Infertility Veterans

this cycle is a disaster

This cycle really isn't going well at all. I am so frustrated and sad. Today is day 9 of stims. My right ovary is on vacation and not doing much of anything at all. My left is doing ok, but I will be surprised if we get more than 5-6 eggs. I am now on 2x the amount of stims I've ever been on before. I am not sure why my response has tanked this time around. My progesterone unfortunately rose a lot today, which is probably the biggest of my problems, since premature luteinization is associated with lower pg rates (the idea is that the premature rise in progesterone matures the lining out of phase with the stage of development of the embryo).

My understanding from my RE is that this means a fresh transfer is out. In addition, there is now some fluid in my uterus as well as a small echogenic area (thought to perhaps be the last remnants of retained placenta after my operative hysteroscopy). Lastly, my lining has inexplicably become thinner instead of thicker. I don't even know how that is possible (!). 

The plan now is to trigger on Friday for a Sunday retrieval. My RE doesn't think he will get many eggs but wants to cut our losses at this point and not go much further since the rising progesterone is a problem. Also, I saw my hematologist yesterday andthe pathology came back with clots in the twins' placentas so we will now do the clotting tests, but even if I have a clotting disorder I am not a candidate for clexane/lovenox due to my bleeding disorder. I am also feeling a little stressed out about that. I wish this didn't have to be so freaking hard and I know this is just the beginning.

IUIs #1-3 (1x unmedicated, 2x Clomid) = 2 BFNs, 1 m/c at 7w3d
IUIs #4-6 (injects) = 3 BFNs
IVF #1 = BFN
FET #1 = BFN
FET #2 = BFN
IVF #2 = BFP, b/g twins lost at 20w due to partial abruption/PPROM
IVF #3 = c/p 5w2d
Long-shot Clomid/Prednisone cycle before next IVF = BFP, our beautiful, healthy girl born 6/26/13!
~~
TTC again March 2014
FET #3 - May/June 2014
-
all embryos arrested before xfer - back to the drawing board...
IVF #4 - July/August 2014 
beta 1 (11dp3dt) 220, beta 2 (13dp3dt) 671, beta 3 (19dp3dt) 10762

Re: this cycle is a disaster

  • OMG!  I am so very sorry blueberries!  HUGE (((HUGS)))  Lots of T&P's coming your way!
    BabyFruit Ticker

    06.10.12 +HPT 06.12.12 Beta #1 = 2,770 06.14.12 Beta #2 = 6,300
    1st U/S 06.18.12 2nd U/S 06.25.12
    09.24.12 It's a Boy!! ---> Jacob Owen

    Our IF Journey Began: October 2009
    **8 Failed IUI's, 1 Blighted Ovum, & 1 Failed IVF**
    Dx: MFI, DOR w/MTHFR Homozygous A1298C & Hypothyroidism
    03.2012 Lab Results: FSH 6.83 AMH 0.67 TSH 3.8 E2 17
    SA 156 million 93% motility 3% morphology

    Follow Me on Pinterest
    **~PAIF/SAIF Always Welcome~**
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  • may2806may2806 member
    I'm sorry this cycle isn't working out like you hoped ((HUGS))
    Dx: High FSH, stage IV endo, homozygous C677T MTHFR and PAI-1
    Early loss 10/08
    Lap 1/09
    IVF #1 "natural IVF" - 1 egg retrieved, missed m/c
    Tried several mini-stim cycles with no response
    Switched clinics - dx'd as carrier for Fragile X
    IVF #2 MDL protocol Jan/Feb converted to IUI, BFN
    IVF #2 take 2: Antagonist, one embie, BFN
    IVF #3: Antagonist, no fertilization
    One last ditch effort at OE IVF (antagonist with Clomid) cancelled
    DE cycle #1 Jan/Feb 2011, BFP, ectopic
    DE cycle #2 June/July 2011 - BFP
    10/28/11 Baby girl lost at 17 weeks due to pre-term labor. We love and miss you.
    DE cycle #3 June/July 2012 - BFP, twins, both heartbeats stopped, D&C
    2 frosties but don't know what's next
    FET Dec 2012: BFP! Praying this one sticks for the long haul!
  • mm29mm29 member

    I'm so sorry!  I am keeping my fingers crossed that things turn around!!!  

     (((Huge Hugs)))

    ::: Married June 2003:::
    TTC #1 since: Aug. 2008
    Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo
    DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA
    Tx History: IUI 1&2= BFN
    IVF# 1 W/ICSI= BFN
    IVF# 2: cancelled d/t no response
    IVF# 3= 1 egg retrieved=immature/not viable
    IVF# 4= c/p
    ***CCRM ODWU***
    Found DHs BT and Me-decreased blood flow to uterus
    Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally
    ***New RE***
    DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture. 
    IVF# 6: (OE/DS) cancelled
    IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5
    Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015


    http://icanhazbabyz.blogspot.com/
    imageimage image 
  • Hang in there honey, sometimes when people thought they were out this cycle, turned out to be there lucky cycle:) thought an postive vibes yours way
    Image and video hosting by TinyPic Me: 28 // DH: 28 TTC #1 since 6/2010 Unexplained Infertility Diagnoses HSG: all clear 07/2011 // SA: Great! 07/2011 SHG : everything normal 08/2011 100mg Clomid, Ovidrel Shot, TI = BFN 09/29/2011 unmediated IUI #1 BFN 10/10/2011 taking a break from fertility treatments 11/2011 Clomid 50 mg IUI #2 BFN 03/2012 Clomid 100 mg IUI #3 BFN IVF scheduled for July 2012 08/29/2012 BFP! Beta #1 on 8/29 250 Beta #2 on 8/31-461 BabyFruit Ticker My Blog
  • reb259reb259 member
    I am so sorry I was hoping to hear something very different.  I am sending T&P's as well as a huge hug!!
    I am AMA and all tests on H came back normal
    3 failed IVF with OE and 2 failed frozen DE cycles
    Last fresh hail mary DE cycle starting Feb 2013
    PAIF/SAIF always welcome
  • I'm so sorry, Sweetie ((BIG HUGS)) After everything you've been through I wish this could just go according to plan.

    I hope they get some good eggs on Sunday and that you can get some answers with your upcoming tests. 

    TTC 12/2009
    Me: 32 - Stage II Endo / DH: 36 - Low count and morphology (1%)
    IUIs 1-3 BFN, lap Dec. 2010, IUIs 4-6 BFN
    IVF w/ICSI #1 - ER 2/8: 24R 19M 9F ET 2/13 2-5 day blasts (no frosties) = BFP - b/g twins!
    E & C Born 10/19/2012
    Lilypie First Birthday tickers
  • i'm sorry cutie.

    i hope everything works out.

    ((HUGS))

    image
    Worrying does not empty tomorrow of its troubles, It empties today of its strength. ~Corrie ten Boom
    Courage doesn't always roar. Sometimes courage is the little voice at the end of the day that says I'll try again tomorrow. ~Mary Anne Radmacher (thank you beadinglady)

    It's been a long journey. TTC since 9/06. multiple IUI's and IVF's and 4 m/c's. IVF#3 = BFP, twins, induced at 34w6d due to baby b passing away (no explanation). Delivered on 35w1d, Baby A - baby girl, and Baby B - baby boy, our little angel.
    MTHFR A1298C & C677T, Immune Issues and Factor II
  • Oh sweetie - I am so sorry.  I wish it could be a little easier too.  Be kind to yourself and your body.  It has been through a lot lately.  huge ((hugs))
    TTC since 07/2009
    Me: PCOS, Blood/Immune Issues DH: Low all 3
    Jun.- Sep. 2010 IUI#1-#3 = BFN
    Oct. 2010 = IVF #1 = B/G Twins (passed away Feb. 2011)
    May 2011 = Myomectomy and trans-abdominal cerclage (TAC)
    Sep. 2011 = Surprise BFP = C/P
    Feb. 2012 = sFET #1 = BFN
    Feb.2012 = Hail Mary IUI #4 = BFN
    April/May 2012 = FET #2 w/our last two embies = BFP (Please let this be it!)
    Beta #1 8dp5/6dt = 234 Beta #2 10dp5/6dt = 695 Beta #3 12dp5/6dt = 1796 Beta #4 17dp5/6dt = 17,888 U/S #1 May 17, 2012 = Twins
    Baby B's heart stop beating at 9 weeks 5 days
    Our little miracle baby is a boy. :)

    Baby Boy Owen and Baby Girl Avery were born too early on Feb. 13, 2011 due to a pedunculated fibroid, incompetent cervix and suspected placental abruption.
    Lilypie Angel and Memorial tickers

    "What the heart has once owned and had, it shall never lose." - Henry Ward Beecher
    SAIF/PAIF Welcome
    Lots of love and luck to my PAIF/3T/IF Veteran ladies, especially my dear friend Zookie. Congrats to Papps, Teach84 and Starbuck on their little ones.
  • Hugs!!!!

     

    I had a cycle where I had no response at all, after 7 days. My e2 was only 92.  I ended up on max Stims and triggered after 13 days of Stims.  It ended up yielding a good egg count, and we weren't expecting much at all.  

     

    Are u thinking of cancelling?  I know I was.  Praying for a good outcome.  

     

     

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  • I hope there are still some good surprises in store for you with this cycle. Big hugs!!
    (Live in Europe) TTC since 1/2010
  • (((hugs)))

    I'm sorry this cycle is not going as planned.

    Me: 35 DH: 37 TTC since 4/2010
    DX: 6/9/2011: Azoo ICSI/IVF only option for biological child
    IVF #1: ER - 9/26 * ET - 10/1 * beta#1 10/13 - 140 * beta#2 10/17 - 477 * beta#3 10/20 - 1101
    1st u/s at 6w6d - one hb * 2nd u/s at 8w3d - no hb detected 11/10/11 * natural m/c 11/13/11
    FET #1 Jan/Feb 2012 - 3 delays - cancelled 2/13
    FET #1.2 - May/June 2012 - ET 6/6/* beta#1 6/15 - 95 * beta #2 6/19 - 322 * beta #3 6/22 - 940
    7/6 1st u/s @ 7 weeks - one beautiful hb - released from RE
    EDD 2/22/2013
    PAIF/SAIF/PGAL welcome
    imageimageimageimage
    BabyFruit Ticker
  • Huge hugs and hoping you ER goes smoothly and your eggs are of great quality.
    +++
  • Hugs.  I'm so sorry you are having more troubles.  For IVF 4.2, I had the same problem.  One ovary decided to take a vacation and we only got 1 from it and 6 from the other, for a total of 7.  That is the lowest number of eggs I ever had for ER.  I was so disappointed.  However, we got the highest fert rate ever with 6 out of 7 fertilizing.  Unfortunately, they all tanked from there.  However, I wanted to say that you shouldn't give up because many ladies only get a few eggs and end up pregnant.  I just hope your little take home baby is in the bunch and don't give up.  It's not over for you yet.
    TTC #1 since October 2008. Dealing with MFI.
    IVF #1 w ICSI in July 2010 = BFN
    IVF #2.1 in Oct 2010 converted to IUI = BFN
    IVF #2.2 w ICSI in Dec 2010 = BFN
    Met with new RE in new city on 1/31/11.
    IVF #3 w ICSI in April 2011. HPT on 5/9 = BFP!
    Beta #1 on 5/10 (10dp5dt) = 99.4. Beta #2 on 5/12 = 284. First u/s on 5/26. = Fraternal TWINS!
    Twin boys born & lost on 8/16/11 at 18w1d due to PPROM & preterm labor.
    IVF #4.1 in Jan 2012 converted to IUI on 1/7/12 = BFN
    IVF #4.2 w ICSI in Feb 2012. Lupron on 2/10. Stims on 2/18. ER on 2/29- 7R,6F
    ET scheduled for 3/5/12- nothing to transfer :(
    Dh seeing new MFI uro & Dh starting meds- June 2012.
    IVF #5 in Dec 2012 = BFFN.
    IVF #6 planned for Spring 2013. Praying for our take home baby/ies.
    **P/SAIF and P/SAL always welcome!**

    Lilypie Angel and Memorial tickers
  • Ugh, so much stress! I'm sorry, blue :(

    All I can think is maybe the decision will be made for you whether you wanted to freeze or do a fresh transfer this cycle. Hopefully, even if you only get a handful of eggs, they'll be GREAT ones. Big ((HUGS)) to you both right now xoxo 

    I suck at getting pregnant
    I really suck at staying pregnant
    image
  • MoFreeMoFree member
    I'm so sorry.  I wish things could be easier for you.  You certainly deserve a break.  
    TTC since 3-08 IVF # 1 Dec 2011 BFP DD born at 31 weeks 6-24-12

    FET #1 Dec 2013 BFN

    FET # 2 Feb 2014 BFN

    No more frosties

    IVF #2. September 2014

    PGD yielded 2 perfect 5d blasts

    SET November 9, 2014
    Nov 23, 2014. Another BFN

    Not sure where to go from here.

    image

    Lilypie Premature Baby tickers
  • Big hugs.  So sorry to hear this, I hope everything works out for you.
    Renee- 37 DH - Chad - 39
    2/06 - surprise pregnancy - twins
    3/06 - m/c 1st baby at 6 weeks 
    5/06 -2nd baby had no heartbeat at 14 wks.
    D&E - Bled out. Blood transfusions. Week in ICU - Cheated Death!
    Diagnosis: Blood clotting and bleeding disorder, immune issues, & cervical stenosis
    5/10 - 1st IVF cycle - BFN
    FET - 10/12/10 - BFN
    1/11 - IVF with PGD - BFN
    IVF - May - BFN
    6/11 New RE - fingers crossed!
    9/11 - IVF - 4 transferred
    10/13 - BFP!!
    It's a boy! Clint Michael, Due in June!!!

    image
    Baby Birthday Ticker Ticker





  • AmCheriAmCheri member
    I am so sorry blue.  :(  It's profoundly unfair.  Keeping my FX that you get some beautiful eggs on Sunday. 
    Baby girl Lila born 2013.
    Baby boy Henry born 2015.
    Expecting our capstone baby (boy) early March 2018.
  • I am so very sorry blueberries.  ((hugs))
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  • Huge huge hugs to you hun! My heart breaks for you!
    Pregnancy Ticker
  • ((((HUGE HUGS))))  I'm so sorry.  Lots of T&Ps heading your way.
    TTC #1 Since 4/2010, Cycle 30
    Positive for HLA-B27, I'm a mutant :p
    Testing - Me ok, gluten issue? DH - borderline count, low motility
    4/28/11 IUI#1 = BFP!(5/25), EDD 2/2/12 - m/c 5w3d
    7/3, 7/31, 9/25 - IUI#2-4=BFN
    IVF#1 - 1 blast = BFP!! (12/30), EDD 9/9/12, confirmed c/p 4w2d
    FET#1 3/2/12 - 2 blasts =BFP!! EDD 11/18/12, us#1 = twins! Confirmed m/c 5w6d
    4/20-surprise BFP and another c/p 4w2d
    FET#2 7/16/12 - 2 blasts = BFN
    FET#3 8/20/12 - 1 blast - BFP!! Beta #1-2=177, 354
    1st u/s 5w6d, one beautiful little HB :), 2nd u/s 146bpm
    baby girl born 5/10/13

    TTC#2 since 12/17/2014, Cycle 8
    Repeat Testing...FSH=12, AMH=3.8, AFC=28. 
    IUI#5 5/10/15- c/p?
    IVF#2 8/19/15 - cancelled due to cysts
    IVF#2 take two 10/2015 - 5 blasts frozen
    FET#4 12/11/2015 - BFN - 4 blasts remaining
    FET#5 2/18/16 - BFP!!!  Beta1-3, 126, 250, 745!!

    Image and video hosting by TinyPicLilypie Angel and Memorial tickers

    Tons of love and ((hugs)) to my IF sister NMscubagirl


  • I am so sorry!!  I can't stand how hard it is, it's just terribly unfair.  :( 

    I had the same progesterone problem with my first IVF, we froze the 2 embies we got from it and xferred them later.  They were of better quality than the 2 we got from IVF2, fwiw.

     Wishing you beautiful quality eggs and embies from this difficult cycle!!

  • OH sweets. I'm so sorry it's so difficult right now. ((hugs))
    TTC with severe MFI since 9/08 IVF w/ ICSI #1 May/June 2010= BFP twins
    Callan George and Bennett Charles born and died 11/7/10
    Lilypie Angel and Memorial tickers
    FET #1 April 2011= BFN
    FET #2 July 2011= no transfer because my lining sucked
    FET #3 February 2012= BFP! 1st beta 9dp5dt=314 2nd beta 11dp5dt=977 1st U/S 3/20 Twins- Heart rates of 111 and 138 Pregnancy Ticker
    Living After Losing
  • Thanks for the kind thoughts, guys. I will let you know how retrieval goes tomorrow. Still feeling sad and disappointed with the way things are turning out.
    IUIs #1-3 (1x unmedicated, 2x Clomid) = 2 BFNs, 1 m/c at 7w3d
    IUIs #4-6 (injects) = 3 BFNs
    IVF #1 = BFN
    FET #1 = BFN
    FET #2 = BFN
    IVF #2 = BFP, b/g twins lost at 20w due to partial abruption/PPROM
    IVF #3 = c/p 5w2d
    Long-shot Clomid/Prednisone cycle before next IVF = BFP, our beautiful, healthy girl born 6/26/13!
    ~~
    TTC again March 2014
    FET #3 - May/June 2014
    -
    all embryos arrested before xfer - back to the drawing board...
    IVF #4 - July/August 2014 
    beta 1 (11dp3dt) 220, beta 2 (13dp3dt) 671, beta 3 (19dp3dt) 10762
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