Success after IF
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Decisions, Decisions

I have been agonizing about how many embryos to transfer ever since receiving the PGD report. If I transfer both and neither implants and grows into our take home child, I will deeply regret having made the wrong decision. If I transfer one successfully I might feel that I 'should' transfer the one remaining frostie although I would consider my family complete.

I am 37, TTC has been a part of my life since 2008 and I want to be finished with this phase of my life. I am so over the shots, the early mornings trips to the RE, the feeling of life being on hold and the emotional roller-coaster. MH and I would be okay with twins despite having previously delivered prematurely. br> Hypothetically, WWYD in my situation. We probably won't decide until a day or two before ET.
TTC since 3-08 IVF # 1 Dec 2011 BFP DD born at 31 weeks 6-24-12

FET #1 Dec 2013 BFN

FET # 2 Feb 2014 BFN

No more frosties

IVF #2. September 2014

PGD yielded 2 perfect 5d blasts

SET November 9, 2014
Nov 23, 2014. Another BFN

Not sure where to go from here.

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Re: Decisions, Decisions

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    What are there grades?
    6 m/c
    Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
    Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011
    1 Clomid/Ovidrel BFN May 2011
    Natural cycle Aug 2011 BFP M/C 4 Weeks
    1 IUI Sept 2011 BFP M/c 7 weeks
    Provera Dec 2011 BFP M/C 3 Weeks
    DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011
    IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
    IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
    Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
    Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) 
    Went to Beer Center- high tnf, low lad, implantation failure
    Nov/Dec 2012 LIT Treatment
    Dec 12 Humira
    Jan 2013 BFP
    Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
    Miracle Born August 2013 Premature

    Yours doesn't have to be a sad story



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    Lilypie - (ugiy)


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    luvboston said:

    What are there grades?


    According to RE, both are Grade A 5-day blasts.
    TTC since 3-08 IVF # 1 Dec 2011 BFP DD born at 31 weeks 6-24-12

    FET #1 Dec 2013 BFN

    FET # 2 Feb 2014 BFN

    No more frosties

    IVF #2. September 2014

    PGD yielded 2 perfect 5d blasts

    SET November 9, 2014
    Nov 23, 2014. Another BFN

    Not sure where to go from here.

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    Lilypie Premature Baby tickers
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    I totally get what you mean about moving past this phase of your life, I've actually said that same thing to multiple people. 

    Hypothetically, I would probably transfer one.  Your embryos sounds like they're great quality and we personally aren't open to twins right now (with a 2 year old at home).  My thinking is - if the first doesn't work, you have a second chance and if it does, then you can worry about the 2nd embryo later.  Our RE always told us that, in our case, transferring 2 would increase our chances of multiples, not necessarily pregnancy.

    Good luck with your decision!

    ___________________________________________________________________________

    Trying for #1 since May 2010   l   DX ~ Unexplained Infertility June 2011

    IUI #1&2 = BFN; IUI #3 = BFP, m/c @ 6 weeks

    November '11 ~ IVF#1 ~ ER 11/18 (29R, 17F) ~ 5dt of one beautiful blast on 11/23 = BFP!!

    Beta #1 9dp5dt = 116, P4 = 28 ~ Beta #2 13dp5dt = 700 ~ Beta #3 20dp5dt = 9500, P4 = 26

    1st u/s 12/27 - hb of 156!! EDD 8.10.12 :)   **TEAM GREEN!**

    Sweet baby boy born 8.18.12

    Baby Birthday Ticker Ticker

    Trying for #2

    FET #1 - October '13 - c/p   l   FET #2 - December '13 - cancelled :(   l   FET #2.2 - 1.30.14 - BFN

    ~ More testing - hysteroscopy, endometrial biopsy & more b/w - all normal / negative~

    Surprise BFP while waiting on FET #3 ~ beta #1 500; beta #2 1600; first u/s 4/3 - measuring 5w5d, no hb yet!; 2nd u/s 4/10 - hb 132, measuring 6w6d - EDD 11.29.14 :)    **TEAM GREEN!**

    Beautiful baby girl born 11.24.14

      Baby Birthday Ticker Ticker

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    Mrs.McIrishMrs.McIrish member
    edited October 2014
    I hope you don't mind me chiming in as I don't post here yet. Since you did PGD you know you have 2 normals, I would do a eSET. I'm carrying twins and it's hard. I've had no complications but it's still painful etc. I don't have any other babies so I can rest when I need to. I'm eternally grateful to be carrying twins so I never have to go to the RE again so I completely get your need to be done with IF treatments. But Running around after your DD while carrying twins would be tough. Do people do it? Yes. But I'd try to avoid it if possible especially since you delivered DD at 31 weeks. Spending all that time in the NICU with twins and DD at home would be really difficult. I totally get not wanting to leave one embryo un-transferred if the first ET works but you don't need to "go there" right now. Hope this helps.

    TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
    DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
    5 IUI's: 2/11 to 6/11 and 1/12= BFN
    OE IVF#1-4 8/11-6/12= all BFN
    DE IVF#1 11/12 bad embryos= BFN
    DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
    CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
    DE IVF #3 1/14  ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d

    DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
    First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!

    K & K born 11/21/14 at 38wks 4 days

    imageimage

    SAIF/PAIF Welcome


    http://waitingforraintostop.wordpress.com

  • Options
    Question..can you go back for round two and use the second then? Is cost no issue? 

    Married: 5/09 ~ TTC Since: 10/10 ~ PCOS ~ Progesterone from 10/10 - 2/11 ~ HSG on 3/18 - Clear ~ Started Metformin 1000mg & Clomid 50mg 2/11 ~ Metformin upped to 1500mg 4/6 ~ 6/7 Now going to SG and put on Clomid, Ovidrel, Gonal F, Prometrium, Estrace ~ IUI #1 7/2 = BFP!!!!!! March 6th our little man was born. 

    6/17/13 - Ovidrel, Follistim, Prometrium ~ IUI #1 7/2 = BFP! March 17th our St. Pattys day baby arrived

    10/29/17 - Started process for IVF, got pregnant & miscarried a 2nd time since summer. 2/22 started stims - Menopur, Gonal F, Cetrotide - retrieval 3/6 - , PIO, estrace 3xday - FET 4/18 = Beta 1: 616; Beta 2: 1342 = BFP 

  • Options
    Well, I was pregnant with twins while caring for DS. He turned two during my pregnancy and was almost 28 months when K&A were born. I'm not going to lie. It was hard, and I didn't have any complications. I am a SAHM and my H used four weeks of vacation he had saved up to take the last month of my pregnancy off. It would have been very, very difficult for me to do it on my own. I basically laid on the couch all day from weeks 34-38. Luckily, my h also got 4 weeks paternity leave and it all happened to fall so that his vacation time reset just when he got back to work a month after the girls were born.

    That being said, I wouldn't change things for the world. Twins are a lot of work, but they are also a lot of fun. We have always wanted 3 or 4 kids so going from one to three wasn't outside of our plans to start with.

    It is such a personal decision, and only you know what is right for you and your family. Wishing you all the best hon!
    image
    Unexplained Infertility

    After two Clomid cycles, three injectable IUI cycles, two IVFs, two miscarriages, and one lap surgery, IVF #2 has brought us our little boy!

    Baby Birthday Ticker Ticker

    TTC #2
    After months of being postponed or cancelled, FET #1.3 (Natural FET) brought us twin girls!

    Baby Birthday Ticker Ticker


    Surprise! Baby #4 is due in March!
  • Options
    That is such a hard (and unfair) decision to have to make Mo. I've been thinking about it and keep going back and forth. If you are ok with twins, and are ready to be done with this, I would lean towards transferring both. But I'm a super practical person. And I feel like I would rather have another chance if the first time didn't work out. There is no easy answer for this question Mo. Big hugs, and wishing peace for you and YH in your decision.
    TTC with PCOS since November 2009
    IUI#1 Femara/Ovidrel (cd 3-7) = BFP, m/c
    IUI#2 Femara/Ovidrel (cd 5-9) = BFN
    IUI#3 Femara/Ovidrel (cd 3-7) = BFP!
    beta #1 11/23 = 270, P4 = 75
    beta #2 11/28 = 2055
    Our daughter E was born 7/29/2012!
    Surprise, our 2nd daughter P was born 5/22/14!
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  • Options
    @MoFree, this is such a personal and hard decision.  I do not believe there is a wrong decision.  If I had two beautiful PGD normal embryos that were frozen separately, I would probably transfer one at a time.  If the first transfer worked, I would figure out what if anything I wanted to do with the second embryo (more likely than not, I would want to transfer it to give it a chance at a future date).  If, however, the embryos were frozen together such that to thaw one I had to thaw both, I would probably transfer both of them because if I didn't and the first transfer didn't work and then the second transfer didn't work, I would always wonder if the second one would have worked had I not needed to refreeze.

    This is such a tough decision.  Thinking of you and praying that you are able to find peace with whatever you decide.

    imageimage


    ~SAIF/PAIF/Everyone Welcome~ 

    Me= 37 and DH = 41 

    Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)

    IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN

    IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.

    IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132.  Lil is here!

    TTC#2:  Trigger + TI = BFN; Clomid + Trigger + IUI = BFN.

    IVF #4:  BCP + MDLF + Lovenox = 7R, 1F = Transferred 1 6-cell embryo on day 3 = BFN

    IVF #5:  MDLF + Lovenox = 4R, 1F = Transferred 1 10-cell compacting embryo on day 3 = BFN

    IVF #6:  (New RE):  Long Antagonist November 2014 (transferred two 8 cell grade 1 embryos and froze one blast) = BFN

    FET#1:  BFN

  • Options
    I'm really sorry you are in such a tough spot. Many hugs and prayers for you to make a decision that brings you a wonderful outcome and peace.

    As far as a WWYD, I would transfer one. One of my boys was a BB and one was so behind in development he wasn't even graded (they were both blasts, but one was making the transition to blast when we arrived for ET). So, with those wonderful grades, I think you have a great shot at both sticking. Here's the thing, I adore my boys and love that they are twins. They are each other's best buds and worst enemies, but the cuteness factor is out of this world. There's something so cool about being a twin mom and seeing them interact. They wrestle and giggle and it is so fun.

    With that being said, I still wish I'd had them as singletons. Like @Mrs.McIrish said, twin pregnancy is hard. You grow big and fast and it is wrought with potential complications and risks (although, there's always a chance of an easy pregnancy, the possible trouble made me uneasy throughout my whole pregnancy and I only ever had minor complications and no NICU time). I was in so much pain and having as many as 10 contractions/ hour (not even labor related, just ineffective contractions) for weeks. I could hardly function in the end. Caring for a toddler and being pregnant with twins would be so difficult.

    And, if I thought the pregnancy was rough, the newborn experience felt near impossible. I slept 20 minutes the first night home from the hospital. Nursing was hard, getting them to sleep was hard. I felt like someone was always crying and sometimes it was me. I'd fall asleep in the middle of sentences. Only now am I comfortable taking them to a park by myself (and it has to be fenced because they run). A solo museum or zoo trip is out of the question. They've just missed out on a lot because they are twins and have to share my attention. And, if you value privacy- kiss that goodbye. It takes us twice as long to run errands because we are constantly stopped by strangers. We get stared at and asked if they are "natural" more times than I'd like to admit.

    So, I realize this sounds awful and I really do love being a twin mom. If you transfer two and both stick, you will love it and have a wonderful time. But, I really believe it's only fair to present some of the challenges you might not normally consider. That's just my honest (and very long winded!) answer to your question.
    TTC in 2009, Dx: Unexplained IF
    Three TI cycles (BFP...miscarriage), five IUI attempts and 2.5 IVF cycles later...BFP!!
    12dp5dt: 765; 15dp5dt: 1979; 17dp5dt: 3379...TWINS!!!!!
    Our perfect baby boys were born at 36w1d!! 








  • Options
    I would transfer one.
    6 m/c
    Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
    Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011
    1 Clomid/Ovidrel BFN May 2011
    Natural cycle Aug 2011 BFP M/C 4 Weeks
    1 IUI Sept 2011 BFP M/c 7 weeks
    Provera Dec 2011 BFP M/C 3 Weeks
    DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011
    IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
    IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
    Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
    Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) 
    Went to Beer Center- high tnf, low lad, implantation failure
    Nov/Dec 2012 LIT Treatment
    Dec 12 Humira
    Jan 2013 BFP
    Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
    Miracle Born August 2013 Premature

    Yours doesn't have to be a sad story



    image
    image


    Lilypie - (ugiy)


  • Options
    I would say 1 but I struggled with my last decision of transferring 1 two weeks ago. My son and his vanishing twin (at 9 weeks) were both 4AA 5-day blast and the one I just lost was a 4AB (no PGD). You just never know the outcome sadly and have to follow your gut.

              image      image    

    IVF #1 September 2012, beta #1: 213; beta #2: 580. Expecting Twins! 
    EDD 6/9 lost one angel at 9w3d :( 
    Baby boy arrived 6/1/13
    FET #1 10/14, BFP -Chemical Pregnancy :(
    Everyone Welcome

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    ccam said:

    I totally get what you mean about moving past this phase of your life, I've actually said that same thing to multiple people. 

    Hypothetically, I would probably transfer one.  Your embryos sounds like they're great quality and we personally aren't open to twins right now (with a 2 year old at home).  My thinking is - if the first doesn't work, you have a second chance and if it does, then you can worry about the 2nd embryo later.  Our RE always told us that, in our case, transferring 2 would increase our chances of multiples, not necessarily pregnancy.

    Good luck with your decision!


    This! All of it. And I just wanted to add that I am rooting very very hard for you. I have echoed SO MANY of the feelins you've expressed this cycle. I really hope this is it for you guys :)


    "I won't give up on us, even if the skies get rough, I'm giving you all my love, I"m still looking up."
    TTC #1 since August 2011 MFI Diagnosis - April 2012
    IVF #1 - July 2012 - Stims start 7/2, ER 7/12, 20 retrieved, 16 mature, 13 fertilized!
    ET - 7/17 - 1 blast transferred. Beta - 7/26 273, Beta 2 7/30 - 1143. Beta 3 8/6 - 11,597
    12/25 - Santa tells us "IT'S A GIRL!" EDD - April 4th

    Our Little Easter Bunny has arrived!

    Molly Mildred born 03/31/13


    TTC A Sibling....... FET #1 11/14/14, Transferred one beautiful blast

    Remaining four frosties arrested due to "embryologist error"

    Plllllleasssee stick little icicle.....Beta 11/23...BFN

    Starting ALL over with a fresh IVF cycle

    Stims start 11/28/14, ER December 10th, 13 eggs retrieved, 11 mature, only 4 fertilized 

    1 Blast Transferred on December 15th..... Beta Christmas Eve... Please Santa, bring me a baby!

    Beta #1 345.....Beta #2....750/ First U/S 1/13/15/HB 131....EDD 9/2/2015

  • Options
    This is such a tough decision.  DH & I could be faced with a similar decision next week if I have more then 1 embryo to transfer.  We have never had any make it to freeze so I'm inclined to think if we have 2 embryos we will transfer both.  I have always had 3 day transfers.  If I had enough embies to make it to a 5dt, I would probably only transfer 1.  Whatever decision you make, it will be the right one.  Hugs to you!

    Me 35, DH 36
    TTC summer 2008
    Diagnose me. DOR, DH perfect
    IUI # 1 6/2010, BFN
    IUI # 2 8/2010, BFN
    IVF # 1 10/2010 Canceled poor response
    IVF 1.2 12/2010 BFP! mc 6 weeks 2 days
    Mental health break for 10 months
    IVF # 2 10/2011 BFN
    IVF # 3 5/2012 BFP! 10 eggs retrieved (best ever)
    7 fertilized transferred 3
    Beta #1 14dpo - 72, Beta #2 17dpo 145 Beta 3 20dpo 521
    First u/s June 15 saw HB 126 bpm missed m/c 7/5/12 10 weeks D&C 7/6/12
    IVF#4 ER 9/30 ET 10/3 Beta 10/16 BFFN. IVF #5 final with o/e. ER 1/21 only 1 retrieved, hoping my lonestar is the one. Beta #1 2/6/13 = 209.... please let this be it! Keep growing lonestar! Beta #2 2/8/13 - 586! , Beta #3 2/10/13 = 1898. First u/s perfect little heart beat at 116 bpm. Measure 6 weeks 1 day. EDD 10/14/13
    3/4/13 measuring right on track beautiful heartbeat 171 bpm, graduated from RE to OB... bittersweet.
    PAIF/SAIF always welcome! Its a girl! 

    Maggie Grace is here!  10/5/13... 8lbs 6 ounces of pure joy!

    TTC#2  No birth control since DD was born.  Getting ready to jump back in the saddle.  Weaning this month. RE
    appt scheduled 5/8.   Here we go again!

    IFV# 6.  10/27  6 retrieved 4 mature 3 fertilized.  2 made it to 3dt 10/30. 1"very pretty 8 cell" and 1 6 cell.  Beta
    11/13.   Please stick embies!!!!  We love you so much already! 11/12/14  POAS, BFP... beta tomorrow!
    11/13 beta #1  924!!!  2nd bet 11/15 1906, one more on 11/17 3rd & final beta 3430.  First u/s 12/5, 7w4d, 2 heartbeats,
    both measuring right on track....2nd u/s... all is well... both beans measuring right on track... released from RE... first
    appointment with MFM 1/5.  Looks like this is really happening!

    image




  • Options
    I don't have any advice, but wanted you to know I'm thinking of you. I agree with pp that whatever you do decide will be the right one. This can't be easy. Hugs.
    Warning No formatter is installed for the format bbhtml
  • Options
    Hey lady! Tough decision. I would personally do an eSet for many of the reasons stated. For me, I had an amazing birthing center experience, which I would love to repeat and they don't deliver twins. Since you know both are high quality normal, you are most likely looking at two or zero. An eSet gives you two chances. 

    I understand the struggle with what to do with the unused embie if you are only interested in putting IF behind you. I will say that ive had many friends say the FET process is a cake walk compared to a full IVF cycle. So if you would be up for another pregnancy, it is worth considering. 

    Ultimately, what you decide is the best decision for you and your family. We will be here for you either way! Hugs and good luck with your choice. 
    TTC Since 3/2010
    Me-36, Unexplained Infertility, DH-35, all clear
    Clomid 50mg 12/2011 = BFN
    Clomid 100mg 1/2012 = BFN, with Cyst
    IVF #1 Lupron/Menopur/Gonal-f/HCG Trigger
    ER 4/19/12 = 11 retrieved, 6 fertilized,
    ET 4/22/12 = 2 transfered (day 3), remaining 3 weren't good enough to freeze
    Beta 5/3 = BFP, 87 Beta #2 5/7 560.9 Beta #3 5/9 1376.5 First u/s One Baby, 125bpm!
    Second u/s, 176bmp! Kicked over to the OB by the RE at 8w. Team Green!! 
    Baby girl J arrived two weeks early! Born into water, med-free. Hooray for Team Pink!

    TTC #2 - back to the RE, treatment started 12/2014. 

    image
  • Options
    I didn't have a choice because I only had one normal embryo, but if I had had two, I would have only transferred one. My RE encourages only transferring one when you have genetically normal embryos and I agreed with him. 

    Good luck with your decision!
    Dx: Unexplained Infertility

    TTC #1 
    IUI's #1 - #3 Clomid = BFN's, IUI #4 Follistim = BFP
    Grayson arrived via emergency c-section on 7/28/12!

    TTC #2 
    IUI's #1 - #4 Follistim = BFN's
    IVF #1 w/ ICSI + PGS: Lupron/Follistim/Menopur
    ER 4/13 - 19R, 13F, 4 PGS tested embryos, 1 normal
    5/14 FET: BFP. Beta #1: 123, Beta #2: 327, Beta #3: 854
    Cora arrived 1/23/15 via RCS!
  • Options
    I would only transfer one based on your history of PTL.      
    *My Loves, My Life, My Littles*

    02/18/11, 05/24/12 and 12/03/13



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