Hi all! Recently, I found out that I am positive for the MTHFR gene mutation. I know that it means I will struggle with infertility (no shock here lol), and that I have a higher risk of miscarriage (both early and late). I was wondering if there are any ladies who are currently pregnant or have been pregnant that also has the MTHFR gene mutation? I am trying to learn a little bit more about it. I want to know my chances of being pregnant with a healthy and safe pregnancy.
Thanks for your help!
Me 30 || DH 36
Unexplained Infertility- Postive for MTHFR Gene Mutation
Natural cycles with 1 miscarriage
-3 IUI's w/ Clomid= BFN
-IVF #1-Follistim and Menopur= BFN
***11 Eggs, 10 mature, 8 fertilized, transferred 1 (day 5) 2 made it to freeze
-FET #1- Transferred 2, day 5 embryos =BFN
-IVF #2- Follistim and Menopur = BFN
***11 retrieved, 8 mature, 6 fertilized, transferred 2 (day 3), 4 made it to freeze (Follistim and Menopur) = BFN
-FET #2- Transferred 2, day 3 embryos = BFN
**Changed doctor**
-IUI #4- natural cycle = BFN
-IUI #5- Follistim (5 eggs) BFP- lead to Miscarriage

-Laproscopic Surgery for Endometriosis, Polyp removal and Cyst removal.
-IVF #3- Menopur, Follistim, Lupron, Ganirellex- BFP lead to Eptopic Pregnancy

***11 Eggs retrieved, 10 Mature, 8 fertilized, transferred 3 embryos (day 3), 0 made it to freeze
-Lapropscopic surgery- Removal of Fallopian Tube
-IVF #4- Estrogen Priming with Vivelle dot, Menopur, Follistim, Ganirellex- BFP

***15 Eggs retreived, 11 mature, 11 fertilized, 2 embryos transferred (day 3), 2 made it to freeze
Found out I was positive for MTHFR Gene Mutation during TWW of IVF #4
Re: MTHFR gene mutation and pregnant
Homozygous is different, the standard is usually at minimum methyl folate in conjunction with blood thinner injections. I have to take blood thinner injections the whole pregnancy and 6 weeks after I deliver.
Compound (1 copy of each) I don't know much about.
Also, it's my understanding that being homozygous doesn't cause too many issues in regards to getting pregnant-it's staying pregnant (so often this is looked at when women have reoccurrent loss) and preventing a baby with neural tubal defects etc...Also, to prevent mommy from clotting and/or having a worn placenta. My RE didn't even start me on blood thinners until after I was clinically confirmed as pregnant.
Lastly, what copy do you have? I have c677t .
Took a break and ttc naturally
7.) IUI Cycle 7 February 2016-100mg clomid days 3-7, U/S day 12 showed 2 follicles (22mm and 24mm), Ovidrel trigger shot day 12 at 9:00pm, IUI cycle day 14 at 10:00am. BFN
Meeting scheduled for 2/29/2016 to discuss iui with injectables vs. IVF
8.) IUI Cycle 8 March 2016-Injectables (Gonal F), U/S showed 2 mature follicles, Ovidrel Trigger BFN
April-May I lost my mind.
IVF#1 July 2016-Transferred 2 fair blasts. 9dp5dt BFP 129 BETA, 13dp5dt 944 BETA, 20dp5dpt 8776 BETA, 8/19/2016-1 beautiful heartbeat of 100 BPM at 6 weeks 1 day! Growing baby grow!! 8/25/2016-another ultrasound at 7 weeks and baby has a heart beat of 129 BPM and is 10mm/1cm! Grow baby grow some more!! Graduated from RE at 10 weeks and had ObGyn appointment at 13 weeks. It's a girl (found out via panorama test) EDD 4/13/2017
Im going to find out more on friday when I go to the doctor, I only spoke to the PA on the phone for a few minutes. My head was spinning from hearing the results so I didn't think to ask too many questions.
I really appreciate you taking the time to explain it. I have have 3 miscarriages, we have been assuming they were bad embryos but now learning this, I'm wondering if it wasn't bad embryos at all.
Were you considered to be a high high risk pregnancy due to potential to clot and miscarry? Or were they not too concerned since you were n the lovanex?
Unexplained Infertility- Postive for MTHFR Gene Mutation
Natural cycles with 1 miscarriage
-3 IUI's w/ Clomid= BFN
-IVF #1-Follistim and Menopur= BFN
***11 Eggs, 10 mature, 8 fertilized, transferred 1 (day 5) 2 made it to freeze
-FET #1- Transferred 2, day 5 embryos =BFN
-IVF #2- Follistim and Menopur = BFN
***11 retrieved, 8 mature, 6 fertilized, transferred 2 (day 3), 4 made it to freeze (Follistim and Menopur) = BFN
-FET #2- Transferred 2, day 3 embryos = BFN
**Changed doctor**
-IUI #4- natural cycle = BFN
-IUI #5- Follistim (5 eggs) BFP- lead to Miscarriage
-Laproscopic Surgery for Endometriosis, Polyp removal and Cyst removal.
-IVF #3- Menopur, Follistim, Lupron, Ganirellex- BFP lead to Eptopic Pregnancy
***11 Eggs retrieved, 10 Mature, 8 fertilized, transferred 3 embryos (day 3), 0 made it to freeze
-Lapropscopic surgery- Removal of Fallopian Tube
-IVF #4- Estrogen Priming with Vivelle dot, Menopur, Follistim, Ganirellex- BFP
***15 Eggs retreived, 11 mature, 11 fertilized, 2 embryos transferred (day 3), 2 made it to freeze
Found out I was positive for MTHFR Gene Mutation during TWW of IVF #4
I am not considered high risk as far as I'm aware, but I had never been pregnant. I do get scans monthly though and after 32 weeks I'm getting seen every 2 weeks for some testing.
Took a break and ttc naturally
7.) IUI Cycle 7 February 2016-100mg clomid days 3-7, U/S day 12 showed 2 follicles (22mm and 24mm), Ovidrel trigger shot day 12 at 9:00pm, IUI cycle day 14 at 10:00am. BFN
Meeting scheduled for 2/29/2016 to discuss iui with injectables vs. IVF
8.) IUI Cycle 8 March 2016-Injectables (Gonal F), U/S showed 2 mature follicles, Ovidrel Trigger BFN
April-May I lost my mind.
IVF#1 July 2016-Transferred 2 fair blasts. 9dp5dt BFP 129 BETA, 13dp5dt 944 BETA, 20dp5dpt 8776 BETA, 8/19/2016-1 beautiful heartbeat of 100 BPM at 6 weeks 1 day! Growing baby grow!! 8/25/2016-another ultrasound at 7 weeks and baby has a heart beat of 129 BPM and is 10mm/1cm! Grow baby grow some more!! Graduated from RE at 10 weeks and had ObGyn appointment at 13 weeks. It's a girl (found out via panorama test) EDD 4/13/2017