This is a place for those of us who have already started TTC, but have started infertility testing and/or treatments. You can express your thoughts, feelings, and frustrations on infertility. TTC can be a long journey naturally, then add in the difficulties associated with infertility, and it becomes a whole new ball game. The road to infertility can be lonely, frustrating, and complicated, so let's make this a place where we can vent, ask questions, and support one another. Feel free to resurrect this thread at any point in the week if you have something to say. Treat this as an ongoing conversation.
Diagnosis (if you've been):
Status (WTO/TWW/TTA):
What are you doing this cycle? (Testing? Treatment?):
How are things going?:
Any questions?:
GTKY: Vacation style: do ALL the activities or just chill & eat/drink?
What are you doing this cycle? (Testing? Treatment?): Less than a week out from our 3rd FET.
How are things going?: Good! My lining was at a whopping 10.7mm this morning which, if you've been following my saga, you'll know why that's a big deal because I've never been able to get it over 7mm. I credit that to a number of factors, *TW* one being that I think your body is just naturally more fertile after a loss, *end TW* but also because I added extra acupuncture, L-arginine, an herbal formula called yuan support, extra vit C, extra vit E, extra zinc, and anything else we could think of to the mix. Whether it's just a fluke or it actually works, I'll take it!
Any questions?: Not right now.
GTKY: Vacation style: do ALL the activities or just chill & eat/drink? Eating/drinking is the activity sometimes, so I guess a little of both! Depends where we're going. If the vacay is meant to be for R&R then for sure we just eat, drink and soak in the quiet, but most of our vacations are "destinations" so we have itineraries planned out down to the minute, including food options in each area, all of which can change if we see something better once we arrive. God I miss traveling
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
@kiki047 yay for awesome lining this time! I’m still waiting for my period to start so we can kick off my transfer cycle, and I’m admittedly clueless about that part of the process, so I’ll be living vicariously through you for a bit!
Diagnosis (if you've been): unexplained/old
Status (WTO/TWW/TTA): umm, waiting to start transfer cycle
What are you doing this cycle? (Testing? Treatment?): just did first (and probably only) egg retrieval last week
How are things going?: Good, just waiting to hear how many embryos we have to test. I think we’re getting that news tomorrow, so yeah, today is all about distracting myself so I don’t needlessly dwell on things.
Any questions?: Someone talk to me about what to expect during a FET 🙂 I keep reading stuff online but for some reason I can’t find very detailed stuff, and I’m sure I’ll hear about it from my RE when the time comes, I just don’t want to bug him and I’m impatient, haha.
GTKY: Vacation style: do ALL the activities or just chill & eat/drink? Chill. Absolutely chill.
@lisa3379 we have a couple ladies still on here (as well as our favourite lurkers!) who have at least one FET under their belts. Happy to share my own experience. For one, it's a lot less daunting than it seems. And we'll be here every step of the way if you have any questions! I'll put the rest in a spoiler so I'm not taking up half the screen:
There is usually only 2, maybe 3 monitoring sessions as opposed to constant monitoring during your retrieval cycle. What they're looking for is a clear, thick endometrial lining, which for most clinics seems to be a minimum of 7-8mm.
Do you know if your RE is going to have you do a medicated or natural FET? Medicated meaning they would normally have you on estrace (estradiol) starting on CD2, and some form of progesterone which will usually start 3-5 days prior to your transfer and most often continued until a positive pregnancy test through to 12 weeks gestation (suppository is most common, but some take it in tablet form, some will do progesterone in oil, aka PIO, injections). A natural FET usually just means you'll be monitored to watch when you're ready to ovulate, then some will give you an HCG trigger then you transfer a 5-day embryo 5-6 days later.
You'll go in on the day of your transfer with a full bladder, and if you've ever had an IUI it basically feels like that. You'll be in the stirrups, put the speculum in, usually lightly swab your cervix with an antiseptic, then they take the catheter with the embryo loaded in it then using ultrasound guidance they'll place it in your uterus. You won't have any anaesthesia like the ER but it shouldn't hurt, feels like a pap smear. Mine have taken a max of maybe 5-10 mins including lying on the table with your legs up for 5 mins after the procedure before they let you go pee lol. Some women experience a little bit of spotting or discharge but that's most likely from a bit of cervical irritation and the liquid from the catheter draining out. The embryo itself will "stick" to your uterine wall where it is implanted. I've always been told that the embryo should implant within 24hours.
Every clinic is different, some say you should take it easy but you can basically go back to your regular activities (within reason) in the next few days. No hot showers/saunas/hot tubs (so you don't raise your body temperature too much), no baths (I think this is in case of infection), no sex (again, for infection), no strenuous activity. For me personally I've been put on bed rest following my transfers for about a week but unless you're high risk I think the norm is 48hrs. Other than that, you'll basically just enjoy the next 10-14 days of being PUPO (pregnant until proven otherwise) until your beta!! I promised myself I wouldn't POAS until at least 10dp5dt but I know many who test earlier as long as they didn't do an HCG trigger.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
@kiki047 thanks so much for that! Doesn’t sound too bad... some of the stuff I was reading online said that they took birth control pills for a couple weeks beforehand? It wasn’t super clear. Sounded like too much time to wait for me, haha.
@Lisa3379 my clinic had my on BCPs prior to my FETs. It's part of their standard protocol. At a minimum they'd put people on it for 18 days but I always ended up on it for 40+ simply because they were scheduled so far out for procedures. To give you an idea - I had my ER on 6/11/19, got my period within 2 weeks, and had my FET date scheduled for 9/10/19 based on that CD1 date. I spent all of July and half of August on BCP before I got to start the lupron and estradiol when the FET cycle started. @kiki047 pretty much covered it all. They monitor your lining and check your hormone levels as you go along and that's really it before the transfer itself. It's a lot less needles, that's for sure. They also had me on some antibiotics for a few days leading up to the transfer as well.
*TW* History:
Me: 34 DH: 36 | Together since 2007 | Married July 2016
TTC #1 since 7.2017 Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3| all BFN IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name" RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer 2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks TTCAL naturally | starting 11.22.20 Initial consultation with Reproductive Immunologist | 9.14.21 Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation Saline sono | 10.15.21 | normal Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy DS born 7.19.22 after induction
TTC #2 begins 6.2023 Consultation with RI | 6.6.23 Saline sono, endometritis biopsy, skin & eye check | all normal Labs | high TSH, Factor XIII mutation, high %CD56 Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine Repeat labs after 3 weeks on meds Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox Repeat labs in 8 weeks Follow up | 1.16.24 | Green light continues TTC put on pause
@lisa3379 I was on BCP prior to my 2nd transfer to level out my hormones but based on what I've seen even just from the ladies that pass through TTGP that protocol varies wildly depending on the situation. Sometimes it's used purely for scheduling purposes to make sure they can micromanage your cycle down to the day based on the clinic's availability to schedule procedures (like ITW), other times it's warranted if you have irregular cycles just to make sure your CD1 really is CD1 (which was the case for me). Unlike @inthewoods23 I only go for ultrasounds for my monitoring, they don't do bloodwork. I also haven't used lupron during my FET cycles, which is sometimes used to prevent spontaneous premature ovulation if you're at risk for that. Did they give you an idea of how long it takes for you to hear back about PGT results? A lot of places will prep you for a FET even if you don't have results back yet, then if they have to they'll drag it out as long as possible.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
What are you doing this cycle? (Testing? Treatment?): Since we got the negative COVID test before AF came, we are able to start again this cycle. I start injections tonight.
How are things going?: Okay. I’m not looking forward to starting up again but I also am looking forward to trying to do something. I was almost a week late again so that was sad, especially since I let myself start to hope! Sometimes it feels like I shouldn’t let myself hope.
Any questions?: NATM
GTKY: Vacation style: do ALL the activities or just chill & eat/drink? Chill. Nice restaurants. Outdoor activities - but not packing it full. It’s a vacation so we need to relax as well
@laura-kay Ugh, I’m sorry your were a week late. That is
pure torture. I’m glad your covid test is negative tho and you get to start another
cycle without sitting out!
@acleverusername I’m so sorry AF showed up early over the
weekend. I hope it didn’t ruin your weekend too much and you were able to enjoy
some wine without feeling guilty. I have a theory about what happened last
cycle. Hear me out. Were you doing OPKs before your trigger shot? I remember
you said at your last monitoring cycle that your LH was starting to surge
already. I’m curious what that number was because I always thought it was a bad
thing to start surging before your trigger. You have less control over when you
O and the IUI timing can get messed up. I was actually surprised your clinic
didn’t move your IUI date up based on that (but knowing all the other mistakes
your clinic has made… makes sense). I think it’s likely that you ovulated
earlier than you think. I also know that the meds your on for the IUI, for egg
stimulation and the trigger, can mess with your temps. So I wouldn’t necessarily
trust your O day based on BBT alone. That, on top of your previous cycles where
you O early, makes me think you Oed before your IUI. Which I hate and am ragey
at your clinic for you. Curious what you think.
Diagnosis (if
you've been): Unexplained
Status (WTO/TWW/TTA): WFAF
What are you doing this cycle? (Testing?
Treatment?): Picked
up my letrozole last night!!! Only $3.11 lol
How are things going?: Things are going ok. I’m just excited to get
this next cycle going. I’m super hopeful about it.
Any questions?: What is the point of the baby aspirin and does
anyone take it?
GTKY: Vacation style: do ALL the activities or
just chill & eat/drink? 100% do ALL the activities! But also eat all the foods lol.
I do not particularly enjoy just sitting around and “relaxing.” It gives me a
headache lol.
*TW* TTC history
Me:32 DH:31 Married: 8/2015
TTC #1: 4/2017 Testing: HSG, U/S, BW, and DH's SA all normal DX: Unexplained 8/2018: Clomid + TI = BFN 9/2018: Clomid + TI + Progesterone = BFN 11/2018: Clomid + IUI + Progesterone = BFN 12/2018: Letrozole + IUI + Progesterone \\ Cancelled due to cyst 1/2019: Letrozole + IUI + Progesterone = BFP! \\ EDD Sept 30th, 2019 10/7/2019: Healthy baby boy!
@kiki047 I can't remember if I was told specifically, but everything I've read said a couple weeks for the PGT results?
@laura-kay I totally get the feeling of being happy that something is happening, even if it's injections! For me, being idle is the worst. And you gotta let yourself hope. I'm a firm believer in the power of positivity - not that positivity will make what you want to have happen happen, but I think it gets you in the best mindset to deal with whatever comes down the road. Sending hugs.
@LJMoon6 No idea with the baby aspirin, haha! I barely take regular aspirin. And fingers crossed for your new cycle!
@LJMoon6 low-dose (or baby) aspirin is usually used to treat chronic inflammation which could impact fertility. It can often address underlying undiagnosed blood clotting disorders too in cases where that is negatively impacting fertility and they might not even know it. **Edited to add: yes I've been prescribed baby aspirin for all 3 of my FETs (and only stopped when I was spotting) and for both of my IUIs.
@laura-kay that's a double relief of negative Covid test and getting the all-clear to start again. I'm so sorry you had to go through that gut-wrenching plummet that follows a false sense of hope when AF is late, it's a special kind of torture to someone who is having TTTC/going through IF. Hugs.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
@lisa3379 YAY! That's a great update!! Go little embies!!! @acleverusername thank you friend!! I'm SO relieved not to have to stress over my lining this time around. It's been such a sore point for me with my past transfers so it's giving me hope!! GL with your rescheduled consult with TEW tomorrow, looking forward to hearing your recap!
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
@kiki047 +1 to your "God I miss traveling." Thank you for remembering that my consult w/ TEW is tomorrow! I'm so eager for it; I hope I'm not disappointed. I sent ahead 2 1/4 pages of questions for her.
@Lisa3379 hopefully you get a few more blasts tomorrow! Re: vacation style, I'm absolutely with you re: "chill" category.
@laura-kay I am so sorry your body gave you such false hope! Are you switching up your protocol at all for this next IUI round?
@LJMoon6 I am excited that you're excited! I take a low-dose aspirin for inflammation issues since I evidently have some. I've also heard (from @keikilove maybe?) that it's good if you have an MHTFR mutation (although doctors have told met that since I take loads of extra folate, I don't need to _also_ take baby aspirin). I would be careful taking it just because (i.e. without consulting a doctor) as it _can cause_ blood to thin which would be an issue if you injure yourself and have bleeding. Also, your assessment of my situation is not completely out of the realm of possibility (i.e. it's totally possible that my IUI was too late). However, I have typically had luteal phase issues (i.e. spotting a few days before period), including a 9-day luteal phase (with 2 days of spotting before) mid-last year, before I started medicated cycles. I was also NOT surging (LH was still low) on the morning of Jan 25; the surge started that evening. However, The Egg Whisperer says that ovulation can occur 12-72hrs after the onset of the LH surge, so it's entirely possible that I ovulated earlier, though I wouldn't think it was more than 1 day earlier.
Diagnosis (if you've been): I honestly don't know anymore. Unexplained plus MFI? Hypoandrogenic PCOS? Hashimoto's Thyroidism
Status (WTO/TWW/TTA): WTO
What are you doing this cycle? (Testing? Treatment?): taking a break + trying to find a new RE; was gonna prep for IVF, but decided to just take a break (more on that later).
How are things going?: I am not doing all that well. After the fiasco with my now former clinic, I reached out to the fertility therapist I was seeing last year (I was doing really well, so I haven't felt the need to have a session with her since just before Thanksgiving). So I had that session today, and boy oh boy, it was good to talk through it all with a 3rd party. I kind of walked/ranted/cried through everything I was feeling, and how I feel like I can't trust anything the former clinic did anymore (cause I only caught 2 of their mistakes; what didn't I notice?) and that I'm making plans to go into IVF feeling that I've wasted the last 4 cycles because we operated on the basis of sh*t data. After that, I realized that I'm STILL not ready to move on to IVF. I don't feel like I have a clear understanding what what issues is preventing us from getting KUed other than "unexplained" and I don't buy "unexplained" because there's obviously issues here (luteal phase deficiency - LPD - is a symptom of something).
Anyway, I'm going to see what TEW says tomorrow. I.e. does she think it's worthwhile to run more diagnostic tests (i.e. check for endo since LPD can be a symptom), karyotype testing, etc. Does she think we ought to try superovulation + IUI (she does believe in that for older women; usually targets 2-3 follicles) at least 1 or 2x? I will have a full report tomorrow or Thu.
Oh, and at the end of the meeting with my therapist, I started talking about how unsupported I felt by my own parents, and the waterworks started. Putting that whole thing into spoiler:
This weekend, my Mom calls me to tell me that "dad is very upset with you." Why?! Because 2 weeks ago, I get a call from them asking "what your address? I need to know this right away because I'm going to order something to your house and have you ship it to Canada." I had to get on my email THAT instant to send them (both of my parents), my address. I was riled up and said "guys, I'm not going to ship it to you. It's EXPENSIVE to ship stuff from US to Canada." (In the past, they've been OK waiting until I go visit to bring anything they've ordered. Alas, I'm really not sure when the next time will be.) So yeah, apparently my Dad was upset that I said that I wasn't going to ship anything to him. So I had explain to my Mom that "hey, do you really want me to pay $30 to ship something that you paid $10 for?" (I don't actually know how much it cost, but I wanted to make sure she was aware just how expensive it is, without tracking.) Then, I tell her "MH and I are going to Arizona for a few months at the end of Feb for IVF." and Mom replies "Ok dear." That's fucking it! Anyways, I didn't realize just how I upset I was about this until I started talking to my therapist. She recommended that I need a break from talking to my parents (who are also the kind who never CALL ME to chat / see how I am, but instead call me if I haven't called them in a week-10 days to ask "why haven't you called?" Anyways, I ended up sending my mom a WhatApp message after saying "hey, I'm not gonna call for a while because I don't have the emotional bandwidth to deal with you right now." (Or something like that.)
Any questions?: for those of you who have had repeat SA's, is it normal for TMC to vary between 6.3M to 154M to 44M within the space of 6 months? I know that men can have an "off day", but is that kind of variability normal? In early Dec, MH's TMC pre-was was 154M; post-wash it was 54M; 2 months later, TMC pre-wash was 44M; post-wash it was 7.5M.
GTKY: Vacation style: do ALL the activities or just chill & eat/drink? I'm definitely in the chill, relax, see some of the sights, while I eat my way through my holiday! I've always been of the opinion that if I like a place enough, I'll come back and see more of the sights. No point in trying to cram everything into 1 vacation (I know some people are like "I'm going to come here only once in my life because there are so many other places in the world to see, so I need to see EVERYTHING." Nope, that's not me.)
@LJMoon6 I don't know what grade they are - all he said was that they were ready to freeze and biopsy today. I also don't know exactly how many we're waiting on. I'm one of those that only asks questions that are super pressing for myself, haha. I hate bugging people with tons of questions, although in cases like this I probably should get over it. I figure that once everything is done, I'll get the final assessment of how many made it to freezing stage.
@acleverusername We are definitely doing PGS testing. We're just waiting on some genetic test results to see if we need to do PGT-M testing. And I have no clue about a mock cycle. I'm so ignorant of all kinds of things regarding this stuff! I'm just going with the flow, and figure that when my period starts and we do the saline ultrasound, then we'll talk about the plan for the next step. And I'm hoping that your consult with TEW goes well tomorrow! Just reading your whole account regarding the therapy and your parents makes me just want to hug you. That's SO MUCH to deal with. I'm sorry you're having a rough time.
@Lisa3379 SO happy to see your updates! Grow little guys, grow!!
@kiki047 YAY for an awesome cushy lining! Sending you all the good vibes for your FET!
@LJMoon6 hoping the letrozole helps! I feel much better this cycle now that I'm "doing something" even though I know I don't have much control over the outcome.
@acleverusername thinking of you today and hope your consult with TEW gets you some great info and a plan moving forward! Can't wait to see your update!
Diagnosis (if you've been): unexplained
Status (WTO/TWW/TTA): WTO
What are you doing this cycle? (Testing? Treatment?): Clomid + IUI
How are things going?: So far so good. Dealing with the Clomid mood swings making me quickly very emotional. sad, or irritated. I got teary hearing that Christopher Plummer had passed, and thinking about the Sound of Music which was my grandmother's favorite movie and one of my strongest memories of her. Shed a few tears on my way to work which is not me! Keeping it mostly in check around others so I do not annoy my spouse or office-mate. Thankfully, office-mate has also been through IF, both her kids are IVF babies so she totally gets it and is a great sounding board. This week I'm taking my OPKs to get ready for IUI. Got my first positive yesterday, and usually get 2-3 positive/high days before peak day, so I'm guessing my IUI will be Friday or Saturday. (My RE has me using the ClearBlue smiley face tests so I get flashing smileys during the estrogen surge before the solid smiley face that indicates the LH surge). Tests are great for trying naturally, but not great when you have to wait for a fresh sample to do IUI! Might try for "extra credit" after the IUI though! Gotta make the most of this Clomid!
Any questions?: No questions right now
GTKY: Vacation style: do ALL the activities or just chill & eat/drink? I am a do ALL the things kind of girl but DH is just chill. We both love the eating and drinking, so I plan activities for some of our days but also look for interesting food and bars around them that he will enjoy! Our honeymoon was in Maui which was the perfect mix of activities and lying on the beach/pool + cocktails. Hoping by the fall DH and I can make a quick weekend getaway.
@acleverusername I’m glad you reconnected with your
therapist. Your parents make me a little ragey. I’m glad you told them you need
space.
I was told to take a baby aspirin for both my IUIs, so I’m
just wondering if I should take it for my medicated TI cycle or not. I’ll
probably skip it this cycle, just because like you said, I probably shouldn’t
be taking it without doctors instructions.
I guess my theory isn’t as sounds as I thought lol. I must
have mis-read your post about your LH surging early. It makes more sense why
your clinic didn’t move the date now too. I guess it’s still possible you Oed
the day after your trigger, the day before your IUI. But that still only gives
you a 10 day LP. I’m sorry you’re struggling with what to do next. I liked what
you said last week, or the week before, about how you still haven’t had a “perfect”
IUI yet. I think the 3-6 recommendation is for when everything lines up
perfectly, which I don’t think you’ve had yet. I’m super excited to hear what TEW
has to say today. I think trying for super ovulation would be a good next step?
My experience with SAs comes from counting millions of fungal
spores lol. It does sound like something it going on with YH, but I thought I
would just explain what I know about counting anyways. When you’re trying to
count something that small and in that quantity, it’s obviously unrealistic to
count them all. What we did with fungal spores, which I think is similar to counting
sperm (at least the way my RE explained it to me), is take just a small little
sample. Place it on a special slide that has a grid pattern (called a
hemocytometer). Count how many are in a square, then extrapolate (there’s a
little bit more that goes into it but I don’t want to bore you with math lol).
With that said, it’s not an exact science. It depends greatly on the small
little sample that was grabbed.
@Lisa3379 I get that, not wanting to bug people with too
many questions. I’m a nosy MF. I ask all the questions lol. Maybe it’s my analytical/sciencey
mind lol.
@quitandknit I’m sorry you’re experiencing clomid mood
swings. Sounds like you’re getting ready for your IUI soon! I’m so excited for
you!
edit to fix tag
*TW* TTC history
Me:32 DH:31 Married: 8/2015
TTC #1: 4/2017 Testing: HSG, U/S, BW, and DH's SA all normal DX: Unexplained 8/2018: Clomid + TI = BFN 9/2018: Clomid + TI + Progesterone = BFN 11/2018: Clomid + IUI + Progesterone = BFN 12/2018: Letrozole + IUI + Progesterone \\ Cancelled due to cyst 1/2019: Letrozole + IUI + Progesterone = BFP! \\ EDD Sept 30th, 2019 10/7/2019: Healthy baby boy!
@LJMoon6 No, I think that's great! It just never really occurs to me to ask a bunch of questions, maybe because I'm not a very science-y person and I just take people's word for it. Kinda like, "well, he's a doctor, so I'm assuming he'll tell me what's up when I need to know what's up". Haha. I'm a very go with the flow person, probably to a fault.
@acleverusername Haha I know! When I read your earlier post about your 3 pages of questions I was super impressed by that! I mean, you've been proven right in your tactics, honestly - it's super important to be well-informed during things like this. You actually influenced me to do way more research into everything than I started out doing, so thank you
@Lisa3379 all this can be very intimidating, and not knowing what questions to ask can be paralyzing. And Dr. Google does more harm than good! Not to mention if you go down the path of reading research papers (I usually just read the abstract), the studies are mostly of poor quality (low sample numbers) and for every question you hypothesize, you will almost always find a totally opposite opinion. This is why I really like this thread... it's great for asking and answering questions, even if the question is "what should I ask my doctor?"
@acleverusername I'm so sorry things are a bit rough at the moment. I just wanted to pop in to add some perspective to the whole "LPD" thing. I personally had shorter LPs (typically 11-12 days) and in fact when I was particularly stressed out leading up to our IF dx and my IVF cycles, my LP dropped like a stone. I had a couple of 9-10 day LPs including even earlier spotting. IMO, I was experiencing extreme stress and anxiety over IF, and my body was reacting poorly. In my experience, LPD is not necessarily the be-all and end-all. *TW below*
**TW** At the end of the day, my body was definitely producing a good lining, and implantation did happen multiple times, despite my fears.
Our issue ended up that there was not sperm ever meeting my eggs, meanwhile I was beating myself up over a perceived problem that wasn't actually the problem. In the end, LPD is usually solved by progesterone, which is part of every IVF cycle anyway.
me: 35 / so: 34 | ttc #1 since 9/2018
DX: MFI IVF Cycle #1 February 2020 4 embryos frozen, 1 fresh transfer = CP FET #1 Natural Cycle March 2020 CXL'd due to Covid-19 FET #1 Natural Cycle June 2020 - CP #2 FET #2 Natural Cycle July 2020 - BFP!!!!!! Beta #1 = 273
@mvt2003 thank you so much for your perspective re: stress & LPD. It makes total sense since last luteal phase was when all the crap with my former clinic started happening, so I was extra-wound up (as evidenced in my breakdown during my therapy appointment). I know now to take progesterone always.
Okay, TEW consult update! First of all, can I just say how amazing it's been to get PMs and tags in the dailies/random channels wishing me good luck on my consult?! Thank you everyone. 🙏🏻😘It once again reminded me of how grateful I am to have found this place as we TTGP.
Now, for the "good stuff". Basically, TEW is everything I hoped she would be and more. Henceforth, I'll refer to her as my fertility fairy godmother. I even teared up after our call ended because I was so relieved / grateful.
I'm gonna put everything in a spoiler because there's a lot.
First of all, she was SO EXCITED to meet with us! I had sent her like a 30-page "summary" of our journey so far, and she was buzzing with excitement that she was finally meeting us. She said "anyone who bothers to send this to me... well, I know I'm gonna get along with them VERY well." She also had the 4 pages of questions I had sent her printed out and ready to go, and we ended up methodically going through all of the questions!
Her first question to us was "have you done the chromosome analysis yet? That's the only thing that didn't immediately pop out to me as you having had it?" and I said "no, because our previous RE didn't recommend it because of cost/value" Then I asked her she (TEW) focused on that so quickly, and she replied "because... why they heck aren't you pregnant yet? There's nothing wrong with you!" For added context, previous RE said it would cost $1500-2000 per person and there was a 1/500 chance that we had a balanced translocation issue. TEW said cash cost is $250-$300; but, this is a diagnostic test and my insurance should cover it.
We went on to do a review of my/MH's medical history, and she had some additional questions about tests we've hadn't yet done. Our diagnosis, according to her, is a fertilization issue. She felt that egg and sperm were likely meeting in the fallopian tubes. But why they weren't doing more, that's still TBD. She felt that there are still pieces of the puzzle that are missing that might help us make better decisions about next steps. At this point, we're going to be doing the following:
- chromosome analysis for both MH and I - anti-sperm antibodies test for MH (TEW described this condition as sperm wearing a little helmet which makes it impossible to fertilize an egg. I LOLed) - repeat SA with morphology for MH - ultrasound in the office with TEW to check for polyps, endometriosis and adenomyosis (EVEN though I've had an HSG, a saline sonogram, and a pelvic MRI... she says she has a sneaky feeling about this.) - recheck my Vit D - recheck my TSH/TPO antibodies (she doesn't like to see the number increasing especially when we're talking about a potential transfer) - stop taking DHEA / increase NAD to 300mg / add Pterostilbene 150mg
As for treatment, she doesn't think that we need to rush into IVF just yet; she says if we're not pregnant by June, then we can talk about fertilizing the eggs I have on ice, or doing another egg retrieval. What's even more interesting is that she said she wants to be involved in the egg warming / fertilization process at the clinic where my eggs are frozen. AND, she said it would be a good idea to send sperm there instead of shipping eggs here (those eggs are in Canada as I started all of that process just before moving to US, so I went back to Canada for the ER.)
Finally, she's gung-ho about having me achieve super-ovulation and has no problem with me ovulating 3 eggs at my age. She talked about much higher dosage of both Letrazole (10mg) and Gonal-F (didn't discuss dosage) for the combo-cycle than previous RE to make sure that happens. She also suggested using a Zymot device (I've only previously heard it used as part of IVF) for MH's sperm for the IUI AND she wants to do double-insemination... i.e. IUI 1 day post-trigger and 2 days post trigger. Honestly, the whole appointment was a completely different experience. I felt that here is someone who is 100% focused and ready to go to bat for me.
MH was equally impressed. We had a bubble friend over because MH was helping her with a work thing, and as she was leaving, and we were summarizing the appointment to her, he said: "she is the first doctor who's read our file before our consult." MH has heard me playing her podcast shows before, so he knew that she was "good", but she really significantly exceeded both our expectations.
@LJMoon6 you fungal spores counting example was THE PERFECT analogy! I now totally understand how they count sperm, and to be frank, never really thought to much about it.
Just popping in to say I am SO PUMPED for you @acleverusername !!!! What an amazing consult and a freaking fantastic plan to move forward in your treatment. (and yay for good colonoscopy/endo results too!)
@acleverusername What an amazing update! I love how excited she
was to talk with you guys. It sounds like you guys really clicked! Will you be
continuing treatment with her? Or just taking her suggestions to another RE? I
wonder what her “sneaky” feeling is. I have never heard about the Zymot device.
That’s super interesting. I always wondered how they “washed” the sperm. A centrifuge
seems so destructive. I’m just imagining those poor sperm getting dizzy,
bahaha. As an aside, I work in a nano lab, where microfluidic devices are made.
So learning about the Zymot is super cool to me!!
*TW* TTC history
Me:32 DH:31 Married: 8/2015
TTC #1: 4/2017 Testing: HSG, U/S, BW, and DH's SA all normal DX: Unexplained 8/2018: Clomid + TI = BFN 9/2018: Clomid + TI + Progesterone = BFN 11/2018: Clomid + IUI + Progesterone = BFN 12/2018: Letrozole + IUI + Progesterone \\ Cancelled due to cyst 1/2019: Letrozole + IUI + Progesterone = BFP! \\ EDD Sept 30th, 2019 10/7/2019: Healthy baby boy!
@acleverusername I'm so happy to hear your consultation went well! Sounds pretty promising, and I'm sure it felt like a relief to have your questions answered in such a positive way.
@LJMoon6 we're going to do at least 1 IUI (Hybrid: Letrazole + Injectables) with TEW. This was our plan all along when we booked a consult with her, but then I felt totally rushed into starting IVF and the therapy appointment plus her saying "no need to rush into IVF" made me feel so much better so we've returned to our original plan. I'm also gonna see about warming up/fertilizing my Canada eggs and depending on the results of that, doing a transfer with TEW. Heck... maybe I can get enough genetically tested embryos from that 1 ER round I did in 2019! 🙏🏻🤞🏻
I'm also gonna see about warming up/fertilizing my Canada eggs and depending on the results of that, doing a transfer with TEW. Heck... maybe I can get enough genetically tested embryos from that 1 ER round I did in 2019! 🙏🏻🤞🏻
@acleverusernameJust out of curiosity, how many eggs do you have on ice? I'm sure you know this already but I feel like I have an obligation to say it anyway... the idea of having "enough" embryos is so subjective, and there are still so many factors that come into play before you can consider a certain # of embryos to be "enough" to guarantee you a THB. I know you've done your own research so maybe you have your own idea in your head of what your ideal # is to feel comfortable but I see it more often than not that people kind of get a number in their head of how many blasts they think they'll end up with based on a certain # of eggs retrieved and equate that with the same number of THBs, and it's hard when reality sinks in once you factor in attrition rates and failed transfers, etc.
I'm so glad TEW lived up to your expectations and that she's ready to go to bat for you. Based on what I've read about her online she seems to have the ideal setup as a boutique clinic that doesn't have the constraints of needing to coordinate with insurance, etc, and that she's willing and/or has the knowledge/experience to run all the relevant diagnostic tests to try to figure out the best course of action for each of her patients. If only all doctors were willing to go that extra mile, maybe people wouldn't be so unhappy in their current situations. Dr Aimee seems great in all the areas where others have failed so I'm excited for you! You always said you wanted to find the kind of relationship I have with my RE, and it really sounds like this might be it!
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
@laura-kay I hope the ganirelix does the trick for you! So happy that your doc added that to your protocol.
@kiki047 I have 11 mature eggs on ice; they were retrieved when I was 35.98 yrs old (Lol; 2 days before my 36th bithday). Statistically speaking, I was told to "budget" 2 embryos per desired child, so I think I'd be comfortable with having 4 frozen, genetically tested embryos. I don't know if I'll get those from my existing frozen eggs, but I'm hoping I'll get 2-3 so maybe I'll only need 1 additional retrieval. But, given my profession (Project Manager), I am cognizant that I could have a total bust with those eggs, or get 5-6 embryos. I just don't know and I won't know until we warm/fertilize them.
I am really hoping that Dr. Aimee will be for me the kind of support your RE has been for you. 🤞🏻
Re: IF Testing & Treatment w/o 2.8
Status (WTO/TWW/TTA): WFFET!
What are you doing this cycle? (Testing? Treatment?): Less than a week out from our 3rd FET.
How are things going?: Good! My lining was at a whopping 10.7mm this morning which, if you've been following my saga, you'll know why that's a big deal because I've never been able to get it over 7mm. I credit that to a number of factors, *TW* one being that I think your body is just naturally more fertile after a loss, *end TW* but also because I added extra acupuncture, L-arginine, an herbal formula called yuan support, extra vit C, extra vit E, extra zinc, and anything else we could think of to the mix. Whether it's just a fluke or it actually works, I'll take it!
Any questions?: Not right now.
GTKY: Vacation style: do ALL the activities or just chill & eat/drink? Eating/drinking is the activity sometimes, so I guess a little of both! Depends where we're going. If the vacay is meant to be for R&R then for sure we just eat, drink and soak in the quiet, but most of our vacations are "destinations" so we have itineraries planned out down to the minute, including food options in each area, all of which can change if we see something better once we arrive. God I miss traveling
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
Status (WTO/TWW/TTA): umm, waiting to start transfer cycle
What are you doing this cycle? (Testing? Treatment?): just did first (and probably only) egg retrieval last week
How are things going?: Good, just waiting to hear how many embryos we have to test. I think we’re getting that news tomorrow, so yeah, today is all about distracting myself so I don’t needlessly dwell on things.
Any questions?: Someone talk to me about what to expect during a FET 🙂 I keep reading stuff online but for some reason I can’t find very detailed stuff, and I’m sure I’ll hear about it from my RE when the time comes, I just don’t want to bug him and I’m impatient, haha.
GTKY: Vacation style: do ALL the activities or just chill & eat/drink? Chill. Absolutely chill.
I'll put the rest in a spoiler so I'm not taking up half the screen:
Do you know if your RE is going to have you do a medicated or natural FET? Medicated meaning they would normally have you on estrace (estradiol) starting on CD2, and some form of progesterone which will usually start 3-5 days prior to your transfer and most often continued until a positive pregnancy test through to 12 weeks gestation (suppository is most common, but some take it in tablet form, some will do progesterone in oil, aka PIO, injections). A natural FET usually just means you'll be monitored to watch when you're ready to ovulate, then some will give you an HCG trigger then you transfer a 5-day embryo 5-6 days later.
You'll go in on the day of your transfer with a full bladder, and if you've ever had an IUI it basically feels like that. You'll be in the stirrups, put the speculum in, usually lightly swab your cervix with an antiseptic, then they take the catheter with the embryo loaded in it then using ultrasound guidance they'll place it in your uterus. You won't have any anaesthesia like the ER but it shouldn't hurt, feels like a pap smear. Mine have taken a max of maybe 5-10 mins including lying on the table with your legs up for 5 mins after the procedure before they let you go pee lol. Some women experience a little bit of spotting or discharge but that's most likely from a bit of cervical irritation and the liquid from the catheter draining out. The embryo itself will "stick" to your uterine wall where it is implanted. I've always been told that the embryo should implant within 24hours.
Every clinic is different, some say you should take it easy but you can basically go back to your regular activities (within reason) in the next few days. No hot showers/saunas/hot tubs (so you don't raise your body temperature too much), no baths (I think this is in case of infection), no sex (again, for infection), no strenuous activity. For me personally I've been put on bed rest following my transfers for about a week but unless you're high risk I think the norm is 48hrs. Other than that, you'll basically just enjoy the next 10-14 days of being PUPO (pregnant until proven otherwise) until your beta!! I promised myself I wouldn't POAS until at least 10dp5dt but I know many who test earlier as long as they didn't do an HCG trigger.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
@Lisa3379 my clinic had my on BCPs prior to my FETs. It's part of their standard protocol. At a minimum they'd put people on it for 18 days but I always ended up on it for 40+ simply because they were scheduled so far out for procedures. To give you an idea - I had my ER on 6/11/19, got my period within 2 weeks, and had my FET date scheduled for 9/10/19 based on that CD1 date. I spent all of July and half of August on BCP before I got to start the lupron and estradiol when the FET cycle started. @kiki047 pretty much covered it all. They monitor your lining and check your hormone levels as you go along and that's really it before the transfer itself. It's a lot less needles, that's for sure. They also had me on some antibiotics for a few days leading up to the transfer as well.
TTC #1 since 7.2017
Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies
IUI #1-3 | all BFN
IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
TTCAL naturally | starting 11.22.20
Initial consultation with Reproductive Immunologist | 9.14.21
Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
Saline sono | 10.15.21 | normal
Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
BFP! | 11.3.21 | EDD 7.14.22 | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
DS born 7.19.22 after induction
TTC #2 begins 6.2023
Consultation with RI | 6.6.23
Saline sono, endometritis biopsy, skin & eye check | all normal
Labs | high TSH, Factor XIII mutation, high %CD56
Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
Repeat labs after 3 weeks on meds
Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
Repeat labs in 8 weeks
Follow up | 1.16.24 | Green light continues
TTC put on pause
Did they give you an idea of how long it takes for you to hear back about PGT results? A lot of places will prep you for a FET even if you don't have results back yet, then if they have to they'll drag it out as long as possible.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
Status (WTO/TWW/TTA): WTO
What are you doing this cycle? (Testing? Treatment?): Since we got the negative COVID test before AF came, we are able to start again this cycle. I start injections tonight.
How are things going?: Okay. I’m not looking forward to starting up again but I also am looking forward to trying to do something. I was almost a week late again so that was sad, especially since I let myself start to hope! Sometimes it feels like I shouldn’t let myself hope.
Any questions?: NATM
GTKY: Vacation style: do ALL the activities or just chill & eat/drink? Chill. Nice restaurants. Outdoor activities - but not packing it full. It’s a vacation so we need to relax as well
@kiki047 I’m so glad you got in for another scan!!! That lining is looking sooooo good! I’m so excited for you!
@Lisa3379 I can’t wait to hear your update today!
@laura-kay Ugh, I’m sorry your were a week late. That is pure torture. I’m glad your covid test is negative tho and you get to start another cycle without sitting out!
@acleverusername I’m so sorry AF showed up early over the weekend. I hope it didn’t ruin your weekend too much and you were able to enjoy some wine without feeling guilty. I have a theory about what happened last cycle. Hear me out. Were you doing OPKs before your trigger shot? I remember you said at your last monitoring cycle that your LH was starting to surge already. I’m curious what that number was because I always thought it was a bad thing to start surging before your trigger. You have less control over when you O and the IUI timing can get messed up. I was actually surprised your clinic didn’t move your IUI date up based on that (but knowing all the other mistakes your clinic has made… makes sense). I think it’s likely that you ovulated earlier than you think. I also know that the meds your on for the IUI, for egg stimulation and the trigger, can mess with your temps. So I wouldn’t necessarily trust your O day based on BBT alone. That, on top of your previous cycles where you O early, makes me think you Oed before your IUI. Which I hate and am ragey at your clinic for you. Curious what you think.
Diagnosis (if you've been): Unexplained
Status (WTO/TWW/TTA): WFAF
What are you doing this cycle? (Testing? Treatment?): Picked up my letrozole last night!!! Only $3.11 lol
How are things going?: Things are going ok. I’m just excited to get this next cycle going. I’m super hopeful about it.
Any questions?: What is the point of the baby aspirin and does anyone take it?
GTKY: Vacation style: do ALL the activities or just chill & eat/drink? 100% do ALL the activities! But also eat all the foods lol. I do not particularly enjoy just sitting around and “relaxing.” It gives me a headache lol.
Married: 8/2015
TTC #1: 4/2017
Testing: HSG, U/S, BW, and DH's SA all normal
DX: Unexplained
8/2018: Clomid + TI = BFN
9/2018: Clomid + TI + Progesterone = BFN
11/2018: Clomid + IUI + Progesterone = BFN
12/2018: Letrozole + IUI + Progesterone \\ Cancelled due to cyst
1/2019: Letrozole + IUI + Progesterone = BFP! \\ EDD Sept 30th, 2019
10/7/2019: Healthy baby boy!
TTC #2: 12/2020
2/2021: Letrozole + TI = BFN
3/2021: Letrozole + TI = BFN
4/2021: Surprise! Natural BFP! \\ EDD Jan 6th, 2022 \\ Chemical, betas not rising
8/2021: Letrozole + IUI + Progesterone = BFN
9/2021: Letrozole + IUI + Progesterone = BFN
10/2021: Letrozole + IUI + Progesterone = BFN
11/2021: Letrozole + IUI + Progesterone = BFP! \\ EDD July 29th, 2022
@laura-kay I totally get the feeling of being happy that something is happening, even if it's injections! For me, being idle is the worst. And you gotta let yourself hope. I'm a firm believer in the power of positivity - not that positivity will make what you want to have happen happen, but I think it gets you in the best mindset to deal with whatever comes down the road. Sending hugs.
@laura-kay that's a double relief of negative Covid test and getting the all-clear to start again. I'm so sorry you had to go through that gut-wrenching plummet that follows a false sense of hope when AF is late, it's a special kind of torture to someone who is having TTTC/going through IF. Hugs.
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
Married: 8/2015
TTC #1: 4/2017
Testing: HSG, U/S, BW, and DH's SA all normal
DX: Unexplained
8/2018: Clomid + TI = BFN
9/2018: Clomid + TI + Progesterone = BFN
11/2018: Clomid + IUI + Progesterone = BFN
12/2018: Letrozole + IUI + Progesterone \\ Cancelled due to cyst
1/2019: Letrozole + IUI + Progesterone = BFP! \\ EDD Sept 30th, 2019
10/7/2019: Healthy baby boy!
TTC #2: 12/2020
2/2021: Letrozole + TI = BFN
3/2021: Letrozole + TI = BFN
4/2021: Surprise! Natural BFP! \\ EDD Jan 6th, 2022 \\ Chemical, betas not rising
8/2021: Letrozole + IUI + Progesterone = BFN
9/2021: Letrozole + IUI + Progesterone = BFN
10/2021: Letrozole + IUI + Progesterone = BFN
11/2021: Letrozole + IUI + Progesterone = BFP! \\ EDD July 29th, 2022
@kiki047 OMG that lining!!! ❤️❤️❤️❤️❤️❤️❤️❤️Transferring your embaby into that cushy setting on Valentine's Day give me high hopes! 🤞🏻
@Lisa3379 5 blasts! That's spectacular! Are you doing PGS testing? Mock cycle (with ERA / Receptiva Dx testing?)
TTC#2
TTC #2 ... preparing as of March 2024
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
@acleverusername thank you friend!! I'm SO relieved not to have to stress over my lining this time around. It's been such a sore point for me with my past transfers so it's giving me hope!! GL with your rescheduled consult with TEW tomorrow, looking forward to hearing your recap!
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
@Lisa3379 hopefully you get a few more blasts tomorrow! Re: vacation style, I'm absolutely with you re: "chill" category.
@laura-kay I am so sorry your body gave you such false hope! Are you switching up your protocol at all for this next IUI round?
@LJMoon6 I am excited that you're excited! I take a low-dose aspirin for inflammation issues since I evidently have some. I've also heard (from @keikilove maybe?) that it's good if you have an MHTFR mutation (although doctors have told met that since I take loads of extra folate, I don't need to _also_ take baby aspirin). I would be careful taking it just because (i.e. without consulting a doctor) as it _can cause_ blood to thin which would be an issue if you injure yourself and have bleeding. Also, your assessment of my situation is not completely out of the realm of possibility (i.e. it's totally possible that my IUI was too late). However, I have typically had luteal phase issues (i.e. spotting a few days before period), including a 9-day luteal phase (with 2 days of spotting before) mid-last year, before I started medicated cycles. I was also NOT surging (LH was still low) on the morning of Jan 25; the surge started that evening. However, The Egg Whisperer says that ovulation can occur 12-72hrs after the onset of the LH surge, so it's entirely possible that I ovulated earlier, though I wouldn't think it was more than 1 day earlier.
Diagnosis (if you've been): I honestly don't know anymore. Unexplained plus MFI? Hypoandrogenic PCOS? Hashimoto's Thyroidism
Status (WTO/TWW/TTA): WTO
What are you doing this cycle? (Testing? Treatment?): taking a break + trying to find a new RE; was gonna prep for IVF, but decided to just take a break (more on that later).
How are things going?: I am not doing all that well. After the fiasco with my now former clinic, I reached out to the fertility therapist I was seeing last year (I was doing really well, so I haven't felt the need to have a session with her since just before Thanksgiving). So I had that session today, and boy oh boy, it was good to talk through it all with a 3rd party. I kind of walked/ranted/cried through everything I was feeling, and how I feel like I can't trust anything the former clinic did anymore (cause I only caught 2 of their mistakes; what didn't I notice?) and that I'm making plans to go into IVF feeling that I've wasted the last 4 cycles because we operated on the basis of sh*t data. After that, I realized that I'm STILL not ready to move on to IVF. I don't feel like I have a clear understanding what what issues is preventing us from getting KUed other than "unexplained" and I don't buy "unexplained" because there's obviously issues here (luteal phase deficiency - LPD - is a symptom of something).
Anyway, I'm going to see what TEW says tomorrow. I.e. does she think it's worthwhile to run more diagnostic tests (i.e. check for endo since LPD can be a symptom), karyotype testing, etc. Does she think we ought to try superovulation + IUI (she does believe in that for older women; usually targets 2-3 follicles) at least 1 or 2x? I will have a full report tomorrow or Thu.
Oh, and at the end of the meeting with my therapist, I started talking about how unsupported I felt by my own parents, and the waterworks started. Putting that whole thing into spoiler:
Any questions?: for those of you who have had repeat SA's, is it normal for TMC to vary between 6.3M to 154M to 44M within the space of 6 months? I know that men can have an "off day", but is that kind of variability normal? In early Dec, MH's TMC pre-was was 154M; post-wash it was 54M; 2 months later, TMC pre-wash was 44M; post-wash it was 7.5M.
GTKY: Vacation style: do ALL the activities or just chill & eat/drink? I'm definitely in the chill, relax, see some of the sights, while I eat my way through my holiday! I've always been of the opinion that if I like a place enough, I'll come back and see more of the sights. No point in trying to cram everything into 1 vacation (I know some people are like "I'm going to come here only once in my life because there are so many other places in the world to see, so I need to see EVERYTHING." Nope, that's not me.)
TTC#2
TTC #2 ... preparing as of March 2024
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
@acleverusername We are definitely doing PGS testing. We're just waiting on some genetic test results to see if we need to do PGT-M testing. And I have no clue about a mock cycle. I'm so ignorant of all kinds of things regarding this stuff! I'm just going with the flow, and figure that when my period starts and we do the saline ultrasound, then we'll talk about the plan for the next step. And I'm hoping that your consult with TEW goes well tomorrow! Just reading your whole account regarding the therapy and your parents makes me just want to hug you. That's SO MUCH to deal with. I'm sorry you're having a rough time.
@kiki047 YAY for an awesome cushy lining! Sending you all the good vibes for your FET!
@LJMoon6 hoping the letrozole helps! I feel much better this cycle now that I'm "doing something" even though I know I don't have much control over the outcome.
@acleverusername thinking of you today and hope your consult with TEW gets you some great info and a plan moving forward! Can't wait to see your update!
Diagnosis (if you've been): unexplained
Status (WTO/TWW/TTA): WTO
What are you doing this cycle? (Testing? Treatment?): Clomid + IUI
How are things going?: So far so good. Dealing with the Clomid mood swings making me quickly very emotional. sad, or irritated. I got teary hearing that Christopher Plummer had passed, and thinking about the Sound of Music which was my grandmother's favorite movie and one of my strongest memories of her. Shed a few tears on my way to work which is not me! Keeping it mostly in check around others so I do not annoy my spouse or office-mate. Thankfully, office-mate has also been through IF, both her kids are IVF babies so she totally gets it and is a great sounding board. This week I'm taking my OPKs to get ready for IUI. Got my first positive yesterday, and usually get 2-3 positive/high days before peak day, so I'm guessing my IUI will be Friday or Saturday. (My RE has me using the ClearBlue smiley face tests so I get flashing smileys during the estrogen surge before the solid smiley face that indicates the LH surge). Tests are great for trying naturally, but not great when you have to wait for a fresh sample to do IUI! Might try for "extra credit" after the IUI though! Gotta make the most of this Clomid!
Any questions?: No questions right now
GTKY: Vacation style: do ALL the activities or just chill & eat/drink? I am a do ALL the things kind of girl but DH is just chill. We both love the eating and drinking, so I plan activities for some of our days but also look for interesting food and bars around them that he will enjoy! Our honeymoon was in Maui which was the perfect mix of activities and lying on the beach/pool + cocktails. Hoping by the fall DH and I can make a quick weekend getaway.
@acleverusername I’m glad you reconnected with your therapist. Your parents make me a little ragey. I’m glad you told them you need space.
I was told to take a baby aspirin for both my IUIs, so I’m just wondering if I should take it for my medicated TI cycle or not. I’ll probably skip it this cycle, just because like you said, I probably shouldn’t be taking it without doctors instructions.
I guess my theory isn’t as sounds as I thought lol. I must have mis-read your post about your LH surging early. It makes more sense why your clinic didn’t move the date now too. I guess it’s still possible you Oed the day after your trigger, the day before your IUI. But that still only gives you a 10 day LP. I’m sorry you’re struggling with what to do next. I liked what you said last week, or the week before, about how you still haven’t had a “perfect” IUI yet. I think the 3-6 recommendation is for when everything lines up perfectly, which I don’t think you’ve had yet. I’m super excited to hear what TEW has to say today. I think trying for super ovulation would be a good next step?
My experience with SAs comes from counting millions of fungal spores lol. It does sound like something it going on with YH, but I thought I would just explain what I know about counting anyways. When you’re trying to count something that small and in that quantity, it’s obviously unrealistic to count them all. What we did with fungal spores, which I think is similar to counting sperm (at least the way my RE explained it to me), is take just a small little sample. Place it on a special slide that has a grid pattern (called a hemocytometer). Count how many are in a square, then extrapolate (there’s a little bit more that goes into it but I don’t want to bore you with math lol). With that said, it’s not an exact science. It depends greatly on the small little sample that was grabbed.
@Lisa3379 I get that, not wanting to bug people with too many questions. I’m a nosy MF. I ask all the questions lol. Maybe it’s my analytical/sciencey mind lol.
@quitandknit I’m sorry you’re experiencing clomid mood swings. Sounds like you’re getting ready for your IUI soon! I’m so excited for you!
edit to fix tag
Married: 8/2015
TTC #1: 4/2017
Testing: HSG, U/S, BW, and DH's SA all normal
DX: Unexplained
8/2018: Clomid + TI = BFN
9/2018: Clomid + TI + Progesterone = BFN
11/2018: Clomid + IUI + Progesterone = BFN
12/2018: Letrozole + IUI + Progesterone \\ Cancelled due to cyst
1/2019: Letrozole + IUI + Progesterone = BFP! \\ EDD Sept 30th, 2019
10/7/2019: Healthy baby boy!
TTC #2: 12/2020
2/2021: Letrozole + TI = BFN
3/2021: Letrozole + TI = BFN
4/2021: Surprise! Natural BFP! \\ EDD Jan 6th, 2022 \\ Chemical, betas not rising
8/2021: Letrozole + IUI + Progesterone = BFN
9/2021: Letrozole + IUI + Progesterone = BFN
10/2021: Letrozole + IUI + Progesterone = BFN
11/2021: Letrozole + IUI + Progesterone = BFP! \\ EDD July 29th, 2022
TTC#2
TTC #2 ... preparing as of March 2024
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
TTC#2
TTC #2 ... preparing as of March 2024
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
@acleverusername I'm so sorry things are a bit rough at the moment. I just wanted to pop in to add some perspective to the whole "LPD" thing. I personally had shorter LPs (typically 11-12 days) and in fact when I was particularly stressed out leading up to our IF dx and my IVF cycles, my LP dropped like a stone. I had a couple of 9-10 day LPs including even earlier spotting. IMO, I was experiencing extreme stress and anxiety over IF, and my body was reacting poorly. In my experience, LPD is not necessarily the be-all and end-all. *TW below*
Our issue ended up that there was not sperm ever meeting my eggs, meanwhile I was beating myself up over a perceived problem that wasn't actually the problem. In the end, LPD is usually solved by progesterone, which is part of every IVF cycle anyway.
IVF Cycle #1 February 2020 4 embryos frozen, 1 fresh transfer = CP
FET #1 Natural Cycle March 2020 CXL'd due to Covid-19
FET #1 Natural Cycle June 2020 - CP #2
FET #2 Natural Cycle July 2020 - BFP!!!!!! Beta #1 = 273
June Signature Challenge - Favorite TV Quotes
Okay, TEW consult update! First of all, can I just say how amazing it's been to get PMs and tags in the dailies/random channels wishing me good luck on my consult?! Thank you everyone. 🙏🏻😘It once again reminded me of how grateful I am to have found this place as we TTGP.
Now, for the "good stuff". Basically, TEW is everything I hoped she would be and more. Henceforth, I'll refer to her as my fertility fairy godmother. I even teared up after our call ended because I was so relieved / grateful.
I'm gonna put everything in a spoiler because there's a lot.
Her first question to us was "have you done the chromosome analysis yet? That's the only thing that didn't immediately pop out to me as you having had it?" and I said "no, because our previous RE didn't recommend it because of cost/value" Then I asked her she (TEW) focused on that so quickly, and she replied "because... why they heck aren't you pregnant yet? There's nothing wrong with you!" For added context, previous RE said it would cost $1500-2000 per person and there was a 1/500 chance that we had a balanced translocation issue. TEW said cash cost is $250-$300; but, this is a diagnostic test and my insurance should cover it.
We went on to do a review of my/MH's medical history, and she had some additional questions about tests we've hadn't yet done. Our diagnosis, according to her, is a fertilization issue. She felt that egg and sperm were likely meeting in the fallopian tubes. But why they weren't doing more, that's still TBD. She felt that there are still pieces of the puzzle that are missing that might help us make better decisions about next steps. At this point, we're going to be doing the following:
- chromosome analysis for both MH and I
- anti-sperm antibodies test for MH (TEW described this condition as sperm wearing a little helmet which makes it impossible to fertilize an egg. I LOLed)
- repeat SA with morphology for MH
- ultrasound in the office with TEW to check for polyps, endometriosis and adenomyosis (EVEN though I've had an HSG, a saline sonogram, and a pelvic MRI... she says she has a sneaky feeling about this.)
- recheck my Vit D
- recheck my TSH/TPO antibodies (she doesn't like to see the number increasing especially when we're talking about a potential transfer)
- stop taking DHEA / increase NAD to 300mg / add Pterostilbene 150mg
As for treatment, she doesn't think that we need to rush into IVF just yet; she says if we're not pregnant by June, then we can talk about fertilizing the eggs I have on ice, or doing another egg retrieval. What's even more interesting is that she said she wants to be involved in the egg warming / fertilization process at the clinic where my eggs are frozen. AND, she said it would be a good idea to send sperm there instead of shipping eggs here (those eggs are in Canada as I started all of that process just before moving to US, so I went back to Canada for the ER.)
Finally, she's gung-ho about having me achieve super-ovulation and has no problem with me ovulating 3 eggs at my age. She talked about much higher dosage of both Letrazole (10mg) and Gonal-F (didn't discuss dosage) for the combo-cycle than previous RE to make sure that happens. She also suggested using a Zymot device (I've only previously heard it used as part of IVF) for MH's sperm for the IUI AND she wants to do double-insemination... i.e. IUI 1 day post-trigger and 2 days post trigger. Honestly, the whole appointment was a completely different experience. I felt that here is someone who is 100% focused and ready to go to bat for me.
MH was equally impressed. We had a bubble friend over because MH was helping her with a work thing, and as she was leaving, and we were summarizing the appointment to her, he said: "she is the first doctor who's read our file before our consult." MH has heard me playing her podcast shows before, so he knew that she was "good", but she really significantly exceeded both our expectations.
TTC#2
TTC #2 ... preparing as of March 2024
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
TTC#2
TTC #2 ... preparing as of March 2024
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
@acleverusername What an amazing update! I love how excited she was to talk with you guys. It sounds like you guys really clicked! Will you be continuing treatment with her? Or just taking her suggestions to another RE? I wonder what her “sneaky” feeling is. I have never heard about the Zymot device. That’s super interesting. I always wondered how they “washed” the sperm. A centrifuge seems so destructive. I’m just imagining those poor sperm getting dizzy, bahaha. As an aside, I work in a nano lab, where microfluidic devices are made. So learning about the Zymot is super cool to me!!
Married: 8/2015
TTC #1: 4/2017
Testing: HSG, U/S, BW, and DH's SA all normal
DX: Unexplained
8/2018: Clomid + TI = BFN
9/2018: Clomid + TI + Progesterone = BFN
11/2018: Clomid + IUI + Progesterone = BFN
12/2018: Letrozole + IUI + Progesterone \\ Cancelled due to cyst
1/2019: Letrozole + IUI + Progesterone = BFP! \\ EDD Sept 30th, 2019
10/7/2019: Healthy baby boy!
TTC #2: 12/2020
2/2021: Letrozole + TI = BFN
3/2021: Letrozole + TI = BFN
4/2021: Surprise! Natural BFP! \\ EDD Jan 6th, 2022 \\ Chemical, betas not rising
8/2021: Letrozole + IUI + Progesterone = BFN
9/2021: Letrozole + IUI + Progesterone = BFN
10/2021: Letrozole + IUI + Progesterone = BFN
11/2021: Letrozole + IUI + Progesterone = BFP! \\ EDD July 29th, 2022
TTC#2
TTC #2 ... preparing as of March 2024
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
I'm so glad TEW lived up to your expectations and that she's ready to go to bat for you. Based on what I've read about her online she seems to have the ideal setup as a boutique clinic that doesn't have the constraints of needing to coordinate with insurance, etc, and that she's willing and/or has the knowledge/experience to run all the relevant diagnostic tests to try to figure out the best course of action for each of her patients. If only all doctors were willing to go that extra mile, maybe people wouldn't be so unhappy in their current situations. Dr Aimee seems great in all the areas where others have failed so I'm excited for you! You always said you wanted to find the kind of relationship I have with my RE, and it really sounds like this might be it!
TTC History:
Me: 36 MH: 39, TTC since Dec 2017
Aug '18: PCOS dx
Nov '18: MH SA - 19mil
Dec '18-Mar '19: Letrozole + TI - all BFN
Apr '19: Letrozole + TI, - BFN. Repeat SA (27mil) & DNA fragmentation test (17%)
Aug '19: Letrozole + HCG trigger + IUI + prog supp - BFN (MH: 16mil)
Sep '19: 2nd IUI, same protocol - BFN (MH: 16mil)
Dec '19: IVF #1 w/ICSI, PGT. 5 retrieved, 4 fertilized, 3 blasts, 3 PGT-A normal.
Mar '20: FET #1, perfect 5AA blast transferred. BFN.
Sept '20: FET #2, 5BB tsf. 9/18/20 BFP!! EDD: 5/27/21. MMC 11w
Feb ‘21: FET #3, last 6BB blast transferred. BFP, EDD 11/2/21. MC 5w3d.
May '21: IVF #2 w/ICSI, PGT. 8R, 7M, 6F, 6 blasts - 3AB, 3AB, 3BB, 4BB, 5BB, 6BA. Fresh tsf 5/13/21 - BFN.
June '21: PGT-A results = 3 abnormal, 1 low level mosaic. Referred to new REI, had consult with 2nd RE in between.
Sept '21: RPL, immune testing normal
Oct '21: IVF #3 w/IMSI, PGT. 33R, 26M, 23F, 9 blasts (7 day 6, 2 day 7). PGT-A = 5 normal, 1 mosaic
Dec '21: Positive for endometritis, RX Flagyl & Keflex
Jan '22: FET #5 - Kitchen sink immune/RIF protocol incl. PRP, intralipids, prednisone, medrol, nivestym, fragmin - CP
Feb '22: FET #6 - Kitchen sink immune/RIF protocol w/higher doses of pred & fragmin - BFN
Mar '22: Mock cycle for ERA - cancelled, repeat endometrial biopsy instead. Still positive for endometritis. RX ciprofloxacin & amoxicillin.
Apr '22: IVF #4 w/IMSI, PGT. 28R, 23M, 16F, 11 blasts. PGT-A = 6 normal.
June '22: FET #7 - Microdose lupron downreg w/kitchen sink immune/RIF protocol - double embryo transfer. BFN.
July '22: FET #8 - Mini stim w/Puregon + trigger, kitchen sink immune/RIF protocol. BFN.
Sep '22: Taking a break
Dec '22: Attempted abdominal myomectomy, fibroid too close to cervix and major blood vessels. Wasn't removed.
Feb '23: FET #9 - Modified natural w/baby asp, HCG trigger, PIO, PRP, Medrol, HCG wash, embryo glue - BFP!! EDD 11/11/23
@kiki047 I have 11 mature eggs on ice; they were retrieved when I was 35.98 yrs old (Lol; 2 days before my 36th bithday). Statistically speaking, I was told to "budget" 2 embryos per desired child, so I think I'd be comfortable with having 4 frozen, genetically tested embryos. I don't know if I'll get those from my existing frozen eggs, but I'm hoping I'll get 2-3 so maybe I'll only need 1 additional retrieval. But, given my profession (Project Manager), I am cognizant that I could have a total bust with those eggs, or get 5-6 embryos. I just don't know and I won't know until we warm/fertilize them.
I am really hoping that Dr. Aimee will be for me the kind of support your RE has been for you. 🤞🏻
TTC#2
TTC #2 ... preparing as of March 2024
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
TTC#2
TTC #2 ... preparing as of March 2024
TTC #1
TTC #1 02/2020 - 07/2022
2009 | Dx PCOS; likely a misdiagnosis
07/14/20 | Dx Hashimoto's Thyroditis
07/21/20 | 1st RE appointment
07/2120 - 08/20/20 | so much testing; no signs of PCOS
08/20/20 | Dx Unexplained; AMA
09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
09/30/20 | Urology consult; more testing required
10/2020 | Clomid + OPK + TI + Prometrium | BFN
10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing
03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
04/07/2021 | Natural cycle while we regroup | BFN
04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
05/10/2021 | New RE consult & plan for IVF
05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH.
06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
05/20/2022 | D&C; recovering...
06/21/2022 | Trying naturally until October 2022
07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023
@kiki047 Sending positive vibes your way!!!