Pregnant after IF

MaterniT21 test?

LeoLaurenLeoLauren member
edited February 2014 in Pregnant after IF
My MFM told me about this test and asked me if I wanted it. She said it will one day replace the NT test. It's not 100% accurate testing for downs (NT is 90%) but it does test for all the trisomy's and for gender. She said with multiples it's less accurate. My insurance doesn't cover it (it's almost $2800 but I read that you may be able to get reimbursed by the testing company for all but $200-$300). Anybody do this test? Thoughts? Know anything more?
Me: 34 - low ovarian reserve
DH: 40 - no issues  

3 failed IUI's 

IVF #1 3/12 - 13 eggs, 9 fertilized,  2 transferred (1 grade 2 blast, 1 early blast), no frosties, 3/30/12 - 9dp5dt spotting, BFNs

IVF #2. 7/12 - 18 days of stims, 3 mature eggs, 3 fertilized (ICSI), 3 transferred (9, 8, 7 cell) on day 3.  First beta - 8/21/12 = 105, beta #2 - 8/23/12 = 268, beta #3 - 8/30/12 = 2,352. 2nd u/s - 9/4/12. Baby Boy born 5/1/2013.

IVF #3 Now (12/13). AMH is very low - 0.19. ER (12/5) 12 eggs, 10 mature, 7 fertilized using ICSI. 3 transferred (8,8,8 cell - all grade 2) on day 3. First beta - 12/21/13 = 126, beta #2 - 12/23/13 = 400, beta #3 - na (office was closed for new year's). First sonogram - TWINS aka OMG! -  


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Re: MaterniT21 test?

  • From what I've heard from friends, the Maternit21 is not a good option for twins. If you get a positive, they have no idea which twin it would be. An NT scan will allow measurements for Baby A and Baby B. That's just my knowledge though, I'm not a twin momma :)

    My OB recommends NT first to everyone and then the Maternit21. His opinion was that the Maternit is newer and he likes to use it as a backup should the NT have something arise.

    Personally, I would go straight for the NT. Instant feedback that your babies are looking good and the bloodwork section comes back in about 4 days.
    IVF #1- BFP- DD 4/8/2011
    FET #1- 3BB and 3B-B
    Beta #1 (4w0d)- 504
    Beta #2 (4w4d)- 4,577
    Beta #3 (6w0d)- 78,399 HB 115 bpm
    U/S #2 7w0d- HB 155 bpm

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  • Thanks @bbcolt78! Just posted to the multiples board too. I did the NT test for sure. My thinking was the same - get the results, then go from there...
    Me: 34 - low ovarian reserve
    DH: 40 - no issues  

    3 failed IUI's 

    IVF #1 3/12 - 13 eggs, 9 fertilized,  2 transferred (1 grade 2 blast, 1 early blast), no frosties, 3/30/12 - 9dp5dt spotting, BFNs

    IVF #2. 7/12 - 18 days of stims, 3 mature eggs, 3 fertilized (ICSI), 3 transferred (9, 8, 7 cell) on day 3.  First beta - 8/21/12 = 105, beta #2 - 8/23/12 = 268, beta #3 - 8/30/12 = 2,352. 2nd u/s - 9/4/12. Baby Boy born 5/1/2013.

    IVF #3 Now (12/13). AMH is very low - 0.19. ER (12/5) 12 eggs, 10 mature, 7 fertilized using ICSI. 3 transferred (8,8,8 cell - all grade 2) on day 3. First beta - 12/21/13 = 126, beta #2 - 12/23/13 = 400, beta #3 - na (office was closed for new year's). First sonogram - TWINS aka OMG! -  


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  • There are other tests besides mat21 that are similar and may have better results with twins. My OB prefers the Verifi test and I know they have a specific test for twins. My OB also only gives you the option of the verifi test or the NT w/ blood work, which kind of stunk. I was really looking forward to another u/s! I would talk to your OB about doing the nt and then backing it up with a twin approved non-invasive DNA test. GL!
    TTC Since January 2012 Me:37 DH:34      DX July 2013: Unexplained Infertility      New DX Dec 2013: DOR
    BFP#1 6/4/12 EDD 2/13/13 M/C 6/6/12  BFP#2 2/21/13 EDD 11/3/13 M/C 2/26/13 BFP#3 C/P
    4 rounds of clomid, 2 with IUI = BFN
    November/December Retesting/Natural Cycle = Surprise BFP @ 11dpo! Beta#1 76.6@13dpo Beta #2 276@15dpo u/s#1 6w2d hb113 u/s#2 8w2d, measuring 8w4d hb168! 10w2d hb171 12w3d Verifi results are in and good! EDD 8/23 Our Baby Girl Rainbow Baby born 8/20/2014!!!
    Um...what? BFP 11/2/15!?! EDD 7/4/16
  • edited February 2014
    The Harmony and Verifi are much cheaper (Harmony $800, Verifi $1500ish). Here's my two cents after just getting a Trisomy X diagnosis from a Harmony test (Trisomy X and other sex chromosome issues don't impact the neck fold on the NT - my measurement was 1.25).

    For the rare case, something like mine, these tests are invaluable. My little girl's condition is amazingly treatable particularly when diagnosed prenatally. 90% are never diagnosed, or diagnosed later at school age, and miss out on early interventions which we will do for sure.

    It was hard news to get but we are so grateful to know vs. not, especially since early intervention leads to much better outcomes.
    Lil'mamaz was born on Aug 21, 2014! She's PERFECT!

    It's been a long road to here...
    Me (43) and J (45) - same sex couple. And we don't feel 40+!
    June'12 - First RE Visit
    Sept. '12 - Tubes removed
    Dec. '12 - Donor Egg/Donor Sperm IVF Cycle - 4 good embies!
    Dec. '12 - Fresh transfer, BFP! EDD 8/29/13
    Mar. '13 - Missed m/c at 16w1d, baby boy stopped growing at 15w4d
    Loss due to umbilical cord clot...baby was perfect. :(
    Jul '13 - FET#1 - c/p
    Sept. '13 - FET#2 - BFN
    Dec.' 2, 2013 - FET#3 with our last chance embie - BFP!!!
    Dec' 26, 2013 - hb!!
    EDD 8/20/14 with a baby girl!
    Little S was born on 8/21/14 - 8lb, 14 oz and 20 inches long.
    We live in Seattle and used SRM for our donor egg IVF cycle


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  • edited February 2014
    My Doc said the Harmony21 is supposed to be more accurate than the NT Scan.  I'm over 35 so it was covered by my insurance so we went straight to that.  She also said that if there was any question on the NT, they would do the Harmony21 to clarify.  

    If you do the NT and the MFM recommends the Mat21 for follow up, you may be able to get your insurance to pay for it.  

    Bonus...you can find out the sex earlier too :)  
    ****Siggy Warning****

    IVF Cycle #1 - 4/06/2013 -3dt of 2 embryos, nothing to freeze - BFN 
    IVF Cycle #2 - 7/18/2013- 3dt of 3 embryos.Froze one 3AA 6 Day Blast! - BFN
    IVF Cycle #3 - 9/15/2013 - 3dt of 4 embryos, nothing to freeze - BFP!!!
    10/7 - +HPT - Beta #1 10/10 - 72, Beta#2 10/14 - 518,Harmony 21 @ 12 weeks shows one very healthy little BOY!!


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  • I had it done a couple of weeks ago. I called Sequenom customer service and they said they will bill your insurance. However, no matter what your insurance tells you your portion is, it won't be more than $220 (I think? It was 200 something...) out of pocket. I was happy to have this test run, and we got the results back in only 4 business days. Good luck!

    ************ Signature/Ticker Warning ************
    Me (32) DH (36) - Finding our way to baby #1
    Me: POF/DOR - AMH <0.16, heterozygous c677t MTHFR, insulin resistant and gluten intolerant
    DH: Severe MFI

    12/2/11 - IUI #1- BFN 
    8/1/12 - IVF #1 - Zero response from max stims (600iu intramuscularly)

    My ovaries are just for decoration

    12/6/12 - Adopted five embryos that had been frozen for over ten years!
    2/11/13 - DEmbryo FET #1 Thawed four, sadly two didn't survive. Transferred two beautiful blasts. 
    2/16/13 - First BFP of my life @ 6dp5dt! EDD 10/30/13
    3/27/13 - After beta and u/s hell, no heartbeat ever detected. D&C at 9w1d.

    6/5/13 - Adopted four new embryos that had been frozen for seven years!
     
    9/12/13 - DEmbryo FET #2. Thawed and transferred two beautiful blasts
    9/17/13 - BFP @ 5dp6dt! EDD 05/31/14
    9/29/13 - m/c @ 5w1d. :(

    11/19/13 - DEmbryo FET #3. Thawed and transferred one blast from each batch. Wow!
    11/23/13 - BFP @ 4dp6dt! EDD 8/7/13
    Beta #1 @ 13dp6dt - 522  Beta #2 @ 16dp6dt - 1373 
    6w5d ultrasound showed one perfect baby with a beautiful heartbeat of 134bpm!

    Snowflake baby is a girl! 
    Our beautiful Snowflake girl arrived on July 22, 2014!   
    My embryo adoption blog: Wishing on a Snowflake
     
        image      image 
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