PGS after repeated miscarriage

smartie161 · July 2018

Hi,
Over the last couple of years I’ve had 8 miscarriages, we’ve done 3 rounds of IVF ( 1 fresh and 2 FET)and now we have be advised that PGS may help.
I’ve also got the MFTHR mutation and myself and my DH have a slight incompatility which can be treated, but apart from this there seems no apparent reason for all our losses.
I’m now 39 and it seems I have low reserves, I started stimulating for the PGS, the first was cancelled as I only had 3 follicles, and this time again only 4 (the doc wants at least 10 for the PGS) and due to do the retrieval Monday. After we are going to do one more stimulation and then PGS.
Im really not confident that PGS will help, especially if we only end up with 2/3 embryos.
Id really appreciate any success stories and experiences of any one who had a similar situation.
Thanks.x

kristimh80 · July 2018

@smartie161 So sorry you're having to go thru all of this! PGS is helpful as it makes sure you aren't transferring abnormal embryos which many times do lead to miscarriages. I assume they have you on certain prenatals, etc for the MFTHR. We did PGS due to age and wanted to avoid ore heartbreak if possible. PGS isn't always 100% either though. Have they done any immune panels to see if there's something else going on?

ndz2018 · July 2018

@smartie161 I agree with @kristimh80. Though PGS isn’t 100% guaranteed we rather not take the chance. As we get older our egg quality obviously plummets as well as our egg reserve. I’m so sorry to hear about your struggles

like Kristi said most MC are due to abnormal embryos and if you could avoid that, you should. Has your doctor spoken to you about banking your embryos and doing multiple rounds of IVF? I know A few ladies on here that have done them and gotten 1 PGS normal one cycle, none the next and 2 PGS normals the next. I also agree that you should talk to your RE about testing like an immune panel. Hoping In some way this is helpful and wishing you the best of luck.

embryoman · July 2018

Embryologist here. Abnormal embryos will likely result in miscarriage. Your RE is suggesting you have them tested to screen out the abnormals because of your recurrent miscarriages. Regardless of follicle count they can be banked on day 3 then thawed, hatched, and brought to day 5/6/7 for potential biopsy. But realize this might be a costly and long road before success! Immune panel is a good idea as this may give insight to the miscarriages that isn't embryo related.

cashewchicken · July 2018

I did PGS and for me, it was the best decision. I was 38 when I moved onto IVF, so I knew that due to my advanced maternal age, we were more likely to have chromosomally abnormal embryos than someone in her early 30's. Chromosomally abnormal embryo is one of the most common causes of miscarriage, especially for AMA patients like us. I did not want to go through the heartache of BFN, chemical pregnancy or miscarriage. I also didn't want to experience any delays due to miscarriage. I had five blasts after my second ER and sent all five for testing and all five came back abnormal. The third ER I had seven blasts and four were normal. ***TW*** I transferred one of the four and that became my son.***End*** If I hadn't done the PGS, I would have spent a considerable amount of time transferring the abnormal blasts from ER#2.

That said, PGS is not for everyone. If you have a low ovarian reserve and likely to obtain one or two blasts per retrieval, it might make more sense to just transfer all and see what happens. Especially if you are not planning to have more children in the future (either OAD or this is baby #2 or more). There is also a concern about how reliable the PGS is. There were several cases where transferring of an abnormal embryo resulted in successful pregnancy and birth.

Momifbysea · July 2018

I wanted to share my story as well (see my signature for the whole detail). I’m 43 and over the course of the last year plus, we did 4 rounds of IVF with low numbers retrieved and then nothing to freeze or PGS test, but the 5th round had 3 blasts to test. 2 came back PGS normal so it can happen with small numbers. I know you said your dr wants 10 but I’d consider testing anything you get since I was DOR too and wouldn’t be here without that. On the flip side like pp said, I have heard of abnormal transferred that resulted in normal. My re said PGS isn’t perfect but it’s the best we have to prevent the miscarriage heartbreak. Best of luck to you!

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