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Letrozole Questions

RachaeleighRachaeleigh member
in Trouble TTC
Hi :-)

So, everyone in my REs office seemed to be grumpy the last two days. My usual, favorite nurse wasnt in and I have some questions, just out of curiosity, that didnt get answered. I figured that all of you lovely ladies could help shed some light.
So, after 3 failed follistim IUIs, we just did our first letrozole IUI today.

When using follistim, I didn't go in for 7dpo progesterone check, but with letrozole I have to.
On follistim, after O, I start progesterone supps, but on letrozole I don't.

What's the difference? Or are these just quirks specific to my RE?

Thanks ladies :D

4 Losses (2003, 2008, Apr 2012, & Oct 2012)
All RPL and IF testing with multiple REs = normal

5 IUIs = BFN

All AL are welcome
Image and video hosting by TinyPic

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Re: Letrozole Questions

  • MARISAV77MARISAV77 member
    Maybe it's just your REs preference? I was on progesterone with my IUI and Letrozole, so not sure what or if there is a difference?
    Me: 37 DH: 37, married since Sept. 2013. "actively" TTC for a total of 13 months (after 7 months of TTC, took a 1 1/2 year hiatus due to work scheduling and wedding planning. Started up again after our wedding in Sept.) First evaluation by an RE November 2013

    HSG-normal
    OH-tiny polyp found, but RE assured me she doesn't think it's contributing to infertility and doesn't recommend me to remove it because it's so small.
    DH's SA-normal
    Hormones all within normal levels
    Ovarian Reserve-RE says "is great" she's not concerned about my egg quantity (which I was until I saw her and results came back good!) 

    04/2012 50mg Clomid=BFN (prescribed by OBGYN, not monitored)
    06/2012 50mg Clomid=BFN (prescribed by OBGYN, not monitored)
    11/2013 100mg Clomid, with HCG trigger=BFN (prescribed by RE, monitored with US (2 dominant follicles) and baseline bloodwork done)
    01/2014 100mg Clomid, with HCG trigger-(prescribed by RE, monitored with US-1 dominant follicle)=BFN
    06/2014 7.5mg Letrozole, HCG trigger (prescribed by RE, monitored with US-2 dominant follicles), IUI #1 on 7/3/14=BFN
    07/2014 7.5mg Letrozole, benched for IUI#2 this cycle, because I ovulated on my own before my follicular US. Progesterone suppositories=BFN Diagnosed with PCOS this month too. Testosterone levels high at 76. =( 
    08/2014 7.5mg Letrozole, HCG trigger with 19mm follicle. IUI#2 on 8/31 cancelled last minute due to family emergency. 
    09/2014 Taking a 3 month break starting this month. If not pregnant in 3 months, will start up again with medicated cycles and IUIs. Had all my labs and AFC re-evaluated this month also. RE says nothing much has changed since my eval last November, okay for me to take a little break. =) 




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  • RachaeleighRachaeleigh member
    @rainbowbridge14‌ no, I specifically asked about starting the progesterone and the nurse said not to, unless I wanted to. Honestly, I don't want to bc I hate the side effects (of course I'll take it if it means a healthy pregnancy).
    I asked her why and she said she didn't know. Which is what she said to every question that I asked :-/

    4 Losses (2003, 2008, Apr 2012, & Oct 2012)
    All RPL and IF testing with multiple REs = normal

    5 IUIs = BFN

    All AL are welcome
    Image and video hosting by TinyPic

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  • BookishMommaBookishMomma member
    I don't know about Follistim, but I do know that progesterone after O is part of my RE's protocol for Letrozole + IUI cycles. I don't think my doctor will have me come in for a CD7 progesterone check, though. So I imagine the progesterone supplementation is precautionary.
    image
    image
    DX: I'm a Recurrent Loser
    Me (35) + DH (37) - Married Sept. 2007
    BFP #1 - DS born 7/11/11
    BFP#2 11/13/13 - EDD 7/29/14 - M/C at 5w3d
    BFP #3 12/28/13 - EDD 9/7/14 - M/C at 4w6d
    BFP#4 3/27/14 -  EDD 12/5/14 - Girl lost to 45X at 8w6d - D&C 
    BFP#5 10/15/14 - EDD 6/30/15 - M/C at 7w2d
    BFP #6 1/5/15 - EDD 9.16.14 [CLICKY for progress]
    In search of a image


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  • BunnyBerryBunnyBerry member
    I really dislike nurses like that! Sometimes these decisions can make all the difference and they're very important to us. I would call back again with your own nurse and get some real answers so you can feel confident. And perhaps ask them to check with your RE for his/her decision. Good luck!
    January 3T Siggy Challenge - New Year's Resolutions
    image
    imageimage

    Me (29), DH (30) TTC actively 54 55+ cycles | All BFNs
    MFI (low everything) | Endo Stage 1 & Stenotic Cervix (treated) | PCO
    Married - July 2008 | Started TTC - Jan 2009 | RE Visit #1 - Mar 2014 
    IUI #1 ICI #1 - June | IUI #1.1 Laparoscopy - Aug
    IUIs #1.2, 2, 3 - Sept, Oct, Nov (Letrozole) - BFNs 
    IUI #4 - Dec (Bravelle) | IUI #5 - Dec/Jan (Bravelle) - 5 follies + TI - BFNs
    IUI #5.1 - Jan (Bravelle) Cancelled 
    Planning to start IVF in March!
    ***All Welcome***
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  • mmmKayymmmKayy member

    I've taken progesterone for all 4 cycles. First 3 were Letrozole only, but the 4th one I was on Letrozole AND Follistim... and still took the progesterone. And I only did b/w for progesterone the 1st cycle.

    I agree with @BunnyBerry (as I usually do).. I would call your nurse and try to get answers. I know with my nurse, I'll call and ask her questions, and she gives me kinda half-assed answers. But I don't sweat it because every single time I've called with questions she has called me back within 5 min, saying she talked to my RE and has some definite answers. I love dealing with her because she is incredibly nice and very easy to talk to.

    :: Me: 30 ~ DH: 27 ::
       :: TTC since Oct 2013 ~ NTNP since Dec 2010 ::
    :: DX: PCOS Characteristics & MFI ::
    ~May 2014: 1st Consult with RE~
    ~SA #1/#2 (low on all #'s), HSG (found non-threatening uterine fibroid)~
    ~*1500mg Metformin Daily*~
    *June: Medicated Cycle #1: 5mg Letrozole + Trigger + TI + Progesterone = BFN* 
    *July: Medicated Cycle #2: 5mg Letrozole + Trigger + TI + Progesterone = BFN*
     *Aug: Medicated Cycle #3: 5mg Letrozole + Trigger + TI + Progesterone = BFN*
    *Sept: IUI #1: 5mg Letrozole + Follistim + Ovidrel + IUI + Progesterone = BFN*
    Possibly Looking at IVF.. RE Suggested DH See a Urologist Before Moving On With Treatments 
    *Currently on a Break*
    ~*All Welcome*~
     

    image 

     ::: 3T November Siggy Challenge: Animals Being Jerks:::
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  • lisa89760lisa89760 member
    I had to keep asking about progesterone supplements because when I was originally tested, my levels were fine.  I did progesterone on my femara cycle and now I just started again on my first follistim cycle.  

    i got a similar answer from my doctor before my second progesterone check...the you can do it if you want, but you don't need to.  Luckily I got re-tested.  It can be frustrating!!
    Me (29), DH (32)
    Aug 2011  - Married
    Jan 2013   - Started TTC
    Jan 2014   - OB started some testing 
                         - HSG - Normal
                         - Ultrasound - Normal
                         - SA - Normal, but tested positive for Ureaplasma
                         - Both of us on antibiotics to treat ureaplasma
                         - Blood work - progesterone: 15.9, TSH: 0.89, FT4: 1.2, Prolactin: 33.4 
    Feb 2014   - Endometrial Biopsy - Normal
    Mar 2014   - Prolactin: 22.9, referred to RE
    Apr 2014   - First RE appointment, put on medication for high prolactin levels 
                      - Clomid (50 mg) 1 follicle, Trigger shot - BFN
                      - Second SA - All Normal, borderline morph (5%) 
    May 2014   - Clomid (100mg) 2 follicles, Trigger shot - BFN
                      - blood work: Estradiol: 32.7, FSH: 5.3, Prolactin: 14.1
    June 2014  - IUI #1, Clomid (150 mg), 3 follicles, Trigger shot - BFN 
    July 2014   - IUI #2, Clomid (150 mg), 4 follicles, Trigger shot - BFN
    Aug 2014   - IUI #3, Femara 2.5, 3 follicles, Trigger shot (first time done by DH!!) - BFN
                      - Hysteroscopy - Normal
    Sept 2014 - IUI #4 Femara 2.5, 1 follicle, possibility of another one, Trigger shot - BFN
                       -Progesterone test 4 DPIUI - 7.8...started crinone.
    Oct 2014 - IUI #5 Follistim 150 3 possibly 4 follicles - Trigger Shot - BFN
    Oct/Nov 2014 - Follistim 150 with TI & Trigger shot - ???

    **October Siggy Challenge**

    I don't even know what he is supposed to be!
    image


    **EVERYONE WELCOME!! :)**

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