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Intro (losses mentioned)

carterh33carterh33 member
edited October 2016 in Infertility
Hello! DH and I have been TTC for about a year now. I had my first loss at 10 weeks April 1st and my second loss 9/2 at around 3-4 weeks. I do have hypothyroidism and my levels were high when tested during my second pregnancy. After the second loss I got some blood work done and found out I have a MTFHR (A198C and C677T) and prothrombin factor 2 gene defects. My OB referred me to an RE. Any one experience anything similar to the gene defects and what did your RE do? I'm so sorry we all have to be here. 
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Re: Intro (losses mentioned)

  • Marley629Marley629 member
    Hi and welcome! I don't have experience with those genetic conditions but I think there are a few on here who may be able to provide insight.  Good luck with your journey and I hope your stay here is short! 
    DH: 34 | Me: 35
    DS1 9/24/13
    DX Diminished Ovarian Reserve, Factor V Leiden Mutation, Secondary Infertility
    MFI (SA #1    Count 11mill, Motility: 18%, Morphology: 1%)
    MFI (SA #2Count 7 mill, Motility: 18%, Morphology: 1%)
    AMH .328     | FSH 13.2 
    Oct. 2016: Clomid + TI
    IVF: ER 3/1/17; 5 retrieved, 3 mature & fertilized
    Results: 2 PGS normal embryos
    Planned on August 2017 transfer
    **TW**
    Natural BFP 4/3/17,Expecting baby boy via RCS 12/7/17

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  • latershraderlatershrader member
    Welcome! I do not have any insight to the genetic issues and I'm sorry that you have to be here with us. But hopefully you can find some support here! Wishing you lots of luck!
    *TW below*
    Me: 40 DH: 38
    TTC since November 2012
    BFP IUI Cycle 2 Dec 2016
    Baby Boy Due Sept 12 2017
    Elias (Eli) born 9/2/17 at 7:07pm weight 8lbs 10oz and 20.5 inches long!!


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  • lablover78lablover78 member
    Hi! I mostly hang on the TTTC board but I have the same genetic defects you do- 1 copy of each.  My RE is the one who diagnosed me -he ordered tons of lab work (I had transferred care from another RE so I had done a lot of the standard testing -his was way different) he put me on a ton of supplements but also some pharmaceuticals for off label uses because my tumor necrosis factor (TNF) was undetectable, as well as lots of diet recommendations. After my TNF was in range he gave me an intralipid infusion and I am in my TWW. The MTHFR can be so overwhelming and confusing but there are a couple of facebook groups that I belong to for MTHFR & pregnancy you should join. There are not too many ladies here who are familiar. It can also be very individual treatment depending on your issues. If your dr suspects blood clots are affecting your pregnancy s/he may use a blood thinner. PM your name and I can add you to the facebook groups:) 
    TTC since May 2013
    Mild PCOS, Compound Heterozygous MTHFR
    No Folic acid/pharmaceuticals/supplements (too many to list- private message me if interested), IVIL infusion
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  • oxinfreeoxinfree member
    edited October 2016
    @carterh33 I have MTHFR will be on lovenox and am taking Metanx (really important to not take folic acid as it cannot be properly absorbed by the body, you need methylfolate). (I'll also be on prednisone and do intralipids fyi). Like @lablover78 said - there are some Facebook groups floating out there that discuss these things. One I'm part of it Reproductive Immunology Support. Some links below. Good luck. xx

    https://www.dietvsdisease.org/l-methylfolate-5-mthf/
    https://mthfr.net/folate-and-mthfr-are-they-affecting-your-pregnancy/2014/05/29/
    ---
    Started TTC April 2011
    Me: 32, DH: 32
    Diagnosis: Endometriosis

    • 2012 - 3 Rounds clomid - all BFN
    • 2013 - 1 Fresh IVF with 2 day 3 embryos - BFN
    • 2014 - 1 Frozen IVF with 2 day 5 embryos - BFN
    • Took a long break, continuing trying naturally
    • Feb 2016 - Biopsy = Endo, DH sperm improved from 1% to 6% morphology
    • March 2016 - Fresh IVF cycle with acupuncture & intralipids: 20 eggs retrieved (17 mature), 7 ICSI'd fertilized, 9 naturally fertilized. 16 total embryos!
    • April 8th - 2 embryos (1ICSI and 1 Natural) transferred. (7 blastocysts frozen), April 18th - Beta = BFN
    • Sept 23rd - Lupron Depot Injection for Endo control
    • Nov 15th 2016 - Started daily Lupron Injections for upcoming FET
    • Nov 22 - Baseline US/BW - Intralipid Infusion - Start Meds for FET with immune protocol
    • Dec 16th FET transfer of 3 embryos (1 - AA, 2 - BB)
    • TW below
    • Dec 22nd - first ever bfp (very faint lines FRER & cheapie)
    • Dec 27th Beta = 192, Dec 29th Beta = 379
    • EDD - Sept 5th 2017

    - - -
    I'm a YouTube vlogger who talks about Infertility, IVF and Endometriosis. Check it out here!
    Follow along at http://liv4today.blog
    Instagram @liv4todayvlog 


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  • taradise99taradise99 member
    Hi welcome! I am also compound hetero mthfr. I am taking a prenatal with methylfolate, metanx, extra b12, extra b6, baby asprin and lovenox as well as other supplements. I also am taking synthroid for my thyroid. I would have your prolactin level checked as well because it is common with hypothyroid to also have this out of whack. Good luck to you, message me if you need any more info as it seems we have a lot of the same conditions:)
    Me: 34 / Hubs: 35
    Married December 2008
    TTC: 2010
    3 ectopic pregnancies, moved on to IVF 2011
    3 rounds of IVF, 1 miscarraige, two BFN
    Started with new RE Fall 2015
    Diagnosed Compound Hetero MTHFR
    Hysteroscopy to remove abrasions 
    Began Stims for IVF #4 10/11/16
    Long Lupron protocol
    ER 10/23/16 6R, 5M all 5 fertilized via ICSI
    ET 10/28/16 Transferred 2 5bb blasts; 2 frosties! BFP!
    Twins! EDD 6/25/17
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  • carterh33carterh33 member
    Thank you! It's gives me hope that hopefully all this can be managed! 
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