@optimistgardener it _IS_ called WTF appointment. So your gut is correct. I'm sorry you have to wait for so long. Hopefully the nice folks at the clinic can accommodate you earlier. Have you called yet to ask if you can get your name on the next retrievals list? I'm sure you've thought about this/have been asked this before. Would consider flying a bit further for this stuff? I.e. Portland or Seattle? I know you've got a crazy teaching schedule, but... OH, any news on your interview process?
@anniemarie887 your OB sounds like a total saint. I'm so glad that in all this sh*t you have someone so wonderful in your corner. May I ask if you were able to test the pregnancy for genetic (ab)normality?
TTC History TTC#2
Me: 41; MH: 40 | Met 02/2009 | Started Dating 08/2017 | Married 02/02/2020 Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center) Apr/May 2024 | required testing & waiting for a protocol May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025 May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
Me: 36, MH: 34 | Met 02/2009 | Started Dating 08/2017 | Married 02/02/2020 TTC #1 02/2020 - 07/2022 2009 | Dx PCOS; likely a misdiagnosis 07/14/20 | Dx Hashimoto's Thyroditis 07/21/20 | 1st RE appointment 07/2120 - 08/20/20 | so much testing; no signs of PCOS 08/20/20 | Dx Unexplained; AMA 09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN 09/30/20 | Urology consult; more testing required 10/2020 | Clomid + OPK + TI + Prometrium | BFN 10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic 11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN 11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN 12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN 01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN 02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing 03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️ 04/07/2021 | Natural cycle while we regroup | BFN 04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance 05/10/2021 | New RE consult & plan for IVF 05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH. 06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded 07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid 08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d 09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid 11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation 12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN 01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN 02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity 03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022 05/20/2022 | D&C; recovering... 06/21/2022 | Trying naturally until October 2022 07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
The good news is my uterus is beautiful, the bad news is... If I'm normal... WHAT'S THE ISSUE? Still waiting on insurance to authorize my genetic testing for RPL, maybe that will give us a hint on the RPL.
Spoiler for History
Me - 30 DH - 32
April 2009 - 8+ week MC January 2012 - BFP - DS Born 10/21/2012 May 2013 - BFP - Twins MMC @ 13 weeks D&C Oct 2013 - BFP MC @ 6 weeks Dec 2013 - BFP DD Born 8/16/14 - Cholestasis at 36+5 Nov 2016 - BFP MC @ 6 weeks Dec 2016 - BFP DD Born 6/19/17 @ 28+4 Severe Pre-E, IUGR, Cholestasis Nov 2017 - BFP MC @ 6 weeks Jan 2017 - BFP MC @ 6 weeks Jan 2019 - BFP MC @ 6 weeks DH Vasectomy Aug 2019 Feb 2022 - TTC #4 with IVF - RPL testing Protein C and S Deficiency - Blood Thinners for Treatment - Maybe we don't know! June 2022 - IVF - 2 embryos - 1 transferred 6/22/22 - Transfer Failed July 2022 - FET - cancelled Dec 2022 - Vasectomy reversal June 2023 - DH diagnosed with Brain Tumor - TTC put on indefinite hold January 2025 - Surprise BFP! Due 9/13/2025 - CP January 2025 - Trying Again
@acleverusername i've been shortlisted! final interview stage at the end of the month/beginning of march. as for going further afield, i shouldn't complain because we all know with what grace and aplomb @keikilove manages her hectic professional schedule while also jetsetting across the pacific all the time for her appointments, but i am not sure i have the wherewithal to manage it in the same fashion. i know there are clinics in range of pdx/sea/sfo, but, ugh. i just dunno. I guess i need to think more about it. Re: what I plan to ask my RE about when and if I ever get his ear, is re: maybe switching up my stims regimen since the one we've tried doesn't seem to be getting me normal eggs, but also about maybe adding HGH in the runup? i need to look more into the studies on that. i also just generally need to hear him talk about what he thinks happened with this transfer. His clinic does not do back-to-back retrievals because it's a small clinic, there's just him and the junior RE, and they seem to manage their schedule by batching retrievals and transfers. but i'd like to do something as much like a back-to-back retrieval as the clinic can manage, and just try to build up a couple of good embryos or whatever i can scrounge as my last ditch effort here.
@mambo5-2 don't let this scare you but i just had to laugh when I read your update because I, too, have been told my uterus is beautiful.
History
I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
Began TTC in Aug '18 @ age 35
5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
Mar-Jun '19 IUIs, all BFN
Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
May '19 HSG shows open tube, but ultrasound suggests fibroids
MRI in June '19 confirms two large fibroids, one growing through wall of uterus
In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
April '20 --> June '20, natural IUIs, all BFN.
July? saline ultrasound and bubble test demonstrate open tube
July '20 clomid cycle cancelled for thin lining
Aug-Oct, 3 femara cycles, all BFN
RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
May '21, first IVF round cancelled due to cyst.
July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal. Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow. Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal. Feb '22 FET (low-level mosaic): CP. May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy. July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen. Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized. From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos! Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN. July 23, Natural FET + baby aspirin. BFN.
@acleverusername of course, and yes. We got the chromosomes back last week. All 46 there, and “normal male karyotype”. I even have images of them which is kind of fascinating. So, what my OB said is that there could have been an issue with the placenta or the cord not developing correctly or implanting incorrectly, something no test is going to tell us.
@mambo5-2 I hope I don’t upset you, you might fall into that unexplained category. It’s obviously worth continuing the tests to rule things out. But one thing I’ve learned over the years is that in medicine sometimes all they can do is rule out xyz but not actually make a diagnosis. The other ladies in this group will have much more specific thoughts re fertility.
also @acleverusername remind me what does WTF actually stand for in the context of the failed transfer appointment, apart from the obvious?
History
I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
Began TTC in Aug '18 @ age 35
5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
Mar-Jun '19 IUIs, all BFN
Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
May '19 HSG shows open tube, but ultrasound suggests fibroids
MRI in June '19 confirms two large fibroids, one growing through wall of uterus
In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
April '20 --> June '20, natural IUIs, all BFN.
July? saline ultrasound and bubble test demonstrate open tube
July '20 clomid cycle cancelled for thin lining
Aug-Oct, 3 femara cycles, all BFN
RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
May '21, first IVF round cancelled due to cyst.
July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal. Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow. Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal. Feb '22 FET (low-level mosaic): CP. May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy. July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen. Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized. From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos! Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN. July 23, Natural FET + baby aspirin. BFN.
Is anyone else mildly disappointed when testing results come back "normal"? Thinking of you and your beautiful uteruses @mambo5-2 and @optimistgardener. My thyroid panel came back normal across the board. One more thing to cross off the potential problem list, I suppose.
@abjm0325 it makes sense to me. No one wants there to be something wrong, BUT there is a feeling of if something is wrong we can target a treatment, which can feel more productive than trial and error.
@optimistgardener unless I am missing something WTF is exactly what it is. As in "WTF went wrong here?" Congrats on being shortlisted! I'm hopeful that at least _that_ part of your life stabilizes.
@mambo5-2 +1 on having heard numerous times, from numerous doctors that I have a beautiful uterus.
@anniemarie887 maybe one day, there will be a test that will with 100% certainty diagnose the RC of infertility.
@abjm0325 10000% to being "disappointed" when some test comes back normal and "elated" when some test comes back abnormal. In the latter case, I'm always asking my doctor "so could this be a reason why this hasn't worked for us?"
TTC History TTC#2
Me: 41; MH: 40 | Met 02/2009 | Started Dating 08/2017 | Married 02/02/2020 Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center) Apr/May 2024 | required testing & waiting for a protocol May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025 May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
Me: 36, MH: 34 | Met 02/2009 | Started Dating 08/2017 | Married 02/02/2020 TTC #1 02/2020 - 07/2022 2009 | Dx PCOS; likely a misdiagnosis 07/14/20 | Dx Hashimoto's Thyroditis 07/21/20 | 1st RE appointment 07/2120 - 08/20/20 | so much testing; no signs of PCOS 08/20/20 | Dx Unexplained; AMA 09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN 09/30/20 | Urology consult; more testing required 10/2020 | Clomid + OPK + TI + Prometrium | BFN 10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic 11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN 11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN 12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN 01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN 02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing 03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️ 04/07/2021 | Natural cycle while we regroup | BFN 04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance 05/10/2021 | New RE consult & plan for IVF 05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH. 06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded 07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid 08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d 09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid 11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation 12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN 01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN 02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity 03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022 05/20/2022 | D&C; recovering... 06/21/2022 | Trying naturally until October 2022 07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
@keikilove learning 3 languages sounds amazing!! I hope you get some rest this week. When is your beta?
@acleverusername I'm interested to hear what the plan is going forward after your results. That's a lot to unpack.
@optimistgardener *TW* with my loss, I had a heavier period and more cramps but about the same length *end TW* I'm so sorry, friend. I hope the RE is able to give you more answers and a better plan for next time. Congrats on the job front!
@abjm0325 I don't think it could hurt to try the Letrozole. It can make you ovulate more than one follicle so it increases the chances of conception.
@anniemarie887 your OB sounds amazing!! I'm glad you have such great support. That's amazing that you were able to get the entire karyotype report.
@mambo5-2 has your doctor ever mentioned endometriosis? I feel like a lot of times when people are "unexplained", endo ends up being the culprit. Most people don't get diagnosed with it though because you can only get diagnosed through surgery. I had no idea I had it because I didn't have any symptoms and all of my fertility testing was normal but the only symptom of endometriosis I had was that I could not get pregnant.
TTC History
Me: 35 DH: 34 Married 07/2012 DD born 07/2014 DD2 born 10/2018 DS born 10/2022
IF history: TTC #2 since January 2016 June-Aug 2017: 3 IUIs w/Clomid = BFN Sept 2017: Dx w/Endometriosis Oct 2017: IUI w/Letrozole = BFN Nov 2017: IUI w/Letrozole = BFN Dec 2017: pre-IVF testing Jan-Feb 2018: IVF--17 eggs retrieved, 13 fertilized, 9 frozen and 1 transferred on 2/10 = BFP on 2/19!!! EDD 10/29/2018 FET Oct 2021: BFP on 10/31! MC at 5 weeks FET Feb 2022: BFP on 2/15! EDD 10/29/22
I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
Began TTC in Aug '18 @ age 35
5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
Mar-Jun '19 IUIs, all BFN
Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
May '19 HSG shows open tube, but ultrasound suggests fibroids
MRI in June '19 confirms two large fibroids, one growing through wall of uterus
In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
April '20 --> June '20, natural IUIs, all BFN.
July? saline ultrasound and bubble test demonstrate open tube
July '20 clomid cycle cancelled for thin lining
Aug-Oct, 3 femara cycles, all BFN
RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
May '21, first IVF round cancelled due to cyst.
July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal. Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow. Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal. Feb '22 FET (low-level mosaic): CP. May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy. July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen. Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized. From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos! Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN. July 23, Natural FET + baby aspirin. BFN.
I’ll come back tomorrow when I’m not mobile bumping to respond to others but just wanted to pop in to answer @optimistgardener’s question - I believe WTF usually stands for “why transfer failed” but pretty sure it is universally understood to mean exactly as it sounds, “WTF happened?!”
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
@kiki047 thanks! i knew there was some plausibly non-potty-mouth version of the acronym.
History
I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
Began TTC in Aug '18 @ age 35
5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
Mar-Jun '19 IUIs, all BFN
Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
May '19 HSG shows open tube, but ultrasound suggests fibroids
MRI in June '19 confirms two large fibroids, one growing through wall of uterus
In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
April '20 --> June '20, natural IUIs, all BFN.
July? saline ultrasound and bubble test demonstrate open tube
July '20 clomid cycle cancelled for thin lining
Aug-Oct, 3 femara cycles, all BFN
RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
May '21, first IVF round cancelled due to cyst.
July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal. Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow. Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal. Feb '22 FET (low-level mosaic): CP. May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy. July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen. Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized. From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos! Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN. July 23, Natural FET + baby aspirin. BFN.
Happy long-weekend to those who get tomorrow off! Just wanted to do a quick post and say...
@shortstack930... fingers crossed for your beta tomorrow! @keikilove... always thinking & keeping my fingers and toes crossed for you! 🤞🏻
I'll post my update with tomorrow's thread since I've dominated this week's enough.
TTC History TTC#2
Me: 41; MH: 40 | Met 02/2009 | Started Dating 08/2017 | Married 02/02/2020 Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center) Apr/May 2024 | required testing & waiting for a protocol May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025 May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
Me: 36, MH: 34 | Met 02/2009 | Started Dating 08/2017 | Married 02/02/2020 TTC #1 02/2020 - 07/2022 2009 | Dx PCOS; likely a misdiagnosis 07/14/20 | Dx Hashimoto's Thyroditis 07/21/20 | 1st RE appointment 07/2120 - 08/20/20 | so much testing; no signs of PCOS 08/20/20 | Dx Unexplained; AMA 09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN 09/30/20 | Urology consult; more testing required 10/2020 | Clomid + OPK + TI + Prometrium | BFN 10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic 11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN 11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN 12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN 01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN 02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing 03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️ 04/07/2021 | Natural cycle while we regroup | BFN 04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance 05/10/2021 | New RE consult & plan for IVF 05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH. 06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded 07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid 08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d 09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid 11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation 12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN 01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN 02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity 03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022 05/20/2022 | D&C; recovering... 06/21/2022 | Trying naturally until October 2022 07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
Re: IF Weekly Testing & Treatment w/o 2/14
@anniemarie887 your OB sounds like a total saint. I'm so glad that in all this sh*t you have someone so wonderful in your corner. May I ask if you were able to test the pregnancy for genetic (ab)normality?
TTC History
TTC#2
Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
Apr/May 2024 | required testing & waiting for a protocol
May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered
Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing
Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025
May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
April 2009 - 8+ week MC
January 2012 - BFP - DS Born 10/21/2012
May 2013 - BFP - Twins MMC @ 13 weeks D&C
Oct 2013 - BFP MC @ 6 weeks
Dec 2013 - BFP DD Born 8/16/14 - Cholestasis at 36+5
Nov 2016 - BFP MC @ 6 weeks
Dec 2016 - BFP DD Born 6/19/17 @ 28+4 Severe Pre-E, IUGR, Cholestasis
Nov 2017 - BFP MC @ 6 weeks
Jan 2017 - BFP MC @ 6 weeks
Jan 2019 - BFP MC @ 6 weeks
DH Vasectomy Aug 2019
Feb 2022 - TTC #4 with IVF - RPL testing
Protein C and S Deficiency - Blood Thinners for Treatment - Maybe we don't know!
June 2022 - IVF - 2 embryos - 1 transferred 6/22/22 - Transfer Failed
July 2022 - FET - cancelled
Dec 2022 - Vasectomy reversal
June 2023 - DH diagnosed with Brain Tumor - TTC put on indefinite hold
January 2025 - Surprise BFP! Due 9/13/2025 - CP
January 2025 - Trying Again
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
@mambo5-2 +1 on having heard numerous times, from numerous doctors that I have a beautiful uterus.
@anniemarie887 maybe one day, there will be a test that will with 100% certainty diagnose the RC of infertility.
@abjm0325 10000% to being "disappointed" when some test comes back normal and "elated" when some test comes back abnormal. In the latter case, I'm always asking my doctor "so could this be a reason why this hasn't worked for us?"
TTC History
TTC#2
Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
Apr/May 2024 | required testing & waiting for a protocol
May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered
Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing
Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025
May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
@acleverusername I'm interested to hear what the plan is going forward after your results. That's a lot to unpack.
@optimistgardener *TW* with my loss, I had a heavier period and more cramps but about the same length *end TW* I'm so sorry, friend. I hope the RE is able to give you more answers and a better plan for next time. Congrats on the job front!
@gingermama29 beta is on Monday!!
@abjm0325 I don't think it could hurt to try the Letrozole. It can make you ovulate more than one follicle so it increases the chances of conception.
@anniemarie887 your OB sounds amazing!! I'm glad you have such great support. That's amazing that you were able to get the entire karyotype report.
@mambo5-2 has your doctor ever mentioned endometriosis? I feel like a lot of times when people are "unexplained", endo ends up being the culprit. Most people don't get diagnosed with it though because you can only get diagnosed through surgery. I had no idea I had it because I didn't have any symptoms and all of my fertility testing was normal but the only symptom of endometriosis I had was that I could not get pregnant.
Married 07/2012
DD born 07/2014
DD2 born 10/2018
DS born 10/2022
IF history:
TTC #2 since January 2016
June-Aug 2017: 3 IUIs w/Clomid = BFN
Sept 2017: Dx w/Endometriosis
Oct 2017: IUI w/Letrozole = BFN
Nov 2017: IUI w/Letrozole = BFN
Dec 2017: pre-IVF testing
Jan-Feb 2018: IVF--17 eggs retrieved, 13 fertilized, 9 frozen and 1 transferred on 2/10 = BFP on 2/19!!! EDD 10/29/2018
FET Oct 2021: BFP on 10/31! MC at 5 weeks
FET Feb 2022: BFP on 2/15! EDD 10/29/22
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
@shortstack930... fingers crossed for your beta tomorrow!
@keikilove... always thinking & keeping my fingers and toes crossed for you! 🤞🏻
I'll post my update with tomorrow's thread since I've dominated this week's enough.
TTC History
TTC#2
Mar 2024 | consult to get established with a new reproductive immunologist (Alan Beer Center)
Apr/May 2024 | required testing & waiting for a protocol
May 2024 | protocol given / decided to go back to my old reproductive immunologist, Dr. Jubiz
Jun / Jul 2024 | more testing, incl. SIS, ultrasound, and endometrial biopsy
Jul 2024 | Dx chronic endometritis; 14 days of 100mg of doxy given
Sep 2024 | Repeat endometrial biopsy; still + for chronic endometritis. 2 more antibiotics + an antiviral
Oct 2024 | Hysteroscopy turned polypectomy; endometriosis consult w/ specialist who confirmed high likelihood of endo based on symptoms and ultrasound; lots of blood tests ordered
Mar 2025 | Endo excision surgery. Stage 3 endo found! Recoveing
Apr 2025 | Planning transfer w/ RE & green light protocol w/ RI; target transfer July or August 2025
May 2025 | Surprise BFP! EDD 1/11/2026
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023