Infertility

PIO needle size and does it make a difference?

So I've read a lot of old posts, and it looks that majority of the people use 22G 1.5 inch needles for their PIO injections.
Last might I checked my needles, and they are 21G. I also heard of many people using ice to numb the area, but also that some RE say it's a bad idea, as it might mess with absorption (even if the oil is warmed up, it can get more solid once injected into the cold area)

My DH does the shots on me, but I use some numbing cream every time (put a little indies a water-proof bandage and slap in on for an hour prior to injection), and it really helps. However, I didn't really ask my RE if that's safe to use every day (and on the same area) for this long, so I'm considering my other options, just in case.

I wonder if the smaller needle (22G instead of 21G) would make a difference. I actually heard that thicker needle might be even better, since it's easier to pump the oil through, but does it make any difference during the time the needle goes in?

Looking forward to hear you experience with it, and if you tried different size needles.
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My story in signature spoiler. Children mentioned.
Me: 37 DH: 45
I don't produce FSH, so no natural menstrual cycle. DH has reduced morphology.
Summer 2014 IUI (with first husband): cancelled after almost a month of stims due to too many follicles
Time off to divorce, get back on my feet, find a new hubby and get married again 💑
March 2017 IVF#1: ~70 follicles, 13R, 10M, 7F, 3B = 2 PGS Normal (both XY) - no transfer due to ohss
Sept 2017 FET#1: BFP, Beta#1 (10dpt) - 253, Beta#2 (12dpt) - 528, DS born 05/31/2018 👨‍👩‍👦
Dec 2019 FET#2: BFN
Changed clinic, planning March 2020 IVF#2 - postponed due to the pandemic
April 2020 IVF #2: ~30 follicles, 24R, 12M, 8F, 4B = 2XY & 2XX, all normal  <3
Sept 2020 FET#3: one XX embryo, BFP, Beta#1 (9dpt) - 161, Beta#2 (11dpt) - 519, Beta#3 (19dpt) - 7174, Due date 05/30/2021
DD born 05/23/2021 👨‍👩‍👧‍👦 - My family is now complete <3

Re: PIO needle size and does it make a difference?

  • Hey @FuzzyDust I would think that a 1 gauge difference wouldn't change the way the needle feels to an extent that you'd notice. I could totally be wrong, but I wouldn't worry too much unless you're in a good deal of pain. I personally never had any issues with the PIO (I use 22g). I warm up the oil before the injection but have never iced. Every once in awhile my husband gets me in a spot that hurt for a few seconds, but I was usually okay until the next day when I felt like I'd worked out too hard or something. Using numbing cream is a new one for me - I've never heard of anyone doing that, but if it works for you, great! I just always assumed numbing cream only numbed the skin and the real issue with the PIO is how deep it needs to go into the muscle, not really that initial 'prick.' Let us know if you do change needle gauges, though. I'd be interested to hear if it helps!
  • @sarcasticowl - It actually hasn't really hurt inside until yesterday. I think as I do more shots in the same area, the muscle under is getting more and more sore. And DH is being a sniper - purposely aiming for exact same spot every time :(
    And yes, the numbing cream only numbs the outer layer, where the prick happens. I must be a cry baby, that that's the scary part for me. I'm going to ask my nurse about the safety of the cream when they call me with Beta results (probably not until next Monday).
    -----------------------------------------------------------------------------------------------------
    My story in signature spoiler. Children mentioned.
    Me: 37 DH: 45
    I don't produce FSH, so no natural menstrual cycle. DH has reduced morphology.
    Summer 2014 IUI (with first husband): cancelled after almost a month of stims due to too many follicles
    Time off to divorce, get back on my feet, find a new hubby and get married again 💑
    March 2017 IVF#1: ~70 follicles, 13R, 10M, 7F, 3B = 2 PGS Normal (both XY) - no transfer due to ohss
    Sept 2017 FET#1: BFP, Beta#1 (10dpt) - 253, Beta#2 (12dpt) - 528, DS born 05/31/2018 👨‍👩‍👦
    Dec 2019 FET#2: BFN
    Changed clinic, planning March 2020 IVF#2 - postponed due to the pandemic
    April 2020 IVF #2: ~30 follicles, 24R, 12M, 8F, 4B = 2XY & 2XX, all normal  <3
    Sept 2020 FET#3: one XX embryo, BFP, Beta#1 (9dpt) - 161, Beta#2 (11dpt) - 519, Beta#3 (19dpt) - 7174, Due date 05/30/2021
    DD born 05/23/2021 👨‍👩‍👧‍👦 - My family is now complete <3
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  • @fuzzydust- I actually switched the two needles the first few times I did PIO (so injected with the big one used to draw) and I didn't have any issues. Surprisingly it didn't hurt any worse than the smaller ones. I have seen some ladies ice, but I also haven't from fear that it can create lumps since the progesterone doesn't dissipate as much. I think your DH needs to space the injections as far apart as he can, still being within the circles. have you tried doing alot of rubbing and heat pads after? That seems to help too!
    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
  • Thanks, @JamieH200, for the info! Good to hear that the needles gauge doesn't affect the pain much! My draw needle is 18G - it looks HUGE! Wow, can't believe you were brave enough to use drawing needle for injections!
    I told DH after the last one to please try to leave at least 1cm space between the new and the old spot. He tried rubbing 2 days ago, but I felt like it made me bleed a bit more at the site of injection. Yesterday he tried just pressing hard a few time, and it felt quite sore, but bled less - just a small red dot. 
    -----------------------------------------------------------------------------------------------------
    My story in signature spoiler. Children mentioned.
    Me: 37 DH: 45
    I don't produce FSH, so no natural menstrual cycle. DH has reduced morphology.
    Summer 2014 IUI (with first husband): cancelled after almost a month of stims due to too many follicles
    Time off to divorce, get back on my feet, find a new hubby and get married again 💑
    March 2017 IVF#1: ~70 follicles, 13R, 10M, 7F, 3B = 2 PGS Normal (both XY) - no transfer due to ohss
    Sept 2017 FET#1: BFP, Beta#1 (10dpt) - 253, Beta#2 (12dpt) - 528, DS born 05/31/2018 👨‍👩‍👦
    Dec 2019 FET#2: BFN
    Changed clinic, planning March 2020 IVF#2 - postponed due to the pandemic
    April 2020 IVF #2: ~30 follicles, 24R, 12M, 8F, 4B = 2XY & 2XX, all normal  <3
    Sept 2020 FET#3: one XX embryo, BFP, Beta#1 (9dpt) - 161, Beta#2 (11dpt) - 519, Beta#3 (19dpt) - 7174, Due date 05/30/2021
    DD born 05/23/2021 👨‍👩‍👧‍👦 - My family is now complete <3
  • @fuzzydust- did you nurse draw circle where you are supposed to inject? Alot of ladies do them a little too low sometimes. Bleeding should be really minimal unless you hit a vein (which is rare for most), so if yours are bleeding most times maybe double check you are doing them in the right area? The 18G was huge but I thought the bigger the number, the bigger the gauge and it said to inject with the 22G.. so definitely my fault and i realized it after 2 nights!
    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
  • @JamieH2000 haha, I did the same thing for like a week. I had the smaller needles stored away and forgot about them
  • prudence9-2prudence9-2 member
    edited September 2017
    I use the 21G as my draw and 22G to inject. I don’t think ice prior is good because the muscle will be more stiff. 

    I do the injection with no icing of the spot or warming of the PIO. But after the injection I put heat pad on my butt. 

    Back in August when I used it I had crazy reactions to it. So I would do the injection in the morning, followed by heat pad. But then at night I’d put ice patch on my butt.
    TTC history in spoiler box:
    Me: 42, single
    Hysteroscopy: 2013
    IUI #1-2: 2013 BFN
    Surgery 10/2015: Planned to start trying again but had a surgery. (Not related to fertility)
    Surgery 5/2016: Planned to start trying again but had another surgery. (Not related to fertility)
    IUI  #3-5 (with Clomid): summer 2016 BFN
    IVF #1: 11/2016. 30R; 21M; 20F; 8B (6 day5 & 2 day6); 4 normal after PGS
    Medicated FET #1: 1/31/2017 transferred 1 embryo 3AA. BFP. Embryo stopped growing at 6w 1d. MUA at 9w 3d.
    Medicated FET #2June 2017 - cancelled...
    Hysteroscopy #2: June 2017
    Medicated FET #2: 8/7/2017 transferred 1 embryo 5BB. BFP. Ended in CP.
    Medicated FET #3: 10/11/2017 transferred 1 embryo 3AA. BFN
    ERA: December 2017 - need an extra 12 hours of PIO
    Medicated FET #4: 1/24/2018 transferred 1 embryo 4AA. BFN
    Out of embryos.  :'(
    IVF #2: 03/2018.

  • @FuzzyDust I actually used a 25 g needle which most people avoid because it takes longer for the oil to be pushed through. I preferred that over a larger needle gauge like the 22. 
  • JamieH2000 I had a nurse draw a circle for my trigger shot for IVF, so I kinda remember where they were. Also, someone mentioned on this forum earlier - the way you find the spot is putting your thumb on a hip bone, and then extending fingers all the way around, parallel to the floor, and then inject where the index finger hits - it was exactly where I was marking it for DH! Since I use a bandage with numbing cream for an hour prior, he has nice bandage imprint to aim at!
    The bleeding is minimal, just a little drop once the needle is out.

    prudence9-2, I like the heat pad idea. I currently use my DH as a heat pad, since we do it right before the bed, and then I tuck my injection site into his warm belly :)

    rachel2107, have you tried the 22G? Did it feel different from the 25G?
    -----------------------------------------------------------------------------------------------------
    My story in signature spoiler. Children mentioned.
    Me: 37 DH: 45
    I don't produce FSH, so no natural menstrual cycle. DH has reduced morphology.
    Summer 2014 IUI (with first husband): cancelled after almost a month of stims due to too many follicles
    Time off to divorce, get back on my feet, find a new hubby and get married again 💑
    March 2017 IVF#1: ~70 follicles, 13R, 10M, 7F, 3B = 2 PGS Normal (both XY) - no transfer due to ohss
    Sept 2017 FET#1: BFP, Beta#1 (10dpt) - 253, Beta#2 (12dpt) - 528, DS born 05/31/2018 👨‍👩‍👦
    Dec 2019 FET#2: BFN
    Changed clinic, planning March 2020 IVF#2 - postponed due to the pandemic
    April 2020 IVF #2: ~30 follicles, 24R, 12M, 8F, 4B = 2XY & 2XX, all normal  <3
    Sept 2020 FET#3: one XX embryo, BFP, Beta#1 (9dpt) - 161, Beta#2 (11dpt) - 519, Beta#3 (19dpt) - 7174, Due date 05/30/2021
    DD born 05/23/2021 👨‍👩‍👧‍👦 - My family is now complete <3
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