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Progesterone Suppository Side Effects

jazziepjazziep member
in Infertility
My doctor has me on progesterone twice a day following our IUI. This is our first IUI.

Of all the meds so far, I've found the side effects from this the hardest.
Tired, nodding off, vaginal burning, distracted, feel high at times, two hours after I take it my sinuses stuff right up (wth?), constipation, head aches, easy crying, cramping, and generally irritable. I have at least a week and a half to go on it.

Has anyone else had side effects from progesterone? I appreciate you listening. I'm sure there are drugs with even worse side effects for fertility treatments. I'm very sensitive to medications and I'm nervous that if we have to go to IVF, I'll have bad reactions based on how the IUI drugs have made me feel.

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Re: Progesterone Suppository Side Effects

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    JWatt5JWatt5 member
    The progesterone did that to me too. A lot of early pregnancy symptoms right away so I wasn’t sure what was what, constipation, gas (so bad), vaginal irritation/sensitivity. All sounds about right to me what you are experiencing.  
    Me: 37 DH: 37 - Married 10.2015 ❤️ Canadian 
    DX: Endometriosis - Stage 4, DOR, RPL
    TTC #1 07.2015
    03.2016 - Natural BFP - MC 5w4d
    04.2016 - Natural BFP - Chemical
    10.2016 - IUI w/ Injections #1 = IUI Cancelled (cyst/no mature follicle)
    11.2016 - IUI w/ Injections #2 = BFP, EDD 08.2017 - It's a BOY!
    TTC #2 06.2019
    08.2019 - IUI w/ Injections #1 = Chemical
    09.2019 - IUI w/ Injections #2 = BFN
    10.2019 - IUI w/ Injections #3 = BFN
    01.2020 - IUI w/ Injections #4 = BFN
    08.2020 - Natural BFP - MC 9w5d
    11.2020 - IVF Retrieval - 3AB & 4BB
    05.2021 - FET #1 = BFP, EDD 02.2022 - It's a BOY!

           
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    wishiwaspreggowishiwaspreggo member
    I get tons of symptoms from the suppositories, too. It sucks. Taking progesterone basically mimics all my early pregnancy symptoms so in addition to being very uncomfortable it messes with my mind big time. That being said, if your treatments work and you get KU the symptoms are well worth the outcome. Hang in there and good luck!
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    more14more14 member
    Progesterone gave me the worst symptoms. Head aches, moody, gas, bloating, cramps, sore boobs, super tired, and all these are also early pregnancy symptopms so it messes with your head. The vaginal discharge was especially gross.
    It's the hormone I hate the most when it comes to IF treatments.

    All that said, everything is temporary and that's a comforting thought.
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    MamaK225MamaK225 member
    Same! Progesterone suppositories were the worst, as far as side effects. Especially the bloating and the tiredness. And *super* wild, crazy dreams. It mimics pregnancy for sure, so when you get BFP, expect it to intensify after week 7 or so, but mine stopped after week 11. Best of luck and baby dust!!
    **History in Spoiler**
    Me-35, DH-36 - TTC since 08/10
    Me - anovulatory, non-Insulin PCOS, DH - low end of "normal" sperm count
       IUI#1   - 02/15 - Cancelled due to scrubbed sperm count <1MM
       IVF#1  - 08/15 - 13x5-day blastocysts (ranging from AA-BB, most are 5 or 6), not PGS, on ice
       FET#1 - 10/15 - 1 emb - BFP (DD 07/16) (estrace + PIO sesame oil + prometrium)
       FET#2 - 07/17 - 1 emb - BFN (estrace + PIO sesame oil + prometrium)
       FET#3 - 08/17 - 1 emb - BFN (estrace + PIO sesame oil + prometrium)
       FET#4 - 10/17 - 2 emb - BFN (changed to estrace + prometrium because of allergic reaction to PIO sesame oil)
    ERA Testing - 12/17 - window moved (-1 day)
       FET#5 - 03/18 - 2 emb - BFN (estrace + prometrium, ERA-timing used)
    Karyotype Testing - 04/18 - Negative (we're ok)
       FET#6 - 06/18 - 2 emb - BFN (estrace + prometrium, ERA-timing used)
       FET#7 - 10/18 - 2 emb - BFN (estrace + prometrium, ERA-timing used)
       FET#8 - 11/18 - 2 emb - BFP; looks like one baby is going to make it, DD is due 8/16 (though likely to be 8/9)


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    ChristenMA83ChristenMA83 member
    The progesterone is tearing me up this round.  Headaches, bloat, dreams and a floaty feeling.  Didn't bother me nearly this bad my last round.
    December FET Spreadsheet
    TTC History in spoiler  Instagram
    Me 35 - DH 42
    Married Oct 2007
    TTC Since Oct 2010 - MFI Diagnosis 2012 (Morphology 1% + High DNA Frag)
    IUI x2 in 2012 - BFN
    IVF #1 Feb 2018 - 9 Retrieved - 8 Mature - 5 Fertilized - 2 Snowbabies - no testing
    FET#1 March 2018 - BFP - MMC May @ 10w4d
    FET#2 July 2018 - BFN
    IVF #2 Nov 2018 - 10 Retrieved - 10 Mature - 8 Fertilized - 2 Snowbabies - no testing
    “Never give up on something that you can't go a day without thinking about.”― Winston Churchill
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    MamaK225MamaK225 member
    @ChristenMA83 That's how mine has been my last few rounds and I don't see it letting up :neutral:  Hopefully you're on the sunny side of your journey and won't have to deal with it but for a few more weeks. Also, LOVE your quote <3 
    **History in Spoiler**
    Me-35, DH-36 - TTC since 08/10
    Me - anovulatory, non-Insulin PCOS, DH - low end of "normal" sperm count
       IUI#1   - 02/15 - Cancelled due to scrubbed sperm count <1MM
       IVF#1  - 08/15 - 13x5-day blastocysts (ranging from AA-BB, most are 5 or 6), not PGS, on ice
       FET#1 - 10/15 - 1 emb - BFP (DD 07/16) (estrace + PIO sesame oil + prometrium)
       FET#2 - 07/17 - 1 emb - BFN (estrace + PIO sesame oil + prometrium)
       FET#3 - 08/17 - 1 emb - BFN (estrace + PIO sesame oil + prometrium)
       FET#4 - 10/17 - 2 emb - BFN (changed to estrace + prometrium because of allergic reaction to PIO sesame oil)
    ERA Testing - 12/17 - window moved (-1 day)
       FET#5 - 03/18 - 2 emb - BFN (estrace + prometrium, ERA-timing used)
    Karyotype Testing - 04/18 - Negative (we're ok)
       FET#6 - 06/18 - 2 emb - BFN (estrace + prometrium, ERA-timing used)
       FET#7 - 10/18 - 2 emb - BFN (estrace + prometrium, ERA-timing used)
       FET#8 - 11/18 - 2 emb - BFP; looks like one baby is going to make it, DD is due 8/16 (though likely to be 8/9)


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    stephers620stephers620 member
    I’m getting headache and stuffy nose ( not all day just some parts of day) which is weird and feeling hot trouble sleeping
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    ivfmeerutivfmeerut member
    Side effects of progesterone suppositories following IUI are not uncommon. Symptoms like fatigue, vaginal discomfort, sinus congestion, and mood changes can occur. It's essential to discuss these concerns with your doctor, who can adjust the dosage or explore alternative options if necessary.
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