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Endo Biopsy?

BeeBee08BeeBee08 member
in Infertility
I have an IRL friend who had an endo biopsy yesterday and will have another one right after ovulation, then next cycle she will be doing FET.  She said that there has been research showing that the biopsy helps improve implantation rates.  Do any of your clinics do this?  Has anyone had one done and why did you do it?

 
me 33/DH 36
ttc since 10/2008; d/x: mild MFI, stageII endo
~~PAIF/SAIF Welcome~~
11 IUI’s = 1 m/c (7w4d)
IVF#1 January 2012 BFN, FET #1 April 2012 BFN
Surprise BFP October 2012 m/c (7w), Surprise BFP April 2013 m/c (6w4d)
IVF #2: July 2013, ET 1 embryo 7/18, beta 1 @ 14dp3dt - 757, beta 2 @ 16dp3dt - 1762
U/S 1 @ 6w4d = 1 little frogger with HB of 118, U/S 2 @ 7w3d measuring right on track with HB of 160
Stick Frogger Stick! Please!!!!!!!!!!!!!   It's a Girl, EDD April 7, 2014

BabyFruit Ticker

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Re: Endo Biopsy?

  • STL34STL34 member
    I had one before IVF #2.  I had a cyst aspiration and hysteroscopy.  They found a polyp and removed it.  And, since my RE was already in doing a bunch of stuff, he did an endo biopsy because of the research that shows it may help with implantation rates.  It didn't help me, though.

    imageimage


    ~SAIF/PAIF/Everyone Welcome~ 

    Me= 37 and DH = 41 

    Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)

    IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN

    IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.

    IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132.  Lil is here!

    TTC#2:  Trigger + TI = BFN; Clomid + Trigger + IUI = BFN.

    IVF #4:  BCP + MDLF + Lovenox = 7R, 1F = Transferred 1 6-cell embryo on day 3 = BFN

    IVF #5:  MDLF + Lovenox = 4R, 1F = Transferred 1 10-cell compacting embryo on day 3 = BFN

    IVF #6:  (New RE):  Long Antagonist November 2014 (transferred two 8 cell grade 1 embryos and froze one blast) = BFN

    FET#1:  BFN

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  • Edwina.McDunnoughEdwina.McDunnough

    If you google scratch biopsy IVF you'll get a lot of information. This is one of the things that was suggested to me by SIRM, but we did not proceed with this clinic, and the procedure seems very specific and different from biopsies of other kinds.

    https://www.bellaonline.com/articles/art20828.asp

    Otherwise, I have had them done for tissue testing (with a mini scrubby brush instrument) and for my cocultures (with a catheter and suction type thing).

    +++
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  • BeeBee08BeeBee08 member
    imageEdwina.McDunnough:

    Otherwise, I have had them done for tissue testing (with a mini scrubby brush instrument) and for my cocultures (with a catheter and suction type thing).

    That's what I had thought it was more for diagnostic testing.  But thank you both for the additional info.  I'm wondering if it's something I should ask my RE to do while she's in there for the lap and hysteroscopy. 

    Edit: spelling

     
    me 33/DH 36
    ttc since 10/2008; d/x: mild MFI, stageII endo
    ~~PAIF/SAIF Welcome~~
    11 IUI’s = 1 m/c (7w4d)
    IVF#1 January 2012 BFN, FET #1 April 2012 BFN
    Surprise BFP October 2012 m/c (7w), Surprise BFP April 2013 m/c (6w4d)
    IVF #2: July 2013, ET 1 embryo 7/18, beta 1 @ 14dp3dt - 757, beta 2 @ 16dp3dt - 1762
    U/S 1 @ 6w4d = 1 little frogger with HB of 118, U/S 2 @ 7w3d measuring right on track with HB of 160
    Stick Frogger Stick! Please!!!!!!!!!!!!!   It's a Girl, EDD April 7, 2014

    BabyFruit Ticker

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  • thewormstheworms member

    there are a few clinics that do this to improve implantation and as edwina said they call it a scratch biopsy.

    it can't hurt to discuss it.


    image
    Worrying does not empty tomorrow of its troubles, It empties today of its strength. ~Corrie ten Boom
    Courage doesn't always roar. Sometimes courage is the little voice at the end of the day that says I'll try again tomorrow. ~Mary Anne Radmacher (thank you beadinglady)

    It's been a long journey. TTC since 9/06. multiple IUI's and IVF's and 4 m/c's. IVF#3 = BFP, twins, induced at 34w6d due to baby b passing away (no explanation). Delivered on 35w1d, Baby A - baby girl, and Baby B - baby boy, our little angel.
    MTHFR A1298C & C677T, Immune Issues and Factor II
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  • blueberries8blueberries8 member

    Here's a good review article on the topic: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025807/?tool=pubmed

    The basic idea is that if you cause local injury to the endometrium during the luteal phase of the cycle preceding IVF, it causes an inflammatory response that for poorly understood reasons seems to improve implantation rates. The increased implantation rates achieved in the original study, which I believe was all women with multiple failed IVFs, was pretty impressive. I think it's definitely worth asking about...I am interested in doing it before my next fresh cycle if my RE is open to the idea.

    IUIs #1-3 (1x unmedicated, 2x Clomid) = 2 BFNs, 1 m/c at 7w3d
    IUIs #4-6 (injects) = 3 BFNs
    IVF #1 = BFN
    FET #1 = BFN
    FET #2 = BFN
    IVF #2 = BFP, b/g twins lost at 20w due to partial abruption/PPROM
    IVF #3 = c/p 5w2d
    Long-shot Clomid/Prednisone cycle before next IVF = BFP, our beautiful, healthy girl born 6/26/13!
    ~~
    TTC again March 2014
    FET #3 - May/June 2014     -     all embryos arrested before xfer - back to the drawing board...
    IVF #4 - July/August 2014 
    beta 1 (11dp3dt) 220, beta 2 (13dp3dt) 671, beta 3 (19dp3dt) 10762
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  • BeeBee08BeeBee08 member

    Thank you for the great article!  I am definitely going to ask about this tomorrow.  It might be bad timing if I O after the lap, but it could still be worth a shot.

     
    me 33/DH 36
    ttc since 10/2008; d/x: mild MFI, stageII endo
    ~~PAIF/SAIF Welcome~~
    11 IUI’s = 1 m/c (7w4d)
    IVF#1 January 2012 BFN, FET #1 April 2012 BFN
    Surprise BFP October 2012 m/c (7w), Surprise BFP April 2013 m/c (6w4d)
    IVF #2: July 2013, ET 1 embryo 7/18, beta 1 @ 14dp3dt - 757, beta 2 @ 16dp3dt - 1762
    U/S 1 @ 6w4d = 1 little frogger with HB of 118, U/S 2 @ 7w3d measuring right on track with HB of 160
    Stick Frogger Stick! Please!!!!!!!!!!!!!   It's a Girl, EDD April 7, 2014

    BabyFruit Ticker

    Report Reply
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