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Lupron --- Anyone been told it oversuppressed them

teridanielleteridanielle member
in Infertility

As much of you know my first IVF got cancelled this week.  They coverted into an IUI for a last ditch effort to salvage what eggs I had produced.  I was cancelled, according to my RE, from a lack of response from the drugs.  I guess that means I was a poor responder to the long lupron protocol.  My RE believes that I am one of a small group of women that is "sensitive" to Lupron.  He stated he believes it oversuppressed me.  I had around 15 follies to start off with, but very few (only 4) grew to maturity by day so he decided to pull the plug.  Has anyone heard of this "sensitivity" to Lupron???  I have been trying to research this, but really can't find much on Mr. google about it. 

I will be on a new protocol come february (if this IUI is unsuccessful).  He wants to take Lupron out all together, do three weeks of BCPs, and start stimming with follistim and Menupor, with the addition of Ganirelix.  Has anyone had success with this protocol?  I've read this protocol is used mostly for woman w/ DOR/POF.  I asked specifically if he believed I suffered from this and he said absolutely not... so why the protocol?   I also read this protocol produces less eggs.  Well, agonist protocol I was on didn't produce a substanital amount of eggs so how is a protocol that produces less eggs supposed to help me???? 

 Sorry for the long drawn out saga, but I'm just trying to understand this IVF process.  Still upset I got cancelled :( 

All Welcome

Me: 29 DH: 30

IF DX Endo Stage III/IV SA: PERFECT!

7/16/2011 Married handsome hubby!
9/2012 Lap/Hystercopy DX w/ Stage III endo
Bilaterial Uterine Suspension/D&C/HSG
HCG/D&D on R/L ovaries/chromaltubation/Uterine Polyp
10/2012 RE consult. DX move straight to IVF
IVF #1 11/27/2012
IVF #1 Cancelled for Low Response and Converted to IUI #1 --- BFN

IVF #1.2 BCP 12/29 Stims 1/21 w/ New Protocol - Antongonist (225 Menopur, 150 Follistim, & Ganirelix)
ER 2/2/13 11R,9M,8F -- ET 2/7/13 2 Beautiful Perfect Blasts/5 made it Freeze! -- 2/12/12 +HPT -- 2/14/13 Beta #1 71 -- 2/18/2013 Beta #2 521 YAY! Let this be our take home baby!

4/21/13 Massive Hemorrhage from unDX placenta previa.  Bed Rest for 7 months.

10/17/13 Gave Birth to our 8lb 2oz baby boy! 

8/30/15 Started Meds for FET schedule on 10/13/15

10/13/15 TX two great blasts.  Beta scheduled for 10/22/15

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Re: Lupron --- Anyone been told it oversuppressed them

  • cupcake201cupcake201 member

    I was on a long lupron protocol for my first IVF and we didn't have great results.  My E2 rose verrrry slowly and we ended up with 7 eggs but only 3 were mature.  My RE thinks I am overly sensitive to lupron and was oversuppressed.  We switched to a new RE for IVF #2 (for a variety of reasons) but he agreed and said he probably would've canceled me given my poor response if he had been my doctor then.  

    We are moving forward with IVF #2 next month with an Estrogen Priming Protocol, which is an aggressive approach.  Hopefully this new protocol does toe trick for you and you see an improvement.   


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    TTC#1 since 4/11 : m/c in 9/11 & 11/11
    DH dx with Balanced Translocation 5/12 
    Did 3 IVFs - 10/12, 1/13 & 4/13 before
    1 embryo passed PGD and transferred - BFP
    Our beautiful baby girl has arrived!
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  • J&D2007J&D2007 member
    My RE never used the word 'oversuppressed', but she said I had a poor response to stims. I was on long lupron protocol with bravelle and menopur for stims. This time we are using 3 weeks of bcps followed by Microdose lupron for only 2 days before adding in stims (and much more stims). She never mentioned taking me off of lupron all together. Btw, I had 16 follicles to start and 5 retrieved/5mature.
    Me: 37, DH: 38: ttc 7 years, dx: unknown
    10/11: after 2 years, saw a RE, FSH 5.4
    11/11: BFP! (surprise after thyroid & normal hsg),
    12/11: missed m/c after 7 week u/s, 1/12: D&C
    6/12 IUI#1-IUI #3: clomid = BFP!, C/P
    IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
    IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
    IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
    IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
    10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
    Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
    Baby Will born 8/18. He's perfect.
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  • kflynn81kflynn81 member
    I haven't had that happen with Lupron but it happened with the Ganirelix for me. For some reason it shut everything down and my cycle had to be cancelled. The microdose Lupron really worked well for me....in the sense that I've completed 2 cycles because of it.
    Me: 33, Endocrine issues & FVL       DH: 32, Nothing 
    NTNP 2009-2012         TTC since 2012:
    • Clomid, 2 IUI cycles, and 5 IVF cycles = BFN
    • FET #1   August 2013 = BFP!     EDD 5/11/14
    • Jack dx at 19w1d with Dandy Walker on 12/16/13
    • Severe Pre-e /HELLP set in Jack born sleeping at 20w1d on 12/23/13
    • FET #2 --July 2014  BFP!  ---  EDD  4/5/15

    Jack has handpicked his sibling up there :)

    My blog about IF and loss ... Kate's IF Blog

            Lilypie Angel and Memorial tickers 

                                                      

                                                                              Lilypie Pregnancy tickers


                  Anniversary





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  • teridanielleteridanielle member
    Thanks ladies! I'm hoping my next protocol works our better for me!

    All Welcome

    Me: 29 DH: 30

    IF DX Endo Stage III/IV SA: PERFECT!

    7/16/2011 Married handsome hubby!
    9/2012 Lap/Hystercopy DX w/ Stage III endo
    Bilaterial Uterine Suspension/D&C/HSG
    HCG/D&D on R/L ovaries/chromaltubation/Uterine Polyp
    10/2012 RE consult. DX move straight to IVF
    IVF #1 11/27/2012
    IVF #1 Cancelled for Low Response and Converted to IUI #1 --- BFN

    IVF #1.2 BCP 12/29 Stims 1/21 w/ New Protocol - Antongonist (225 Menopur, 150 Follistim, & Ganirelix)
    ER 2/2/13 11R,9M,8F -- ET 2/7/13 2 Beautiful Perfect Blasts/5 made it Freeze! -- 2/12/12 +HPT -- 2/14/13 Beta #1 71 -- 2/18/2013 Beta #2 521 YAY! Let this be our take home baby!

    4/21/13 Massive Hemorrhage from unDX placenta previa.  Bed Rest for 7 months.

    10/17/13 Gave Birth to our 8lb 2oz baby boy! 

    8/30/15 Started Meds for FET schedule on 10/13/15

    10/13/15 TX two great blasts.  Beta scheduled for 10/22/15

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  • new+tothisnew+tothis member
    I haven't started IVF yet but that's the protocol I'll be on (antagonist). My RE said she's choosing this for me because she's worried about OHSS. She's expecting a good number of eggs. She's hoping for 6-9 mature, fertilized eggs. I have low AMH but not low enough to have much of an impact on IVF. I also have endo.
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  • nawlinsgrlnawlinsgrl member

    I don't think there's anything wrong with trying the antagonist protocol.  That one worked for me the first time, but I did respond significantly better with the microdose lupron and a short dose of BCPs this time, and I was15 months older, which at my age, is significant. 

    It is so hard to say what's best, because it depends on age and dx, both of which are different between us.  Also, I never used the long lupron, so I can't speak to the effects of that on my cycle.  Did you discuss microdose lupron as an option?  I would think if you did a shorter dose of BCPs with that, any oversuppression issues might be averted.

    10/10: Married; 5/11: Dx: Blocked Fallopian Tube; 7/11: D&C/Hysteroscopy to remove polyp
    IVF #1: 9/11: ER: 12R, 11M, 10F, No Frosties; 5dt: 2 blasts, 1 morula; DD born 6/3/12
    IVF #2: 11/12-12/12: ER: 20R, 20M, 16F, 4 Frosties; 5dt: 3 blasts, DS born 8/9/13
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