Tylenol P.M. vs. Benadryl the lesser of two evils???? — The Bump
3rd Trimester

Tylenol P.M. vs. Benadryl the lesser of two evils????

I prefer to take neither, but if I don't get some freaking sleep I'm going to officially lose it. Anybody use either, and how often? Which one will knock me out more?
Jenny BabyName Ticker

Re: Tylenol P.M. vs. Benadryl the lesser of two evils????

  • mizzmegmizzmeg
    Long-Lasting Membership 1000 Comments 100 Love Its Name Dropper
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    One Benadryl and one tylenol PM have the same amt of medicine that makes you sleepy. 25mg. Only difference is tylenol stops all pain. 


  • Benadryl saved my life during the 3d tri. I took it 2-3 days a week. They both work the same... it's the same ingredient. Tylenol will just help with aches and pains.
  • With Tylenol PM you are exposing the baby to 2 medications (acetaminophen) which is the Tylenol part of Tylenol PM and a sleep aid (I believe diphenhydramine or an equivalent which is an antihistamine) the PM part. FYI: diphenhydramine is the generic name for benadryl.

    Speak your doctor before taking either of these medications. These message boards should not substitute for your doctors advise.

  • I take Tylenol PM every night. Either one is fine to take during pregnancy.


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  • I took Tylenol PM and it worked once for me. I hadn't had an hour of sleep in 3 days.  And finally last night, I fell asleep!!! 6 hours straight.  Benadryl would not me out but keep me tired for a couple of days.  If you don't have to work, maybe Benadryl would be good.
  • kacellekacelle
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    I was in L&D on Friday for an NST, and the sheet they gave me advises taking Benedryl to sleep.
    Married to my best friend 6/5/10
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  • Thanks. Of course I checked with my Dr.'s office. They said both were okay.
    Jenny BabyName Ticker
  • BeabsBeabs
    2500 Comments Fourth Anniversary
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    Tylenol PM = Benadryl + Tylenol

    The normal dosage of diphenhydramine in Benadryl is 25 mg per pill. Tylenol PM is 500 mg acetaminophen + 25 mg diphenhydramine per pill.

    Everyone's different, but what works best for me is 1000 mg acetaminophen and 25 mg diphenhydramine. Good luck!

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  • I ended up taking two Tylenol P.M.'s since that's what I had at my house, and it tool me over an hour and a half to fall asleep, but then 8 selpt for 7-8 hours!!!! That felt nice.
    Jenny BabyName Ticker
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