Trying to Get Pregnant

TTCAL w/o 9/5

**This is a general trigger warning that CP, miscarriage / spontaneous abortion, selective abortion due to medical complications, and/or stillbirth may be mentioned.**

Introduce yourself and anything you think is important: number of loss(es), when you had the loss(es), diagnosis/conditions surrounding loss, etc.

Status:

How are things going? What is something that you are struggling with and/or what is going well?

Any testing coming up/any recent results

Questions?

GTKY: What is your favorite Halloween/fall movie to watch?

Re: TTCAL w/o 9/5

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  • *lurking* welcome back @maggiemadeit
    History
    I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
    Began TTC in Aug '18 @ age 35
    5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
    Mar-Jun '19 IUIs, all BFN
    Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
    May '19 HSG shows open tube, but ultrasound suggests fibroids
    MRI in June '19 confirms two large fibroids, one growing through wall of uterus
    In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
    Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
    April '20 --> June '20, natural IUIs, all BFN.
    July? saline ultrasound and bubble test demonstrate open tube
    July '20 clomid cycle cancelled for thin lining
    Aug-Oct, 3 femara cycles, all BFN
    RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
    Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
    Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
    Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
    May '21, first IVF round cancelled due to cyst.
    July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal.
    Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
    Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
    Feb '22 FET (low-level mosaic): CP.
    May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
    July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
    Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
    From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
    Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
    July 23, Natural FET + baby aspirin. BFN.
  • @maggiemadeit wow, how exciting! Welcome back! When do you get to jump back on the wagon?
    TTC History:
    Me: 36 H: 40 Married 2015. Together since 2010.
    TTC: Sept 2016-Oct 2017
    BFP Oct 2017. DD born July 2018.
    TTC: March 2020. BFP March 2020
    Due date was Nov 2020
    DS born Sept 2020. DS passed away Nov 2020 due to prematurity and birth trauma.
    TTC: March 2021
    IUI #1 Nov 2021, BFN
    IUI #2 Dec 2021 BFP.  MC Jan 2022
    IUI #3 Aug 2022 BFN
    IUI #4 Sept 2022 BFN
    AMH test came back at .081. Was going to move on to IVF with DE, but have decided not to. Will be leaving it up to the universe now.



  • Welcome back @maggiemadeit, how wonderful that YH is ready and willing to try again. Baby aspirin won't hurt to add to your protocol either way, and LP progesterone support is fairly common so hopefully that's easy enough for your OBGYN to get you started. 


    Introduce yourself and anything you think is important: number of loss(es), when you had the loss(es), diagnosis/conditions surrounding loss, etc. TTC for almost 5 years, been doing IVF for ~3.5 of those years (PCOS, MFI). No spontaneous pregnancies, FET #2 MMC @ 11w (SCH), FET #3 MC @ 5w2d (unknown cause). 

    Status: Taking a forced break between cycles due to scheduling conflicts, letting my body rest after 3 years of back to back to back cycles

    How are things going? What is something that you are struggling with and/or what is going well? I've had a lot going on lately, but specifically fertility-related, I guess a small win is that I had a perfectly normal, predictable 29 day cycle which is basically a miracle since IVF meds usually cause my hormones to go all haywire and my cycles are irregular to begin with. That said, I'm struggling with the idea that we're essentially benched since we can't conceive naturally and at this rate it's looking like we might not be able to try again until November, which feels like an eternity. 

    Any testing coming up/any recent results? No, we're basically benched but I do want to pressure my REI for a hysteroscopy because I refuse to believe that we can't find some more answers before we move to surrogacy. 

    Questions? Is it conceivable that I might have scar tissue/retained POC without having had a D&C for my other losses? I did several rounds of misoprostol but we believed we got everything. I've done two SHGs since then and they were supposedly clear but that's the extent of my inter-uterine examinations. 

    GTKY: What is your favorite Halloween/fall movie to watch? Is it an UO that I don't really like Hocus Pocus? I dunno, I'm not really a scary movie kinda gal so I can't think of a favourite. 

    TTC History:

    Me: 36  MH: 39, TTC since Dec 2017

    Aug '18: PCOS dx

    Nov '18: MH SA - 19mil

    Dec '18-Mar '19: Letrozole + TI - all BFN

    Apr '19: Letrozole + TI, - BFN.  Repeat SA (27mil) & DNA fragmentation test (17%)

    Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)

    Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil) 

    Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.

    Mar '20: FET #1, perfect 5AA blast transferred. BFN.

    Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w                                                  

    Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d. 

    May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN. 

    June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between. 


    Sept '21: RPL, immune testing normal

    Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic

    Dec '21: Positive for endometritis, RX Flagyl & Keflex

    Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP

    Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN

    Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin. 

    Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal. 

    June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.

    July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN. 

    Sep '22: Taking a break

    Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed. 

    Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23


  • @optimistgardener @bearmomma1 @kiki047   Thank you. Of course I wish each of you were not still here, but I appreciate the warm welcome back! 

    @kiki047 Congratulations on your beautiful cycle! I’m sorry you have to wait until November. That must feel like an eternity.

    It was a bit of a shock to me honestly that my husband changed his mind, and I’ve been living my life with no regard to TTC, so out this cycle for sure due to my newfound love of retinal, (did you know they can cure wrinkles now??!!), which is apparently not TTC safe. 

    I am currently trying to decide if it makes more sense to just jump in once we have a plan with my OBGYN, or if I should wait to get 3 months of egg quality supplements on board and get my shit together with eating and drinking for our best chances of catching a healthy egg. Either way, I am feeling just extremely grateful to have another chance. 
  • @maggiemadeit so glad you are back! and it's sooooo unfair so much skincare isnt' ttc safe. i did just happily botox my forehead yesterday in hopes that we are out of being benched in the next 2 weeks and i hopefully can get pregnant again.
    @kiki047 i don't know if there is a difference in accuracy between HSG and SHG... but my HSG was VERY evident something was wrong. not sure if you saw when i had posted about it... it wound up being retained tissue in an old implantation site. but, on a positive note - yay for your body cooperating!

    Introduce yourself and anything you think is important: number of loss(es), when you had the loss(es), diagnosis/conditions surrounding loss, etc. CP - Sept '21, MMC - Jan '22, the never ending MC - March '22

    Status: benched on doxy, and waiting for f/u biopsy to make sure endometritis is gone 

    How are things going? What is something that you are struggling with and/or what is going well? kind of all over the place - glad i am prioritizing myself and working out but also i think that's my control freak coming out in a weird coping way - ya know, control the controllable. today is my last day on doxy and i am so ready for this like crying level in pain heartburn to go away. in the land of TTC i just really want to be able to TRY again. *TW pg announcement* had a friend who knows everything from the last year send a group text update that she is 13 weeks which was just a brutal thing to wake up to this morning *end TW*

    Any testing coming up/any recent results? 2nd biopsy on 9/26

    Questions? natm

    GTKY: What is your favorite Halloween/fall movie to watch? oh boy, um, i don't like scary movies. we'll go with Nightmare Before Christmas.
  • @anniemarie887 I was thinking maybe I'd ask for an HSG, if an exploratory hysteroscopy is off the table. So sorry you had to wake up to that text, ugh. My cousin also just announced publicly on her socials so it's everywhere I look. I unfollowed her and her H but I forgot about my aunt and uncle. Blahhh. 

    TTC History:

    Me: 36  MH: 39, TTC since Dec 2017

    Aug '18: PCOS dx

    Nov '18: MH SA - 19mil

    Dec '18-Mar '19: Letrozole + TI - all BFN

    Apr '19: Letrozole + TI, - BFN.  Repeat SA (27mil) & DNA fragmentation test (17%)

    Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)

    Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil) 

    Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.

    Mar '20: FET #1, perfect 5AA blast transferred. BFN.

    Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w                                                  

    Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d. 

    May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN. 

    June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between. 


    Sept '21: RPL, immune testing normal

    Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic

    Dec '21: Positive for endometritis, RX Flagyl & Keflex

    Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP

    Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN

    Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin. 

    Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal. 

    June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.

    July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN. 

    Sep '22: Taking a break

    Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed. 

    Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23


  • @anniemarie887 Just getting caught up on what's been going on in the old threads. I'm so sorry, what an absolute nightmare you've been through. I hope this next biopsy will give you the all clear to begin again. 
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