RPL Study

KyCade3013

Hi All, just got my RPL paperwork from the MFM and on the first page it states a study. It's a Danish study that says your chances of loss for 1 loss, 2 losses and so on and compares to under 35 vs over 35. It basically said if you have two losses in a row is increases your chances of miscarriage from 10-20% to 23% and did not find it that relatively significant for women under 35. It went on to talk about rolling a 6 sided dice and that the probability of rolling a 6 twice is not that unlikely and can happen by chance. It further went on to say that this may be the reason why 50% or more RPL cases go undiagnosed, they could purely happen by chance. Has anyone else heard this? I was kind of annoyed because I felt like it gives false hope to the patient when something could be seriously wrong and I just have no clue until tests are done or maybe ill
never know but technology isn't advanced enough to find out. Anyways - thought I'd ask!!! 

chloe97

I agree with you. I am 37 with 2 losses and was told I have a 25% chance of miscarrying again if I try naturally. Thats a great statistic, but it doesn't take into consideration individual factors such as PCOS, low AMH, etc. Those conditions, without intervention, increase your risk. I get pregnant very easily, so I might be superfertile. 

DungeonTrollMel

I was basically told that most of the type with RPL, progesterone and a baby aspirin are enough in 60% of women to then go on to have a healthy pregnancy. I actually got that same number from both my MFM and RE. To me that still leaves a 40% chance of failure which seems high. I have been the less than 1% of people with almost everything so I try not to set and expectations by statistics anymore. 

chloe97

DungeonTrollMel said:

I was basically told that most of the type with RPL, progesterone and a baby aspirin are enough in 60% of women to then go on to have a healthy pregnancy. I actually got that same number from both my MFM and RE. To me that still leaves a 40% chance of failure which seems high. I have been the less than 1% of people with almost everything so I try not to set and expectations by statistics anymore. 

^^^^^^^Yes to all of that^^^^^

It reminds me of that stupid "your chance of MC by week" post that makes the rounds on the BMBs. I lost my pregnancies at 10 and 13 weeks, giving me a less than 2% risk 2 times in a row. So yeah, I don't like statistics either.

KyCade3013

Thanks Ladies. Exactly why this study on the first page of my packet none the less, really bothered me. I've been the 1% too!

TScalei

I hate that miscarriage by week board that I found on my October BMB it gave me such a false security and I think blindsided me when I mc at 10 weeks. I have been in 1% group a few times with this too so statistics don't really comfort me anymore. I just met with my RE for the first time this week and she said mostly the same thing that even after 2 losses that my chance of going on to have a healthy pregnancy were "high". I kind of like the rolling of the dice analogy though bec I guess eventually you have to stop rolling a 6.


**Question** Did anyone start taking Baby Aspirin as a precautionary measure? I forgot to ask my dr about it at my appt but I am afraid she will say if I don't have a clotting disorder ( which she already suspects that I don't) there is no need to take it. I have read that it could help and it seems like it can't hurt so I thought there could be no harm in taking it? Any thoughts on this? I will talk to my dr too but just wanted to see what other people had found about this.

DungeonTrollMel

@TScalei I take a baby aspirin but I am homozygous MTHFR so I have to take mine for life. Most doctors have a "why joy add it" mentality unless you have any known bleeding conditions. It's only 81mg so very minimal risk associated with taking it daily 

RiverSong15

chloe97 said:

DungeonTrollMel said:

I was basically told that most of the type with RPL, progesterone and a baby aspirin are enough in 60% of women to then go on to have a healthy pregnancy. I actually got that same number from both my MFM and RE. To me that still leaves a 40% chance of failure which seems high. I have been the less than 1% of people with almost everything so I try not to set and expectations by statistics anymore. 

^^^^^^^Yes to all of that^^^^^

It reminds me of that stupid "your chance of MC by week" post that makes the rounds on the BMBs. I lost my pregnancies at 10 and 13 weeks, giving me a less than 2% risk 2 times in a row. So yeah, I don't like statistics either.

That list is based on dubious numbers to begin with and most people on the BMBs don't understand how to interpret statistics. Even IF these numbers weren't pulled from someone's BLOG and were actually legit, those stats would only apply for people whose pregnancy was progressing normally. Until you get to your first appointments, you don't know what your risk really is. Hate hate hate that chart.

It also doesn't help that the Nov 16 BMB called us loss moms "fear mongerers" for pointing this out. 

RiverSong15

@TScalei When I had one APS antibody come back slightly elevated, my OB said we'd add in baby aspirin. When I asked if I could take it even if my repeat bloodwork came back negative for clotting disorders, she said yes. I'd talk to your doctor, but mine, at least, didn't see any harm in it.

Aera11

@TScalei I am on baby aspirin too.  I have a blood clotting issue I guess and am now on it.

ladipale

I will also be on BA once I get a BFP - and might start adding it in after ovulation in another cycle or two. I am compound Homo MTHFR - but that hasn't stopped me from having two previous children so who knows if it really is a factor in my recent loss (my OB and others I have talked to think it is not and as a PhD, I try really really hard to believe MDs)

yolandamunoz

My first APS test came out positive, but my second one was negative, so my RE said not to worry. I'm not taking the aspiring or heparin.

when I had my first test, my prolactin was still high, and now it's under control with medication. I also had high insulin and now under control with metformin.

After 2 MC stats are sad for me too, and I am trying to keep my hopes up. My doctor says that there is no reason to not be hopeful according to my current health. This cycle I am trying naturally, still scared about mc again.... Next cycle will be medicated and supervised... I hope that will ease my worries.

dpjennifer

I was added on baby aspirin after talking to a MFM specialist after my second loss. Her opinion was that for my situation it couldn't hurt.

TScalei

@dpjennifer - do you start taking the baby aspirin after you ovulate or do you take it all the time with a pre natal?

dpjennifer

@TScalei I'm taking one every day with a pre-natal, regardless of ovulation.