Did you get pgt/ pgs -testing why or why not?

KTB81 · July 2021

My doctor isn’t recommending it because I am 39 and he doesn’t feel enough embryos will develop, but I want to reduce the risk of disability. Any thoughts?

cashewchicken · July 2021

I did and it was worth it. I was 38 when I had my egg retrievals (ER) and I did PGS because of my advanced age (in terms of reproduction) and I wanted to bank normal embryos for future pregnancy. My first two retrievals weren’t successful and 5 blasts I had, they were all aneuploid (abnormal). The third cycle produced 7 blasts, 4 of which were euploid (normal) blasts. I transferred two of the blasts (one at a time) and I now have two children. If I hadn’t tested the embryos, I would have wasted a year transferring the 5 blasts from my second ER and failing (no implantation, cp, or worse, miscarriage). At my age, I couldn’t afford to waste anymore time.

With my first child, nuchal translucency test came back above the cutoff, which raised the risk of having a chromosomal disorder like Trisomy 21. If I hadn’t had PGS I would have been quite worried.

Lisa3379 · July 2021

TW: mention of loss, living children

I’m also 39, and we did testing, and I am so glad we did. We had a couple losses in 2020, and just like @cashewchicken said, we felt like we didn’t want to waste the time and money to transfer embryos that were probably not going to be viable/have problems in the end. Plus, we had already spent the time and money on IVF, why stop at testing? Like, let’s just do everything we can to make this as successful as possible since we’d already come this far.

Anyway, we got 5 embryos and all of them thankfully tested fine, which was a massive relief. We also knew the sex of each one, so we chose a girl since we already have two boys. When it came time for the NT and NIPT, I was still a bit nervous, but nowhere near as nervous as I’d be if I wasn’t already reasonably sure the baby was likely to be ok.

inthewoods23 · July 2021

@KTB81 I would definitely discuss with your doctor and advocate for it. I don't regret doing PGT-A (I was 30 at the time) because it eliminated a possible reason for transfer failure since we'd only be transferring normal embryos.

Your doctor may be thinking about the relative cost per embryo for the testing. When ours was through CooperGenomics, they had a rate for up to 8 embryos and then $X additional for every embryo beyond that. So the cost could seem very significant if you only have 2 embryos (for example).

Not sure, but some doctors may like to manipulate embryos as little as possible with AMA patients since they may not be "hardy" if you know what I mean. Does your doc want to do a fresh transfer? That seems more common for those AMA since some embryos don't make it out of the freeze/thaw process. I happen to lose an embryo in the thawing process so we used up 2 in 1 transfer cycle (which was unsuccessful).

KTB81 · July 2021

Thank you so much ladies. I really appreciate your advice. I asked for a meeting with my doctor tomorrow. My doctor didn’t want to do testing because of AMA, but I was told today (day 1) that we have 5 embryos. My doctor was not expecting this many. Can we still do testing on them?

Lisa3379 · July 2021

@KTB81 What do you mean by day 1? Do you have 5 fertilized eggs? Or have the embryos made it to day 3 or 5? My doctor waited until they made it to day 5 before taking samples to do testing. FWIW, my doctor had zero concerns about doing PGS because of AMA for me.

KTB81 · July 2021

Yes, 5 fertilized eggs. (Not day 3 or day 5) and yes, he wants to do a fresh transfer.

Lisa3379 · July 2021

@KTB81 Then you should definitely have time to test the embryos that make it to day 3 or 5 (whenever your doctor decides to biopsy for the test).

KTB81 · July 2021

You have been very helpful! I am so happy to hear you got your baby girl

thank you!

Lisa3379 · July 2021

@KTB81 Glad I could help, and thanks! I hope everything goes well for you, too.

KTB81 · July 2021

Well, doc said we can’t do the pgt test as it needed to be part of my treatment plan and the lab is full Kind of upsetting. I’m just trying to focus on the positive.

isabelherna · September 2021

Oh no... Okay, focus on the positive for now. How are you doing? Do you have any updates?

gavinandsara · September 2021

Our doctor suggested against the testing. He said the test requires taking a cell around the embryo and there is a risk that it may damage the embryo or prevent it from holding. He said he would do it if we insist.

Maybe it's better that your RE does not leave it to you. one less decision! Good luck!

blacksnoww · October 2021

A few friends of mine had issues with abnormalities and failed IVFs, and PGS NGS worked out for them

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Did you get pgt/ pgs -testing why or why not?

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