This is a place for those of us who have already started TTC, but have started infertility testing and/or treatments. You can express your thoughts, feelings, and frustrations on infertility. TTC can be a long journey naturally, then add in the difficulties associated with infertility, and it becomes a whole new ball game. The road to infertility can be lonely, frustrating, and complicated, so let's make this a place where we can vent, ask questions, and support one another. Feel free to resurrect this thread at any point in the week if you have something to say. Treat this as an ongoing conversation.
Diagnosis (if you've been):
Status (WTO/TWW/TTA):
What are you doing this cycle? (Testing? Treatment?):
How are things going?:
Any questions?:
GTKY: What are you looking forward to the most in the month of August?
I’m not gonna do an update this week and probably next week because it’s just a whole lot of waiting for now. I asked around on our local Facebook group and it sounds like the PGT testing provider contracted by our clinic has been taking 14 days to get results. But I’ll be around lurking and commenting on all of your updates!!!
@bumblebee0210 yes, my clinic biopsied all of the embryos and I am hoping for at least 1 normal 🤞🏻🤞🏻🤞🏻 May I ask you to share the doses of your EPP protocol? We’re gonna try that next. I’m specifically curious about your doses and starts. 🙏
@acleverusername I hope the wait is short and/or tolerable. My EPP details are in the spoiler. FWIW, I am actually not doing EPP with my duostim because my doctor didn’t think it made much of a difference for me, and the timing works better for me to not do it.
I started 2 tabs estrace at 7 DPO (continued through CD1, total of 5 days for me). I got my period 11 DPO, and on CD1 started Clomid and dexamethasone. Clomid was to be continued for 5 days, and dex until trigger.
Then on CD3 I started stims: 200 follistim and 225 menopur. They upped my follistim to 275 when they started my antagonist on day 6. I did a total of 10 days of stims.
I did have higher estrogen and a shorter stim phase than previous cycles, but I only got 5 eggs. In 4 retrievals, I have gotten 7, 10, 2 and 5, so it’s pretty in line with previous. One possibility why it didn’t work well for me was that my luteal phase is so short that its only 5 days of estrace. My theory is just that it was a “bad month”— my AFC was only 7 I think (when it is typically 10).
Still the “best” cycle I have had was my first, when I started with BCP, so I am doing that again this time.
My doctor is wanting to try not a straight up EPP but modified. Using Aygestin to prime but stopping for 4 days before Clomid (he’s admitted that the last time he had me take Aygestin, it over-suppresed me). Then Clomid only for 2 days before adding Gonal and Menopur. But he’s also wanting lower doses for everything: 100mg Clomid; 150 of each Menopur and Gonal-F. But he is also “allowing” me to take dexamethasone.
Hi ladies! I survived vacation, barely, and my mom's meltdown/temper tantrums weren't even instigated by me this time so ... yay? lol. I am stupidly beyond swamped at work this week, as is always the case when I return from vacation, and *TW* I just found out my mom's dog is dying so that's kind of looming over me this week *end TW* so I wasn't going to do a check-in this week in case I end up ghosting y'all but selfishly I have a question about the 1st RE's proposed protocol so here I am.
Diagnosis (if you've been): PCOS, RIF/RPL, MFI
Status (WTO/TWW/TTA): WTO
What are you doing this cycle? (Testing? Treatment?): Still in limbo, but MH is doing his karyotyping test this week through a private lab (mine was covered by insurance, his will cost us $600 CAD OOP, woof), and the new RE also prescribed ProFortil, which appears to be a needlessly expensive antioxidant supplement that I went ahead with anyway because it would cost me that much to buy a 3 month supply of each of those components separately. He is already taking most of these things but what the hell, now it's all in two little capsules.
Ingredient list, for inquiring minds:
Ingredients
Amount
L-Carnitine
440 mg
L-Arginine
250 mg
CoQ10
15 mg
Vitamin E
120 mg
Zinc
40 mg
Folic acid
800 mcg
Glutathione
80 mg
Selenium
60 mcg
How are things going?: Mehhh. I had a few weeks where I felt more at peace with limbo but our follow up with the 1st RE isn't until mid-Sept to try to give the ProFortil time to kick in and also have time for the test results to come back. Our 2nd consult is still over 2 weeks away and despite talking to my RE every day for the last 4 days, he's not having any luck pulling strings to move it up even a week. We're feeling a bit "doom and gloom"y about it all, knowing that the earliest we might start back up again is October/November, and probably won't do a FET for 2-4 months after that because we don't plan to do any immune testing until we know we have euploid embryos to transfer.
Any questions?: My old RE went through the referral notes with me on Saturday and gave me the proposed protocol from the new RE. He is planning for IVF with "second ejaculate" - what does this mean? I haven't heard this before... is it exactly as it sounds and he literally has to give two samples in a row? This is going to be a problem, ha.
Protocol: Gonal-F, 300; Luveris,150; Letrozole start Day 6. Has anyone heard of/used letrozole during a stim cycle? What is the purpose of this?
I was on low doses the last two rounds. IVF #1 was Lupron, Gonal-F 75, increased to 100, then down to 32.5 near the end. Menopur was 75 but only in the last 3 days, and an HCG trigger. AFC was 17, only got 5 eggs, 4 mature. IVF #2 was Lupron, Gonal-F 150, Menopur 150 for 2 days, then stopped the menopur because I had such a bad reaction to it, then went back on it for only 2 days right at the end @ 32.5. HCG trigger. AFC was 19, retrieved 8 eggs, 7 were mature.
GTKY: What are you looking forward to the most in the month of August? It already happened, survived the week with family at the cottage and the rest of the month feels like a bit of a lunchbag letdown because of concerns with C19 cases rising and "nothing" to look forward to (I'm obviously being dramatic here but that's my current mood).
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Tags from last week: @mokay19 yes, I took L-arginine as 1,000mg pills because the recommended dosage is 6,000mg a day. My naturopath suggested I try to find it in powdered form but I had already bought the capsules so I didn't bother. They should be taken on an empty stomach too. @keikilove oh goodness, I think my heart stopped for a second reading your update. You are the strongest, most capable person I "know" but I am sending strength and love across the ocean to get through these crucial next few weeks as you wait for news. @acleverusername I was so damn relieved when you said you got 8 eggs! And to have 3 blasts is great!! I am doing a happy dance for you! Glad you have the wedding and your trip to keep you occupied while you wait for PGT results. @optimistgardener I knew someone who used PIO for like 6 weeks before she started developing a reaction to it. I think she said they used sesame oil as a compound for hers as well, so she ended up switching to the crinone gel. It was an extremely delayed reaction though, she was fine for weeks. It is entirely possible to try to find one that uses a different carrier oil but like legallykate mentioned, it may just be easier to switch to pessaries instead. FWIW, I used both compounded vaginal suppositories (not the tablets), and PIO.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
qCycle day 1 is the first full day of a full flow. Start checking for ovulation on cycle day 11 with an ovulation predictor kit (for patients with REGULAR cycles that are <25 days or >32days, take the average cycle length and subtract 17. This is the day that they should start LH kits). Patient to call the office with a positive surge. If no positive surge by cycle day 17, have them come in for a progesterone level
§If day 17 P4 is >5, then consider the patient post ovulatory
§If P4 is <5, then repeat progesterone level q 2-4 days until >5
§If second P4 is 1.5-3, repeat in 2-4 additional days;
§If second P4 is still <1.5 patient can start estrace
qOne week after the LH surge or day of confirmed ovulation (Progesterone >5), the patient will start Estrace 4 mg (2 mg x 2 tablets) PO q hs. Estrace is usually taken 3-10 days and the patient will menstruate while on the Estrace. The patient should take their last Estrace on day one of menses
qPatient to call first day of full menstrual flow. Appointment for ultrasound, E2 and beta hCG on CD2. Expect estradiol level to be elevated
qOn the evening of CD1 (evening before baseline appointment), the patient should start Clomid 100mg (50 mg x 2 tablets) each evening for 5 days AND Dexamethasone 1 mg (0.5 mg x 2 tablets). Dexamethasone is continued until the day of trigger
§Tamoxifen 20mg po can be substituted for clomid 100mg at provider’s discretion
qOn CD3, the patient should start gonadotropin medications which should be taken at the same time every day between 7-9 pm. This is stim day 1
qThe first ultrasound appointment will be on stim day 4 (after three days of gonadotropin stimulation and five days of Clomid)
§If E2 <100, increase FSH by 75 IU, and repeat monitoring in 2 days
§If E2 100-150, increase FSH by 37.5-50 IU, and repeat monitoring in 2 days
§If E2 150-200, increase FSH by 25-37.5 IU, and repeat monitoring in 2 days
§If E2 200-400, no change in dose and repeat monitoring in 2-3 days based on follicular size
§If E2 400-600, decrease FSH by 37.5-50 IU, and repeat monitoring in 2 days
§If E2 600-750, decrease FSH by 50-75 IU, and repeat monitoring in 2 days
§If E2 >750, consider cancelling cycle
qWhen E2 400 OR stim day 6 OR lead follicle >14, start antagonist that night and then q am
qAfter any needed adjustments to current gonadotropin dose are made, add Menopur75 IU q pm to the patient’s regimen when antagonist is started - if not already using an LH product
qPlan for hCG trigger when there are at least 3 follicles greater than 18mm and several 14-18mm.
I feel bad even posting here right now because I know everyone has so kindly been waiting with me for test results, but it seems that the clinic probably didn't send the embryo samples out until the end of the week when the biopsies were done (so, maybe they sent them on the 23rd?). I guess the clinic sends its biopsy samples in batches to the genetics lab). And the clinic nurse says the genetics lab hasn't sent the results back yet for anyone's samples from that batch and they're a bit tardy on returning those, so... Fingers crossed we hear this week. sheesh. In the meantime, @bumblebee0210, since I know you are a math and stats kind of woman, you'll perhaps be proud to hear that I've been teaching myself (or reteaching myself? I probably learned this math in middle school) basic probability formulas and running my numbers (re: what are my chances of at least 1 normal embryo) according to various plausible aneuploidy rates for my age. I really am losing my mind.
@kiki047 please do keep us in the loop when you learn what "second ejaculate" means! I am *fascinated.*
History
I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
Began TTC in Aug '18 @ age 35
5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
Mar-Jun '19 IUIs, all BFN
Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
May '19 HSG shows open tube, but ultrasound suggests fibroids
MRI in June '19 confirms two large fibroids, one growing through wall of uterus
In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
April '20 --> June '20, natural IUIs, all BFN.
July? saline ultrasound and bubble test demonstrate open tube
July '20 clomid cycle cancelled for thin lining
Aug-Oct, 3 femara cycles, all BFN
RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
May '21, first IVF round cancelled due to cyst.
July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal. Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow. Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal. Feb '22 FET (low-level mosaic): CP. May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy. July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen. Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized. From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos! Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN. July 23, Natural FET + baby aspirin. BFN.
@optimistgardener. Ugh, sorry this wait is interminable. Pro tip on the math: the probability you have at least one normal embryo is one minus the probability that all 4 are aneuploid (or mosaic). So if, say, the normal rate for your age is 40% (just guessing), then the probability that you have at least one normal is 1-(1-.4)^4 = 87%.
I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
Began TTC in Aug '18 @ age 35
5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
Mar-Jun '19 IUIs, all BFN
Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
May '19 HSG shows open tube, but ultrasound suggests fibroids
MRI in June '19 confirms two large fibroids, one growing through wall of uterus
In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
April '20 --> June '20, natural IUIs, all BFN.
July? saline ultrasound and bubble test demonstrate open tube
July '20 clomid cycle cancelled for thin lining
Aug-Oct, 3 femara cycles, all BFN
RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
May '21, first IVF round cancelled due to cyst.
July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal. Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow. Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal. Feb '22 FET (low-level mosaic): CP. May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy. July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen. Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized. From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos! Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN. July 23, Natural FET + baby aspirin. BFN.
(I hope it's okay to post this question here because I feel like this makes the most sense, but someone please let me know if it's off base here!)
Background: My husband had a semen analysis done last month and his motility and morphology were low (morphology at 1%, progressive motility 24%, non-progressive motility 4%). We had a visit with my obgyn who went over the results with us, and suggested he start taking vitamins C and E, and that we keep trying until we hit the year mark, since our insurance won't cover anything until 1 year. She said we'd be good candidates for IUI if we don't conceive naturally in the meantime, and that once we hit a year we could go straight to the RE without making another appointment with her (she gave us a referral slip too).
My question: I know waits for REs can be months long. Would it make sense for me to call now to schedule an appointment for November (our year mark) so that we don't have to hit a year and then wait even more months? I'm assuming I'd just let them know that we have the semen analysis stuff, and that I have PCOS but had CD3 bloodwork done that all looked good, but is there anything else specific I should ask about or let them know?
@fantasyflyte it wouldn't hurt to just call now and ask how far out they're scheduling new patients. I'm sure they would be fine with scheduling you a little further out than their earliest openings. Is this RE in the same medical group as your OB? If not, you'll need to forward your records which can be a pain (and take time!). I didn't have to worry about it when we got referred to the urologist and the RE because they are part of the same medical group as my OB.
*TW* History:
Me: 34 DH: 36 | Together since 2007 | Married July 2016
TTC #1 since 7.2017 Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3| all BFN IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name" RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer 2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks TTCAL naturally | starting 11.22.20 Initial consultation with Reproductive Immunologist | 9.14.21 Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation Saline sono | 10.15.21 | normal Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy DS born 7.19.22 after induction
TTC #2 begins 6.2023 Consultation with RI | 6.6.23 Saline sono, endometritis biopsy, skin & eye check | all normal Labs | high TSH, Factor XIII mutation, high %CD56 Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine Repeat labs after 3 weeks on meds Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox Repeat labs in 8 weeks Follow up | 1.16.24 | Green light continues TTC put on pause
@fantasyflyte may I make other vitamin recommendations for YH?! It’s actually basically everything that @kiki047 listed as ingredients in her H’s new supplement. Although MH isn’t taking L-Argentine and Glutathione yet. Gonna have to add those to his pill box when I get back.
@kiki047 okay, lots to answer her. I get that waiting limbo you’re in; too bad your wonderful RE hasn’t been able to pull the professional strings. In terms of Letrazole, you have to think about how that drug works. It’s an “aramatose inhibitor” which essentially stops the converstion of testosterone into estrogen, which makes the brain release more endogenous FSH. I’m guessing that exogenous and endogenous FSH works differently and hopefully in a complimentary way. My new protocol calls for Clomid alongside Menopur and Gonal-F and the desired outcome is the same. But… like… not a fertility doc over here… take everything I say with a healthy dash of salt. No idea WTF secondary ejaculation is. 🤷♀️
@bumblebee0210 thanks for sharing those excruciating details!!! 🙏
Question for the team: I got all of my day-3 levels checked in January when I started with my RE. My FSH was 9.2 and my Estradiol was 25. My AFC was 10. But, my AMH was 0.42, which is really low (I am 34, was 33 then). At the time, my doctor said it was like "borderline DOR". This was part of the reason we decided to go for IVF-- I want more than 2 kids and was worried I might not be able to get pregnant again, so I wanted to freeze embryos (I came in for RPL, not IF). I got some bloodwork done for my next cycle, and my doctor was like "let's check AMH again". IT IS 1.39. WTF?? That is normal!
I know like, my actual experience with IVF is more informative than these levels at this point, and I sure do look like someone with DOR. But how is this possible? Do AMH levels fluctuate that much? Don't tell me it's "supplements"!
@bumblebee0210 woah!! that's an impressive jump! I've done a little bit of looking around at studies on AMH because I have sh**ty numbers (.36 as of Dec, but I'm also 38 and only have the one ovary, so in my context it makes sense). I have read that surgery (esp. of the ovaries and uterus) can cause a temporary trend downward in one's AMH levels, so (for the sake of argument) it wouldn't seem completely outside of the realm of possibility that other forms of recently experienced physical stress or disruption might have lead you to have a low AMH when it was last checked in January. know you don't want me to say supplements, and I'm not really, but there may or may not be a weak relationship between DHEA levels and AMH/AFC. So, have you been taking DHEA? The linked studies are nothing special, just examples I've come across in my wanderings.
None of this explains the kind of leap you've just experienced. Does your doc have any theories?
It would be interesting to check it again in a few months to triangulate things and see whether your January reading or your more recent reading is the outlier.
History
I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
Began TTC in Aug '18 @ age 35
5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
Mar-Jun '19 IUIs, all BFN
Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
May '19 HSG shows open tube, but ultrasound suggests fibroids
MRI in June '19 confirms two large fibroids, one growing through wall of uterus
In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
April '20 --> June '20, natural IUIs, all BFN.
July? saline ultrasound and bubble test demonstrate open tube
July '20 clomid cycle cancelled for thin lining
Aug-Oct, 3 femara cycles, all BFN
RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
May '21, first IVF round cancelled due to cyst.
July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal. Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow. Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal. Feb '22 FET (low-level mosaic): CP. May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy. July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen. Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized. From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos! Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN. July 23, Natural FET + baby aspirin. BFN.
@bumblebee0210 yes apparently it can "fluctuate" like that. My AMH when we started IF testing was around 4.5. 2 years later when I got a 2nd opinion at another RE my AMH was 5.6! That RE states that doesn't mean I've become more fertile. Apparently it can depend on how they run the test or how they interpret it??? I can't remember exactly what she said but there can be variance between clinics
*TW* History:
Me: 34 DH: 36 | Together since 2007 | Married July 2016
TTC #1 since 7.2017 Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3| all BFN IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name" RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer 2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks TTCAL naturally | starting 11.22.20 Initial consultation with Reproductive Immunologist | 9.14.21 Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation Saline sono | 10.15.21 | normal Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy DS born 7.19.22 after induction
TTC #2 begins 6.2023 Consultation with RI | 6.6.23 Saline sono, endometritis biopsy, skin & eye check | all normal Labs | high TSH, Factor XIII mutation, high %CD56 Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine Repeat labs after 3 weeks on meds Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox Repeat labs in 8 weeks Follow up | 1.16.24 | Green light continues TTC put on pause
What are you doing this cycle? (Testing? Treatment?): Letrozole + Clomid, TI, trigger, progesterone
How are things going?: not good. I finished the meds over the weekend and had my mid-cycle monitoring scheduled for Wednesday. But with the storms that came through, the doctor was out of power most Wednesday so I had to go this morning. I wasn’t worried about missing my ovulation because I’m slow to respond and I didn’t feel my normal bloat. So, because I didn’t feel like normal, I was convinced that nothing developed. And I, unfortunately, was right.
My lining is only at 7mm and doesn’t show a good start on the trilaminar structure. My left ovary has 2 follicles at 8-9 mm and my right has 1 follicle at 7-8 mm.... so essentially nothing. I have to wait for bloodwork to come back but they think I’ll probably just have to do another round of both the meds.
I’m just getting really annoyed that my body is just not responding and I’m having myself a pity party this morning.
Any questions?: natm
GTKY: What are you looking forward to the most in the month of August?
I’m switching jobs! So I leave my current company tomorrow and I’m taking off 2 WEEKS before starting my next job!
@optimistgardener I was so hoping your update would be ... well, THE update. Sorry you're still waiting for those results. FX for you!! and lol yeah, still super intrigued by what "second" ejaculate could possibly mean. I'm lucky if I can even get MH going again the next morning, nvm twice in a row. It's giving me @keikilove vibes from her H's regimen of daily ejaculation to stimulate new/more production. @fantasyflyte I've heard of other RE's not even allowing you to put your name on a list or pre-book an appt until you hit that 1 year mark, but it's certainly worth a shot. Especially knowing what you know about some of the main contributing factors to possible/probable IF once you hit that arbitrary 1 year mark. But +1 on @acleverusername's recommendations on starting YH on some extra supplements during this time. They have helped maintain/improve MH's sperm parameters despite his advancing age and the other factors working against us so it doesn't hurt to add those in if you're already adding Vit C/E. I personally liked FertilAid, which has almost everything he could need, and it's only 3 capsules per day as opposed to individual pills. MH was on it for 2 years. I'm only now switching because it's no longer available in Canada. @acleverusername that makes sense about the Letrozole, thank you! I read some interesting (ongoing) studies looking at the use of letrozole in fresh transfer cycles to increase endometrial receptivity because it helps lower serum E2 levels, but of the few abstracts I read it seemed like it was mainly used for stim cycles in women who are poor responders because it can effectively lower the amount of gonadotropins required, which is interesting. I'm curious what that means for me, when I've only ever been given lower doses of stims so I'm not necessarily a poor responder, I just wasn't over-stimulated. *shrug* Guess we'll see! I'm curious what the second RE has to say, given that he's the most aggressive of the 3. @bumblebee0210 I don't have anything to add re: AMH other than just hearsay that I know of other women whose AMH levels have fluctuated like that as well, often also with no real explanation.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
@mokay19 ugh get it together body!! Mine decided to be dumb and gift me with AF a couple days early but I did get the vaccine 2 weeks ago so it's likely from that.
@kiki047 my very brief search on second ejaculate is essentially what it sounds. They collect the sample from the second round. The one study I looked at the second round occurs like 4 hours later. Not all the ejaculate once then ejaculate ASAP like I thought it would be. Seems that motility is better in that sample. I wonder if that's why some people seem to swear by having sex multiple times a day and that's the cycle they got KU?
What are you doing this cycle? (Testing? Treatment?): ehhh just covid vaccine dose 2 I guess. I will be working on getting myself on the schedule with an RI
How are things going?: my period came WAY early and I was in no way prepared when spotting showed up yesterday morning while working in the office. On the bright side I don't live too far from work so I quickly drove home for some pantiliners and my cup (just in case it was going to truly start). We had another nasty and windy thunderstorm the night before so I decided to check out before I left the massive branches that fell in our backyard that DH had heard while he was out there grill (yep grilling in the rain AGAIN!). And it just so happened that I spotted my neighbor's cat that has been missing for 2 months (hadn't been spotted for around 1) rounding our barn shed. I think she used to be feral or a stray so she's apparently completely content being outside. She's not the loving on my human type. But it just was lucky that I happened to go home and look out back at that time and saw her. So in the end it was good that spotting started way earlier than I expected with AF really starting in the late evening.
Any questions?: Anyone else with shorter LPs in their cycles with the covid vaccine?
GTKY: What are you looking forward to the most in the month of August? Nothing really. I do have the opportunity to spend half a day cleaning up our warehouse at work in preparation for our building move (pizza included!) which would be a nice change of pace. Also by the end of next week they'll announce the winners for the conference room themes. We got to make suggestions which senior staff had narrowed down to 8. If one of yours gets picked you get a $100 gift card of your choice. 2 of the 8 were my ideas and a 3rd was also my idea but likely many others also suggested it since the theme was our city. So I have at least a 25% chance of winning since there's 2 conference room themes to be named!
*TW* History:
Me: 34 DH: 36 | Together since 2007 | Married July 2016
TTC #1 since 7.2017 Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3| all BFN IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name" RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer 2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks TTCAL naturally | starting 11.22.20 Initial consultation with Reproductive Immunologist | 9.14.21 Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation Saline sono | 10.15.21 | normal Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy DS born 7.19.22 after induction
TTC #2 begins 6.2023 Consultation with RI | 6.6.23 Saline sono, endometritis biopsy, skin & eye check | all normal Labs | high TSH, Factor XIII mutation, high %CD56 Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine Repeat labs after 3 weeks on meds Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox Repeat labs in 8 weeks Follow up | 1.16.24 | Green light continues TTC put on pause
Oops I just realized I posted without finishing my tags. @mokay19 ugh that's so frustrating that your body isn't responding as hoped. I'm so sorry. Congrats on the new job though, hope you enjoy your break in between! @inthewoods23 that makes sense about motility improvements in the second sample. I read the same about DNA fragmentation, that regular, frequent ejaculation has been shown to improve both parameters and might be worth the sacrifice in sperm count especially during IVF when we'd probably be doing some by ICSI anyway. What a story about AF, the storm, and your neighbour's cat! As much as AF was unexpected and unwelcomed, it sounds like those were kind of serendipitous circumstances for that sighting. Did you tell your neighbour you saw their cat? Were they relieved?
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
@inthewoods23 my friend had a short cycle and then a couple longer ones after her vaccine! But she’s the only person that I’ve talked to about it so one data point isn’t much 😄 Were you guys okay from the storms? We are south of most the people that lost power and branches.
@kiki047 yes I let her know! She's hoping her cat more willing to come inside when winter comes. At least the cat seems to be just hanging around the woods and under sheds and hasn't gone far.
*TW* History:
Me: 34 DH: 36 | Together since 2007 | Married July 2016
TTC #1 since 7.2017 Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3| all BFN IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name" RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer 2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks TTCAL naturally | starting 11.22.20 Initial consultation with Reproductive Immunologist | 9.14.21 Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation Saline sono | 10.15.21 | normal Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy DS born 7.19.22 after induction
TTC #2 begins 6.2023 Consultation with RI | 6.6.23 Saline sono, endometritis biopsy, skin & eye check | all normal Labs | high TSH, Factor XIII mutation, high %CD56 Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine Repeat labs after 3 weeks on meds Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox Repeat labs in 8 weeks Follow up | 1.16.24 | Green light continues TTC put on pause
@mokay19 I'm sorry-- that really sucks. Are you doing anything differently than with your previous attempts? (sorry if I missed this!)
@optimistgardener. Ugh, yes, I am taking DHEA, but only 25 mg so I didn't really expect it to do anything. tw mc
I was ~4 months out from a D&C when I got it tested the last time, and my body is super slow in processing hormones generally, so it's *possible* that played a role? Maybe it's just that + random cycle variation + DHEA + maybe stims matter?
It's just weird because if I had gotten this level in January, I don't think I would have gone down the road. Any of course I think, if I was trying naturally that whole time I would be pg by now. And also my head in generally being f-ed with because we didn't really TTA as planned this cycle, so I am technically in a TWW, which brings back all of the old feelings.
@bumblebee0210 sorry that you’re having so many questions about that fluctuating number. The uncertainty of everything is awful.
For my treatment, I’ve previously just used Letrozole. But the recent cycles didn’t do anything with just Letrozole so we added Clomid last cycle and I developed 1 follicle. Now I started this cycle with 7.5mg Letrozole and 100mg Clomid. But they think it’s likely that I need another dose of both of those to get my ovaries over my body’s threshold.
@bumblebee0210 i feel you on the feelings and especially on the "what if i had known this, would i have done things differently?" front. I'm not sure if it's any help, but I think you made the right decision to bank embryos, even though it's been a rough road. If nothing else, it gives you options you wouldn't otherwise have, and a degree of security. For me, there were several junctures in my TTC journey at which I was told, "you could go the aggressive and interventionist route, or just keep trying for a few more months and see what happens" since my doctors had a tendency to tell me that they figured I had a decent chance at being spontaneously fertile, based on what they could make of my bloodwork (barring my bad AMH) and my basic checkups. And in those circumstances, I tended to choose the "wait and see" path. I am doing my best not to revisit those moments and kick myself for not embracing a more interventionist approach earlier. So anyway, I guess what I'm saying here is: hey there, my experience of the road you didn't take has been full of bumps and disappointments. Your choice to bank embryos was a solid one.
Also *mc ref*
as for the possibility of the miscarriage having an effect, it seems like a reasonable conjecture, although (I have done a brief search and) there does not appear to be any data on it. as far as i can tell, AMH is still a pretty new data point for the fertility world, and they're still getting the basics down as to how they should expect it to behave and under what circumstances. there have been studies that go the other direction (low amh is associated with higher miscarriage rates, which isn't surprising because low amh is also obviously associated with DOR and with being old, etc., and we all know how those things are usually tied together). I'll be curious to learn if your AMH changes in a few months (although I would of course prefer it if you didn't have to do more bloodwork).
History
I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
Began TTC in Aug '18 @ age 35
5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
Mar-Jun '19 IUIs, all BFN
Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
May '19 HSG shows open tube, but ultrasound suggests fibroids
MRI in June '19 confirms two large fibroids, one growing through wall of uterus
In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
April '20 --> June '20, natural IUIs, all BFN.
July? saline ultrasound and bubble test demonstrate open tube
July '20 clomid cycle cancelled for thin lining
Aug-Oct, 3 femara cycles, all BFN
RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
May '21, first IVF round cancelled due to cyst.
July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal. Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow. Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal. Feb '22 FET (low-level mosaic): CP. May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy. July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen. Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized. From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos! Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN. July 23, Natural FET + baby aspirin. BFN.
What are you doing this cycle? (Testing? Treatment?):
Pending decision of next steps.
How are things going?: ok. We were taking a break for a bit and are now actively deciding next steps. We are thinking we will try at least once more, maybe twice. We have leftover meds, so we want to use them and get another shot at things. We are also debating IVF with egg freezing. If we did that, we may try a few times to take advantage of the frozen eggs, if we can harvest enough.
(struggling with some religious issues caused a lot of delays with our choice. Freezing eggs instead of embryos might allow that to work.)
Any questions?: Not right now
GTKY: What are you looking forward to the most in the month of August?
Being one month closer to our anniversary trip to Maine (October)
What I’m not looking forward to is turning 38 in September!!!
well folks, i got a call this morning from the clinic to let me know that they, too, are becoming concerned about why the genetics lab hasn't returned my PGT-A results yet. it turns out they in fact sent my biopsies to the lab in the earlier batch (not, as the nurse told me earlier this week, in the later batch) in the week after my retrieval, which means that the lab received my embryo biopsies more than three weeks ago. the nurse said they'd reach out to the lab today and she hoped to get back to me with news soon, but it's past 5pm here now so i guess i'll hear from them early next week, hopefully with actual news. there's obviously some kind of issue going on at the lab end of things, but it isn't helped that this past week my clinic's primary nurse coordinator has been on vacation, as has their embryology person. stuff is falling through the gaps in their absence. now i'm kicking myself for not getting after them more aggressively last week and early this week.
eta @laura-kay 38 isn't so awful! it's pretty much like 37 but with a few more laugh lines.
History
I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
Began TTC in Aug '18 @ age 35
5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
Mar-Jun '19 IUIs, all BFN
Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
May '19 HSG shows open tube, but ultrasound suggests fibroids
MRI in June '19 confirms two large fibroids, one growing through wall of uterus
In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
April '20 --> June '20, natural IUIs, all BFN.
July? saline ultrasound and bubble test demonstrate open tube
July '20 clomid cycle cancelled for thin lining
Aug-Oct, 3 femara cycles, all BFN
RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
May '21, first IVF round cancelled due to cyst.
July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal. Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow. Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal. Feb '22 FET (low-level mosaic): CP. May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy. July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen. Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized. From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos! Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN. July 23, Natural FET + baby aspirin. BFN.
Me: 34 DH: 36 | Together since 2007 | Married July 2016
TTC #1 since 7.2017 Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3| all BFN IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name" RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer 2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks TTCAL naturally | starting 11.22.20 Initial consultation with Reproductive Immunologist | 9.14.21 Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation Saline sono | 10.15.21 | normal Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy DS born 7.19.22 after induction
TTC #2 begins 6.2023 Consultation with RI | 6.6.23 Saline sono, endometritis biopsy, skin & eye check | all normal Labs | high TSH, Factor XIII mutation, high %CD56 Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine Repeat labs after 3 weeks on meds Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox Repeat labs in 8 weeks Follow up | 1.16.24 | Green light continues TTC put on pause
Re: IF Testing & Treatment w/o 8/9
@bumblebee0210 yes, my clinic biopsied all of the embryos and I am hoping for at least 1 normal 🤞🏻🤞🏻🤞🏻 May I ask you to share the doses of your EPP protocol? We’re gonna try that next. I’m specifically curious about your doses and starts. 🙏
TTC#2
TTC #2 ... preparing as of March 2024
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
Then on CD3 I started stims: 200 follistim and 225 menopur. They upped my follistim to 275 when they started my antagonist on day 6. I did a total of 10 days of stims.
I did have higher estrogen and a shorter stim phase than previous cycles, but I only got 5 eggs. In 4 retrievals, I have gotten 7, 10, 2 and 5, so it’s pretty in line with previous. One possibility why it didn’t work well for me was that my luteal phase is so short that its only 5 days of estrace. My theory is just that it was a “bad month”— my AFC was only 7 I think (when it is typically 10).
Still the “best” cycle I have had was my first, when I started with BCP, so I am doing that again this time.
BFP 11/30/2017 | MMC 12/31/2017
BFP 6/22/2018 | CP 6/27/2018
BFP 10/5/2018 | EDD 6/14/2019
Baby girl born 6/19/19
TTC #2 May 2020-November 2021
BFP 7/18/2020 | MonoDi Twins | MMC 9/10/2020
BFP 11/7/2020 | CP 11/9/2020
RE Consult January 2021 | Dx "borderline DOR"/RPL
IVF with PGT:
Standard Antagonist:
ER #1 3/27/2021 7R | 5M | 3F | 2B | 1 PGT-A Normal, 1 low-level mosaic
ER #2 4/22/2021 10R | 7M | 3F | 2B | 0 normal, 2 aneuploid
ER #3 5/19/2021 2R | 1M | 0F
Estrogen Priming Antagonist:
ER #4 7/10/2021 5R | 4M | 3F | 1B | 1 PGT-A Normal
Duostim (Standard Antagonist):
ER #5 9/22/2021 13R | 11M | 8F | 5B | 2 PGT-A Normal, 1 low-level mosaic, 2 aneuploid
ER #6 10/9/2021 9R | 6M | 4 F | 1B | 1 aneuploid
FET #1 11/5/2021 | EDD 7/24/2022
Baby boy born 7/19/22
TTC #3 since May 2023 (ntnp)
IVF Started Fall 2023 (Standard Antagonist)
ER #7 10/6/2023 | 9R | 6M | 5F | 3B | 2 aneuploid, 1 high-level mosaic
ER #8 10/31/2023 | 5R | 4M | 3F | 1B | 1 PGT-A Normal
FET #2 11/27/23 | CP (bHCG = 8)
FET #3 planned Jan 2024
My doctor is wanting to try not a straight up EPP but modified. Using Aygestin to prime but stopping for 4 days before Clomid (he’s admitted that the last time he had me take Aygestin, it over-suppresed me). Then Clomid only for 2 days before adding Gonal and Menopur. But he’s also wanting lower doses for everything: 100mg Clomid; 150 of each Menopur and Gonal-F. But he is also “allowing” me to take dexamethasone.
TTC#2
TTC #2 ... preparing as of March 2024
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
Diagnosis (if you've been): PCOS, RIF/RPL, MFI
What are you doing this cycle? (Testing? Treatment?): Still in limbo, but MH is doing his karyotyping test this week through a private lab (mine was covered by insurance, his will cost us $600 CAD OOP, woof), and the new RE also prescribed ProFortil, which appears to be a needlessly expensive antioxidant supplement that I went ahead with anyway because it would cost me that much to buy a 3 month supply of each of those components separately. He is already taking most of these things but what the hell, now it's all in two little capsules.
Ingredient list, for inquiring minds:
How are things going?: Mehhh. I had a few weeks where I felt more at peace with limbo but our follow up with the 1st RE isn't until mid-Sept to try to give the ProFortil time to kick in and also have time for the test results to come back. Our 2nd consult is still over 2 weeks away and despite talking to my RE every day for the last 4 days, he's not having any luck pulling strings to move it up even a week. We're feeling a bit "doom and gloom"y about it all, knowing that the earliest we might start back up again is October/November, and probably won't do a FET for 2-4 months after that because we don't plan to do any immune testing until we know we have euploid embryos to transfer.
Protocol: Gonal-F, 300; Luveris,150; Letrozole start Day 6. Has anyone heard of/used letrozole during a stim cycle? What is the purpose of this?
I was on low doses the last two rounds.
IVF #1 was Lupron, Gonal-F 75, increased to 100, then down to 32.5 near the end. Menopur was 75 but only in the last 3 days, and an HCG trigger. AFC was 17, only got 5 eggs, 4 mature.
IVF #2 was Lupron, Gonal-F 150, Menopur 150 for 2 days, then stopped the menopur because I had such a bad reaction to it, then went back on it for only 2 days right at the end @ 32.5. HCG trigger. AFC was 19, retrieved 8 eggs, 7 were mature.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
@mokay19 yes, I took L-arginine as 1,000mg pills because the recommended dosage is 6,000mg a day. My naturopath suggested I try to find it in powdered form but I had already bought the capsules so I didn't bother. They should be taken on an empty stomach too.
@keikilove oh goodness, I think my heart stopped for a second reading your update. You are the strongest, most capable person I "know" but I am sending strength and love across the ocean to get through these crucial next few weeks as you wait for news.
@acleverusername I was so damn relieved when you said you got 8 eggs! And to have 3 blasts is great!! I am doing a happy dance for you! Glad you have the wedding and your trip to keep you occupied while you wait for PGT results.
@optimistgardener I knew someone who used PIO for like 6 weeks before she started developing a reaction to it. I think she said they used sesame oil as a compound for hers as well, so she ended up switching to the crinone gel. It was an extremely delayed reaction though, she was fine for weeks. It is entirely possible to try to find one that uses a different carrier oil but like legallykate mentioned, it may just be easier to switch to pessaries instead. FWIW, I used both compounded vaginal suppositories (not the tablets), and PIO.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
q Cycle day 1 is the first full day of a full flow. Start checking for ovulation on cycle day 11 with an ovulation predictor kit (for patients with REGULAR cycles that are <25 days or >32days, take the average cycle length and subtract 17. This is the day that they should start LH kits). Patient to call the office with a positive surge. If no positive surge by cycle day 17, have them come in for a progesterone level
§ If day 17 P4 is >5, then consider the patient post ovulatory
§ If P4 is <5, then repeat progesterone level q 2-4 days until >5
§ If second P4 is 1.5-3, repeat in 2-4 additional days;
§ If second P4 is still <1.5 patient can start estrace
q One week after the LH surge or day of confirmed ovulation (Progesterone >5), the patient will start Estrace 4 mg (2 mg x 2 tablets) PO q hs. Estrace is usually taken 3-10 days and the patient will menstruate while on the Estrace. The patient should take their last Estrace on day one of menses
q Patient to call first day of full menstrual flow. Appointment for ultrasound, E2 and beta hCG on CD2. Expect estradiol level to be elevated
q On the evening of CD1 (evening before baseline appointment), the patient should start Clomid 100mg (50 mg x 2 tablets) each evening for 5 days AND Dexamethasone 1 mg (0.5 mg x 2 tablets). Dexamethasone is continued until the day of trigger
§ Tamoxifen 20mg po can be substituted for clomid 100mg at provider’s discretion
q On CD3, the patient should start gonadotropin medications which should be taken at the same time every day between 7-9 pm. This is stim day 1
q The first ultrasound appointment will be on stim day 4 (after three days of gonadotropin stimulation and five days of Clomid)
§ If E2 <100, increase FSH by 75 IU, and repeat monitoring in 2 days
§ If E2 100-150, increase FSH by 37.5-50 IU, and repeat monitoring in 2 days
§ If E2 150-200, increase FSH by 25-37.5 IU, and repeat monitoring in 2 days
§ If E2 200-400, no change in dose and repeat monitoring in 2-3 days based on follicular size
§ If E2 400-600, decrease FSH by 37.5-50 IU, and repeat monitoring in 2 days
§ If E2 600-750, decrease FSH by 50-75 IU, and repeat monitoring in 2 days
§ If E2 >750, consider cancelling cycle
q When E2 400 OR stim day 6 OR lead follicle >14, start antagonist that night and then q am
q After any needed adjustments to current gonadotropin dose are made, add Menopur75 IU q pm to the patient’s regimen when antagonist is started - if not already using an LH product
q Plan for hCG trigger when there are at least 3 follicles greater than 18mm and several 14-18mm.
BFP 11/30/2017 | MMC 12/31/2017
BFP 6/22/2018 | CP 6/27/2018
BFP 10/5/2018 | EDD 6/14/2019
Baby girl born 6/19/19
TTC #2 May 2020-November 2021
BFP 7/18/2020 | MonoDi Twins | MMC 9/10/2020
BFP 11/7/2020 | CP 11/9/2020
RE Consult January 2021 | Dx "borderline DOR"/RPL
IVF with PGT:
Standard Antagonist:
ER #1 3/27/2021 7R | 5M | 3F | 2B | 1 PGT-A Normal, 1 low-level mosaic
ER #2 4/22/2021 10R | 7M | 3F | 2B | 0 normal, 2 aneuploid
ER #3 5/19/2021 2R | 1M | 0F
Estrogen Priming Antagonist:
ER #4 7/10/2021 5R | 4M | 3F | 1B | 1 PGT-A Normal
Duostim (Standard Antagonist):
ER #5 9/22/2021 13R | 11M | 8F | 5B | 2 PGT-A Normal, 1 low-level mosaic, 2 aneuploid
ER #6 10/9/2021 9R | 6M | 4 F | 1B | 1 aneuploid
FET #1 11/5/2021 | EDD 7/24/2022
Baby boy born 7/19/22
TTC #3 since May 2023 (ntnp)
IVF Started Fall 2023 (Standard Antagonist)
ER #7 10/6/2023 | 9R | 6M | 5F | 3B | 2 aneuploid, 1 high-level mosaic
ER #8 10/31/2023 | 5R | 4M | 3F | 1B | 1 PGT-A Normal
FET #2 11/27/23 | CP (bHCG = 8)
FET #3 planned Jan 2024
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
BFP 11/30/2017 | MMC 12/31/2017
BFP 6/22/2018 | CP 6/27/2018
BFP 10/5/2018 | EDD 6/14/2019
Baby girl born 6/19/19
TTC #2 May 2020-November 2021
BFP 7/18/2020 | MonoDi Twins | MMC 9/10/2020
BFP 11/7/2020 | CP 11/9/2020
RE Consult January 2021 | Dx "borderline DOR"/RPL
IVF with PGT:
Standard Antagonist:
ER #1 3/27/2021 7R | 5M | 3F | 2B | 1 PGT-A Normal, 1 low-level mosaic
ER #2 4/22/2021 10R | 7M | 3F | 2B | 0 normal, 2 aneuploid
ER #3 5/19/2021 2R | 1M | 0F
Estrogen Priming Antagonist:
ER #4 7/10/2021 5R | 4M | 3F | 1B | 1 PGT-A Normal
Duostim (Standard Antagonist):
ER #5 9/22/2021 13R | 11M | 8F | 5B | 2 PGT-A Normal, 1 low-level mosaic, 2 aneuploid
ER #6 10/9/2021 9R | 6M | 4 F | 1B | 1 aneuploid
FET #1 11/5/2021 | EDD 7/24/2022
Baby boy born 7/19/22
TTC #3 since May 2023 (ntnp)
IVF Started Fall 2023 (Standard Antagonist)
ER #7 10/6/2023 | 9R | 6M | 5F | 3B | 2 aneuploid, 1 high-level mosaic
ER #8 10/31/2023 | 5R | 4M | 3F | 1B | 1 PGT-A Normal
FET #2 11/27/23 | CP (bHCG = 8)
FET #3 planned Jan 2024
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
TTC #1 since 7.2017
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC put on pause
TTC#2
TTC #2 ... preparing as of March 2024
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
I know like, my actual experience with IVF is more informative than these levels at this point, and I sure do look like someone with DOR. But how is this possible? Do AMH levels fluctuate that much? Don't tell me it's "supplements"!
BFP 11/30/2017 | MMC 12/31/2017
BFP 6/22/2018 | CP 6/27/2018
BFP 10/5/2018 | EDD 6/14/2019
Baby girl born 6/19/19
TTC #2 May 2020-November 2021
BFP 7/18/2020 | MonoDi Twins | MMC 9/10/2020
BFP 11/7/2020 | CP 11/9/2020
RE Consult January 2021 | Dx "borderline DOR"/RPL
IVF with PGT:
Standard Antagonist:
ER #1 3/27/2021 7R | 5M | 3F | 2B | 1 PGT-A Normal, 1 low-level mosaic
ER #2 4/22/2021 10R | 7M | 3F | 2B | 0 normal, 2 aneuploid
ER #3 5/19/2021 2R | 1M | 0F
Estrogen Priming Antagonist:
ER #4 7/10/2021 5R | 4M | 3F | 1B | 1 PGT-A Normal
Duostim (Standard Antagonist):
ER #5 9/22/2021 13R | 11M | 8F | 5B | 2 PGT-A Normal, 1 low-level mosaic, 2 aneuploid
ER #6 10/9/2021 9R | 6M | 4 F | 1B | 1 aneuploid
FET #1 11/5/2021 | EDD 7/24/2022
Baby boy born 7/19/22
TTC #3 since May 2023 (ntnp)
IVF Started Fall 2023 (Standard Antagonist)
ER #7 10/6/2023 | 9R | 6M | 5F | 3B | 2 aneuploid, 1 high-level mosaic
ER #8 10/31/2023 | 5R | 4M | 3F | 1B | 1 PGT-A Normal
FET #2 11/27/23 | CP (bHCG = 8)
FET #3 planned Jan 2024
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
TTC #1 since 7.2017
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC put on pause
@fantasyflyte I've heard of other RE's not even allowing you to put your name on a list or pre-book an appt until you hit that 1 year mark, but it's certainly worth a shot. Especially knowing what you know about some of the main contributing factors to possible/probable IF once you hit that arbitrary 1 year mark. But +1 on @acleverusername's recommendations on starting YH on some extra supplements during this time. They have helped maintain/improve MH's sperm parameters despite his advancing age and the other factors working against us so it doesn't hurt to add those in if you're already adding Vit C/E. I personally liked FertilAid, which has almost everything he could need, and it's only 3 capsules per day as opposed to individual pills. MH was on it for 2 years. I'm only now switching because it's no longer available in Canada.
@acleverusername that makes sense about the Letrozole, thank you! I read some interesting (ongoing) studies looking at the use of letrozole in fresh transfer cycles to increase endometrial receptivity because it helps lower serum E2 levels, but of the few abstracts I read it seemed like it was mainly used for stim cycles in women who are poor responders because it can effectively lower the amount of gonadotropins required, which is interesting. I'm curious what that means for me, when I've only ever been given lower doses of stims so I'm not necessarily a poor responder, I just wasn't over-stimulated. *shrug* Guess we'll see! I'm curious what the second RE has to say, given that he's the most aggressive of the 3.
@bumblebee0210 I don't have anything to add re: AMH other than just hearsay that I know of other women whose AMH levels have fluctuated like that as well, often also with no real explanation.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
@kiki047 my very brief search on second ejaculate is essentially what it sounds. They collect the sample from the second round. The one study I looked at the second round occurs like 4 hours later. Not all the ejaculate once then ejaculate ASAP like I thought it would be. Seems that motility is better in that sample. I wonder if that's why some people seem to swear by having sex multiple times a day and that's the cycle they got KU?
TTC #1 since 7.2017
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC put on pause
@mokay19 ugh that's so frustrating that your body isn't responding as hoped. I'm so sorry. Congrats on the new job though, hope you enjoy your break in between!
@inthewoods23 that makes sense about motility improvements in the second sample. I read the same about DNA fragmentation, that regular, frequent ejaculation has been shown to improve both parameters and might be worth the sacrifice in sperm count especially during IVF when we'd probably be doing some by ICSI anyway.
What a story about AF, the storm, and your neighbour's cat! As much as AF was unexpected and unwelcomed, it sounds like those were kind of serendipitous circumstances for that sighting. Did you tell your neighbour you saw their cat? Were they relieved?
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
Were you guys okay from the storms? We are south of most the people that lost power and branches.
TTC #1 since 7.2017
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC put on pause
@optimistgardener. Ugh, yes, I am taking DHEA, but only 25 mg so I didn't really expect it to do anything.
tw mc
It's just weird because if I had gotten this level in January, I don't think I would have gone down the road. Any of course I think, if I was trying naturally that whole time I would be pg by now. And also my head in generally being f-ed with because we didn't really TTA as planned this cycle, so I am technically in a TWW, which brings back all of the old feelings.
BFP 11/30/2017 | MMC 12/31/2017
BFP 6/22/2018 | CP 6/27/2018
BFP 10/5/2018 | EDD 6/14/2019
Baby girl born 6/19/19
TTC #2 May 2020-November 2021
BFP 7/18/2020 | MonoDi Twins | MMC 9/10/2020
BFP 11/7/2020 | CP 11/9/2020
RE Consult January 2021 | Dx "borderline DOR"/RPL
IVF with PGT:
Standard Antagonist:
ER #1 3/27/2021 7R | 5M | 3F | 2B | 1 PGT-A Normal, 1 low-level mosaic
ER #2 4/22/2021 10R | 7M | 3F | 2B | 0 normal, 2 aneuploid
ER #3 5/19/2021 2R | 1M | 0F
Estrogen Priming Antagonist:
ER #4 7/10/2021 5R | 4M | 3F | 1B | 1 PGT-A Normal
Duostim (Standard Antagonist):
ER #5 9/22/2021 13R | 11M | 8F | 5B | 2 PGT-A Normal, 1 low-level mosaic, 2 aneuploid
ER #6 10/9/2021 9R | 6M | 4 F | 1B | 1 aneuploid
FET #1 11/5/2021 | EDD 7/24/2022
Baby boy born 7/19/22
TTC #3 since May 2023 (ntnp)
IVF Started Fall 2023 (Standard Antagonist)
ER #7 10/6/2023 | 9R | 6M | 5F | 3B | 2 aneuploid, 1 high-level mosaic
ER #8 10/31/2023 | 5R | 4M | 3F | 1B | 1 PGT-A Normal
FET #2 11/27/23 | CP (bHCG = 8)
FET #3 planned Jan 2024
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
LH = 13.9
Estradiol = 20.3
Progesterone = 0.27
Pending decision of next steps.
How are things going?: ok. We were taking a break for a bit and are now actively deciding next steps. We are thinking we will try at least once more, maybe twice. We have leftover meds, so we want to use them and get another shot at things. We are also debating IVF with egg freezing. If we did that, we may try a few times to take advantage of the frozen eggs, if we can harvest enough.
Being one month closer to our anniversary trip to Maine (October)
What I’m not looking forward to is turning 38 in September!!!
Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
Feb '22 FET (low-level mosaic): CP.
May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
July 23, Natural FET + baby aspirin. BFN.
TTC#2
TTC #2 ... preparing as of March 2024
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
@acleverusername loving the pineapples!
TTC #1 since 7.2017
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC put on pause
@optimistgardener I’m sure you’re so frustrated/concerned... I’m hoping and praying that they get you some good news back ASAP!