2 IVF Cycles and 28 years old — The Bump

2 IVF Cycles and 28 years old

Hi everyone, I've been looking for an outlet to talk to people about IVF and have finally decided to write my story on here and see if anybody has had any similar situations to ours. 

We have been TTC for 2 years now and began with a fertility clinic a year ago. 

We have tried timed intercourse, clomid cycles, several IUIs and now IVF. 

I am 28yo and DH is 30. We have other medical conditions (I have a brain condition which I've had two brain surgeries for; DH has advanced Crohn's with an ileostomy bag). 

We completed our first IVF in May 2017 - using GonalF, Cetrotide and Ovidrel trigger - egg retrieval yielded 9 eggs, only 4 we're good enough for ICSI. Two died by Day 3, one died on Day 4 and the last one made it to Morula and died on Day 5. So our first cycle was a big failure. 

We're in our second cycle of IVF now - using 450 IU Menopur, Cetrotide and Lupron trigger. Egg retrieval will be in a few days from now and so far I have 12 follicles on the right and 5 on the left. 

We haven't triggered yet but it's coming. 

I wanted to know if there's anyone out there who has had similar results, or has done this max dose of Menopur before. 

This whole process has been devastating for me and I'm losing hope. RE has said that if this round ends up like the last one then he will not be recommending IVF anymore. 

Re: 2 IVF Cycles and 28 years old

  • Hi @dalody - welcome! I'm glad you found us but sorry you have to be here. Have you been diagnosed with anything that might affect fertility?

    17 follicles sounds really promising! Don't lose hope!

    Your protocol sounds different than mine - I just did a round of IVF with about 450IU of FSH hormones, but half of those were menopur (225IU) and half were another FSH product, similar to Gonal F (puregon). 

    I'm keeping my fingers crossed for you! Sounds like you have been through a lot - that last IVF round must have been devastating!

    Me: 34 DH: 35
    TTC #1 since Nov 2015.
    dx: unexplained
    Dec 2016 - Apr 2017 - IUI + clomid x 4 - all BFN
    July 2017 - IVF#1 - 4 frozen embryos, medical freeze
    Oct 2017 - D&C
    Nov 2017 - Apr 2018 - 3x FET - all BFN
    Sep 2018 - IVF#2 w PGS - 3 frozen normal embryos
    Nov 2018 - FET #4 - BFP

  • I'm sorry you have to be here but glad you joined.  I can't give you any insight as DH and I are just starting to look at IVF. GL on your next cycle, I will be keeping my Fx for you. :)
    Me:33, DH:38 Married: 8/2/2014
    TTC #1 Since: April 2015
    Unexplained Infertility

    Cycle 1&2 : Clomid 50mg- BFN
    Cycle 3: Letrozole 2.5mg- BFN
    Cycle 4: Letrozole 5mg- BFN
    Cycle 5: HSG-normal
                  Clomid 100mg+ Estrace- BFN
    Cycle 6: Letrozole 5mg+Trigger shot+IUI+Progestrone- BFN
    Cycle 7: Letrozole 5mg, Cyst found during follicle check
    Cycle 8: Birth control to treat left ovary cyst
    Cycle 9: Letrozole 7.5mg+Trigger shot+IUI+Progesterone- BFN
    Cycle 10: Letrozole 7.5mg, 2 Cysts found during follicle check
    Cycle 11: Clomid 100mg+Estradiol+Trigger shot+IUI+Progesterone- BFN
    Cycle 12: Clomid 100mg- BFN
    Cycle 13-16: Natural attempts while awaiting IVF 
    Cycle 14: IVF-BFN

  • I would say don't lose hope. I have a DOR diagnosis, my max number of follicles in one cycle was 9 and that was a bust as I only had 3 eggs and none fertilized. But I am at my 6th IVF cycle and there are a lot of protocols you can try (antagonist, micro dose lupron, estrogen priming, testosterone priming, sher - and these are just for DOR, I am convinced there are others.) My fist cycle was antagonist (folistim, menopur, ganirelix) and was the best as I had 5 eggs, 2 fertilized and transferred After that the fertilization rate went down and I suspect it was because of the DHEA I was on for a year. I tried cycle 5 without DHEA but I ovulated on my own and now I am trying cycle 6 same protocol hopefully it will be better.  
    I would say if this doesn't work out and your RE doesn't want to try anymore just find another RE.
    DOR (FSH 13, AMH 0.48, AFC 6-9)
    IVF #1 -2016 March, antagonist, 5 eggs, 2 fertilized, 3DT - 8 cell and 6 cell no frag, chemical pregnancy
    IVF #2 - 2016 June, micro dose lupron, 3 eggs, 1 fertilized, 3DT 6 cell, BFN
    IVF #3 - 2016 November, estrogen priming + antagonist, 9 follicles, 3 eggs, none fertilized
    IVF #4 - 2017 March, testosterone priming + micro dose lupron, 2 eggs, none fertilized
    IVF #5 - 2017 May, A/ACP protocol, 4 follicles out of 7 seemed to get to required size, ovulated before retrieval, converted into IUI - BFN
    IVF #6 - 2017 July, A/ACP protocol, 3 follicles one stopped growing, LH rising, converted to IUI - BFN
    IVF #7 - 2017 September, antagonist, 5 follicles, 6 eggs,  3 immature, 3 injected, 1 fertilized, stopped growing day 3
  • hang in there and don't lose hope! I am also younger (29) and its especially hard to be in this situation when all my peers are pregnant so easily and all the time! I think this cycle sounds super promising with 17 follicles. I did max doses of stim (450 of follistim and 150 of menopur) and it was my best cycle ever. Unfortunately I am not a good example of a success story, as we are now moving onto donor eggs, but I have been on these boards over a year, and have seen soooo many ladies have success on their second, third, fourth IVF! 
    History in Spoiler

    Age: 30 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
  • I echo what all of these lovely ladies have said!  You've been through a lot already I'm sorry IVF has to be part of your journey.  I did 300 gonalf and 300 menupar which is the max.  There are many protocols out there and unfortunately its sometimes trial and error.  Hopefully age is on your side and you'll have better luck next cycle.  You move on to other options when YOU'RE the one that is making that decision.  So far this cycle seems to be progressing nicely, hoping it continues!!
    History of TTC in spoiler box
    TTC since 2014
    Unexplained Infertility - but I am 40...Low AMH .30
    7 - IUI (50mg-150mg Clomid) Feb - August 2016 all BFN 
    IVF#1 August 2016 (Antagonist protocol 4/5 eggs) Cancelled cycle :( RE thought I would get at least 10.
    IVF#2 Sept 2016 (microdose luporn pro - disappearing follies, ONLY ONE, convert to IUI) BFN
    IVF#3 November 2016 (4 ER, 3 F,  3DT)-BFP  with TWINS // MC both at almost 10wks  :'( 
    IVF#4 March 2017 //EPP  (10 ER (1 wonky so 9 ER) 7F, 3B (5AB, (2)5BB) PGS tested- ALL abnormal  :'( 
    IVF#5 April 2017 // EPP (7 ER, 7F yes! 6B) 2/5 day 4/6 day - 2 PGS normal! yes!! :)
    IVF#6 May 2017 // Antagonist didn't have time for Estrogen Priming...(4 ER, 3 F, 3B) (5AB, (2) 5BB) 2 PGS normal, yes!! :)
    IVF#7 June 2017 // EPP praying this is it and then on to an FET!

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