Hi everyone! I've been hanging out for a little bit, but I figured I'd say hello with my first IUI a bust. Long story short, TTC 20 months, lost 2 pregnancies. 4 mos of clomid, 1 month letrozole + IUI.
I had some massive follicles at my last two mid-cycles, (32 and 34 mm respectively). I'm looking into whether this can effect treatment outcome.
We've been married 9 years, and have a 4 year old daughter.
Welcome and good luck! 32 and 34 sound quite large. Were you using clomid, letrozole or injectables? I know clomid and letrozole they tend to let follicles grow a little larger. But, even on clomid they triggered me before 25. Did you use a trigger or were they waiting for you to naturally ovulate?
~SAIF/PAIF/Everyone Welcome~
Me= 37 and DH = 41
Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)
IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN
IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.
IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132. Lil is here!
I am very sorry for your losses. 32 and 34? I just had a 26 mm cyst that was pretty uncomfortable so I can't imagine that felt good. Welcome to the group.
Me: 35 DH: 35 - Married 10 years PCOS and MF Two failed rounds IUI in 2010 IVF #1 in 2011 - BFP 8/5/11 - Our IVF miracle was born 4/8/12 FET 9/23/13; BFP -Twins-10/3/13; EDD 6/10/14; MC 11/1/13; D&C 11/4/13 FET 3/28/14; BFN - 4/7/14 IVF #2 - Transfer 2 embryos 11/14/14; BFP 11/24/14 - Beta 265; 11/26/14 - Beta 612; 11/28/14 - Beta 1263; 12/1/14 - Beta 3571; 12/3/14 - first u/s - two gestational sacs; 12/17/14 - two healthy heartbeats (132 and 134) Our IVF miracles were born 7/16/15
IVF #1, Stimmed for 12 days, ER 8/22/14, 9 retrieved, 7M, 7F!! Freeze all due to fluid in uterus.
FET end of October 2014 cancelled due to fluid in uterus due to possible c-scar defect
Surgery scheduled 12/12/14 to fix possible isthmocele
3/26/15 transferred one 8 cell grade 4 embryo and one 6 cell grade 3 embryo = slow rising betas for 2+ weeks = ectopic MTX shot 4/29/15
Repeat c-scar surgery June 2015
2nd and last IVF cycle August 2015, stimmed for 12 days, 2 egg retrieved, both mature and both fertilized. Transferred both 8-cell embryos on Day 3, beta 9/5/15 = BFFN
I was on letrozole 5 mg cd 3-7. My midcycle was on cd 13. I surged naturally that morning, however the ewcm I did have was gone by cd 11. Like my brain was late to the ovary party.
Best of luck moving forward. Have you considered requesting a trigger shot to move up ovulation a little? Those follicles are on the larger side and you said ovulation didn't coincide with ewcm, so maybe that would help. Obviously, your doctor knows more than me. Just wondering.
I'm so sorry for you losses and difficulties. I hope you find the combination that works for you.
~SAIF/PAIF/Everyone Welcome~
Me= 37 and DH = 41
Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)
IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN
IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.
IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132. Lil is here!
That is exactly what I was thinking. There is a study linking follicle size, endometrial thickness, and pregnancy success. With letrozole, anything over 30mm or so has a near 0% chance of pregnancy regardless of thickness of lining.
Thank you, and you as well. I just hope he is receptive. I know he's the expert, but we're completely oop on this and would prefer to optimize our chances.
Baseline u/s today revealed a 22mm cyst. Boo. But had a good discussion about follicle size. He is pretty convinced that this oversized follicle--->cyst cycle I have going on is the cause of all of my nonsense. As long as this cyst isn't pumping out hormones, we will proceed with a day 10 u/s with a trigger when the follicle is normal sized. He said he has no idea why I would produce such massive follicles.
BFP #4 2/18/14. EDD 10/30/14... Ruptured ectopic with L tube removed & D&C 3/7/14.
BFP #5 7/27/14. EDD 4/9/15... m/c @ 5w4d.
IVF #1 Oct 2014 - antagonist protocol: 9R, 7M, 5F. 3dt of 3 Grade 2 embies. BFN.
IVF #2 Jan 2015 cancelled due to dominant follicle. Converted to IUI #1. BFFN
IVF #2.1 March 2015 cancelled due to dominant follicle.
BFP #6 (SUPRISE!) 3/19/15. EDD 11/30/15... CP at 4w2d.
IUI #2: Clomid + Follistim = 3 follies. BFN.
IVF #2.2 May 2015 - horrible response to micro lupron flare protocol: 3R, 3M, 3F. 3dt of 2 Grade 3 embies. BFFN.
BFP #7 (beyond surprised again!) 4/26/16. EDD 1/5/17. beautiful betas!!!! and then near-fatal hemorrhagic corpus luteum. turns out baby was ectopic after all; another lap 5/6 (@24dpo).
the universe can fuck off.
"You are
overly paranoid and delusional that every one is out to get you."
-lastsliverofhope
Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)
IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN
IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.
IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132. Lil is here!
Re: Hello and Intro!
TTC #2 since 1/1/13
Spontaneous pregnancy #1
DD1 July 31, 2011
Trying for #2 since Oct 11
Spontaneous pregnancy #2= Ectopic #2= lost left tube
Spontaneous pregnancy #3= DD2 January 29, 2016
Spontaneous pregnancy #4= Ectopic #3
Spontaneous pregnancy #5= Baby #3 is a BOY!!!
~SAIF/PAIF/Everyone Welcome~
Me= 37 and DH = 41
Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)
IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN
IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.
IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132. Lil is here!
TTC#2: Trigger + TI = BFN; Clomid + Trigger + IUI = BFN.
IVF #4: BCP + MDLF + Lovenox = 7R, 1F = Transferred 1 6-cell embryo on day 3 = BFN
IVF #5: MDLF + Lovenox = 4R, 1F = Transferred 1 10-cell compacting embryo on day 3 = BFN
IVF #6: (New RE): Long Antagonist November 2014 (transferred two 8 cell grade 1 embryos and froze one blast) = BFN
FET#1: BFN
PCOS and MF
Two failed rounds IUI in 2010
IVF #1 in 2011 - BFP 8/5/11 - Our IVF miracle was born 4/8/12
FET 9/23/13; BFP -Twins-10/3/13; EDD 6/10/14; MC 11/1/13; D&C 11/4/13
FET 3/28/14; BFN - 4/7/14
IVF #2 - Transfer 2 embryos 11/14/14; BFP 11/24/14 - Beta 265;
11/26/14 - Beta 612; 11/28/14 - Beta 1263; 12/1/14 - Beta 3571;
12/3/14 - first u/s - two gestational sacs; 12/17/14 - two healthy heartbeats (132 and 134)
Our IVF miracles were born 7/16/15
TTC #3 since June 2013
BFP #1 7/21/2013--EDD 3/30/14--D&C 9/24/13
BFP #2 1/28/14--MC 2/7/14
IUI #1 5mg Femara + trigger = BFN
IUI #2 5mg Femara + trigger = BFN
IUI #3 5mg Femara + trigger = BFN
~SAIF/PAIF/Everyone Welcome~
Me= 37 and DH = 41
Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)
IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN
IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.
IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132. Lil is here!
TTC#2: Trigger + TI = BFN; Clomid + Trigger + IUI = BFN.
IVF #4: BCP + MDLF + Lovenox = 7R, 1F = Transferred 1 6-cell embryo on day 3 = BFN
IVF #5: MDLF + Lovenox = 4R, 1F = Transferred 1 10-cell compacting embryo on day 3 = BFN
IVF #6: (New RE): Long Antagonist November 2014 (transferred two 8 cell grade 1 embryos and froze one blast) = BFN
FET#1: BFN
BFP #7 (beyond surprised again!) 4/26/16. EDD 1/5/17. beautiful betas!!!! and then near-fatal hemorrhagic corpus luteum. turns out baby was ectopic after all; another lap 5/6 (@24dpo).
the universe can fuck off.
"You are overly paranoid and delusional that every one is out to get you." -lastsliverofhope
Me: 41, DH: 45
DD, 6/15/2013
TTC #2 beginning January 2014
AMH 1.05; FSH range 7-11
July 2014: IUI #1. Follistim + Pregnyl. 2 follicles--BFN
September 2014: IUI #2. Follistim + Pregnyl + Ganirelix + Crinone. 4(?) follicles--BFN
October 2014: IUI #3. More Follistim + More Ganirelix + Pregnyl + Crinone. 4 follicles--BFP! Beta #1=10 Beta #2=33 Beta #3=97 Beta #4=158. M/C 11/1/14
December 2014: IVF #1. Microdose Lupron protocol. 9R, 9M, 9F. 3 5-day blasts transferred 12/15. BFFN.
August 2015: IVF #3. 14R, 13M, 11F. Froze 5 blasts for CCS testing. 3 normals. FET planned for 10/2015.
My Ovulation Chart
~SAIF/PAIF/Everyone Welcome~
Me= 37 and DH = 41
Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)
IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN
IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.
IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132. Lil is here!
TTC#2: Trigger + TI = BFN; Clomid + Trigger + IUI = BFN.
IVF #4: BCP + MDLF + Lovenox = 7R, 1F = Transferred 1 6-cell embryo on day 3 = BFN
IVF #5: MDLF + Lovenox = 4R, 1F = Transferred 1 10-cell compacting embryo on day 3 = BFN
IVF #6: (New RE): Long Antagonist November 2014 (transferred two 8 cell grade 1 embryos and froze one blast) = BFN
FET#1: BFN