TTC after 35

First post - Anyone have experience with HGH or microflare protocol? (Child and losses mentioned)

Hello and thank you for creating a space where people like me can find support during this challenging time.

I had my DS with my first husband when I was 31. I am now 36 and remarried TTC my second child (but my DH's first). Our first two pregnancies and losses came fast last year. After that happened, my OB and RE both recommended TTC again (with a randomly occurring egg) via IUI since it is so rare to lose a third in a row. Those efforts didn't work, but honestly I was OK because I felt IVF with PGD/AS testing would a great solution for our issues. I expected to produce a normal amount of eggs, and several people I know successfully overcame IF with IVF.

Our first cycle was a total failure. It turns out I have diminished reserve and the quality of my eggs appears to be unusually poor for my age. The first cycle was a standard long protocol (Lupron, Follistim, and Menopur) with bumped up doses of Follistim in the beginning. Not one of the four fertilized embies made it to blast, let alone freezing and testing. Our hearts broke.

Round 2 starts tomorrow, March 20th. It's the short microflare protocol with HGH. This time I'm on micro Lupron, max doses of Brevelle and Menopur, and six days of HGH (omnitrope). My RE said protocol is known to be better for people like me. He also said we may have serious cause for concern if this doesn't yield quality embies.

Have any of you integrated HGH in your treatment? If so, can you share the results? I'm also hoping to hear from people who switched to the microflare protocol.

Thank you for sharing your experiences or support!

Me: 35 DOR - AMH 1.1 FSH 5.6

DH: 39

09/01/10 - First pregnancy - my sweet son was born 

04/25/14 - Miscarriage at 9 weeks - Turner Syndrome 

08/01/14 - Miscarriage at 8 weeks - Trisomy 9 

October 2014 - Unsuccessful IUI 

November 2014 - IUI month skipped due to cyst 

December 2014 - Unsuccessful IUI 

January/February 2015 - Failed IVF (standard long protocol) - 7 eggs, 6 mature, 4 fertilized (ICSI), 0 made it to blast, 0 for testing 

March/April 2015 - Microflare IVF protocol with HGH - 6 eggs, 6 mature, 5 fertilized (ICSI), 2 blasts for biopsy! 

May/June 2015 - Microflare IVF protocol with HGH - 9 eggs, 6 mature, 5 fertilized (ICSI), 3 blasts for biopsy!

06/18/15 -  Two healthy embies based on PGS testing by Natera!

June/July 2015 - FET cycle with estradiol & PIO shots, a Neupogen treatment, and accupuncture

07/08/2015 - Transferred one lovely embie 

07/17/2015 - Beta #1 136

07/20/2015 - Beta #2 529 -- BFP!!!

Re: First post - Anyone have experience with HGH or microflare protocol? (Child and losses mentioned)

  • I'm sorry for your losses and challenges. I don't have any experience but offering a welcome and support.
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  • Welcome to the board.  Everyone here is so supportive and we have several ladies who have undergone IVF.  I'm sure they'll respond soon.  Good luck.  I'm so sorry you're going through this.
    *** Child & current pregnancy mentioned ***
    Me - 41 (PCOS), Hubby - 43 (healthy)
    7/2013 - Sweet baby girl born (Clomid + TI)
    3/2014 - TTC #2, return to RE 7/2014
    12/2015: IVF #1 transferred two great looking embryos - BFP!
    First ultrasound: TWO beautiful little heartbeats!!
    Harmony: negative; level 2: babies look great and are boy/girl! :) 
  • I am on Estrogen Priming Protocol with Microdose Lupron.  So similar but not quite, I just wanted to wish you well :)
    H: 34 dx Azoospermia due to CBAVD from CF  
    ME: 39 IS FINE!!!  DOR and poor AMH/FSH/LH
    IVF/ICSI/PESA #1 Beta 1 373 Beta 2 1783 BOY/GIRL TWINS!! Born April 2010!!
    Natural FET 5/26/12 2 blasts Beta 1 207 Beta 2 513 Beta 3 1377 U/S 6/28 Pregnancy not viable d & c scheduled :( 
    IVF/ICSI/PESA #2 ER 11/15/12 Nothing to transfer :( 
    IVF/ICSI #3 April 2013 MDLF 3dt of 3 embryos, chemical :(  
    IVF #4/ICSI/MESA/CCS/FET EPP April 2015
    ODWU CCRM with Dr. Sch COMPLETE!!!! Put on acai supplement they are studying for DOR and embryo quality.
    DAY 3 Labs Drawn 2/26 put on vitamin D and calcium supplements
    Regroup and Protocol Reveal 3/04 "Bazooka Protocol" EPP with MDLF "Protocol 6 with patches"
    ER/MESA 4/10 ER 9 eggs retrieved MESA success found live swimmers :)
    Fertilization Report 6 eggs mature and ICSI'd 4 eggs fertilized normally
    Day 6 Report to Blast for CCS 4/16: 2 DAY 5 BLASTS BIOPSIED FOR CCS a 4AB and a 3AB!!!!
    CCS Results BOTH BLASTS CCS NORMAL!!!!!!  call on 4/24
    Regroup call to discuss CCS results and FET call on 5/20
    FET prep: CD 1 6/08 CD 3 Start BCP 6/10, HSG 6/12 Lupron Start 10 iu 6/17 End BCP 6/21 CD 1 6/23!!!
    Start vivelle patches 6/25 change e/o/d reduce Lupron to 5iu 6/25 Blood Draw 7/01, 7/08, 7/15, 7/19
    Increase vivelle patches 7/03 2 change e/o/d and 7/05 change e/o/d 3 and 7/07 4 change e/o/d add vaginal estrace 2x a day
    Lining Check/Blood Draw 7/08 and 7/15 End Lupron 7/18  Start PIO 1ml daily 7/18  Blood  Draw 7/19
    Flight to clinic 7/22
    FET 2 CCS BLASTS :):)  7/23 :):) YES YES both thawed and both fully expanded :):)
    7/26 :):) 3dp5dt PM very very faint positive FRER
    7/27: 4dp5dt Neg Digi AM but very very faint positive FRER PM POSITIVE DIGI CLEARBLUE PREGNANT 1-2 :):) 
    7/31:8dp5dt AM POSITIVE DIGI CLEARBLUE PREGNANT 2-3!!!! :):) 
    Beta 1 8/01= 408!!!!!!!!!! at 9dp5dt FET
    Beta 2 8/03 = 1014!!!!!!!!!! at 11dp5dt FET
    8/05/2015 AM POSITIVE DIGI CLEARBLUE PREGNANT 3+!!!! :):) 
    First Ultrasound: 8/20!!!!!! TWINS!!!!!!!!!!!!!!!!!  Genetics says BOTH BOYS!!!!!!!!!
    Second Ultrasound: 9/03!!!!!!!!!!










     










  • i will just be starting my first round of ivf next week so can't share any experiences. But i wanted to welcome you and wish you well this cycle. 
    Me (42) w/ partner for 16+ years
    TTC #1: 11/2012 - 9/2013; 6/2014 - present
    Follistim + TI (3x): All BFNs
    Follistim + IUI (1x): BFN 
    IVF #1: 17 retrieved,15 fertilized, Day 3: 15, Day 5/6: 3 biopsied
    Result; 1 frozen blast (inconclusive PGS results)
    IVF #2; ER: 6/22 16 retrieved, 6/25: 5 transferred (CP), 2 frozen
    FET 9/17: BFN
    Current FET -- Transferred 2 day-3 embryos - BFN

  • CML11CML11 member
    **lurking**
    I had 3 cycles of IVF, first two were antagonistic protocol with Gonal, MenoPur, Ganirelex with the trigger shot of the HCG.
    Cycle 3 was the MicroFlare protocol with Lupron, Gonal with the trigger shot of the HCG. I also did assisted hatching. I also did acupuncture which may have improved the quality of my eggs. Whatever was the lucky component, Cycle 3 was the one that worked for me.
    I know everyone is different, many people reported negative results with the same protocol that I used. Feel free to message me anytime if you have more IVF questions :)
  • Thank you very much for the support, @CML11. I appreciate you (and everyone else) sharing your experiences. I'm also doing acupuncture this round as well. Everything but the kitchen sink! My baseline went great today (no cysts!) which is a positive start. Now I'm just waiting for my bloodwork to come in before I take my first shot.

    Me: 35 DOR - AMH 1.1 FSH 5.6

    DH: 39

    09/01/10 - First pregnancy - my sweet son was born 

    04/25/14 - Miscarriage at 9 weeks - Turner Syndrome 

    08/01/14 - Miscarriage at 8 weeks - Trisomy 9 

    October 2014 - Unsuccessful IUI 

    November 2014 - IUI month skipped due to cyst 

    December 2014 - Unsuccessful IUI 

    January/February 2015 - Failed IVF (standard long protocol) - 7 eggs, 6 mature, 4 fertilized (ICSI), 0 made it to blast, 0 for testing 

    March/April 2015 - Microflare IVF protocol with HGH - 6 eggs, 6 mature, 5 fertilized (ICSI), 2 blasts for biopsy! 

    May/June 2015 - Microflare IVF protocol with HGH - 9 eggs, 6 mature, 5 fertilized (ICSI), 3 blasts for biopsy!

    06/18/15 -  Two healthy embies based on PGS testing by Natera!

    June/July 2015 - FET cycle with estradiol & PIO shots, a Neupogen treatment, and accupuncture

    07/08/2015 - Transferred one lovely embie 

    07/17/2015 - Beta #1 136

    07/20/2015 - Beta #2 529 -- BFP!!!

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