Adding MTHFR to the diagnosis — The Bump
TTC After a Loss

Adding MTHFR to the diagnosis

I don't know how these blood tests weren't done before by the first RE, but I just got an email from the current RE's nurse saying this last round of testing shows I'm compound heterozygous for MTHFR.  Yay.  Let's just add that to my LPD, low AMH and the fact that I'm AMA.  I'm seriously starting to feel like everything is wrong with me.  It's getting depressing. I'll start adding baby aspirin today and we'll do lovenox starting at transfer for the IVF cycle in January.

I've seen some posts recently about MTHFR on here, so I know I'm not alone I'm not alone in dealing with this.  Anyone have a similar MTHFR diagnosis and protocal? 

Also, whenever I see "MTHFR", in my mind I think "mother flucker."  Anyone else? Stick out tongue

TTC #1 since 6/08. Cycle #6 - BFP 12/22/08, EDD 9/3/09, DD 8/14/09 at 37w1d
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TTC #2 since 6/11
me=36 - low AMH, DH=38
BFP #2 - 8/31/11, EDD 5/10/12, M/C 9/23/11
BFP #3 - 3/4/12, EDD 11/14/12, CP 3/11/12
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Re: Adding MTHFR to the diagnosis

  • image egsquared:

    Also, whenever I see "MTHFR", in my mind I think "mother flucker."  Anyone else? Stick out tongue

    that's 100% what I think when I see it... sorry for all your bad news :( 

    BFP #1 - Mango - 6/11/12, EDD 2/22/12 Natural MC 7/15/12
    BFP #2 - Nacho - 10/14/12, EDD 6/20/13, MMC 8 weeks, D&C 11/16/12
    All testing shows both H and I are perfectly normal. Baby Nacho had triploidy. 
    Back to normal business December 2012
    BFP #3 - Froggy - 1/15/13, EDD 9/27/13 TEAM GREEN
    It's a girl! Alice - Born 9/20/13, 8lbs 2oz

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  • I'm Homo Motherflucker on the A gene.

    Ask your doctor for a RX for Metanx,  it's better than Folgard or just super dosing on folic acid as it's essentially a pre-processed version of the B's (MTHFR is essentially the inabilty to process B's). It's also not a bad idea to have your homocyteine & all your B levels checked to see if the MTFHR is actually having an effect on you.

     

    I'm also on the  Baby Aspirin and Lovenox regiment

     

    ETA: There's also a fair amount of discussions to whether MTHFR is a viable cause in recurrent loss. But IMO, better safe than sorry. Baby Aspirin & Lovenox also has more benefits than just the blood thinning aspect, so it's a smart protocol when your RPL

    Married My Love on 6/18/2006
    BFP#1 10/1/2011. Our perfect little girl, Her heart stopped @ 12w1d. D&E 11/23/11
    BFP#2 3/13/12 Weird CP/Possible EP @ 6w0d
    BFP#3 5/28/12 CP @ 5w0d
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  • image egsquared:

    Also, whenever I see "MTHFR", in my mind I think "mother flucker."  Anyone else? Stick out tongue

    Yep, every time I see it that is what goes through my head. Sorry for all the bad news hon. (((hugs)))

    July TTCAL Siggy Challenge - Favorite Children's Book
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    Surprise BFP 5/15/12, EDD 1/29/13, mm/c @ 8wks, discovered at 11wks, D&C 7/11/12
    AF finally arrived on Christmas after 167 days of waiting.
    TTA until January 2014
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  • image katharine25:

    Ask your doctor for a RX for Metanx,  it's better than Folgard or just super dosing on folic acid as it's essentially a pre-processed version of the B's (MTHFR is essentially the inabilty to process B's). It's also not a bad idea to have your homocyteine & all your B levels checked to see if the MTFHR is actually having an effect on you.

    Thanks, will do!

    TTC #1 since 6/08. Cycle #6 - BFP 12/22/08, EDD 9/3/09, DD 8/14/09 at 37w1d
    Baby Birthday Ticker Ticker
    TTC #2 since 6/11
    me=36 - low AMH, DH=38
    BFP #2 - 8/31/11, EDD 5/10/12, M/C 9/23/11
    BFP #3 - 3/4/12, EDD 11/14/12, CP 3/11/12
    BFP #4 - 5/9/12, EDD 1/19/13, CP 5/11/12
    BFP #5 - 8/22/12, EDD 5/5/13, CP 8/24/12
    IVF#1 - January 2013 - EPP/Antagonist - 7R, 3M, 2F, 3dt of 2 8-cell embies
    BFP #6 - 2/3/13, EDD 10/15/13, DS 9/18/13 at 36w1d
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  • First off, I work in a lab and "mother-flucker" is actually how we refer to that test and gene. I almost referred to it that way to my OB once but caught myself just in time. I have the mutation too and was on Lovenox for my most recent pregnancy. I made it to about 9 weeks, which is way farther than I've ever made it before, so I think maybe it helped. I was also put on extra folic acid for it.

    TTC since April 2010
    BFP #1 – March 2011, missed m/c April 2011
    BFP #2 – October 2011, m/c November 2011
    Surprise BFP #3 – December 2011, diagnosed as cornual, terminated January 2012
    BFP #4 – June 2012, m/c July 2012
    Diagnosed with bicornuate ute and MTHR gene mutation
    BFP #5 – October 2012, missed m/c November 2012
    BFP #6 – January 2013, m/c March 2013
    No longer TTC. Diagnosis: Hostile ute. Heartbroken and bitter. Pursuing surrogacy.
    June 2013 - Carrier found! Could this really happen?!
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    ~All AL always welcome~

  • image egsquared:

    I don't know how these blood tests weren't done before by the first RE, but I just got an email from the current RE's nurse saying this last round of testing shows I'm compound heterozygous for MTHFR.  Yay.  Let's just add that to my LPD, low AMH and the fact that I'm AMA.  I'm seriously starting to feel like everything is wrong with me.  It's getting depressing. I'll start adding baby aspirin today and we'll do lovenox starting at transfer for the IVF cycle in January.

    I've seen some posts recently about MTHFR on here, so I know I'm not alone I'm not alone in dealing with this.  Anyone have a similar MTHFR diagnosis and protocal? 

    Also, whenever I see "MTHFR", in my mind I think "mother flucker."  Anyone else? Stick out tongue

    Every single time, haha. I think it sounds worse than it actually is, but I'm not an expert in this area by any means. Just want to give you ((hugs)).

    TTC #1 since January 2011
    BFP#1 April 12, 2011, EDD December 24, 2011, strong heart beat at 7w3d, d&c at 10w6d
    BFP#2 Oct 24, 2011, natural miscarriage, EDD unknown
    After RPL testing my losses and subsequent infertility are considered unexplained.
    Cycle #22: Femara, TI, and progesterone = BFP!! 
    BFP#3 Dec 21, 2012. Beta #1 @14dpo = 134, progesterone 67.8. Beta #2 @ 17dpo = 664! Team green, EDD 9/1/13, healthy baby boy born 9/12/13!
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  • I'm so sorry. Big ((hugs)). I always see mother f*cker when I see MTHFR too!


  • That blows, I'm sorry.

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  • I'm sorry you got bad news :(

    I always think motherf?cker, and even my RE admitted that he does too!

    I have no advice for you, other than to listen to Katharine :)

    PAIF/SAIF, PGAL/PAL welcome.
    TTC since March 2010 ~ Dx Unexplained IF September 2011
    2011: IUI + Clomid = CP#1
    2012: 3 more IUIs + Clomid = 3 more CPs. One on-our-own pg, also CP
    2013: BTB IUI + Lupron/Follistim/Prometrium/PIO = CP #6
    IF testing, RPL testing, Autoimmune testing = all normal
    So lost.
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  • I'm sorry (HUGS).  I think mother f*cker when I see MTHFR as well.

    TTC Since 8/2011
    BFP #1 5/13/12 * EDD 1/24/13 * MC at 7 wks 4 days on 6/11/12
    BFP #2 5/13/13 * Current EDD 1/23/14

    Baby N born 2/8/14


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    Lilypie - (HD7B)

     

     

  • so sorry for the bad news.. i too i'm dealing with this diagnosis,, i too have the same treatment baby aspirin and then lovenox during the pregnancy..  whenever I see the MTHFR diagnosis .. i think of the days of the week: monday, thurs, and friday..
    Lilypie Angel and Memorial tickers BFP 2# 7/5/09,EDD:3/26/10,MC:9/23/09. We Miss our Lucky Charm.
  • Every time I talk to DH about my diagnosis I call it the mother ***gene! haha! I guess we think alike :) 

    So sorry about the diagnosis though :( I also have the gene but I have one copy- not sure what kind- when the RE was explaining everything to us my brain was spinning inside my head! I am currently taking baby asprin and when we did the IUI I was on Lovenox injections.  GL with everything! 

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    TTC #2 Since October 2011
    RE testing results: DH- normal ME- DX:PCOS and One copy of MTHFR gene
    IUI#1 Sept/Oct 2012-Follistim, Ovidrel, Metformin, Baby Asprin, Lovenox, Crinone, and Neevo Beta 10/24=BFN
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  • I think just about everyone refers to it as mother effer. I found a really great blog about it once, wish I would have bookmarked it.

    Apparently mine is the "least worrysome" of the mthfr mutations.  My RE recommends a baby aspirin everyday, especially when I'm not ttc. He said with mine it was kind of up to me if I wanted to do baby aspirin when ttc. I'm kind of on the fence about it right now.

    My homocysteine levels were slightly elevated, so I do take a b-complex and 1mg extra folic acid daily.

    BFP#4 3/17/14 - rainbow Baby BOY arrived 11/10/14 !!

    DX: Uterine Septum - Resection 9/5/13 || MTHFR Hetero A1298C || My Chart

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