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MTHFR...please help:(

jjames2901jjames2901
in Infertility
A little background. I've had 2 mc's in a year. I started going to an RE recently. He started me on clomid and had my husband and I both get bloodowork. I have 1 copy of the MTHFR mutation, which they found in my RPL panel. They said it wasn't a big deal. Well my RE just called me and said my husband has 2 copies and he wants us to go see a hematologist. He made it sound treatable but did mention IVF. Could anyone shed some light on what is going on and what to expect with a hematologist? Does this always mean IVF?
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Re: MTHFR...please help:(

  • PrincessShay80PrincessShay80

    I have two copies of the C677T MTHFR mutation- I was put on baby asprin, extra prescription folic acid and I am on the Lovenex injections (blood thinners) I started them when I started stims for IVF, I stopped right before ER and I will start up again after ET.

    My DH was never tested- but  we had to do IVF becasue of sperm issues, not because of the MTHFR- I was never under the impression that MTHFR had anything do with having to do IVF. Good luck!

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  • outofcntrl82outofcntrl82

    I have the MTFR gene- it means that I can not metabolize folic acid and my doc just put me on a higher dose of folic acid. I also take baby aspirin (81 mg) a day to prevent clotting. MTFR can cause m/c because it is a blood clotting gene but easily treatable.

    It doesnt mean you have to have IVF if you have it.

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  • fallbride110406fallbride110406 member
    Agree with PPs.  I was diagnosed with Compound MTHFR (I have one mutation on each of the two genes) and I take 6.2mg of Folic Acid and low dose aspirin after ER, then Lovenox once I get a BFP.  We're doing IVF because of MFI though, not MTHFR.
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  • ashlyroseashlyrose
    I have 2 copies of C677T MTHFR. It was recently dx just like you after my 2 losses. I started taking over the counter folic acid enough to equal 4mg. Also my RX prenat which only has 1 mg. I asked about baby aspirin & it wasn't prescribed by the dr to take yet. I was told about taking Lovenox in the future but that will be discussed if I can get a healthy pregnancy. My H wasn't tested but I asked about siblings/family to get tested because it's genetic & I have 1 copy of each parent. SInce my brother of course won't be carrying a pregnancy he doesn't need to take that much extra of folic acid that his multi vitamin has. My RE said to have the homocysteine (sp?) levels checked. If that is high, then MTHFR could be causing that. IVF is not done just for MTHFR.
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  • wiscgirl95wiscgirl95 member

    I've tested positive for heterozygous MTHFR A1298C mutation.  I had a superficial blood clot years ago and was given all kinds of tests.    My understanding was since I have 1 copy of the mutation and it's not compounded with C677T that my risk is low for blood clots and miscarriage.  I also tested positive for heterozygous for the prothrombin 20210A gene mutation.  I had numerous visits (mostly to repeat the tests) with a hematologist and after all the tests were concluded he said call me if you get pregnant and I may or may not put you on a blood thinner.  He did advise to take a baby aspirin and that those 2 alone did not have him concerned.  FYI, we figured out it came from my mother's side.  My sister, mother, 3 aunts have had total 13 uneventful pregnancies.


    Good luck. 

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