Infertility

Repeat chemical pregnancies with donor ivf

I am reaching out to see others experiences. I used do or eggs due to not having ovaries and therefore no eggs of my own. We ended up with 5 good eggs, 3 of which made it to blast. I did a fresh transfer of a 4AA in September which resulted in a chemical. First beta 9dpt was 14 and went down from there. FET was a few weeks ago, and again a chemical. Beta at 9dpt was 5 and went down from there. I am so discouraged and devastated. I now have one frozen embryo left and am terrified i will get the same result. If I do thats likely the end for me, because it will be very hard to come up with the money for another egg donor. 
I am just looking for other peoples experiences/happy endings/sad endings/advice etc. becaus I am at a loss on how to proceed. 



A little about me...***TW...child/pregnancy mentioned below***

I just turned 36. I have a 7 year old son conceived naturally. While pregnant for him, growths on my ovaries were discovered and growing rapidly. I was 8 weeks pregnant when i was told I needed surgery otherwise they would continue to rapidly grow and likely overtake the baby. Also the fear was if waited the growths which were likely cancerous could spread and ultimately my health/life could be in danger. At 8 weeks preg, I underwent surgery in which both my ovaries and tubes were removed, leaving me unable to conceive. The growths were determined to be borderline cancerous...whatever that means. Thank god, my baby boy was a strong little fighter and made it through all this like a champ! My hubs and I always wanted more kids, and recently my son started crying out of nowhere begging for a sibling. We had consulted on egg donor ivf in the past but financially it just wasnt possible. Once my son started begging for a sibling, we decided we would find a way to make it happen and that led us to where we are at now. 

Re: Repeat chemical pregnancies with donor ivf

  • @dreamunoz Hi!! I’m so sorry for both of your losses. I know exactly how frustrating that can be! I did not use donor eggs but *TW* I had three CPs from embryos from two different IVF cycles. 

    We don’t know why that happened, which is of course part of the heartbreak of a CP. That said, after our second CP, my RE ran a battery of blood tests—the entire RPL work up as well as autoimmune tests; DH also did a DNA fragmentation (Tunel) Test. Everything was normal, so where it happened a third time, my RE added a hysteroscopy to look for endometritis (which is different than endometriosis)—came back normal—and we thawed and PGS tested the remaining embryos (2 normies out of 3).

    Has your RE run any additional tests? That’s the first place I would start. It’s up to you if it’s worth PGS testing your one remaining embryo. It’s no guarantee, of course. If it were me, I’d probably ask for all of the above (which was all covered by my insurance), but probably skip the PGS testing because it’s so expensive and there’s just one (unless it’s covered by your insurance). 

    Like i said, we’ll never know what happened with those three CPs since none of the embryos were PGS tested and all were good quality. The best bet is that they were abnormal. It’s certainly the way my RE is leaning. *TW* ultimately I got my BFP on my fifth transfer with one of our PGS normal embryos. My RE would definitely chalk it up to that. The only other major changes we made were acupuncture and I did a programmed cycle (but as i’d done both programmed and normal cycles in the past, I can’t really attribute it to that; nor am I going to say it was definitely the acupuncture that helped).

    Tl;DR ask your RE about additional testing before doing another transfer.
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  • @Bababatty I am waiting to get my medical records from the hospital that removed my ovaries in 2011. My RE said he wants to review on the off chance something in there reveals an explanation. He doesn’t believe that it will, but says since I only have one embie left he wants to over turn every stone before jumping to the next transfer. Once I get those records and he reviews, he wants me to come in so he can discuss all possible testing and make a plan to move forward before transferring the last. We did not have the embryos PGS tested, it would have cost about $5000 and given the egg donor costing us about $16,000 we just didn’t have the money. 

    After the fresh transfer failed, i added in acupuncture but was only able to fit in a couple sessions before the next transfer. I plan to continue with the Acupuncture. I’m just so sad and so scared our last transfer is going to fail.
  • @dreamunoz I think you have a good plan! I’m really glad your RE wants to be so thorough. I wouldn’t recommend anything different. And for the PGS testing, I completely agree. It doesn’t seem worth the cost. Continuing with the acupuncture, even while you wait for testing, is a great idea. I did it all summer while waiting for our testing and additional results. At the very least it made me more relaxed, and that’s not nothing. :-)

    As for the terror, I completely understand. I was in a different boat since we still had some embies, but I know the doubt and the fear you must be experiencing. I did not think it was ever going to work. I can’t promise it will for you, and I will not tell you to think positive because I think that just makes people feel worse, but I can say I think you’re putting yourself into the best possible position. I hope so much that you have success!!
  • @Bababatty thanks for the encouragement. I’m just so sad today. When i found out the last transfer was a chemical, first on Friday and then confirmed this past Monday, i was disappointed but it didn’t really hit me like it did the first transfer. Guess i was having a delayed reaction cuz i been crying all day today. 
  • @dreamunoz So many hugs!!  <3<3<3 I think the reaction to every cycle is different, but it never gets easier. Cry all you need; it’s ok to be sad—even cathartic. And don’t feel bad if it’s hard for you to bounce back. And don’t feel like you NEED to even bounce back to how you felt before all of this. Being sad and angry and depressed are all normal. You’re mourning a loss. Don’t let anyone make you feel like it’s any less of a loss or make you feel bad for mourning.  <3<3<3
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