another morph quesiton

itsmyangel · July 2009

Does anyone know if poor morph (0 percent in our case) can be cuased by chormosomal issues which would be the cause of our m/c? I'm worried we ckeep trying or we do tx that then it'll keep resulting in m/c and i know the only way to know for sure is to do a genetic test (super costly)......although one site i saw said that if a pg were to occur with poor morph that shouldn't affect the baby?

EmptyOven25 · July 2009

Typically, an abnormal sperm (what morph measures) is not able to reach and/or fertilize the egg because it is deformed or lacks DNA. I don't think it's possible to get pg with an abnormal sperm trying to fertilize the egg.

This is why I'm saying you need to get a repeat SA, though. Those numbers can change dramatically from one sample to the next. He could go from 0% in this sample to well over 15% in the next. My h went from 10million/ 50%mot/ 12%morph to 23million / 30% mot / 15% morph in his second analysis. I've seen people on here who in one SA have no sperm and who in the repeat have 40+million. You just never know until you have that repeat.

I do not think your m/c's could be related to the morph, because as I said, an abnormal sperm is not able to fertilize the egg.

itsmyangel · July 2009

thanks you made me feel better

PrincessShay80 · July 2009

My DH has 1% morph- we did ICSI with IVF and had a 100% fert rate and had 4 great looking blasts on day 5. So obviously the sperm did not make that much of a difference.

I agree with the PP that an abnormal sperm doesnt really have much of a chance to fertilize the egg. Which is why ICSI is so great for sperm issues. I had a miscarriage very early on which my RE feels is an egg issue- he feels that most miscarriages in the 1st trimester are an egg issue (most times chromsomes) Usually with morph issues the issue is fertilization because the sperm cannot fertilize the egg.

Have you had any recurrent pregnancy loss blood work done? That could be helpful. Also an autoimmune panel may be helpful as well.

EmptyOven25 · July 2009

But then I saw this...

https://www.acubalance.ca/content/miscarriages-linked-defective-sperm-and-lower-sperm-counts

So, I'm not sure.

My first comment was going off of what my RE told me. We have to do IUI to get rid of the "bad" sperm, because they block the "good" sperm from doing their job.

If a second SA comes up bad, definitely get to a uro. There are so many options available to try. Has he had bloodwork? Guys can end up having just as many IF tests as we do sometimes. Good luck!

ginger67 · July 2009

My RE says if it can get in the egg your o.k.

itsmyangel · July 2009

i had the lupus anticoagulant and hsg everything looked normal on my end except pcos...which i know can cause higher m/c rate too *but i was on metformin which should help that* he's not had bloodwork or anything done yet

fallbride110406 · July 2009

There is much more to the RPL panel than just the Lupus Anticoagulant. I would highly suggest getting the full RPL panel to make sure there's not something easily fixed that could be causing your losses. Off the top of my head, here's the tests in the RPL panel:

ANA, ACA, MTHFR, Factor V Leiden, Proteins C and S, Natural Killer Cells, Lupus Anticoagulant

My RE also did a homocysteine check on me, which when I came up positive for MTHFR, gave them a huge indicator of how severe my case was. My homocysteine levels were almost 4 times higher than they should have been.

My RE also ordered karyotypes (the DNA testing for genetic abnormalities) on both my husband and myself to make sure we weren't both recessive carriers for something that was being passed on. All of this was covered by insurance since it was coded as "recurrent pregnancy loss/habitual aborter" and not infertility.

wiscgirl95 · July 2009

When we found out we had zero morph they did an ultrasound, blood tests to check hormones and another genetic test. They said there was a chance that he could have fragmented DNA (????) or something similar. I didn't pay too much attention to all the tests as they were being ordered and now I kind of forget since they all came back normal. But I definitely remember one of the blood tests having to go to some special lab to check for a fragmented chromosone/DNA. Sorry, I'm not science minded and I'm trying to help . . . I just don't remember all the specifics.

fallbride110406 · July 2009

The fragmented DNA might be testing for the Y micro deletion. That can effect morph and the sperm.

wiscgirl95 · July 2009

fallbride110406:
The fragmented DNA might be testing for the Y micro deletion. That can effect morph and the sperm.

YES! Thank you, this is the one I was thinking of. DH had this test.

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