XP: HLA matching questions — The Bump
Secondary IF

XP: HLA matching questions

I think that some (many?) of you may have gone through testing for HLA matching.

My first question is did your RE recommend it, or did you ask for it?  What lab did you use?  If you had a match, what is your strategy for dealing with it?

My situation: original RE did not consider it an important part of work up.  After numerous disappointing cycles, we pursued it with a nationally known expert on our own.  We were told by this expert that there was no matching problem.  Now new RE is suggesting that there actually may be a matching problem after all!  I am super frustrated.  

 Would appreciate any experiences you have had.  TIA!

TTC #1 12/2009
BFP #1 1/2010, M/C 6 weeks
BFP #2 6/2010, DD lost to congenital heart disease, we are heartbroken.

TTC #2 4/2011, diagnosed MTHFR, FVL
Four natural cycles BFN; Clomid IUI BFN; Follistim IUI BFN;
1/2012 IVF #1 BFN
4/2012 FET BFP #3
5/2012 7w1d u/s: anembryonic demise; M/C @ 8w.
6/2012 found Stage II/III endo on laparoscopy, removed w/ laser.
8/2012 IVF #2 epic fail: no viable embryos.

Vacation, break, second opinions, on to new RE.
1/2013 Surprise chemical pregnancy BFP #4 (break cycle), IVF #3 postponed.
2/2013 TI w/ hormonal support, prednisone, aspirin, Lovenox, acupuncture gave us a miracle BFP #5!
Heartbeat on U/S at 6w1d! Baby,please stay!!
Our miracle baby boy arrived 10/2013!  We are so in love!!

10/2014 Surprise BFP #6
Our second daughter arrived in May 2015!  We are so grateful!  

Lilypie Angel and Memorial tickers


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Re: XP: HLA matching questions

  • Did your RE say how HLA matching might help?  Just wondering because I had never heard to HLA matching before, googled it and all I found was a possible relation to recurrent miscarriages.  I would want to know how it would help before doing it.  Maybe you could get the results from the other Doctor so you wouldn't have to do the test again.  Did you tell the RE that you already pursued this with an expert in the area?

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    DD conceived after 3 years of ttc.
    MFI - DH had varicocele repair and took Clomid to get DD b. 02/2010

    TTC #2 since 6/2010
    10/2012 DH diagnosed with Epilepsy
    A few failed IUIs summer 2012 and 2013. 
    DH taking clomid and waiting to see if he needs another vericocele repair. 
    Hoping for a 2015 baby or babies. 
    Wishing, hoping, waiting.


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  • Well, according to some, matching is a potential problem, which can cause an abnormal immune system reaction to the embryo.  In some opinions, it can cause miscarriage or even loss of undiagnosed pregnancy (= infertility).  

     I do have all the results and the doctors are interpreting them in opposite ways.  Yes, the new RE knows about the previous expert opinion.  They disagree.  

     :( 

    TTC #1 12/2009
    BFP #1 1/2010, M/C 6 weeks
    BFP #2 6/2010, DD lost to congenital heart disease, we are heartbroken.

    TTC #2 4/2011, diagnosed MTHFR, FVL
    Four natural cycles BFN; Clomid IUI BFN; Follistim IUI BFN;
    1/2012 IVF #1 BFN
    4/2012 FET BFP #3
    5/2012 7w1d u/s: anembryonic demise; M/C @ 8w.
    6/2012 found Stage II/III endo on laparoscopy, removed w/ laser.
    8/2012 IVF #2 epic fail: no viable embryos.

    Vacation, break, second opinions, on to new RE.
    1/2013 Surprise chemical pregnancy BFP #4 (break cycle), IVF #3 postponed.
    2/2013 TI w/ hormonal support, prednisone, aspirin, Lovenox, acupuncture gave us a miracle BFP #5!
    Heartbeat on U/S at 6w1d! Baby,please stay!!
    Our miracle baby boy arrived 10/2013!  We are so in love!!

    10/2014 Surprise BFP #6
    Our second daughter arrived in May 2015!  We are so grateful!  

    Lilypie Angel and Memorial tickers


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