Infertility Veterans
Mrs.McIrish
member
MTHFR....
Mrs.McIrish
member
I just love getting new problems after 7 transfers... My repeated loss panel showed I'm positive for 2 copies of 677T MTHFR (homozygous) Getting folate and lovenox now. Glad I asked for this test a long time ago and was ignored! I'm pissed that we could have addressed this earlier if I hadn't been ignored.
TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
5 IUI's: 2/11 to 6/11 and 1/12= BFN
OE IVF#1-4 8/11-6/12= all BFN
DE IVF#1 11/12 bad embryos= BFN
DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
DE IVF #3 1/14 ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d
DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!
K & K born 11/21/14 at 38wks 4 days
SAIF/PAIF Welcome
This discussion has been closed.
Re: MTHFR....
***SIGNATURE WARNING***
TTC #1
Me 42, DH 47
Dx = AMA/DOR, MFI
IVF/ICSI #1 = BFN
IVF/ICSI #2 = BFP; early loss
IVF/ICSI #3 (DE) = BFP; early loss
FET = BFN
IVF/ICSI #4 (DE w/ CCS) = BFP
Beta #1 @ 10dp6dt = 265; Beta #2 @ 14dp6dt = 1251.
1st U/S @ 6w2d showed one perfect little heartbeat!
2nd U/S @ 7w2d. HB 132 & everything measuring on track.
Our beautiful little girl arrived January 2015!
************ Signature/Ticker Warning ************
Me (32) DH (36) - Finding our way to baby #1
Me: POF/DOR - AMH <0.16, heterozygous c677t MTHFR, insulin resistant and gluten intolerant
DH: Severe MFI
12/2/11 - IUI #1- BFN
8/1/12 - IVF #1 - Zero response from max stims (600iu intramuscularly)
My ovaries are just for decoration
12/6/12 - Adopted five embryos that had been frozen for over ten years!
2/11/13 - DEmbryo FET #1 Thawed four, sadly two didn't survive. Transferred two beautiful blasts.
2/16/13 - First BFP of my life @ 6dp5dt! EDD 10/30/13
3/27/13 - After beta and u/s hell, no heartbeat ever detected. D&C at 9w1d.
6/5/13 - Adopted four new embryos that had been frozen for seven years!
9/12/13 - DEmbryo FET #2. Thawed and transferred two beautiful blasts
9/17/13 - BFP @ 5dp6dt! EDD 05/31/14
9/29/13 - m/c @ 5w1d.
11/19/13 - DEmbryo FET #3. Thawed and transferred one blast from each batch. Wow!
11/23/13 - BFP @ 4dp6dt! EDD 8/7/13
Beta #1 @ 13dp6dt - 522 Beta #2 @ 16dp6dt - 1373
6w5d ultrasound showed one perfect baby with a beautiful heartbeat of 134bpm!
Snowflake baby is a girl!
Our beautiful Snowflake girl arrived on July 22, 2014!
My embryo adoption blog: Wishing on a Snowflake
TTC summer 2008
Diagnose me. DOR, DH perfect
IUI # 1 6/2010, BFN
IUI # 2 8/2010, BFN
IVF # 1 10/2010 Canceled poor response
IVF 1.2 12/2010 BFP! mc 6 weeks 2 days
Mental health break for 10 months
IVF # 2 10/2011 BFN
IVF # 3 5/2012 BFP! 10 eggs retrieved (best ever)
7 fertilized transferred 3
Beta #1 14dpo - 72, Beta #2 17dpo 145 Beta 3 20dpo 521
First u/s June 15 saw HB 126 bpm missed m/c 7/5/12 10 weeks D&C 7/6/12
IVF#4 ER 9/30 ET 10/3 Beta 10/16 BFFN. IVF #5 final with o/e. ER 1/21 only 1 retrieved, hoping my lonestar is the one. Beta #1 2/6/13 = 209.... please let this be it! Keep growing lonestar! Beta #2 2/8/13 - 586! , Beta #3 2/10/13 = 1898. First u/s perfect little heart beat at 116 bpm. Measure 6 weeks 1 day. EDD 10/14/13
3/4/13 measuring right on track beautiful heartbeat 171 bpm, graduated from RE to OB... bittersweet.
PAIF/SAIF always welcome! Its a girl!
TTC#2 No birth control since DD was born. Getting ready to jump back in the saddle. Weaning this month. RE
appt scheduled 5/8. Here we go again!
11/13 beta #1 924!!! 2nd bet 11/15 1906, one more on 11/17 3rd & final beta 3430. First u/s 12/5, 7w4d, 2 heartbeats,
10/11: after 2 years, saw a RE, FSH 5.4
11/11: BFP! (surprise after thyroid & normal hsg),
12/11: missed m/c after 7 week u/s, 1/12: D&C
6/12 IUI#1-IUI #3: clomid = BFP!, C/P
IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
Baby Will born 8/18. He's perfect.
TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
5 IUI's: 2/11 to 6/11 and 1/12= BFN
OE IVF#1-4 8/11-6/12= all BFN
DE IVF#1 11/12 bad embryos= BFN
DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
DE IVF #3 1/14 ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d
DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!
K & K born 11/21/14 at 38wks 4 days
SAIF/PAIF Welcome
http://waitingforraintostop.wordpress.com
3/22 ER: 25R, 20M, 15F. 9 genetically normal, and 3 survived to Day 5
3/27 ET: transferred 1 embryo, beta 9dp5dt=163, 12dp5dt=639
4/25 1st ultrasound at 7 weeks = identical twins with heartbeats?!!!
It's twin girls!! Born on 11-2-14!
TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
5 IUI's: 2/11 to 6/11 and 1/12= BFN
OE IVF#1-4 8/11-6/12= all BFN
DE IVF#1 11/12 bad embryos= BFN
DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
DE IVF #3 1/14 ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d
DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!
K & K born 11/21/14 at 38wks 4 days
SAIF/PAIF Welcome
http://waitingforraintostop.wordpress.com
My BLOG: www.ivfbabyquest.wordpress.com -Update - old blog.
PAIF/SAIF Welcome!
Me: 42, Hubby: 35, TTC since Jan 2010. Dx: DOR due to advanced maternal age. Also: Hypothyroidism (100mcg Levothyroxin). Positive for MTHFR (hetero-C677T), Factor V Leiden, and Fragile X (on DH side). Taking pre-natal vitamins.
First natural PG 9/27/11; mc: 1/20/12
First RE visit: 8/8/12, Saline Sonogram: 8/28/12, IVF injection class: 10/11/12, add FaBB Tab for FVL, +Vitamin D.
IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Prog- 0.3 The u/s showed 6 follicles in my right & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ nightly. 10/21/12: Add Ganirelix SQ every morning.
ER 10/28/12: 13 Retreived. 7 Mature. 6 Fertilized. 5 Made it to PGS. ET 11/2/12: CANCELED. All 5 came back from PGS as having "severe abnormalities."
IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ nightly. 1/11/13: Add Ganirelix SQ every morning. hCG Trigger 1/16/13
ER 1/18/13: 9 Retrieved. 5 Mature. 5 Fertilized. 2 Made it to PGS. ET 1/23/13: CANCELED. All embryos (he even sent the ones not growing) came back from PGS as having "multiple severe abnormalities."
IVF #3: NEW RE! 3/1/13 Baseline: FSH- 9.6, E2- 61, Prog- 0.94, 3 follicles in my right & 4 in my left. Rx: 150 Bravelle& 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ.
ER 3/11/13: 6R, 2M, 2F. Day 3: one 8 cell, grade 0. Five day ET 3/16/13: one early blast, grade Fair. 3/24/13 AF came a day before beta. BFN
IVF #4: (Added acupuncture to this cycle.) 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Prog- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right & 4 in my left. Rx: 225 Bravelle& 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM.hCG Trigger 4/3/13 SQ.
ER 4/5/13: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). Five day ET 4/10/13: two blastocysts (the 3rd stopped growing.) Beta 4/18/13: 2.5 BFFN. RE recommends we stop trying and focus on living childless, due to the extremely poor quality of my eggs.
***Decided to stop trying and live CFNBC. I couldn't adjust. So, six months later...
IVF #5: Changed RE. Going to one of the big name clinics now. OWDU: 10/29/13. Update: HORRIBLE experience. Disgusted and distraught at their complete unprofessionalism and how much money and precious time they cost us. Sickening. Have now changed RE again. New Patient appt. 1/30/14.
BFP! Out of nowhere, I got KU the old fashioned way! POAS 1/26/14 - Positive! FDLM 12/30/13. Beta #1 16dpo= 373. Beta #2 18dpo= 801. EDD 10/6/14
2/4/14 1st U/S revealed a 5wk2day sac but no fetal pole. Started 200mgs of progesterone suppositories daily
2/11/14 2nd U/S revealed a perfect 6wk1day "diamond ring" embryo with a beating heart! 138bpm! Add 1mg folic acid and 40mg Lovenox
2/25/14 3rd U/S: perfect 8w1d embryo, 178bpm. 3/6 start spotting. 3/11 10w1d U/S shows no heartbeat. Scheduling D&C. The Stork has forsaken me again.
IVF #5.2: New in-state RE. Supplement priming for 1.5 cycles prior to start of cycle, including DHEA 50mg (stopped 5/15), CoQ10 200mg 2x/day, L-Arginine- 1000mg 2x/day (stopped 6/5 due to cold sore!), myo-inositol- 2g 2x/day, melatonin- 3mg, and Neevo (prenatal for MTHFR).
5/16/14 Day 2 bw cycle prior: FSH- 12.22, E2- 38.37, Prog- 1.35, LH- 9.46. 6/2/14 Day 19 bw: Prog- 23
6/12/14 Baseline: E2- 122.7, Prog- 0.4. 5 follicles in left, 4 follicles in right. Start stims: 375IU Follistim & 150IU Menopur. 6/19 Increase Follistim to 425IU, Menopur still 150IU. 6/18 add Ganirelix. 6/23 Ovidrel trigger SQ. 6/25 ER: 8R, 8M, 5F naturally. Start Medrol & Doxy. 6/26 Start Endometrin. 7/2 Start Lovenox.
7/8/14 Beta= 137.4 BFP!!! (My first from IVF!) E2- 1109, Prog- >60. Stop CoQ10, myo-inositol, and melatonin. 7/9 2nd Beta= 281.4. TSH- 2.70. Increasing Synthroid to 100mcg daily. 7/24 6w3d u/s measured 6w3d, hb: 121bmp! 8/5 8w1d u/s measured 8w3d, hb: 164bpm! Graduated from RE to OB. Now I just need to find an OB!
EDD 3/18/15!
From what I was told taking more folic doesn't help much if your body can't break it down.
I'm glad you finally got the test done but dang it shouldn't have taken this long to run a blood test. I'm sorry you keep having to go through all this.
TTC#1 since April 2011
IVF#1 July 2012 5R, 3 made it to blast, sET c/p
FET#1 Aug 2012 2 blasts transferred BFN
IVF#2 Oct 2012
16R/6M/6F/2-8 cell grade 1 transfer
Beta 1-237.9, Beta 2-566, Beta 3-8657
US 6w3d shows one baby w/ HB 115
US 7w1d no more heartbeat/ D&C 11/30/12 normal karyotype
IVF#3 Mar 2013
6R/4M/4F 1 compacting and 2-8 cell transfer
ectopic pg MTX given 3 month break from TTC
IVF#4 Sept 2013--BFN
http://i61.tinypic.com/34zll06IVF#5-7 Apr 2014, Jun 2014 and Aug 2014 banking embryos for CCS testing. Praying for normals!
Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
1 Clomid/Ovidrel BFN May 2011
Natural cycle Aug 2011 BFP M/C 4 Weeks
1 IUI Sept 2011 BFP M/c 7 weeks
Provera Dec 2011 BFP M/C 3 Weeks
IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone)
Went to Beer Center- high tnf, low lad, implantation failure
Jan 2013 BFP
Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
Miracle Born August 2013 Premature
Yours doesn't have to be a sad story
Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
1 Clomid/Ovidrel BFN May 2011
Natural cycle Aug 2011 BFP M/C 4 Weeks
1 IUI Sept 2011 BFP M/c 7 weeks
Provera Dec 2011 BFP M/C 3 Weeks
IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone)
Went to Beer Center- high tnf, low lad, implantation failure
Jan 2013 BFP
Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
Miracle Born August 2013 Premature
Yours doesn't have to be a sad story
It's twin girls!! Born on 11-2-14!
Where are you now? I've been traveling around the East Coast the past 2 years for treatment plus using DE so not sure my opinion on where to get another opinion "counts". No one locally could help me. I think LuvB went to where I get my local monitoring- Fert Solutions. Don't know their stats for your situation but I feel like you get individualized attn there- not a nurse. I never did IVF there so I can't speak to it. But even now the doctor seem interested in why Im doing what Im doing even though they are just running tests for me written by other clinics. (W&I sucks and Brigham kicked me out after 2 IVFs)
TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
5 IUI's: 2/11 to 6/11 and 1/12= BFN
OE IVF#1-4 8/11-6/12= all BFN
DE IVF#1 11/12 bad embryos= BFN
DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
DE IVF #3 1/14 ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d
DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!
K & K born 11/21/14 at 38wks 4 days
SAIF/PAIF Welcome
http://waitingforraintostop.wordpress.com
Me:29 DH:29 TTC since 1/11 Dx: unexplained IF/early DOR/immune issues
8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F.
IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.
ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
ET 5dt 7/24 2 fully expanded blasts. SURPRISE 3 FROSTIES!!!
Beta #1 8/2 335!!!! Beta #2 829!!! 1st u/s 8/14 showed TWINS!!!!!
3/21/14-L&W born at 37w via csection
Here Comes the Sun Blog
PAIF/SAIF welcome!
Where are you now? I've been traveling around the East Coast the past 2 years for treatment plus using DE so not sure my opinion on where to get another opinion "counts". No one locally could help me. I think LuvB went to where I get my local monitoring- Fert Solutions. Don't know their stats for your situation but I feel like you get individualized attn there- not a nurse. I never did IVF there so I can't speak to it. But even now the doctor seem interested in why Im doing what Im doing even though they are just running tests for me written by other clinics. (W&I sucks and Brigham kicked me out after 2 IVFs)
I love love love fert solutions! My re still after not seeing me for a bit always asks my OB how I am and how LO is! They got me pg every time and sent me packing when it was clear I was above their knowledge but sent me in the right direction I went amiss on my own then they pulled me back again. They are totally open to new ideas and financially are a dream, they really work with you. And my re called every day if my 3rd m/c.
Dr Huang is the best but I have heard great things about Anaia
Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
1 Clomid/Ovidrel BFN May 2011
Natural cycle Aug 2011 BFP M/C 4 Weeks
1 IUI Sept 2011 BFP M/c 7 weeks
Provera Dec 2011 BFP M/C 3 Weeks
IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone)
Went to Beer Center- high tnf, low lad, implantation failure
Jan 2013 BFP
Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
Miracle Born August 2013 Premature
Yours doesn't have to be a sad story
*******siggy/ticker warning*****
Me(31). DH (31)
DH SA normal count and motility, 1% morphology
Me .72 AMH, Fragile X premutation carrier
IVF #1 (6/12/13) BFN
IVF #2 (8/16/13) BFN
FET 10/4/13 Chemical
IVF #3 MC 5 weeks 5 days
IVF #4 DE 11/7 BFP, edd 7/28/15
All Welcome
It's twin girls!! Born on 11-2-14!
FYI: 3 of the REs were former RSC who left a few years ago to open an all-women clinic and wanted to get away from the corporateness of RSC.
TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
5 IUI's: 2/11 to 6/11 and 1/12= BFN
OE IVF#1-4 8/11-6/12= all BFN
DE IVF#1 11/12 bad embryos= BFN
DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
DE IVF #3 1/14 ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d
DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!
K & K born 11/21/14 at 38wks 4 days
SAIF/PAIF Welcome
http://waitingforraintostop.wordpress.com
Me (32) DOR, elevated NK Cells/ 2 copies of MTHFR mutation/ MH (35) azoo/high DFI (TTC#1 since 2009)
IVFs#1-4: (4/10-2/12) all BFN
Surprise Bfp (9/11) - c/p
DS IUI#1-2 (9/12, 10/12) - BFN
DS IVF: (11/12) - BFN
DE/DS IVF#1: (10/13) - 2 day 3 embies transferred-BFFN
FET of 2 day 6 blasts: (12/13) - c/p
DE/DS IVF #2: (4/14) - 1 day 5 blast transferred...BFFN...again.
FET 5/14: 1 day 5 hatching blast transferred...another BFFN
Repeat SHG 6/14-normal / Endometrial Receptivity Array biopsy 7/14-Receptive Uterus
New RE, additional testing reveals elevated NK Cells
FET of 1 day 5 blast (RE recommends transferring 1 due to elevated NK cells) with lovenox, steroids & intralipids in October
Hopefully this is the missing piece of your puzzle!
Me:36 DH:38 TTC#1 since 4/2012
Me DX: Hashimotos,Hypothyroid, DOR, MTHFR, DH: normal
IUI #1-#4 BFNs and a few cancelled cycles in the mix.
- poor responder
***Suprise BFP on 6/13/13. Natural MC @6wks 3days
IVF#1 and 2- Cancelled due to no response on max stimms
FET 5/20- BFP
1st Beta- 641
2nd beta- 2166
Sono- TWINS!!!!
Two Boys! Born January 2015 @36 weeks. Healthy and no NICU! So blessed!