Infertility

pio poll

I'm supposed to start pio tomorrow. Initially the re said in the am, but said I could do pm if I need to be able to have someone else do them. I'm also doing crinone daily 12 hrs apart from the shot.

I've never done pio, so for those that have, I need an opinion. Is it better to do it in the am or pm? Thanks!!
"Everything will be alright in the end. So if it's not alright, it is not yet the end."
Me:29 DH:29  TTC since 1/11 Dx: unexplained IF/early DOR/immune issues 
Feb'12- July'12-testing(all clear minus slight arcuate ute), 3 IUI with clomid all BFN
8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F. 
ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN
IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.  
DX: High NK cells, cytokines, DHEAs& PAI1;  hypothyroid, +APA, restricted bloodflow
7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle
(plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim)
ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
ET 5dt 7/24 2 fully expanded blasts.  SURPRISE 3 FROSTIES!!!
Beta #1 8/2 335!!!! Beta #2 829!!!  1st u/s 8/14 showed TWINS!!!!!
11/11: TEAM PURPLE!!!!!
3/21/14-L&W born at 37w via csection

Here Comes the Sun Blog
PAIF/SAIF welcome!

Re: pio poll

  • I've only done them in the evening. I do them around 7pm, massage, walk around some, and sit on a heating pad if need be. 

    Also, I have to say that the PIO is much better than the vag. pills. It really has only hurt a couple times if we got a bad spot, and i was only sore the first few days. Now it's nothing. You just have to get past that first week and then it's easy!  


    Me: 33 DH: 32 SA#1 low count (6mil) SA#2- now in IUI range!(30mil) Dx:MFI
    11/1- IUI#1,12/1- IUI#2, 1/2- IUI#3 all BFFN
    IVF#1. Long Lupron.ER 3/8 10R,4M,5F. ET 3/3-one 1AB, 2 frosties 5dp5dt-BFP!! Beta 3/25-794 Beta 3/27- 1794
    First u/s 4/8 saw hb. 4/22 missed mc 8w3d. d&c 4/26
    FET #1- bcp start 6/9. ET 7/12. 2 perfect blasts.5dpt-BFP!! 
    Beta 7/24 -1,239!! Beta 7/26- 2569 Beta 7/29- 7120.  U/S 8/7 hb 118! U/S 8/14 hb 143! U/S 8/20 hb 170. Graduated!! Stick baby stick! 


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  • I don't know why, but the PIO takes us forever.  I heat up my rear and the oil in my bra for 10 mins or so, give the shot, massage, then back to heating pad.  Evening hours just seems more convenient for all of that!  Plus, I'd have to get up at 5 am if I did it in the morning because I refuse to try to give myself this injection.  DH has to do it.  I just know I'd pass out with the needle still in there!  :)  It's not bad though.  I haven't had any real pain or soreness during the IVF or this FET.  GL
    Me:40 DH: 43 m/c #1 4/8/08 @ 5w::natural
    m/c #2 missed m/c discovered 12/11/08 @ 8w3d :: d&c 12/15/08
    Feb 2009-began seeing an RE:: DX with unexplained IF
    Sept 2009 -2010 TTC using femara ...eventually work called me out of town.
    June 2011 DX with thyroid cancer-forced to put baby making on hold
    11/15/12 IUI #1 BFN and 12/15/12 IUI #2 BFN
    Feb 2013 IVF-BFN:: April 2013 FET-Cancelled:: July 2013 FET-1 frostie
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  • krdesikrdesi member
    I've never done it, but my doctor said to do AM because then you are moving all day and it gets worked into your muscle.

    **Siggy/Ticker Warning**   

             image
                  TTC #1 since May 2012

                  May 2013: First R.E. appointment

                  DH: SA is good

                   May 2013: CD3 Blood work-normal
               June 2013: Hsg-Right tube blocked

                   July 26, 2013: Starting Follistim for IVF #1

                  August 2013: IVF #1 Cancelled- Abnormal embryos

             October/November 2013: IVF #2 w/ICSI

                        November 8, 2013: Transferred two early blasts (no frosties) 

    November 18, 2013: First EVER BFP! 

    Beta#1: 91  Beta#2: 288

    1st U/S- 5w2d Saw yolk sac!

    3rd U/S- 7w4d HB of 157bpm!

    TEAM BLUE!

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  • I do mine in the afternoon right before I go to work. I am on my feet all night as a server and I think that helps work the oil into the muscle bc I've not had any lumps or bad bruising. I do make sure to heat up the oil before injecting.
    Me: 37, DH: 35 :: TCC since 2/11 SA: Perfect! CD3  HSG = Blocked Right Tube
    April- Femara 2.5mg + Trigger + IUI = BFN   May- Femara 5mg = CX - No Response on Left = BFN
    June- Femara 7.5mg + Trigger + IUI = BFN  August- Lap & Hysteroscopy = Blocked & Partially Blocked Tubes
    September- Femara 5mg = CX - No Response on Left = BFN  October- 100mg Clomid + Trigger + TI = BFN
    IVF # 1: Stims 11/30 ER 12/12/12! (10R, 10M, 8F, 2T, 6 F) :: Beta #1- 176  c/p @ 4w4d
    FET #1 February 26th :: Lost 4 to Thaw, Transferred 2 = BFFN
    IVF # 2 Stims 5/10 ER 5/21 (15R, 13M, 13F, 2T, 7F- 6d3 & 1d5) :: Beta # 1- 15 c/p @ 4w
    FET #2 Cancelled, Right Tube Developed a Hydro  8/28 Hydro & Scar Tissue Removed  Cleared for FET
    FET #2.2 Scheduled for September 20th
    2 Thawed, 2 Transferred! Beta #1- 96, Beta #2 906! :: EDD June 10th
    2015- 2 failed FET. We are done
    SURPRISE! BFP 8/8/16   EDD 4/1/17

     
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  • AM!  We started in the PM the first few days but I was SO sore the next day and it bothered me at night (I had DH massage it and everything before I went to sleep).  Asked my RE to switch to the AM and she said I could as long as I did it the very next morning.  Best idea b/c even though I have a desk job, I was still moving around more than I do at night and it wasn't as sore.  Good luck! 

    **Sig warning***

     

     

    TTC since 9/2011. DH - 32, me 32.

    IUI#1 (natural): BFN; IUI#2 (clomid): BFN; IUI#3 (clomid and follistim): BFN.

    IVF #1 March 2013, freeze all (OHSS).

    FET#1 June: BFN

    FET#2 August: delayed due to thin lining (6.3).  Took a few months off to try and thicken the lining with lots of estrodial.  FET#2.2 December: Cancelled due to thin lining (4.8). Two frosties left.

    *New RE* Sonohystrogram and hystereoscopy done in Feb.

    IVF #2: ER 3/4/14  ET 3/7/14, transferred 3, 3 day 9 cell perfect embryos.  No frosties.

    Beta #1 (14dp3dt) 504

    Beta #2 (21dp3dt) 11,561

    First ultrasound on 4/3/14 showed 3 sacs: one empty and two with beating hearts!!  At 7w2d, found out that one baby did not have a heartbeat anymore.  Praying that baby B makes it.  Baby B is a girl!

    EDD 11/25/14 BORN 11/29/14

    **PAIF/anyone welcomed to comment!!  Thank you.


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  • I prefer p.m.  That is what my RE recommended and that seems to work best with my schedule.  I found that using heat after (microwavable compress or heating pad) and sort of massaging the area with it works well to prevent soreness and lumps the next day and there is more time for that in the evening.  


    ***SIGNATURE WARNING***


    TTC #1

    Me 42, DH 47

    Dx = AMA/DOR, MFI

    IVF/ICSI #1 = BFN

    IVF/ICSI #2 = BFP; early loss

    IVF/ICSI #3 (DE) = BFP; early loss

    FET = BFN

    IVF/ICSI #4 (DE w/ CCS) = BFP

    Beta #1 @ 10dp6dt = 265; Beta #2 @ 14dp6dt = 1251. 

    1st U/S @ 6w2d showed one perfect little heartbeat! 

    2nd U/S @ 7w2d. HB 132 & everything measuring on track.

    Our beautiful little girl arrived January 2015!


  • On prior cycles excluding 4th, I always did mine before bed with my crinone.
    Married BF 6/29/2002/
    TTC Since Aug 2011/
    ME:34 all clear/DH:41 DX Severe MFI/
    IVF w/ICSI OCT 2012 Stims started 10/8/ER 10/19/12/ET 10/24/Beta#1 11/2=BFN (beta was 1.2)

    IVF 2.0-Baseline 11/7/12 beta 0/All Clear
    Stim start 11/7/12//ER 11/19 11M//10F
    ET 2 embies 11/24//Beta#1 28 Beta #2 23 Beta#3 29
    stop meds Beta#4 37/C/P 5W5D EDD:8/12/13/IVF#3 in Jan

    Ivf 3-frozen 3 poor 3day/fet=bfn

    Ivf#4 New dr. New protocol=beta1 197 beta#2 677 beta#3 1557
     u/s 8/13 =TWINS 2 strong hb
    Due Date 4/4/14

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  • Evening about an hour before bed.  We are pretty quick at it now, DH assembles the shot while I feed the kitties, gives the shot, and then I change the kitty waterbowls, brush my teeth, shut the blinds, all the nightly chores.. I think the walking around the house after the shot helps.

    I use Progesterone in Ethyl Oleate and I like it better than the sesame oil. The prog ethyl oleate is thinner, you can use the 25gauge needle, goes in pretty quick.  The sesame we had to use a larger needle, and took longer to push in...

    Best of luck

    Me = 39 DH = 50 TTC (since 01/2009 after a short break, I stopped counting *cycles* in 2010)
    DX 2010 : Unknown Infertility , AMA
    HSG 2005 = Normal / HSG 2010 = Normal
    SA 2005 = Normal / SA 2010 /2012 = Slightly low count : motility, morphology GREAT!
    Chromosomal analysis, MTHFR, ANA's, Lupus, Protein C, Protein S, APCR = Normal 2011

    M/C : 2005 (7wk), 2010 (6wk), 2011 (7wk)

    8 IUI's 2010-2011 all BFN

    IVF/ICSI antagonist 01/2012 #1 = BFN

    IVF/ICSI antagonist long 06/2012 #2 = BFN

    IVF/ICSI/CGH MDLF New Clinic/New RE 11/2012 #3 = One beautiful boy blasty frozen PGS normal

    IVF/ICSI/CGH MDLF 02/2013 #4 = One more beautiful boy blasty frozen PGS normal

    FET 6/20 : One 5AA PGS normal transferred Beta 1 6/28 = 53.9 / Beta 2 7/1 = 220 / Beta 3 7/3 = 550!

    1 U/S  6w3d - Heartbeat 119 /  2 U/S - 7w5d- Heartbeat 169 / 3 U/S (OB) 8w5d - Heartbeat still great!

    Baby G welcomed into the world 3/7/2014

    SAIF / PAIF always welcome ****

     

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  • I do mine in the afternoon right before I go to work. I am on my feet all night as a server and I think that helps work the oil into the muscle bc I've not had any lumps or bad bruising. I do make sure to heat up the oil before injecting.
    Me: 37, DH: 35 :: TCC since 2/11 SA: Perfect! CD3  HSG = Blocked Right Tube
    April- Femara 2.5mg + Trigger + IUI = BFN   May- Femara 5mg = CX - No Response on Left = BFN
    June- Femara 7.5mg + Trigger + IUI = BFN  August- Lap & Hysteroscopy = Blocked & Partially Blocked Tubes
    September- Femara 5mg = CX - No Response on Left = BFN  October- 100mg Clomid + Trigger + TI = BFN
    IVF # 1: Stims 11/30 ER 12/12/12! (10R, 10M, 8F, 2T, 6 F) :: Beta #1- 176  c/p @ 4w4d
    FET #1 February 26th :: Lost 4 to Thaw, Transferred 2 = BFFN
    IVF # 2 Stims 5/10 ER 5/21 (15R, 13M, 13F, 2T, 7F- 6d3 & 1d5) :: Beta # 1- 15 c/p @ 4w
    FET #2 Cancelled, Right Tube Developed a Hydro  8/28 Hydro & Scar Tissue Removed  Cleared for FET
    FET #2.2 Scheduled for September 20th
    2 Thawed, 2 Transferred! Beta #1- 96, Beta #2 906! :: EDD June 10th
    2015- 2 failed FET. We are done
    SURPRISE! BFP 8/8/16   EDD 4/1/17

     
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  • Hmm, didn't realize there were different kinds of PIO.  I'm using the ethyl oleate too so I guess my needles are smaller? It's been easy so far. My RE said time of day really didn't matter for my FET so I just started doing it in the morning after my shower.  That's when I change my patches too so it's easy to do it all at once.  It's been almost a week and my butt is sore but no lumps and the injections don't hurt. 

     

    IF, 5 losses, 1 son, 1 on the way.
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  • I take mine at 8pm but man my butt hurts. Out of all the shots I have taken over the past few weeks this is the worst to me. The shot itself is not hard just slow but soreness after is my problem. We do massages, heat etc and I still ache. I think bc my butt was lumpy to begin with lol
  • We've always done it at night.  The process is just too involved for me to want to add it into my morning routine.  I have enough trouble getting out the door!
    Married my wife 8/2007 ~ TTC #1 since 7/2011
    9 IUIs = 9 BFNs
    IVF October 2012: 22 eggs retrieved, 17 fertilized, 5 frozen
    ET #1: 1 blast = BFP; Blighted ovum discovered at 7w5d; D&E
    FET #1: 1 blast = BFP; Missed m/c discovered at 9w5d; D&E
    Karyotyping: normal ~ RPL Testing: normal ~ Hysteroscopy: normal
    FET #2: 1 blast transferred 10/25; BFP 10/31!
    EDD 7/13/14 ~ Induced at 37w4d due to pre-eclampsia ~ Born on 6/28/14
    *Everyone welcome*

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  • imageHappy_Yahoo_Personaler:

    We did them at 6pm every night.  That way, DH was home to inject me (I refused to do it myself) and it was early enough that it wouldn't interfere with dinner/going out.

    This is what we do, although I've only taken one so far. 


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  • kc1218kc1218 member
    Iv only done them in the evening. I would think that doing them in the am would be good too because you use your muscles more and maybe it would absorb better.
  • In the evening before making dinner. I sat on a heating pad later in the evening.

    Three ectopic preganacies in left tube in 1999, 2003 and 2004. HSG in 2010 concluded left tube blockage. IUI with femara in 2012 BFN. IVF #1 June 2013, 20 retreived, 14 mature, 12 fertilized via ICSI, one transferred, four frozen, BFN.  FET in September 2013 - BFN:( FET #2 April 2014 - BFP!!!!

    Whoever watches the wind will not plant; whoever looks at the clouds will not reap. As you do not know the path of the wind, or how the body is formed in a mother’s womb, so you cannot understand the work of God,the Maker of all things. <?xml:namespace prefix = o />

    Ecclesiastes 11 4:5  

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