D2007 Thank you for the answers. I am sorry if I made a mistake posting here. I have been a regular at the infertility board and have been contributing there a lot for the past six months. I feel like many people at the infertility board are newbees who would not have the experience of multiple cycles to be able to answer my question. 

    ---- Siggy warning ------

    Me 34 y/o  DH 35 y/o

    IVF#1 (ICSI)-- April 2014-- MDL with BCP, 5R, 4 ICSID, 3dt with three embryos, 1 six-day freeze (2BA grade)-- BFN

    IVF#2.1 (ICSI)-- August 2014: MDL without BCP-- cancelled

    Natural IUI on 11/8 -- BFN

    IVF#2.2 (ICSI)--Nov/Dec 2014: MDL without BCP, 5R, 1 ICSID, frozen on day 6 (grade 2BB)

    FET #1: transferred two 5 (or 6?)day embryos on January 27. Beta #1 (2/4): 158, Beta #2 (2/6): 391 Beta #3(2/9): 1187 BFP! 

    First u/s at 5w1d showed one gestational sac and yolk sac. Second u/s at 6w showed heartbeat at 102. Third u/s at 7w heart rate 145. EDD 10/15/2015


    image

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    mm29mm29 member
    zeynsom said:
    @mm29 and @J&D2007 Thank you for the answers. I am sorry if I made a mistake posting here. I have been a regular at the infertility board and have been contributing there a lot for the past six months. I feel like many people at the infertility board are newbees who would not have the experience of multiple cycles to be able to answer my question. 
    I understand. Good luck with your cycle and hope you do not have to make the leap to this side!!
    ::: Married June 2003:::
    TTC #1 since: Aug. 2008
    Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo
    DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA
    Tx History: IUI 1&2= BFN
    IVF# 1 W/ICSI= BFN
    IVF# 2: cancelled d/t no response
    IVF# 3= 1 egg retrieved=immature/not viable
    IVF# 4= c/p
    ***CCRM ODWU***
    Found DHs BT and Me-decreased blood flow to uterus
    Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally
    ***New RE***
    DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture. 
    IVF# 6: (OE/DS) cancelled
    IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5
    Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015

    http://icanhazbabyz.blogspot.com/
    imageimage image 
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