March 2014 Moms

Positive quad screen?

Did anyone else have a positive result on the quad screen? We were notified that our result for Trisomy 18 was 1 in 75. I am a bit of a mess now and waiting to hear back when we can do the ultrasound with the maternal fetal specialists. I KNOW there are so many false positives in this test but knowing that before the test and getting that call are two vastly different things. Anyone else in the same boat?
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Re: Positive quad screen?

  • I think the first thing is to remember that the quad screen is a ratio test, not a positive/negative. So 1:75 still means your chances of actually having a kid with T18 is small.
    Is this your final result or preliminary?
    Me - 40, DH 34 Married 11 years, TTC since 7/09 3 rounds of Clomid > Vivienne born 5/28/11
    TTC#2 since 01/13 - 3 rounds of Clomid, 2 IUI w/injectibles, moving to IVF
    IVF #1 - Lupron 20 6/19, Follistim 225 6/21, Menopur 75 6/27, Trigger 6/30
    ER 7/2 (8R, 7M, 5F); ET 7/5 - 2 8 cell, grade 1 and 1 7 cell, grade 1 Stick babies, stick!
    BFP on HPT at 11dp3dt
    Beta #1 13dp3dt 787
    Beta #2 17dp3dt 6,007
    1st u/s 5w2d showing one "good" sac and 2-3 questionable
    2nd u/s 6w2d showing one baby with HR 128bpm
    3rd u/s 7w1d - HR 159bpm - graduated from RE!
    MaternT21 test results: no chromosomal issues, it's a BOY!!!
    EDD March 25, 2014

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  • We had a positive screen for spina bifida on the quad test but the anatomy scan showed that the baby is perfectly healthy. Don't let these results upset you too much before you get more testing and info - chances are the baby is totally fine!
  • I think the first thing is to remember that the quad screen is a ratio test, not a positive/negative. So 1:75 still means your chances of actually having a kid with T18 is small. Is this your final result or preliminary?
    This. I know it sounds bad, but 1:75 odds translates to less than 1.5% chance of having a baby with T18. It's not a positive/negative thing.
    imageimage
    BFP with #1 (twins!) 11/18/2011 - missed m/c at 8weeks3days; d&c 1/19/2012; myomectomy to remove 18cm+,10cm & 5cm fibroids 4/2012; TTC again 7/2012; BFP #2 (twins) 11/13/2012; missed m/c at 7weeks;
    BFP #3: baby girl born 3/5/2014

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  • i have no advice but i hope your anatomy scan brings good news.

    Married 11/27/09 and TTC right away
    Dx: Complete septate uterus with cervical duplication, endometrial polyps, PCOS, endometriosis, hypo thyroid, luteal phase defect
    4 uterus surgeries to correct my complete septum and to remove polyps and 2 years of seeing the RE, medicated cycles and IUIs
    Baby 1 and 2: BFP 3/3/11 with 2 babies EDD 11/1/11, M/C 4/6/11
    Baby #3: 8/11 pregnant EDD 4/27/11 and m/c:(
    Baby #4: 10/12/11 BFP! EDD 6/16/12m/c 10/26/11
    Baby #5: 3/13/12 BFP! EDD 11/25/12 ANOTHER m/c :(

    Baby #6: 2/14/13- BFP! EDD 10/24/13, CP 2/19/13
    Baby #7: 3/15/13- BFP! EDD 11/27/13, another CP
    Baby #8.  BFP 5/19/13 EDD 1/22/14. 8 was not our lucky number

    4th septum resection on 5/31/13.
    Baby #9: 6/29/13 BFP. C section scheduled for March 5th!

    My miracle baby was born March 5 at 9:33am. He was 8 lbs 12.5 oz and 21.25 inches long!

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  • Not to pry, but hold old are you?  The lab takes that into account when they do these calculations.  The chance for all trisomies goes up for age. 

    I'm 35, which means regardless of the quad screen my chances for trisomy 21 is 1 in 400.  If the odds determined by the quad screen come back from the lab at better than 1/200 and the FAP etc. aren't too out of whack, I'm not going to worry.  
    image
  • I just posted about this in another thread. I had an abnormal result for Down syndrome and was panicking! So I know how you feel but after the level 2 US everything looked great. It seems these turn out fine most of the time and its just a bunch of statistics. I hope everything goes well for you and just think positive.
  • I'm so sorry you are dealing with this! After my first trimester screen my risk for Trisomy 21 came back 1/340 and then after my quad screen the risk was lowered to 1/580. I recently went for for an anatomy scan and long story short they found an echogenic foci (calcium deposit in the heart) but everything else was normal. However, this increased my risk by a factor of 2 to 1/240 so I was offered the Maternity21 test. I decided to have the test done as it will give me a yes/no results for Trisomy 21 with 99.9% security. You can ask your OB for this test if it will help put your mind at ease. 
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