I have PCOS and have been trying to get pregnant for 18 months. Soon I will start a diabetes prescription to help my ovulation and cycle to help me get pregnant. Has anyone been prescribed Metformin or a different diabetes medicine to help get pregnant with PCOS? If so which one and how long did it take to conceive? Did you have any side effects?
Hey there. Welcome to 3T. I have PCOS as well and have been taking metformin for about two years. It does give me lots of tummy issues so I have to remember to take it right before I eat.
I second the recommendation for an RE. They're the experts needed to get you KU!
Just a heads up, the vast majority of women here are still still to conceive their first so we won't be able to tell you any success stories.
I hope you find an RE that can help you with your journey!
Me (29) DH (37)
Married 7/11
Actively TTC 3/12
DX: PCOS
Current treatment: Break from IUIs until after the holidays
I also have PCOS, but am not insulin resistant (pre-diabetic) nor do I have weight issues. My RE is still going to put me on Metformin soon because insulin apparently can play a role in inhibiting ovulation (who knew!).
Helpful Excerpt: "Numerous studies have shown that metformin is effective in both obese and thin women correcting insulin metabolism, endocrine parameters or both. Some studies on the effects of metformin have revealed positive trends without achieving statistical significances. This may imply there are subsets of PCOS patients that may not benefit from metformin use."
I like knowing why I'm putting things in my body. My RE is very confident that Metformin and Letrozole will be a successful treatment for my particular PCOS. Everyone is different, but Metformin paired with Letrozole (aka Femera - newer drug with less reported side effects) or Clomid is considered Treatment-As-Usual for PCOS.
I hope this is helpful. Good luck and welcome.
Me: 28 MH:35
Married September 2012. TTC since September 2013
June 2014 - Dx w/ significant PCOS and referred to RE.
July/August 2014 - Testing complete: Testosterone & AMH very high, FSH slightly high, Vitamin D low, tubes and lining all lovely. DH SA: A+
I am not prediabetic and I don't have weight issues either so I was really surprised that they use the diabetes medication to regulate ovulation. I go for my appt on August 4th when he will prescribe me a medication so I just thought I'd see what kind of experiences others are having with these prescriptions
Idk what I was thinking when I posted originally. I didn't mean to offend I just wasn't thinking when I asked how long it took to conceive, my apologies. I'm new to this board and it might sound silly but what is an RE? And also can anyone tell me what KU means or if there's somewhere I can reference to find out what these abbreviations mean?
I have PCOS as well. I actually went off of my Metformin and am getting a new CD3 blood draw done next month as I found the Metformin was making me very dizzy, almost like tunnel vision, and would just make me feel sick and hot. No matter if I ate it before I ate, during, or after. I have a feeling that my blood sugars are getting too LOW after taking it. So we're going to work on that a bit to see if there is anything else I can take since it doesn't seem to be regulating it. I haven't read much about other ladies having that issue though, so if I hear anything helpful at my next blood draw I will let you know.
I hope you get some good info at your appt!
***Signature/Ticker Warning***
March 2008 - DD born - no issues conceiving (surprise). Limited issues during pregnancy/delivery. June 2011 - Married DH. June 2013 - Diagnosis of Endometriosis and PCOS (approximate). December 2013 - First cycle of Clomid - Positive OPK. BFN January 2014 - 2nd Cycle of Clomid - Positive OPK. BFN February 2014 - 3rd Cycle of Clomid - Positive OPK. BFN March 2014 - Took month off to prep for surgery April 2014 - Laporoscopy for endo. Unable to remove endo due to too close of proximity to ureter. HSG done as well. Fillopian tubes open. May 2014 - 1st round of Femara. Positive OPK. BFN. June 2014 - 2nd round of Femara. Moved to RE to have CD10 Follicular U/S. No Follies in left ovary. 5 follies in right. Largest follie 8mm, 1 7mm, 2 3mm, 1 2mm. Positive OPK on day of U/S. BFN. DH has SA done at this time - All results within normal limits. July 2014 - 3rd round of Femara. CD10 Follicular U/S. No follies in left ovary. 7 follies in right. 1 20mm, 1 12mm, 1 10mm, 4 <5mm. Scheduled for IUI. Canceled due to low estrogen level of 145. TI this month. Prepping for Injectables next month. BFN. August 2014 - CD3 BW Normal. Injectables not happening because of stupid miscommunication about "required injectables class." Taking class this month. No medication. TI for the month. SIS scheduled for 8/7/14. SIS results - "I have a beautiful uterus." Huzzah! September 2014 - Cycle cancelled due to stupid AF coming early and making my IUI run in to DH's business trip. Try again next month. October 2014 - Injects with IUI cycle. 75U 5 days. Estrogen at 36. Bumped up to 125 for 4 days. Estrogen 105. Bumped up to 225. Ganirelix for 2 days. 4 mature follies. Triggered 10/9. IUI 10/10. BFP 10/24/2014. Beta #1 - 178 Beta #2 - 398. U/S 11/7/14- TWINS!!!!
Welcome! Sorry you find yourself here. I agree with @amylev80 on getting the extended release. I am also diagnosed with PCOS and am on 1000mg of Metformin extended release. I try and take it right after dinner every night and haven't had any problems on it so far. Definitely look into working with an RE to help you get pregnant!
Me: 26(PCOS - Diagnosed May 2014)DH: 30(Normal - In the process of testing)
Married: 03.16.13
TTC Since: April 2013
Treatment: Daily Metformin + Clomid Days 5-9 each Cycle
May 2014 - June 2014: 50 mg Clomid + timed BD = BFN
June 2014 - July 2014: 50 mg Clomid + timed BD = BFN - progesterone test 1.6
July 2014 - August 2014: 100 mg Clomid + timed BD = CANCELLED due to bleeding on day 14
August 2014 - September 2014: Unfortunately not medicating as we are waiting to see an RE in September!!!
Welcome! I was diagnosed with PCOS at about 20 but my body did a "jump start" at about 38 and now no PCOS. I've heard having kids sometimes will "re-set" your body but regardless, no reason you won't be seeing that bfp soon and I agree with ppl - go to an RE!
41 & single; DX: PCOS TTC #1 with IUI and donor sperm First IUI May, 2014, Clomid + Trigger = BFN Second IUI July, 2014, Clomid + Trigger = BFN Third IUI Dec, 2014, Femara + Follistim + Trigger = BFN Fourth IUI Feb 2015, Femara + Follistim + Trigger = C/P
Hey! I am on Metformin, I do have insulin resistance, but my RE upped my dosage for fertility purposes. One side effect is bowels. It made me double over in stomach pain. It only did it to me when I first started it, and whenever the dosage changed. Docs will usually tell ya that is one of the big ones.
I was recently diagnosed with PCOS too. But my RE said she doesn't recommend me taking metformin because I responded well each time with clomid and Letrozole. Is the metformin prescribed only if you are not ovulating with clomid or Letrozole?
Me: 37 DH: 37, married since Sept. 2013. "actively" TTC for a total of 13 months (after 7 months of TTC, took a 1 1/2 year hiatus due to work scheduling and wedding planning. Started up again after our wedding in Sept.) First evaluation by an RE November 2013
HSG-normal
OH-tiny polyp found, but RE assured me she doesn't think it's contributing to infertility and doesn't recommend me to remove it because it's so small.
DH's SA-normal
Hormones all within normal levels
Ovarian Reserve-RE says "is great" she's not concerned about my egg quantity (which I was until I saw her and results came back good!)
04/2012 50mg Clomid=BFN (prescribed by OBGYN, not monitored)
06/2012 50mg Clomid=BFN (prescribed by OBGYN, not monitored)
11/2013 100mg Clomid, with HCG trigger=BFN (prescribed by RE, monitored with US (2 dominant follicles) and baseline bloodwork done)
01/2014 100mg Clomid, with HCG trigger-(prescribed by RE, monitored with US-1 dominant follicle)=BFN
06/2014 7.5mg Letrozole, HCG trigger (prescribed by RE, monitored with US-2 dominant follicles), IUI #1 on 7/3/14=BFN
07/2014 7.5mg Letrozole, benched for IUI#2 this cycle, because I ovulated on my own before my follicular US. Progesterone suppositories=BFN Diagnosed with PCOS this month too. Testosterone levels high at 76. =(
08/2014 7.5mg Letrozole, HCG trigger with 19mm follicle. IUI#2 on 8/31 cancelled last minute due to family emergency.
09/2014 Taking a 3 month break starting this month. If not pregnant in 3 months, will start up again with medicated cycles and IUIs. Had all my labs and AFC re-evaluated this month also. RE says nothing much has changed since my eval last November, okay for me to take a little break.
Welcome. I have PCOS as well, and I have known so since I was in my teens, as I have had extremely irregular periods and many of the other fun symptoms. I have not been prescribed Metformin, likely because my PCOS does not appear to be insulin related (no indication of diabetes, per-diabetic symptoms, weight issues, etc.) As others have mentioned, most of the women on this board have never been pregnant, so you are less likely to hear success stories/info here. You may want to try the Pregnant after IF or Success after IF boards for that. However, this board is filled with wonderfully supportive women who understand what you are going through.
________ ME: 34, Atypical PCOS (lean, no O without meds) + unexplained; DH: 33, mildly low motility 09/2012: Start TTC after stopping NuvaRing. No cycles seemed to occur. 01/2013 - 05/2013: Tried Provera to "jumpstart" cycles. No luck. 12/2013- 01/2014: Clomid 50mg - no big follies, stepped to 100mg; One mature follie, Ovidrel (HCG trigger), IUI #1 completed - BFN 02/2014: Clomid 100mg; One mature follie, Ovidrel trigger, IUI #2 completed, Crinone - BFN 03/2014: Clomid 100mg -no big follies on 1st round, 2nd round prescribed;One mature follie, Ovidrel, IUI #3completed, Crinone - BFN 04/2014-05/2014: Letrozole 5mg + Ovidrel HG to prep for IUI #4 switched to TI, Crinone - BFN 05/2014-06/2014: Letrozole 5mg; one mature follie, Ovidrel, IUI #4.1 completed, Crinone - BFN 07/2014-08/2014: Letrozole 5mg; one mature follie, Ovidrel, IUI #5 completed, Crinone - BFN 09/2014-10/2014: IVF Prep - Insurance requires IUI #6; Letrozole 5mg -no big follies 1st round, 2nd round prescribed; IUI #6, Crinone - BFN 11/2014: "Break" - Letrozole 5mg to cycle before prepping for IVF - successfully O'ed, but BFN 12/2014: Extending 'break' one more Letrozole-only TI cycle for mental health break - BFN 01/2015-02/2015: Prep for IVF - BCP then Gonal-F, Ganirelex, Novarel trigger; ER scheduled 2/11! http://www.fertilityfriend.com/home/4cf919 PAIF/SAIF Welcome.
December 3T Siggy Challenge: Favorite Holiday Movie
Re: PCOS
I second the recommendation for an RE. They're the experts needed to get you KU!
Just a heads up, the vast majority of women here are still still to conceive their first so we won't be able to tell you any success stories.
I hope you find an RE that can help you with your journey!
Me (29) DH (37)
Married 7/11
Actively TTC 3/12
DX: PCOS
Current treatment: Break from IUIs until after the holidays
-----All Welcome----
~~~January 3T Siggy Challenge: New Year's Resolutions~~~
(I don't do resolutions...so I stole T-Rex's)
I also have PCOS, but am not insulin resistant (pre-diabetic) nor do I have weight issues. My RE is still going to put me on Metformin soon because insulin apparently can play a role in inhibiting ovulation (who knew!).
I hope I'm not annoying anyone with my links to medical stuff, but this is worth a read if you're considering starting Metformin: https://www.infertilityspecialist.com/metformin_kutner.html
Helpful Excerpt: "Numerous studies have shown that metformin is effective in both obese and thin women correcting insulin metabolism, endocrine parameters or both. Some studies on the effects of metformin have revealed positive trends without achieving statistical significances. This may imply there are subsets of PCOS patients that may not benefit from metformin use."
I like knowing why I'm putting things in my body. My RE is very confident that Metformin and Letrozole will be a successful treatment for my particular PCOS. Everyone is different, but Metformin paired with Letrozole (aka Femera - newer drug with less reported side effects) or Clomid is considered Treatment-As-Usual for PCOS.
I hope this is helpful. Good luck and welcome.
Me: 28 MH:35
Married September 2012. TTC since September 2013
June 2014 - Dx w/ significant PCOS and referred to RE.
July/August 2014 - Testing complete: Testosterone & AMH very high, FSH slightly high, Vitamin D low, tubes and lining all lovely. DH SA: A+
Cycle 1 (Nov 2014): 2.5 mg Letrozole/Ovidrel/TI = BFN
Cycle 2 (Dec 2014): 5 mg Letrozole/Ovidrel/TI - BFN
Cycle 3 (Jan 2015): 5mg Letrozole/Ovidrel/TI - BFN
WTF consult scheduled for 1/29
I have PCOS as well. I actually went off of my Metformin and am getting a new CD3 blood draw done next month as I found the Metformin was making me very dizzy, almost like tunnel vision, and would just make me feel sick and hot. No matter if I ate it before I ate, during, or after. I have a feeling that my blood sugars are getting too LOW after taking it. So we're going to work on that a bit to see if there is anything else I can take since it doesn't seem to be regulating it. I haven't read much about other ladies having that issue though, so if I hear anything helpful at my next blood draw I will let you know.
I hope you get some good info at your appt!
***Signature/Ticker Warning***
March 2008 - DD born - no issues conceiving (surprise). Limited issues during pregnancy/delivery.
June 2011 - Married DH.
June 2013 - Diagnosis of Endometriosis and PCOS (approximate).
December 2013 - First cycle of Clomid - Positive OPK. BFN
January 2014 - 2nd Cycle of Clomid - Positive OPK. BFN
February 2014 - 3rd Cycle of Clomid - Positive OPK. BFN
March 2014 - Took month off to prep for surgery
April 2014 - Laporoscopy for endo. Unable to remove endo due to too close of proximity to ureter. HSG done as well. Fillopian tubes open.
May 2014 - 1st round of Femara. Positive OPK. BFN.
June 2014 - 2nd round of Femara. Moved to RE to have CD10 Follicular U/S. No Follies in left ovary. 5 follies in right. Largest follie 8mm, 1 7mm, 2 3mm, 1 2mm. Positive OPK on day of U/S. BFN. DH has SA done at this time - All results within normal limits.
July 2014 - 3rd round of Femara. CD10 Follicular U/S. No follies in left ovary. 7 follies in right. 1 20mm, 1 12mm, 1 10mm, 4 <5mm. Scheduled for IUI. Canceled due to low estrogen level of 145. TI this month. Prepping for Injectables next month. BFN.
August 2014 - CD3 BW Normal. Injectables not happening because of stupid miscommunication about "required injectables class." Taking class this month. No medication. TI for the month. SIS scheduled for 8/7/14. SIS results - "I have a beautiful uterus." Huzzah!
September 2014 - Cycle cancelled due to stupid AF coming early and making my IUI run in to DH's business trip. Try again next month.
October 2014 - Injects with IUI cycle. 75U 5 days. Estrogen at 36. Bumped up to 125 for 4 days. Estrogen 105. Bumped up to 225. Ganirelix for 2 days. 4 mature follies. Triggered 10/9. IUI 10/10.
BFP 10/24/2014. Beta #1 - 178 Beta #2 - 398. U/S 11/7/14- TWINS!!!!
TTC #1 with IUI and donor sperm
First IUI May, 2014, Clomid + Trigger = BFN
Second IUI July, 2014, Clomid + Trigger = BFN
Third IUI Dec, 2014, Femara + Follistim + Trigger = BFN
Fourth IUI Feb 2015, Femara + Follistim + Trigger = C/P
As others have mentioned, most of the women on this board have never been pregnant, so you are less likely to hear success stories/info here. You may want to try the Pregnant after IF or Success after IF boards for that.
However, this board is filled with wonderfully supportive women who understand what you are going through.
ME: 34, Atypical PCOS (lean, no O without meds) + unexplained; DH: 33, mildly low motility
09/2012: Start TTC after stopping NuvaRing. No cycles seemed to occur.
01/2013 - 05/2013: Tried Provera to "jumpstart" cycles. No luck.
12/2013- 01/2014: Clomid 50mg - no big follies, stepped to 100mg; One mature follie, Ovidrel (HCG trigger), IUI #1 completed - BFN
02/2014: Clomid 100mg; One mature follie, Ovidrel trigger, IUI #2 completed, Crinone - BFN
03/2014: Clomid 100mg - no big follies on 1st round, 2nd round prescribed; One mature follie, Ovidrel, IUI #3 completed, Crinone - BFN
04/2014-05/2014: Letrozole 5mg + Ovidrel HG to prep for IUI #4 switched to TI, Crinone - BFN
05/2014-06/2014: Letrozole 5mg; one mature follie, Ovidrel, IUI #4.1 completed, Crinone - BFN
07/2014-08/2014: Letrozole 5mg; one mature follie, Ovidrel, IUI #5 completed, Crinone - BFN
09/2014-10/2014: IVF Prep - Insurance requires IUI #6; Letrozole 5mg - no big follies 1st round, 2nd round prescribed; IUI #6, Crinone - BFN
11/2014: "Break" - Letrozole 5mg to cycle before prepping for IVF - successfully O'ed, but BFN
12/2014: Extending 'break' one more Letrozole-only TI cycle for mental health break - BFN
01/2015-02/2015: Prep for IVF - BCP then Gonal-F, Ganirelex, Novarel trigger; ER scheduled 2/11!
http://www.fertilityfriend.com/home/4cf919
PAIF/SAIF Welcome.