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MTHFR mutation experts needed!

SarahMeyer0823SarahMeyer0823 member
in Trouble TTC

Hi Ladies --

Yesterday I got the results of my RPL bloodwork. Everything came back normal except for MTHFR C677T. It came back as Heterozygous Positive. I'm trying to find some literature but have not had any luck yet. 

When my RE explained the results to me, he said they usually don't intervene unless there is more than one mutation. He said I can take a baby aspirin if I want. (I'm switching REs because I'm moving so I'm going to see what the new RE has to say)

Anyway, just wondering if anyone can give me any insight? TIA!

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TTC #1 since 11/1/2011
Me: 28 DH: 29
DX: Hypothyroidism (2004) & Possible PCOS (2/2012)
CD3 b/w: Elevated LH:FSH ratio HSG: All clear! Y-shaped Uterus; SA: Normal
Round 1 of Clomid (50mg) 8/28-9/1: BFP!
BFP #1: 9/23/12 Edd: 6/4/2013. M/C 9/28/12 @ 4w4d
Round 2 of Clomid (100mg) 10/3-10/7: BFP!
BFP #2: 11/3/12 Edd: 7/16/2013. mmc discovered at 18w2d (our baby girl stopped developing at 15w3d due to Down's Syndrome). d&e 2/15/13
3/28/13: "quite a few" uterine polyps and scar tissue discovered.
Hysteroscopy (4/16/13): Polyps, Scar Tissue removed. Septate confirmed & removed.
Appt with new RE 5/30/13
Surprise BFP (with no treatment!) 6/30/13
Our perfect little boy was born 3/11/14 - 9lbs 2oz, 21 1/4"

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Re: MTHFR mutation experts needed!

  • cupcake201cupcake201 member
    I usually post on IF but was just lurking here. Someone posted asking about MTHFR C667T yesterday on the IF board. I know nothing about MTHFR, so don't know if that one number off makes a big difference, but maybe some of the replies on that post might be helpful to you.

    ETA: changed a word

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    TTC#1 since 4/11 : m/c in 9/11 & 11/11
    DH dx with Balanced Translocation 5/12 
    Did 3 IVFs - 10/12, 1/13 & 4/13 before
    1 embryo passed PGD and transferred - BFP
    Our beautiful baby girl has arrived!
    S/PAIF Welcome

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  • monimu13monimu13 member

    I'm compound heterozygous, which means I have an extra copy of each of the 2 mutations.  My RE just put me on Folgard ( folic acid and B vitamins).  I'm not really an expert, but I think each different mutation has their own treatments/risks involved.  I'm told that mine is not that big of a concern until I hit menopause ( you can't take hormone replacements)...and you don't absorb folic acid appropriately.

    Hope some of this was helpful!

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    TTC since July 2011
    BFP #1: 2/15/12-Ectopic/Mtx at 6 wks
    BFP #2: 10/12/12-m/c at 5 wks. 
    BFP #3: 8/27/13
    Me: MTHFR, Low AMH (1.1), High NK cells and Antiphospholipid Antibodies.
    DH:MFI-Low morph (1%), DNA fragmentation: Excellent!
    5 rounds of clomid, 3 IUIs, and multiple non-medicated cycles- BFFN                                                      
    IVF with ICSI in August 2013 brought us our babies.  ER-9R, 7M, 4F w/ICSI  ET of 2-Grade 2 blasts. 
    + HPT at 6dp5dt. #1 (8dp5dt)- 105    #2 (13dp5dt)- 510  #3 (15dp5dt)- 960  #4 (17dp5dt)- 1889
    Dx shortened cervix, PTL, and preeclampsia during pregnancy.  Lots of medications and 13 weeks of bedrest, babies were born healthy at 34w4d!

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