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PIO side effects

So, I've read that PIO causes a ton of side effects: breast tenderness, constipation, nausea, headaches...I literally have NONE of these.

Anyone else not been effected? I haven't had my progesterone level checked since starting PIO (1 cc 2x/day for the last wk, had FET yesterday). Am I lucky or is it possible I'm not on enough?

***SIGGY WARNING***

Our Story

Me- 35, mild hypothyroidism

DH- 29, low count due to a chromosomal abnormality, only option is IVF/ICSI with PGD.

Married 5/13

TTC since 8/13

IVF/ICSI #1 ER 9/14 - 14R, 6M, 6F, 5 blasts off to PGD- 1 normal female, 2 balanced males

FET 12/8 of 2 frosties - 1 male/1 female - stick babies stick! 

Beta #1 10dp5dt 444! Beta #2 14dp5dt 2,340!  U/S 1/5-- TWINS!!!  EDD 8/26/15

"You'll never see the rainbow if you can't survive the storm"

 image    image

Pregnancy Ticker

Re: PIO side effects

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    I had no symptoms the first round and my biopsy showed low progesterone in my lining. I am now on 2xday and I am feeling more side effects this time but not a lot. If I were you I would get your progesterone checked.
    me 33- everything looks good
    mister 34- PCD zero motilty 
    TTC#1 using donor sperm
    IUI#1 Dec 2nd-BFN
    IUI# Dec 28th-BFN
    IUI#3 Jan 26th-BFN
    IUI#4  Feb 26th-BFP
    mc March 2014
    IUI#5 April 6th prometrium-BFN
    IUI #6 cancled ovulated too early
    IVF# 1 July
    ER: Aug 3rd: 18R 15M 14F
    10 embryos frozen
    ET: Oct. 7th 1x5BA blast-BFN
    ET: Jan 9th 1x3AA blast- Beta 1/21


    imageimageimageDaisypath Anniversary tickers
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    **Ticker warning**

    I didn't have any side effects. Except the butt lumps. 
    **Warning: Losses and living child mentioned**
    BFP#1 1/31/12, EDD 10/6/12 Harrison Gray born sleeping @ 18w6d. You changed our lives little guy.
    BFP#2 EDD 10/29/13, C/P 2/25/13, Bye little Ish, we barely got to know you.
    BFP#3 EDD 12/21/13, Baby Boots born 11/23/13 My rainbow baby!
    image

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    January PAL Siggy Challenge: Good Advice
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    You aren't alone. I had no side effects, and no butt lumps!! But, I was also only on 1mL per day, and had only been on it for 3 weeks. The only thing that I had to deal with was breast tenderness, and general soreness on the side I got the injection the night before. I also found that laying on my side was a bit uncomfortable, but sitting and standing, walking, and even working out was not a problem for me. I will not look that gift horse in the mouth come time for FET #2 in January!
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    I have only been on PIO for 3 days. I am also on crinone 2x day for 7 days so far. No side effects yet.




    ** Losses Mentioned **
    Me(32) - Low AMH (0.46) and DH(33) - All good!
    May 2014 - IUI (Follistim) = BFP! Ectopic. Surgery June 2014.
    August/Sept 2014 - IVF #1. BFP! Chemical Pregnancy.
    November 2014 - IVF #2; ER only - PGS testing 3 Frosties.
    December 2014 - FET #1 - Beta on 12/17!  BFP  *It's TWINS*

    image        image      image  
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    No side effects or lumps for me either after 3 weeks at 1 ml/day. I had my levels checked and they were at 23.9.
    ---------------------------------------------------------------------------------------------------------------------------------------------------------------------
    Our story:
    TTC since 4/13
    Me: 35
    Husband: 45 
    Issues: Moderate MFI, tubal factor, fertilization problems
    10/13 - we find out my husband has MFI, which has since been addressed and mostly remedied. Hate our RE. 
    12/13 - finally find an RE we love.
    1/14-5/14 - using Letrizole
    6/14 - 1st IUI with Clomid, BFN
    7/14 - 2nd IUI with Clomid,  BFN
    7/14 - Insurance reverses decision and agrees to cover HSG, we learn I have tubal factor
    11/14 - IVF #1 = BFN
    1/15/15 - FET with our one frozen embryo scheduled.



    imageimage
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    Few PIO side effects for me. Maybe a little more tired. My progesterone level was 34 on beta day. oral prometrium, on the other hand, was horrible.


    ***siggy warning***

    Me: 29; DH: 53
    TTC since February 2013 --- mild thin PCOS (or not, depending on which RE you ask), MFI

    TI#1: BFN (April 2014; Clomid 50mg x5 days, Estrace x5 days, Clomid 50 mg x4 days)
    IUI#1: c/p (May 2014; Letrozole 2.5 mg x5 days, Estrace x5 days, Bravelle 75 IU x10 days)
    IUI#2: abandoned... O'd early & DH hormone issues (June 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x2 days)
    IUI#2.1: BFN (July 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x4 days)

    Moving on to IVF. (Why we're moving on to IVF)

    IVF#1 (w/ICSI): BCP 9/9-9/23. Gonal-F, Ganirelix, Low-dose HCG (antagonist protocol). 41R/35M/32F... 2 transferred on 10/14, 14 frosties! On cabergoline to help avoid OHSS. BFN, possibly because of 90% drop in estrogen and progesterone a few days after ET.
    FET#1: Transferring 2 on January 8. BFP! beta#1 (1/17): 408, beta#2 (1/20): 1310, first u/s scheduled 2/5

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    AngM123AngM123 member
    edited December 2014
    I experienced no side effects other than constipation. And my levels were always high.
    Me:30 DH:30 
    TTC since January 2013 
    Him: Excellent SA
    Me: 2 clear HSG's, perfect 28 day cycle with ovulation, all testing/blood work good
    1/23/14- **Surgery**
    Diagnosis: severe pelvic adhesions from stage 3/4 endo and old ruptured appendix
    RE Recommends IVF due to likely tubal damage
    IVF #1- November 2014 
                     Started stims 11/7. Antagonist Protocol
                     Trigger 11/17, HCG/Lupron
                     ER 11/19   27R/24m/14F
                     ET 11/24   1 little embie 
                     5 frosties!!! 
                     First ever BFP-  12/4 Beta #1: 35  12/8 Beta #2: 9  CP 

    FET #1- February 2015 



     

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    Ok no side effects either with the progesterone inserts I had cramping and lots of it. With this nothing? Until I did my FET on Tuesday. Now I have cramping. Not serious but twinges and small cramps. Are you cramping too?
    SIGGY WARNING//TICKER WARNING//PAIF

    Long of the Short:
     TTC since April 2013  DH 42 y/o I'm 30  Dh had vasectomy reversal Feb 2013 after 3 months developed scar tissue 
     First Re appt was September 2013 OOP for everything minus meds  
    DH's TESE surgery December 2013
    First cycle was February 2014 BFN none to freeze
     Second cycle was April 2014 BFP ending in Chemical Pregnancy none to freeze
     Third cycle June 2014 BFN none to freez
     Fourth cycle October 30th 28 retrieved, 13 mature and 12 fertilized
    PICSI, assisted hatching and fresh sperm from my DH's TESE surgery used
    5 FROZEN from a freeze all cycle! 
    FET completed on DECEMBER 9TH!!!
    Beta #1 13dp5dt BFP!! 800
    Beta #2 15dp5dt 2100
    Beta #3 17dp5dt 3600 
    First Scan January 5th! Everything looks great! Heart rate of 121!
    Second Scan January 20th. Baby Justone13 looks amazing. Heart rate of 175!
    Baby Girl is due August 27th
    Liv Annmarie born 8/25 7lbs 6oz 21 1/2 inches long 
    image 

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    Thanks ladies for your responses-- it sounds like everything is so individualized! I don't have the butt lumps but my rear looks like I have a rash with all of my injection polka dots. They will be checking my level 12/18 with beta, FX I'm just a lucky one. I have seemed to respond to all of the other meds very well?

    @Justone13‌ - I AM having cramping. Not a ton, just little twinges here and there since FET Monday, like you. And I'm super tired-- I conked out on the couch at 8:15 last night.

    ***SIGGY WARNING***

    Our Story

    Me- 35, mild hypothyroidism

    DH- 29, low count due to a chromosomal abnormality, only option is IVF/ICSI with PGD.

    Married 5/13

    TTC since 8/13

    IVF/ICSI #1 ER 9/14 - 14R, 6M, 6F, 5 blasts off to PGD- 1 normal female, 2 balanced males

    FET 12/8 of 2 frosties - 1 male/1 female - stick babies stick! 

    Beta #1 10dp5dt 444! Beta #2 14dp5dt 2,340!  U/S 1/5-- TWINS!!!  EDD 8/26/15

    "You'll never see the rainbow if you can't survive the storm"

     image    image

    Pregnancy Ticker

  • Options
    @katers79‌ fx that's a good sign for the both of us!!
    SIGGY WARNING//TICKER WARNING//PAIF

    Long of the Short:
     TTC since April 2013  DH 42 y/o I'm 30  Dh had vasectomy reversal Feb 2013 after 3 months developed scar tissue 
     First Re appt was September 2013 OOP for everything minus meds  
    DH's TESE surgery December 2013
    First cycle was February 2014 BFN none to freeze
     Second cycle was April 2014 BFP ending in Chemical Pregnancy none to freeze
     Third cycle June 2014 BFN none to freez
     Fourth cycle October 30th 28 retrieved, 13 mature and 12 fertilized
    PICSI, assisted hatching and fresh sperm from my DH's TESE surgery used
    5 FROZEN from a freeze all cycle! 
    FET completed on DECEMBER 9TH!!!
    Beta #1 13dp5dt BFP!! 800
    Beta #2 15dp5dt 2100
    Beta #3 17dp5dt 3600 
    First Scan January 5th! Everything looks great! Heart rate of 121!
    Second Scan January 20th. Baby Justone13 looks amazing. Heart rate of 175!
    Baby Girl is due August 27th
    Liv Annmarie born 8/25 7lbs 6oz 21 1/2 inches long 
    image 

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