embryos not surviving thaw

Re: embryos not surviving thaw

• Elyse1384 member

  October 2016

  Huh that's odd.  Sorry I don't have experience with that happening, but I wuold recommend you inquire as to the thaw procedure they use and survival rates they see?  My clinic has a 90%+ survival rate.  I'm a bit surprised since these were day 5 embryos for you.  I would ask them for more info.

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• wifeinraleigh28 member

  October 2016

  Wow, I'm so sorry this happened You must feel so crushed and confused. I asked my clinic about survival rates from thawing and they told me that they NEVER see day 5 embryos not survive the thaw. I would absolutely ask your clinic what happened and what their survival rates are, because that just sounds unacceptable to me! Sorry hun.

  ***BFP & Child Warning***
  
  Me: 34, DH: 38 ~ TTC since 2014
  IUI #1-3 (Nov 2015, Feb 2016, May 2016) = BFNs
  IVF ER (July 2016) = 7 PGS normal embryos
  FET #1 (Sept 2016) = BFP! DD born 5/30/17
  FET #2 (April 2019) = BFN
  FET #3 (July 2019) = BFP! DS born 3/27/20

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• JamieH2000 member

  October 2016

  I haven't gotten to ER, so I don't have any experience with the thawing process,  but just wanted to say I'm so sorry this happened since I remember you from our aug group. I would be very upset and definitely want answers. Are you planning to transfer the 1 now or still do pgs? I really hope this last embaby is the one! Thinking of you!

  History in Spoiler
  
  

  Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
  Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
  March-May 2016: 1 TI and 2 IUIs- BFN 
  June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
  August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
  Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
  January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze ), BFN
  May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline
  Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid
  Nov 2017- Hysterscopy to remove polyp
  Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
  Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
  Apr 2018- DE FET cancelled for lining issues
  Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
  Baby Born born early @ 33.5 weeks due to Pre-e
  Back for # 2!

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• oxinfree member

  October 2016

  @teamginger13 Oh no... how devastating. I'm so so sorry that happened. Is the other one off for PGS testing? Did it get thawed to get tested and then re-frozen? I'm a bit confused. I'm really hoping that one that did survive gets put back and turns into a happy healthy little baby. hugs
  
  @wifeinraleigh28 @Elyse1384 - This is making me realize I actually have no clue what my clinic's thaw survival rates are... eek. Probably should have asked that before we froze the other 7 embryos. 
  
  
  

  ---
  Started TTC April 2011
  Me: 32, DH: 32
  Diagnosis: Endometriosis
  
  

  • 2012 - 3 Rounds clomid - all BFN
  • 2013 - 1 Fresh IVF with 2 day 3 embryos - BFN
  • 2014 - 1 Frozen IVF with 2 day 5 embryos - BFN
  • Took a long break, continuing trying naturally
  • Feb 2016 - Biopsy = Endo, DH sperm improved from 1% to 6% morphology
  • March 2016 - Fresh IVF cycle with acupuncture & intralipids: 20 eggs retrieved (17 mature), 7 ICSI'd fertilized, 9 naturally fertilized. 16 total embryos!
  • April 8th - 2 embryos (1ICSI and 1 Natural) transferred. (7 blastocysts frozen), April 18th - Beta = BFN
  • Sept 23rd - Lupron Depot Injection for Endo control
  • Nov 15th 2016 - Started daily Lupron Injections for upcoming FET
  • Nov 22 - Baseline US/BW - Intralipid Infusion - Start Meds for FET with immune protocol
  • Dec 16th FET transfer of 3 embryos (1 - AA, 2 - BB)
  • TW below
  • Dec 22nd - first ever bfp (very faint lines FRER & cheapie)
  • Dec 27th Beta = 192, Dec 29th Beta = 379
  • EDD - Sept 5th 2017

  
  - - -
  I'm a YouTube vlogger who talks about Infertility, IVF and Endometriosis. Check it out here!
  Follow along at http://liv4today.blog
  Instagram @liv4todayvlog 
  

  
  

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• jodes727 member

  October 2016

  @teamginger13  I am sorry that this happened to you! We did PGS testing and have two frozen right now and are planning on transferring one at the beginning of November. I was nervous about the throwing process since we only have two, but my doctor said that has not been an issue that they do not make it through the thawing process. I too would definitely question why this happened! Good luck to you!!

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• Joslynj11 member

  October 2016

  @teamginger13 I am so sorry to hear that you are experiencing this right now. Going into my second transfer we have 6 in the freezer but after waiting over an hour and a half on the "embryos to develop" they thawed the last 2 and said they would let me know if the others made it. It turned out that they didn't so now we are waiting to get started with our 2nd round of IVF. We are going to change protocol to see if we can get some better quality embryos since my Dr thinks that could have been a factor but he was not able to give me anything definite to go off. Hugs to your girlie, I hope you can get some answers.

  Me: 29 DH:38
  

  First RE Consult 3/9/2016
  IVF ER 5/5/2016
  23 eggs retrieved; 15 mature; 8 developed to embryos; 6 frozen day 5; 2 frozen day 6
  Transfer canceled OHSS
  FET #1 6/2/2016 transferred 2 embryos
  Beta #1 6/15/2016 BFN
  FET #2 8/1/2016 transferred last 2 embryos (lost 4 in the thaw)
  Beta #1 8/12/16 BFN
  IVF #2: Started stims 12/2 
  ER #2 12/14/2016; 16 follies retrieved, 8 fertilized to day 1, 4 frozen day 5, and 1 frozen day 6
  Praying my frosties are strong through the next thaw FX
  FET # 3 2/07/2017 2 embabies thawed 2 embabies transferred
  2/14/2017 *TW* First ever BFP
  Beta #1 2/20/2017 277 Beta #2 2/23/2017 8,945...did I hear you right!
  3/10/2017 One beating heart HR 168!! So very happy
  3/10/2017 Official graduate from Jones Institute for Reproductive Health!! Couldn't help but cry
  6/8/2017 Anatomy Scan proves ITS A GIRL! 
  10/30/17 An angel was Born; Riley Charlize 7:50 AM my heart is so full

  *Praying that 3 is our charm*
  
  
  

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• teamginger13 member

  October 2016

  Thanks everyone for your kind words. It is super frustrating and sad. We did end up sending the last one off for PGS testing. We have a meeting scheduled with the RE after the results come back and I plan to get some answers as to why/how this happened.

  Me 35, DH 37

  Unexplained infertility and TTC since December 2014

  February 2016 - May 2016: 3 IUI's -- all BFN

  August 2016: IVF #1 (Lupron, Gonal F and Menopur) -- 12 retrieved, 9 fertilized, 3 frozen and 1 x day 5 hatching blast transferred -- BFN. Sent remaining 3 embryos for PGS testing -- 2 didn't survive thaw, 1 was abnormal.

  February 2017: IVF #2 (Gonal F, Menopur, and Ganirelix) -- 12 retrieved, 6 fertilized, 3 sent for PGS testing and all were abnormal

  March 2018: IVF #3 (Menopur, Follistim, Ganirelix and HGH) -- 14 retrieved, 12 fertilized, 4 sent for PGS testing, and 3 were PGS normal

  May 2018: FET #1 -- BFN

  August 2018: FET #2 -- BFP!!! healthy baby girl born May 2019!!

  July 2020: FET #3 -- embyro did not survive thaw

  September 2020 - IVF #4 (Menopur, Follistim, Ganirelix and HGH) -- 1 PGS normal

  October 2020 - FET #4 -- BFN

  January 2021 - IVF #5 (Menopur, Follistim, Ganirelix and HGH)  -- 2 PGS normal

  February 2021 - FET #5 - BFP!!! Due 11/6/2021

  
  

  
  

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• oxinfree member

  October 2016

  Hoping for some good news to come back your way @teamginger13 !!!

  ---
  Started TTC April 2011
  Me: 32, DH: 32
  Diagnosis: Endometriosis
  
  

  • 2012 - 3 Rounds clomid - all BFN
  • 2013 - 1 Fresh IVF with 2 day 3 embryos - BFN
  • 2014 - 1 Frozen IVF with 2 day 5 embryos - BFN
  • Took a long break, continuing trying naturally
  • Feb 2016 - Biopsy = Endo, DH sperm improved from 1% to 6% morphology
  • March 2016 - Fresh IVF cycle with acupuncture & intralipids: 20 eggs retrieved (17 mature), 7 ICSI'd fertilized, 9 naturally fertilized. 16 total embryos!
  • April 8th - 2 embryos (1ICSI and 1 Natural) transferred. (7 blastocysts frozen), April 18th - Beta = BFN
  • Sept 23rd - Lupron Depot Injection for Endo control
  • Nov 15th 2016 - Started daily Lupron Injections for upcoming FET
  • Nov 22 - Baseline US/BW - Intralipid Infusion - Start Meds for FET with immune protocol
  • Dec 16th FET transfer of 3 embryos (1 - AA, 2 - BB)
  • TW below
  • Dec 22nd - first ever bfp (very faint lines FRER & cheapie)
  • Dec 27th Beta = 192, Dec 29th Beta = 379
  • EDD - Sept 5th 2017

  
  - - -
  I'm a YouTube vlogger who talks about Infertility, IVF and Endometriosis. Check it out here!
  Follow along at http://liv4today.blog
  Instagram @liv4todayvlog 
  

  
  

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• jodes727 member

  October 2016

  @teamginger13 good luck with everything. Waiting to get our test results was a tough wait (2 out 3 came back normal for us).  I would Definitely be asking your RE about things, that just isn't fair...not like much is with IF. 

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• mrsdaddario member

  October 2016

  @teamginger13 I don't have any experience with anything IVF related, but I wanted to say how sorry I am. I know that must have hit you like a ton of bricks. I really hope when you meet with the RE you can get some answers. 

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• APM_SLP member

  October 2016 edited October 2016

  I was worried about this with my frosties.  I asked my nurse if she had ever seen an embie not survive the thaw and she said not in the 5 years she's worked there.  I would definitely inquire about their thawing process or other factors that may cause that etc.  I am so sorry you have to deal this! 

  Me: 35  DH: 36
  Me: 1, possibly 2, blocked tubes
  DH: severe MFI
  Married and TTC since 2/15
  Started stims 7/21/16, ER  8/2 --> 17 eggs, 5 blasts after PGS testing.
  Fresh transfer 8/8/16: Chemical Pregnancy
  FET #1 9/13: PGS tested 5AA, BFN
  Endometrial biopsy 10/18/16: normal result
  ERA test 10/18/16: "receptive" result
  FET #2  1/3/17: natural cycle, BFP!!! TWINS!!  EDD: 9/21 (8/31 with twin adjustment)
  
  

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• ddvj79 member

  October 2016

  @teamginger13 - just wanted to say I'm really sorry.
  In our 2nd cycle, we had just 2 embroys to freeze. On the day of the transfer one did not make it. I know it really crushes you. I hope your 1 embie comes back normal and you get your take home baby from it.
  
  

  DH :  36, has Chronic Kidney Disease, on dialysis & is waiting on the transplant list (average wait for B+ is 5 years)

  Me:   36, Hypothyroidism, PCOS, BMI 32, need to be done with "child bearing" ASAP so that I can be a Kidney donor (was fun realizing we didn't as much time as we thought :-/ )

  We're TTC#1

  IUI #1 : 5mcg Letrozole (CD 3-7) + Ovidrel Trigger + Had the one follicle = BFN  (March 2014)

  IUI #2 : 5mcg Letrozole (CD 3-7) + 150 iu Bravelle on CD9 (after much begging!) + Had the one follicle = BFN (April 2014)

  7th May 2014 - changed REs, this one seems to care (we think....)

  IUI #3 : 7mcg Letrozole (CD 3- 7) + 75 iu Bravelle (CD 8-12) + CD12 Scan 5/16 + Had 3 follicles (2 under 15mm) = BFN(May 2014)

  IUI #4 : 7mcg Letrozole (CD 3- 7) + 75 iu Bravelle (CD 8-12) + CD12 Scan 5/16 + Had 1 follicle + DH gave best sample so far = BFN(June 2014)

  IVF#1 -  ER Only Cycle Sept-Oct 2014, 17  eggs Retrieved, 14 mature, 10 fertilized, 6 made it to Blast & post PGS  5 were not viable due to chromosomal abnormalities
  Not sure where we go from here...

  We're parents to two very adorable, bratty, affectionate & goofy Bernese Mountain Dog pups who would very much like a 2 legged baby brother or sister of their own!

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