Trying to Get Pregnant

IF Testing & Treatment w/o 4/18

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Re: IF Testing & Treatment w/o 4/18

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  • @kiki047 those sound like good numbers, hopefully the time passes quickly for results.

    We have to decide if we are going to do PGT-A testing.  I am thinking no but I waffle on this regularly. My RE says I don't need to. 
    Spoiler for History 

    Me - 30 DH - 32

    April 2009 - 8+ week MC
    January 2012 - BFP - DS Born 10/21/2012
    May 2013 - BFP - Twins MMC @ 13 weeks D&C
    Oct 2013 -  BFP MC @ 6 weeks
    Dec 2013 -  BFP  DD Born 8/16/14 - Cholestasis at 36+5
    Nov 2016 - BFP MC @ 6 weeks
    Dec 2016 - BFP  DD Born 6/19/17 @ 28+4 Severe Pre-E, IUGR, Cholestasis 
    Nov 2017 - BFP MC @ 6 weeks
    Jan 2017 - BFP MC @ 6 weeks
    Jan 2019 - BFP MC @ 6 weeks
    DH Vasectomy Aug 2019
    Feb 2022 - TTC #4 with IVF - RPL testing
    Protein C and S Deficiency - Blood Thinners for Treatment - Maybe we don't know!
    June 2022 - IVF - 2 embryos - 1 transfered 6/22/22 - Transfer Failed
    July 2022 - FET


  • edited April 2022
    @kiki047 i'd been hoping for good numbers on your retrieval- those are great! fx for the slowpokes to catch up. 
    @mambo5-2 out of curiosity what would your reasons be for doing pgt-a? i see you're not yet 30, which for most women is good enough reason to not bother with it and is probably why your RE is not recommending it. Do you have reason to think the RPL has a chromosomal component?
    History
    I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
    Began TTC in Aug '18 @ age 35
    5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
    Mar-Jun '19 IUIs, all BFN
    Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
    May '19 HSG shows open tube, but ultrasound suggests fibroids
    MRI in June '19 confirms two large fibroids, one growing through wall of uterus
    In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
    Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
    April '20 --> June '20, natural IUIs, all BFN.
    July? saline ultrasound and bubble test demonstrate open tube
    July '20 clomid cycle cancelled for thin lining
    Aug-Oct, 3 femara cycles, all BFN
    RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
    Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
    Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
    Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
    May '21, first IVF round cancelled due to cyst.
    July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal.
    Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
    Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
    Feb '22 FET (low-level mosaic): CP.
    May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
    July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
    Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
    From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
    Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
    July 23, Natural FET + baby aspirin. BFN.
  • edited April 2022
    @kiki047 sounds like a pretty solid protocol to me however I’m not too savvy in the IVF world as I just can’t let my mind wander there because it’s not something we are currently considering. From what you’ve shared you’ve had a good retrieval tho (not the process but the outcome lol) hopefully more than 50% come back euploid for you! 

    Letrozole just isn’t an option for me right now but it may be in 6ish months! (Exit to add clomid is first line treatment with our clinic and ya basically have to do 6 cycles before they will move into other things which I know I know very old school but it’s all I’ve got to work with) I am hoping the increased dose of clomid paired with metformin will be enough though! It is very frustrating when your body won’t ovulate even when you are tinkering with it with meds to try and force it. 
  • @optimistgardener ahh hopefully these new variables are what makes it all piece together though! 
  • @optimistgardener the big reasons are I'm not 30 yet, cost, and knowing that an embryo is normal still doesn't guarantee success. I really have no reason to believe that my RPL is chromosome related and the RE doesn't think so either. 
    Spoiler for History 

    Me - 30 DH - 32

    April 2009 - 8+ week MC
    January 2012 - BFP - DS Born 10/21/2012
    May 2013 - BFP - Twins MMC @ 13 weeks D&C
    Oct 2013 -  BFP MC @ 6 weeks
    Dec 2013 -  BFP  DD Born 8/16/14 - Cholestasis at 36+5
    Nov 2016 - BFP MC @ 6 weeks
    Dec 2016 - BFP  DD Born 6/19/17 @ 28+4 Severe Pre-E, IUGR, Cholestasis 
    Nov 2017 - BFP MC @ 6 weeks
    Jan 2017 - BFP MC @ 6 weeks
    Jan 2019 - BFP MC @ 6 weeks
    DH Vasectomy Aug 2019
    Feb 2022 - TTC #4 with IVF - RPL testing
    Protein C and S Deficiency - Blood Thinners for Treatment - Maybe we don't know!
    June 2022 - IVF - 2 embryos - 1 transfered 6/22/22 - Transfer Failed
    July 2022 - FET


  • @mambo5-2 yeah i think in your shoes i would probably not do pgt-a. but i would understand if you wanted to have the added confidence that the embryo you transfer is euploid.
    History
    I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
    Began TTC in Aug '18 @ age 35
    5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
    Mar-Jun '19 IUIs, all BFN
    Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
    May '19 HSG shows open tube, but ultrasound suggests fibroids
    MRI in June '19 confirms two large fibroids, one growing through wall of uterus
    In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
    Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
    April '20 --> June '20, natural IUIs, all BFN.
    July? saline ultrasound and bubble test demonstrate open tube
    July '20 clomid cycle cancelled for thin lining
    Aug-Oct, 3 femara cycles, all BFN
    RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
    Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
    Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
    Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
    May '21, first IVF round cancelled due to cyst.
    July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal.
    Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
    Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
    Feb '22 FET (low-level mosaic): CP.
    May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
    July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
    Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
    From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
    Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
    July 23, Natural FET + baby aspirin. BFN.
  • @kiki047 Haha periods are SO WEIRD. I've been a little TMI myself here lately with my wonky period talk. I don't think it's talked about enough since we all go through it and have to deal with it on a monthly basis. And we all seem to have different experiences that might make us think we're "not normal" #normalizeperiodtalk
    TTC History:
    Me: 36 H: 40 Married 2015. Together since 2010.
    TTC: Sept 2016-Oct 2017
    BFP Oct 2017. DD born July 2018.
    TTC: March 2020. BFP March 2020
    Due date was Nov 2020
    DS born Sept 2020. DS passed away Nov 2020 due to prematurity and birth trauma.
    TTC: March 2021
    IUI #1 Nov 2021, BFN
    IUI #2 Dec 2021 BFP.  MC Jan 2022
    IUI #3 Aug 2022 BFN
    IUI #4 Sept 2022 BFN
    AMH test came back at .081. Was going to move on to IVF with DE, but have decided not to. Will be leaving it up to the universe now.



  • What you explaining is 100% on why I waffle on the PGT-A testing. I do know that one of my losses was genetically normal b/g twins, my others were natural losses so no testing was done on those. 
    TW in spoiler

    @kiki047 I'm so freaking excited about 11 making it to freeze for you! I hope that your PGT-A results are amazing!


    Joining the periods are WEIRD. I go to bed with no period and I wake up in a murder scene and I'm irritated about my messed up bedding.  Come on give me some warning so I can put on the dark sheets and my ugly undies. 
    Spoiler for History 

    Me - 30 DH - 32

    April 2009 - 8+ week MC
    January 2012 - BFP - DS Born 10/21/2012
    May 2013 - BFP - Twins MMC @ 13 weeks D&C
    Oct 2013 -  BFP MC @ 6 weeks
    Dec 2013 -  BFP  DD Born 8/16/14 - Cholestasis at 36+5
    Nov 2016 - BFP MC @ 6 weeks
    Dec 2016 - BFP  DD Born 6/19/17 @ 28+4 Severe Pre-E, IUGR, Cholestasis 
    Nov 2017 - BFP MC @ 6 weeks
    Jan 2017 - BFP MC @ 6 weeks
    Jan 2019 - BFP MC @ 6 weeks
    DH Vasectomy Aug 2019
    Feb 2022 - TTC #4 with IVF - RPL testing
    Protein C and S Deficiency - Blood Thinners for Treatment - Maybe we don't know!
    June 2022 - IVF - 2 embryos - 1 transfered 6/22/22 - Transfer Failed
    July 2022 - FET


  • *lurking* 

    Relevant article in today's edition of NYT: https://www.nytimes.com/2022/04/20/health/pgta-ivf-pregnancy-test.html

    TTC History
    TTC#2
    Me: 41; MH: 40 | Met 02/2009 | Started Dating 08/2017 | Married 02/02/2020
    Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
    Apr/May 2024 | required testing & waiting for a protocol
    May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
    Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
    Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
    Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
    Oct 2024... currently awaiting a hysteroscopy (10/28) to check uterine cavity + check for endometritis


    TTC #1
    Me: 36, MH: 34 | Met 02/2009 | Started Dating 08/2017 | Married 02/02/2020
    TTC #1 02/2020 - 07/2022
    2009 | Dx PCOS; likely a misdiagnosis
    07/14/20 | Dx Hashimoto's Thyroditis
    07/21/20 | 1st RE appointment
    07/2120 - 08/20/20 | so much testing; no signs of PCOS
    08/20/20 | Dx Unexplained; AMA
    09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
    09/30/20 | Urology consult; more testing required
    10/2020 | Clomid + OPK + TI + Prometrium | BFN
    10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
    11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
    11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
    12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
    01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
    02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing 
    03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
    04/07/2021 | Natural cycle while we regroup | BFN
    04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
    05/10/2021 | New RE consult & plan for IVF
    05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH. 
    06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
    07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
    08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
    09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
    11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
    12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
    01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
    02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
    03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
    05/20/2022 | D&C; recovering... 
    06/21/2022 | Trying naturally until October 2022
    07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023


  • My SIL just announced she is expecting her third at a family gathering today and I cried on my way there in the first place because I couldn’t have pizza at the pizza party because of my stupid PCOS and attempt to be gluten and dairy free gah 
  • @tryingktogku No pizza AND an unexpected announcement?! All the hugs, lady. 
  • @kiki047 oh man those numbers are awesome. fx for really excellent pgt-a results, as well!
    History
    I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
    Began TTC in Aug '18 @ age 35
    5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
    Mar-Jun '19 IUIs, all BFN
    Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
    May '19 HSG shows open tube, but ultrasound suggests fibroids
    MRI in June '19 confirms two large fibroids, one growing through wall of uterus
    In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
    Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
    April '20 --> June '20, natural IUIs, all BFN.
    July? saline ultrasound and bubble test demonstrate open tube
    July '20 clomid cycle cancelled for thin lining
    Aug-Oct, 3 femara cycles, all BFN
    RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
    Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
    Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
    Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
    May '21, first IVF round cancelled due to cyst.
    July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal.
    Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
    Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
    Feb '22 FET (low-level mosaic): CP.
    May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
    July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
    Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
    From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
    Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
    July 23, Natural FET + baby aspirin. BFN.
  • Somehow I missed hitting post on my reply to @kiki047 but those are amazing results so far, all the fingers and toes crossed for you!
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