Our baby girl's name will be Keira. It's after DH's grandfather Kyran (pronounced keer-in)  who passed away several years ago. We are very close to my FIL (name is Joseph), so DH wants to incorporate his name somehow.....so we are thinking Keira Jo---here's the question--would you spell it the traditional "female" way, as in "Jo", or "Joe"? DH wants to do "Joe" so that it's truly after his dad...but I like "Jo" better and I think it's still representative of his father, even though it's spelled differently. Thoughts?                
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Re: Middle name help
I think Jo is perfect for naming a girl after a boy.
My mn is Louise named after my Dad Lewis...
I would go with Josephine. More directly relates to the person you want to honor and flows well with Keira.
Heather