So I've read a lot of old posts, and it looks that majority of the people use 22G 1.5 inch needles for their PIO injections.
Last might I checked my needles, and they are 21G. I also heard of many people using ice to numb the area, but also that some RE say it's a bad idea, as it might mess with absorption (even if the oil is warmed up, it can get more solid once injected into the cold area)
My DH does the shots on me, but I use some numbing cream every time (put a little indies a water-proof bandage and slap in on for an hour prior to injection), and it really helps. However, I didn't really ask my RE if that's safe to use every day (and on the same area) for this long, so I'm considering my other options, just in case.
I wonder if the smaller needle (22G instead of 21G) would make a difference. I actually heard that thicker needle might be even better, since it's easier to pump the oil through, but does it make any difference during the time the needle goes in?
Looking forward to hear you experience with it, and if you tried different size needles.
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My story in signature spoiler. Children mentioned.
Me: 37 DH: 45
I don't produce FSH, so no natural menstrual cycle. DH has reduced morphology.
Summer 2014 IUI (with first husband): cancelled after almost a month of stims due to too many follicles
Time off to divorce, get back on my feet, find a new hubby and get married again 💑
March 2017 IVF#1: ~70 follicles, 13R, 10M, 7F, 3B = 2 PGS Normal (both XY) - no transfer due to ohss
Sept 2017 FET#1: BFP, Beta#1 (10dpt) - 253, Beta#2 (12dpt) - 528, DS born 05/31/2018 👨👩👦
Dec 2019 FET#2: BFN
Changed clinic, planning March 2020 IVF#2 - postponed due to the pandemic
April 2020 IVF #2: ~30 follicles, 24R, 12M, 8F, 4B = 2XY & 2XX, all normal

Sept 2020 FET#3: one XX embryo, BFP, Beta#1 (9dpt) - 161, Beta#2 (11dpt) - 519, Beta#3 (19dpt) - 7174, Due date 05/30/2021
DD born 05/23/2021 👨👩👧👦 - My family is now complete

Re: PIO needle size and does it make a difference?
And yes, the numbing cream only numbs the outer layer, where the prick happens. I must be a cry baby, that that's the scary part for me. I'm going to ask my nurse about the safety of the cream when they call me with Beta results (probably not until next Monday).
My story in signature spoiler. Children mentioned.
I don't produce FSH, so no natural menstrual cycle. DH has reduced morphology.
Summer 2014 IUI (with first husband): cancelled after almost a month of stims due to too many follicles
Time off to divorce, get back on my feet, find a new hubby and get married again 💑
March 2017 IVF#1: ~70 follicles, 13R, 10M, 7F, 3B = 2 PGS Normal (both XY) - no transfer due to ohss
Sept 2017 FET#1: BFP, Beta#1 (10dpt) - 253, Beta#2 (12dpt) - 528, DS born 05/31/2018 👨👩👦
Dec 2019 FET#2: BFN
Changed clinic, planning March 2020 IVF#2 - postponed due to the pandemic
April 2020 IVF #2: ~30 follicles, 24R, 12M, 8F, 4B = 2XY & 2XX, all normal
Sept 2020 FET#3: one XX embryo, BFP, Beta#1 (9dpt) - 161, Beta#2 (11dpt) - 519, Beta#3 (19dpt) - 7174, Due date 05/30/2021
DD born 05/23/2021 👨👩👧👦 - My family is now complete
Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
March-May 2016: 1 TI and 2 IUIs- BFN
June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze
May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline
Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid
Nov 2017- Hysterscopy to remove polyp
Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
Apr 2018- DE FET cancelled for lining issues
Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
Baby Born born early @ 33.5 weeks due to Pre-e
Back for # 2!
I told DH after the last one to please try to leave at least 1cm space between the new and the old spot. He tried rubbing 2 days ago, but I felt like it made me bleed a bit more at the site of injection. Yesterday he tried just pressing hard a few time, and it felt quite sore, but bled less - just a small red dot.
My story in signature spoiler. Children mentioned.
I don't produce FSH, so no natural menstrual cycle. DH has reduced morphology.
Summer 2014 IUI (with first husband): cancelled after almost a month of stims due to too many follicles
Time off to divorce, get back on my feet, find a new hubby and get married again 💑
March 2017 IVF#1: ~70 follicles, 13R, 10M, 7F, 3B = 2 PGS Normal (both XY) - no transfer due to ohss
Sept 2017 FET#1: BFP, Beta#1 (10dpt) - 253, Beta#2 (12dpt) - 528, DS born 05/31/2018 👨👩👦
Dec 2019 FET#2: BFN
Changed clinic, planning March 2020 IVF#2 - postponed due to the pandemic
April 2020 IVF #2: ~30 follicles, 24R, 12M, 8F, 4B = 2XY & 2XX, all normal
Sept 2020 FET#3: one XX embryo, BFP, Beta#1 (9dpt) - 161, Beta#2 (11dpt) - 519, Beta#3 (19dpt) - 7174, Due date 05/30/2021
DD born 05/23/2021 👨👩👧👦 - My family is now complete
Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
March-May 2016: 1 TI and 2 IUIs- BFN
June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze
May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline
Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid
Nov 2017- Hysterscopy to remove polyp
Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
Apr 2018- DE FET cancelled for lining issues
Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
Baby Born born early @ 33.5 weeks due to Pre-e
Back for # 2!
I do the injection with no icing of the spot or warming of the PIO. But after the injection I put heat pad on my butt.
Back in August when I used it I had crazy reactions to it. So I would do the injection in the morning, followed by heat pad. But then at night I’d put ice patch on my butt.
Hysteroscopy: 2013
IUI #1-2: 2013 BFN
Surgery 10/2015: Planned to start trying again but had a surgery. (Not related to fertility)
Surgery 5/2016: Planned to start trying again but had another surgery. (Not related to fertility)
IUI #3-5 (with Clomid): summer 2016 BFN
IVF #1: 11/2016. 30R; 21M; 20F; 8B (6 day5 & 2 day6); 4 normal after PGS
Medicated FET #1: 1/31/2017 transferred 1 embryo 3AA. BFP. Embryo stopped growing at 6w 1d. MUA at 9w 3d.
Medicated FET #2: June 2017 - cancelled...
Hysteroscopy #2: June 2017
Medicated FET #2: 8/7/2017 transferred 1 embryo 5BB. BFP. Ended in CP.
Medicated FET #3: 10/11/2017 transferred 1 embryo 3AA. BFN
ERA: December 2017 - need an extra 12 hours of PIO
Medicated FET #4: 1/24/2018 transferred 1 embryo 4AA. BFN
Out of embryos.
IVF #2: 03/2018.
The bleeding is minimal, just a little drop once the needle is out.
prudence9-2, I like the heat pad idea. I currently use my DH as a heat pad, since we do it right before the bed, and then I tuck my injection site into his warm belly
rachel2107, have you tried the 22G? Did it feel different from the 25G?
My story in signature spoiler. Children mentioned.
I don't produce FSH, so no natural menstrual cycle. DH has reduced morphology.
Summer 2014 IUI (with first husband): cancelled after almost a month of stims due to too many follicles
Time off to divorce, get back on my feet, find a new hubby and get married again 💑
March 2017 IVF#1: ~70 follicles, 13R, 10M, 7F, 3B = 2 PGS Normal (both XY) - no transfer due to ohss
Sept 2017 FET#1: BFP, Beta#1 (10dpt) - 253, Beta#2 (12dpt) - 528, DS born 05/31/2018 👨👩👦
Dec 2019 FET#2: BFN
Changed clinic, planning March 2020 IVF#2 - postponed due to the pandemic
April 2020 IVF #2: ~30 follicles, 24R, 12M, 8F, 4B = 2XY & 2XX, all normal
Sept 2020 FET#3: one XX embryo, BFP, Beta#1 (9dpt) - 161, Beta#2 (11dpt) - 519, Beta#3 (19dpt) - 7174, Due date 05/30/2021
DD born 05/23/2021 👨👩👧👦 - My family is now complete