Trigger Loss of PGS embryo

Cossab89 · March 2019

I’m new here, but not new to IVF. I just miscarried a PGS embryo and I’m looking for someone who was successful after a PGS loss. This was my 2nd FET, the first was a fail and this one we made it to 6 weeks. We still have 3 frozen “normal” embryos but we are so scared that something else is going on. Anyone?

somewhereinnyc · March 2019

@Cossab89 I didn’t do PGS but just wanted to chime in about a recent experience and some words from my doc. I had a miscarriage after a fresh ivf cycle and told my doc how petrified I am that if there was no chromosomal abnormality, this could just happen again. She said that chromosomal abnormalities are not the only fluke thing that can cause a miscarriage. Apparently there can be other things wrong w the embryo and when I talked to a genetics counselor, she said it could’ve even implanted in a bad spot. I guess take this w a grain of salt, but just wanted to share those words.. Also, perhaps consider testing the D&C/ miscarriage tissue just to confirm? PGS is pretty accurate but nothing’s perfect.

I know there’s a lot of talk these days about immune issues and embryo rejection. My RE doesn’t seem to want to go down that path so I can’t speak to that arena..

mackorori · March 2019

@cossab89 my two cents...to echo the prior post, there are numerous reasons for miscarriages and abnormalities not compatible with life that PGS cannot eliminate. It can only look at chromosomal abnormalities. But PGS definitely has it’s place for the right circumstances (I won’t get into all of mine). Some FET can just not work (we hate to hear, and scary for me personally given I’m about to transfer the one embryo we have, but true), and sometimes it’s other issues. At the very least I would hope your RE is at least looking to see if there are any potential issues that can be addressed. This process is so difficult, I wish all the best for you.

Cossab89 · March 2019

@mackorori and @somewhereinnyc thank you for responding. I’ve read so much in the last four days about what could be wrong and there are many things I am hoping they will test or at least consider at my next consult. They push PGS testing at the practice for women over 35 and I’m right on the border at 34. They make it sound so promising even when I know deep down that there are so many other things that can happen. My faith is strong but I’m tested with each fail wondering why. I hate that anyone would have to carry this stress around. I hope that you both receive your miracles soon.

caitiemae · March 2019

@Cossab89 I'm so sorry for your loss. I'm a firm believer that even with all the improvement in IVF, there's still a certain amount of "luck" (and bad luck, unfortunately) involved. Maybe see if there's clotting or immune that your RE can easily test for and rule out for peace of mind before transferring another embryo? Crossing my fingers and sending positive vibes that maybe your last embryo just stuck to the wrong spot and that the next transfer will be a healthy pregnancy!

alliem89az · March 2019

You could ask for a recurrent loss panel. It includes some blood tests regarding blood clotting disorders than can cause miscarriages.

ttcinsf · March 2019

@Cossab89 I also had a miscarriage in November from a PGS normal embryo. My REI said the whole system has to work and it could’ve been lining or whole host of other stuff. Don’t give up hope!

manders85-2 · April 2019

@Cossab89 you and I are in the same boat, girl! Our first transfer with PGS tested embryo was a total fail. No pregnancy. Our second, we added a scratch test and then the antihistamine protocol. That time it worked but we found out at our first scan no fetus just a sac. So we miscarried and it was indicative of a genetic abnormality said the doc. We just had our consult today for our next go around. Luckily we have four embryos left that are all allegedly “normal” but I too am afraid the same thing will happen again. This is our third miscarriage. Our first two were from natural cycles. So for our next transfer, doc wants to use levonox even though i haven’t tested positive for a blood clotting disorder. He also wants to put two embryos in. I’m nervous. What does your doc want to do for your next round?

Cossab89 · April 2019

@manders85-2 Hey! It’s so frustrating right?! My doctor is adding Lovenox to our protocol for the clotting precaution. I’m currently waiting on my blood work that I had done Saturday. They are running my thyroid again, clotting, and autoimmune. My doctor is leaning towards clotting or genetically abnormal. I have three more frozen. I just got my period last week. My doctor doesn’t want to start anything for two more cycles. I know it’s not a guarantee, I just feel frustrated that we spent the extra money. I almost want something else to be wrong to give me faith in my other embryos. When do you expect to try again?

prudence9-2 · April 2019

@Cossab89 first, I’m so sorry for your loss. And it’s probably not what you’d want to hear but I had failures with 4 PGS normal embryos. I had 1 MMC, 1 CP and 2 BFN.

All my blood tests came out normal. What gave me some hope was that I’ve done ERA before using my last PGS embryo and it came back that I need another 12 hours of PIO. I felt so confident after that last transfer but unfortunately ended up with the flu the folllowing day. I think that the fever must have been a factor for me getting a BFN.

*TW* I was left with no embryos, did another IVF, this time havent had a good response and ended up transferring on day 3. I’m now holding my almost 5 months old baby.

If i had to suggest something I’d say ask for ERA, blood tests and I also did uterine biopsy to make sure that there is nothing there that’s preventing the embryo from attaching or developing.

Good luck!

marianmet · April 2019

I’ve had a total of 9 miscarriages, 5 early chemicals, and 3 resulting in d&e’s. My first pgs normal is also currently ending in a chemical. My RE also re ran my APS, Lupus, and anticardiolipins. He also is suggesting era but I’m not sure about it since I have no problem getting pregnant just staying pregnant. Just want to let you know you’re not alone! GL!

orchid0404 · April 2019

@marianmet I was in a similar boat. Have had 5 MCs. After the first three had the clotting panel done and found out I have a clotting disorder. For my most recent transfer it was a PGS normal embyro with lovenox added to the protocol...thought that would do it but ended up having another MC. We did another retrieval and got 2 normal embryos. My doctor suggested we do an ERA before our next FET since it has been so hard to get normal embryos. I was torn because I don't have a problem getting pregnant either..just staying pregnant. She explained it to me that even if you are getting pregnant it may not be the ideal time and the implantation may therefore not be as ideal or strong as it could be which can factor into a MC. Don't know if that helps you make your decision or not, but may be worth talking to your RE about it. Currently waiting for the results of my ERA.

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