I'm supposed to start pio tomorrow. Initially the re said in the am, but said I could do pm if I need to be able to have someone else do them. I'm also doing crinone daily 12 hrs apart from the shot.
I've never done pio, so for those that have, I need an opinion. Is it better to do it in the am or pm? Thanks!!
"Everything will be alright in the end. So if it's not alright, it is not yet the end."
Me:29 DH:29 TTC since 1/11 Dx: unexplained IF/early DOR/immune issues
Feb'12- July'12-testing(all clear minus slight arcuate ute), 3 IUI with clomid all BFN
8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F.
ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN
IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.
DX: High NK cells, cytokines, DHEAs& PAI1; hypothyroid, +APA, restricted bloodflow
7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle
(plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim)
ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
ET 5dt 7/24 2 fully expanded blasts. SURPRISE 3 FROSTIES!!!
Beta #1 8/2 335!!!! Beta #2 829!!! 1st u/s 8/14 showed TWINS!!!!!
11/11: TEAM PURPLE!!!!!
3/21/14-L&W born at 37w via csection
Here Comes the Sun Blog
PAIF/SAIF welcome!
Re: pio poll
TTC #1 since February 2011
C/P 5W3D
Betas 8/30 (108) and 9/3 (565)
Me: 29 (3/5/13- high NK cells) DH: 28 (5/8/12- MFI low morph and motility)
Cycle #21 (IUI#1), Cycle #22 (HSG 9/21/12) and Cycle #23 (IUI#2)=
Cycle #24- December Snow Bunny IVF #1
ER 12/6/12 (14R, 11M, 9F), ET 12/9/12 transferred 2 day 3 embies
Bleeding and low betas=very cautious
Cycle #26 March Lucky Duck- FET #1
scheduled 3/20/13- CANCELLED- lining issues
Cycle #27 May Emerald- FET #1.2
delayed- Starting Trental for 3 months + natural cycles Cycle #28-30=
Cycle #31 August Shooting Star- FET #1.3
transferred 1 hatching blast 8/21/13=
U/S 9/19/13- HR is 128! U/S #2 10/4/13- HR is 174!
It's a BOY!
TTC #1 since 1/10
DX: Unexplained/??? MFI issues
Our lil' lost sparks:
5w3d loss 7/30/10 - EDD March 2011
8w loss 4/15/11 - EDD November 2011
8w3d loss 8/2/12 - EDD March 2013
4w c/p loss 10/29/12 - EDD July 2013
Long story: trying on our own + testing testing testing with 6 rounds of Clomid, more testing, injectables + TI, laparoscopy - one tube blocked, 2 IUIs with Follistim...BFNs.
RPL testing all normal, Karyotyping normal
Moving on to IVF.
IVF #1 April 2012 = BFN, IVF #2 June 2012 = BFP. U/S 7/23 = saw heartbeat but measuring behind. Follow up U/S on 7/30 - no heartbeat. D&C 8/2. Trisomy 12. IVF #3 Oct 2012 = Chemical Pregnancy
Phone consult with CCRM on 12/12/12 - ODWU 1/4/13 - both tubes clear(!) - AFC 24, AMH 3.2, FSH 9.6, LH 5.4, E2 25. DH has high frag rate but improved!
IVF #4 March 2013 CCRM. EP protocol w/ Menopur, Gonal-F & Dexamethasone. ER 3/29 & IMSI, PICSI. 43R 13M 10F 6blasts bio'd. CCS testing reveals 3 normals!!!
FET 5/31/13 of 1 4AA blast - thawed and expanded. 4dp5dt BFP.
Beta 9dp5dt = 181, 11dp5dt = 427. 1st u/s showed a healthy heartbeat! EDD 2/16/14
After 4 years of hoping and heartbreak, our sweet little bean was born on 2/19/14
We are so in love with her.
"I'm not telling you it's going to be easy, I'm telling you it's going to be worth it."
Everybody is welcome!!!
First mini-IVF Sept 2011... Only 1 egg! ... BFN
Switching RE
IVF#2 May 2012 9 eggs and only 2 sperm, WTH!
BFN
Switching RE's within practice
*~God gives his hardest battles to his toughest solders. Unknown.
<
, beta #3 3/4: 268 told to stop meds and let nature take its course. requested 4th beta (3/6); Beta hell for 2 months.
Married June 2011 Dx: anovulatory due to prolactinoma (1.5cmx 1.5cm in 2006)
April 2012: MRI- questionable cyst 8mg by 12mm in pituitary ; referred to RE by Ob-gyn after amenorrhea x 4+ months, provera ineffective, low estrogen level
cycle 1: May 2012, clomid 50mg; cycle cancelled, thin lining, no response
cycle 2: June 2012, femara 5mg; cycle cancelled, no response
cycle 3: July 2012, femara 7.5mg; cycle cancelled (largest folli on Cd12 & cd 16: 11, lining 4)
Repeat MRI July 25,2012- Cyst unchanged, likely old infarction.
Aug. 8: met with RE, move to injectables if HSG and SA normal
Aug. 23: HSG all clear; DH- perfect
Switched to a new RE in early Sept. IVF here we come
Genetic testing reveals: Fragile X- Intermediate risk/grey zone.
IVF#1: ER 11/30: 14 retrieved, 10 mature, 7 fertilized. E2 prior to trigger 5200. Decision made to freeze 6 embryos and transfer later due to OHSS.
IVF#1.2/FET #1: estrogen injects start 1/18, FET delayed to try to thicken lining. lining 5.4mm. FET- 2/18- transferred one 3AA expanded blast. BFP 5dp5dt. Beta #1- 2/27 9dp5dt- 102.27 beta #2 3/1: 147
FET # 2: endometrial scratch 5/6, added estrace vaginally and ASA to delestrogen and PIO. June 10- transferred one 4AA hatched embryo, BFP 4dp6dt, Beta 1 (9dp6dt) 187, Beta 2 (11dp6dt): 412; Beta 3 (15dp6dt ): 4452. U/S #1- one beautiful embryo with a heartbeat of 133 at 7 weeks. 8 weeks: heartbeat 156. EDD 2/26/2014: born 2-3-14 induced due to Pre-E and HELLP at 36w5d.
12/1: met with RE to discuss trying for #2
************ Signature/Ticker Warning ************

Me (32) DH (36) - Finding our way to baby #1
Me: POF/DOR - AMH <0.16, heterozygous c677t MTHFR, insulin resistant and gluten intolerant
DH: Severe MFI
12/2/11 - IUI #1- BFN
8/1/12 - IVF #1 - Zero response from max stims (600iu intramuscularly)
My ovaries are just for decoration
12/6/12 - Adopted five embryos that had been frozen for over ten years!
2/11/13 - DEmbryo FET #1 Thawed four, sadly two didn't survive. Transferred two beautiful blasts.
2/16/13 - First BFP of my life @ 6dp5dt! EDD 10/30/13
3/27/13 - After beta and u/s hell, no heartbeat ever detected. D&C at 9w1d.
6/5/13 - Adopted four new embryos that had been frozen for seven years!
9/12/13 - DEmbryo FET #2. Thawed and transferred two beautiful blasts
9/17/13 - BFP @ 5dp6dt! EDD 05/31/14
9/29/13 - m/c @ 5w1d.
11/19/13 - DEmbryo FET #3. Thawed and transferred one blast from each batch. Wow!
11/23/13 - BFP @ 4dp6dt! EDD 8/7/13
Beta #1 @ 13dp6dt - 522 Beta #2 @ 16dp6dt - 1373
6w5d ultrasound showed one perfect baby with a beautiful heartbeat of 134bpm!
Snowflake baby is a girl!
Our beautiful Snowflake girl arrived on July 22, 2014!
My embryo adoption blog: Wishing on a Snowflake
Me:29 DH:29 TTC since 1/11 Dx: unexplained IF/early DOR/immune issues
8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F.
IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.
ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
ET 5dt 7/24 2 fully expanded blasts. SURPRISE 3 FROSTIES!!!
Beta #1 8/2 335!!!! Beta #2 829!!! 1st u/s 8/14 showed TWINS!!!!!
3/21/14-L&W born at 37w via csection
Here Comes the Sun Blog
PAIF/SAIF welcome!
I ended up doing one myself when DH was working at the firestation. SOOO much easier than I thought! Just practice on an apple first maybe? That's what I did and it helped....and use a mirror.
************ Signature/Ticker Warning ************

Me (32) DH (36) - Finding our way to baby #1
Me: POF/DOR - AMH <0.16, heterozygous c677t MTHFR, insulin resistant and gluten intolerant
DH: Severe MFI
12/2/11 - IUI #1- BFN
8/1/12 - IVF #1 - Zero response from max stims (600iu intramuscularly)
My ovaries are just for decoration
12/6/12 - Adopted five embryos that had been frozen for over ten years!
2/11/13 - DEmbryo FET #1 Thawed four, sadly two didn't survive. Transferred two beautiful blasts.
2/16/13 - First BFP of my life @ 6dp5dt! EDD 10/30/13
3/27/13 - After beta and u/s hell, no heartbeat ever detected. D&C at 9w1d.
6/5/13 - Adopted four new embryos that had been frozen for seven years!
9/12/13 - DEmbryo FET #2. Thawed and transferred two beautiful blasts
9/17/13 - BFP @ 5dp6dt! EDD 05/31/14
9/29/13 - m/c @ 5w1d.
11/19/13 - DEmbryo FET #3. Thawed and transferred one blast from each batch. Wow!
11/23/13 - BFP @ 4dp6dt! EDD 8/7/13
Beta #1 @ 13dp6dt - 522 Beta #2 @ 16dp6dt - 1373
6w5d ultrasound showed one perfect baby with a beautiful heartbeat of 134bpm!
Snowflake baby is a girl!
Our beautiful Snowflake girl arrived on July 22, 2014!
My embryo adoption blog: Wishing on a Snowflake
I do all my other shots and am a nurse so I think I can do it. I just worry about being able to reach and hitting the rightspot.
Me:29 DH:29 TTC since 1/11 Dx: unexplained IF/early DOR/immune issues
8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F.
IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.
ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
ET 5dt 7/24 2 fully expanded blasts. SURPRISE 3 FROSTIES!!!
Beta #1 8/2 335!!!! Beta #2 829!!! 1st u/s 8/14 showed TWINS!!!!!
3/21/14-L&W born at 37w via csection
Here Comes the Sun Blog
PAIF/SAIF welcome!
Draw a circle with a sharpie! Then you can't miss!
************ Signature/Ticker Warning ************

Me (32) DH (36) - Finding our way to baby #1
Me: POF/DOR - AMH <0.16, heterozygous c677t MTHFR, insulin resistant and gluten intolerant
DH: Severe MFI
12/2/11 - IUI #1- BFN
8/1/12 - IVF #1 - Zero response from max stims (600iu intramuscularly)
My ovaries are just for decoration
12/6/12 - Adopted five embryos that had been frozen for over ten years!
2/11/13 - DEmbryo FET #1 Thawed four, sadly two didn't survive. Transferred two beautiful blasts.
2/16/13 - First BFP of my life @ 6dp5dt! EDD 10/30/13
3/27/13 - After beta and u/s hell, no heartbeat ever detected. D&C at 9w1d.
6/5/13 - Adopted four new embryos that had been frozen for seven years!
9/12/13 - DEmbryo FET #2. Thawed and transferred two beautiful blasts
9/17/13 - BFP @ 5dp6dt! EDD 05/31/14
9/29/13 - m/c @ 5w1d.
11/19/13 - DEmbryo FET #3. Thawed and transferred one blast from each batch. Wow!
11/23/13 - BFP @ 4dp6dt! EDD 8/7/13
Beta #1 @ 13dp6dt - 522 Beta #2 @ 16dp6dt - 1373
6w5d ultrasound showed one perfect baby with a beautiful heartbeat of 134bpm!
Snowflake baby is a girl!
Our beautiful Snowflake girl arrived on July 22, 2014!
My embryo adoption blog: Wishing on a Snowflake
Great idea, thanks!!
Me:29 DH:29 TTC since 1/11 Dx: unexplained IF/early DOR/immune issues
8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F.
IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.
ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
ET 5dt 7/24 2 fully expanded blasts. SURPRISE 3 FROSTIES!!!
Beta #1 8/2 335!!!! Beta #2 829!!! 1st u/s 8/14 showed TWINS!!!!!
3/21/14-L&W born at 37w via csection
Here Comes the Sun Blog
PAIF/SAIF welcome!
I've always done PIO in the pm. Good luck!
IVF #1 w ICSI in July 2010 = BFN
IVF #2.1 in Oct 2010 converted to IUI = BFN
IVF #2.2 w ICSI in Dec 2010 = BFN
Met with new RE in new city on 1/31/11.
IVF #3 w ICSI in April 2011. HPT on 5/9 = BFP!
Beta #1 on 5/10 (10dp5dt) = 99.4. Beta #2 on 5/12 = 284. First u/s on 5/26. = Fraternal TWINS!
Twin boys born & lost on 8/16/11 at 18w1d due to PPROM & preterm labor.
IVF #4.1 in Jan 2012 converted to IUI on 1/7/12 = BFN
IVF #4.2 w ICSI in Feb 2012. Lupron on 2/10. Stims on 2/18. ER on 2/29- 7R,6F
ET scheduled for 3/5/12- nothing to transfer
Dh seeing new MFI uro & Dh starting meds- June 2012.
IVF #5 in Dec 2012 = BFFN.
IVF #6 planned for Spring 2013. Praying for our take home baby/ies.
**P/SAIF and P/SAL always welcome!**
TTC since March 2009 // Me and DH - 28
Testing Summer/Fall 2010 - Unexplained IF
IUIs #1-4 ~ Clomid/Ovidrel/TI/IUI ~ all BFNs
IUI #5 ~ Femara/Ovidrel/TI/IUI ~ BFN
IUIs #6-9 ~ Research Study Meds/Pregnyl/TI/IUI ~ all BFNs
IVF Consultation, More Testing
Diagnostic Cycle ~ Mucinex/Progesterone/TI ~ BFN
IVF #1 ~ Menopur/Bravelle/Ganirelix/Novarel/Progesterone/Lupron
7R, 6F // 2 transferred // 3 frosties ~ BFN
FET #1 ~ Estrace/PIO/Lupron
3 thawed // 2 transferred // 1 lost // no more frosties ~ BFP!!
Beta #1 - 456 // Beta #2 - 1176 // Beta #3 - 2933 // Beta #4 - 6753
EDD: May 16, 2013
Bedrest for SCH // 6w2d through 10w1d
Elevated TSH and Lazy Thyroid DX @ 10w - Started Synthroid
Finally released from RE at 13w
~~ My IF Blog ~~
Hysteroscopy 3/2011 2 Polyps removed 4/2011
DH on Clomid / Arimidex to address hormonal issues - Sperm found July 2011!
IVF #1 September 2011 - ER 9/8/2011- 8R, 5M - icsi - 1 made it to transfer - BFFN :-(
IVF #2 Lucky November 2011 - ER 11/25/2011 - 15 eggs!, 13 mature, 10 fertilized with isci - 7 made it to transfer! Transferred 1 - 8 cell and 2 - 7 cell. BFP!!!!
1st U/S - Twins! 2nd U/S - 3 heartbeats!!! - HOLY COW!!!
Prayers for our take home babies!
2 babies born on 3/27/12 and lost. Last baby born on 3/29/12 and lost at 20 weeks.
My angels grew wings shortly after birth.
Ahava Raisel, Matisyahu Nissim & Zev Chaim - Mommy and Daddy will always love you.
IVF #3 July 2012 - ER 7/17/2012 - 10 R. 5 F. 4 made it to ET
Transferred 2 on 7/20/2012 no snow babies :-(
Beta on 7/31/2012 = BFMFN
A miracle gift expected to come to us through adoption around 9/2012
Baby girl adopted - Birth Mother changed her mind and took the baby back
IVF #4 October 2012 - New RE. Doing PGD Testing. 8 R, 7F, 2 made it to 5 day blast for PDG testing. Both Normal (Thank you G-d!!!) 1 boy and 1 girl
transferred one beautiful 5day blast (girl)
Please G-d the almighty one - let this be our take home baby!
Beta #1 158, Beta #2 318, 1 Absolutely magnificent HB at 175! Thank you G-d!!!
Baby Girl born August 5th. Thank you G-d for our precious miracle.
AMA. PAIF & SAIF always welcome - I need all the prayers I can get!
Me:29 DH:29 TTC since 1/11 Dx: unexplained IF/early DOR/immune issues
8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F.
IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.
ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
ET 5dt 7/24 2 fully expanded blasts. SURPRISE 3 FROSTIES!!!
Beta #1 8/2 335!!!! Beta #2 829!!! 1st u/s 8/14 showed TWINS!!!!!
3/21/14-L&W born at 37w via csection
Here Comes the Sun Blog
PAIF/SAIF welcome!