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Antagonist vs Long-lupron protocol

alpCRNAalpCRNA member
in Infertility
Hey ladies!  We are switching from the antagonist to the long-lupron protocol for IVF #2.  With the antagonist protocol we had "poor" quality embryos.  We are switching to the long-lupron protocol hoping to improve embryo quality.  So, did anyone have better quality embryos after switching protocols?
Me 27 DH 29 Married since 2007, together since 2001
Off BC since Febuary 2006 3 Clomid Cycles in 2008- symptomatic, US just showed a tilted uterus, otherwise normal, HSG normal.  DH has an ejaculatory duct obstruction and a congenital absence of the vas deferens.  This is common with cystic fibrosis carriers, but he doesn't have cystic fibrosis. IVF #1 with TESE/ICSI (Antagonist protocol) Aug 2014=BFN (poor embryo quality)   IVF #2 ICSI long lupron protocol November 2014
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Re: Antagonist vs Long-lupron protocol

  • Sha259Sha259 member
    I had 0 embryos during my antagonist cycle because I was a crappy responder and only got 4 follicles early on that weren't growing at all, so was cancelled for IVF #1
    IVF #1.2 (with PICSI) was long lupron and I responded okay (thought we had 10 follies but only retrieved 8). However, my quality shocked even my RE. Every embryo that was fertilized made it to 5 day blastocyst, and all were excellent quality.

    So we still got a pretty limited number of eggs to begin with, but it was quality over quantity for my long lupron cycle.

    It will be interesting to hear the experience of others who used the long lupron protocol as well.
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  • emmuffyemmuffy member

    Bump! This is helpful for me too, as I start thinking about whether to do another IVF and whether to talk to my RE about a different protocol.

    Official diagnosis: Unexplained IF. I am 32. I have low ovarian reserve (low AMH), and poor egg quality. I've also been diagnosed with mild glandular developmental arrest (lining problems, detected with EFT).

    We are using open ID donor sperm. IUIs #1-7=BFN. IVF September 2014 antagonist protocol, 8R,5M,3F, 5 day transfer of 1 morula = BFN. IVF#2 planned for January 2015 (antagonist protocol + HGH).

    Image and video hosting by TinyPic image

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  • alpCRNAalpCRNA member
    @Sha259  Thanks for sharing your experience.  Numbers were not really an issue for us, but the embryo quality definitely was.  Hopefully switching to the long-lupron protocol will work well for us.  Good luck with your upcoming FET, I hope to see you in the November group.
    Me 27 DH 29 Married since 2007, together since 2001
    Off BC since Febuary 2006 3 Clomid Cycles in 2008- symptomatic, US just showed a tilted uterus, otherwise normal, HSG normal.  DH has an ejaculatory duct obstruction and a congenital absence of the vas deferens.  This is common with cystic fibrosis carriers, but he doesn't have cystic fibrosis. IVF #1 with TESE/ICSI (Antagonist protocol) Aug 2014=BFN (poor embryo quality)   IVF #2 ICSI long lupron protocol November 2014
    imageimage
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  • CallaLily30CallaLily30 member

    I did the antagonist protocol twice and although I had 20+ eggs retrieved each cycle, only 4 made it to blasts (3 from cycle #1 and 1 from cycle #2).  We are trying the long lupron protocol this time in hopes for better quality.  I just started lupron last night though so I can't tell you what the results are for a few weeks.

    Best of luck to you!

     image

    BFP #1: 1/4/13, EDD 9/8/13, Missed M/C confirmed 2/8/13, Misoprostol

    2013: Three CPs w/ EDDs: EDD 2/10/14, EDD 3/24/14, EDD 6/24/14

    IVF/ICSI #1 (Antagonist) - Jan 2014- 19R, 14M, 11F, 3 penguins (6BB, 4BB, 6BC)  PGD tested- All Normal!

    IVF/ICSI #2 (Antagonist) - Feb 2014 - 23R, 11M, 10F, 1 penguin (3BB) - Another Normal!

    FET #1 - March 26, BFN

    FET #2- Beta #1 (9dp5dt) -332, Beta #2 (11dp5dt) -1027, EDD 1/30/2015, Missed M/C, D&C 6/19/14

    IVF/ICSI #3 (Lupron Down Reg) - Oct 2014 - 38R, 28M, 27F, 20 frozen on day 5, 16 normal penguins!!

    FET#3 - February 1, 2015, Prep begins 1/13

    All Welcome!

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  • alpCRNAalpCRNA member
    @CallaLily30  Good luck!  I may just have to stalk you to see how things progress for you.  lol  You should only be a few weeks ahead of me.
    Me 27 DH 29 Married since 2007, together since 2001
    Off BC since Febuary 2006 3 Clomid Cycles in 2008- symptomatic, US just showed a tilted uterus, otherwise normal, HSG normal.  DH has an ejaculatory duct obstruction and a congenital absence of the vas deferens.  This is common with cystic fibrosis carriers, but he doesn't have cystic fibrosis. IVF #1 with TESE/ICSI (Antagonist protocol) Aug 2014=BFN (poor embryo quality)   IVF #2 ICSI long lupron protocol November 2014
    imageimage
    Report Reply
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