Infertility

PIO injection tips?

So if all goes well at ER tomorrow, I will be starting my PIO injections tomorrow night. I have a huge fear of needles and can't believe I've made it this far!

DH will be administering them, but I was wondering if any of you ladies have any tips for making PIO injections as easy as possible? From what I've read, sometimes the after-effects are worse than the injection itself? Any tricks of the trade for easing this pain in the @ss and preventing lumpy-butt? :)

*** Trigger Warnings ***

TTC #1 since March 2011
Dx = Unexplained IF
1 medicated TI cycle & 4 clomid IUIs = all BFNs
June 2013 IVF #1 = 6 frosties + BFP!
DS1 born 2/14

TTC #2 since December 2014
May 2015 unassisted BFP ended in m/c at 7wks
April 2016 FET #1 = BFN
June 2016 FET #2 = c/p
August 2016 FET #3 = BFP!
DS2 born 4/17

Re: PIO injection tips?

  • I heat the oil up to body temp either with a heating pad or just sticking it in my bra for a few minutes. You can either lay down or bend over a counter, I use our bed bc it sits up high, for the shot itself. Massage and/or a heating pad after will help disperse the oil if you can manage that. I actually have to do my shot right before I go to work and I work on my feet, so I haven't needed to massage it bc the walking around all night seems to do the trick.

    Good Luck!
    Me: 37, DH: 35 :: TCC since 2/11 SA: Perfect! CD3  HSG = Blocked Right Tube
    April- Femara 2.5mg + Trigger + IUI = BFN   May- Femara 5mg = CX - No Response on Left = BFN
    June- Femara 7.5mg + Trigger + IUI = BFN  August- Lap & Hysteroscopy = Blocked & Partially Blocked Tubes
    September- Femara 5mg = CX - No Response on Left = BFN  October- 100mg Clomid + Trigger + TI = BFN
    IVF # 1: Stims 11/30 ER 12/12/12! (10R, 10M, 8F, 2T, 6 F) :: Beta #1- 176  c/p @ 4w4d
    FET #1 February 26th :: Lost 4 to Thaw, Transferred 2 = BFFN
    IVF # 2 Stims 5/10 ER 5/21 (15R, 13M, 13F, 2T, 7F- 6d3 & 1d5) :: Beta # 1- 15 c/p @ 4w
    FET #2 Cancelled, Right Tube Developed a Hydro  8/28 Hydro & Scar Tissue Removed  Cleared for FET
    FET #2.2 Scheduled for September 20th
    2 Thawed, 2 Transferred! Beta #1- 96, Beta #2 906! :: EDD June 10th
    2015- 2 failed FET. We are done
    SURPRISE! BFP 8/8/16   EDD 4/1/17

     
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  • Ask the nurse to draw a circle where you should inject. It's higher than you think! I also stick the vial in my bra to warm it up.
  • **siggy warning**

     

     

     

     

    i ice for 5 minutes before and dont' even feel it.  i use a heating pad for 5-10 minutes after and DH massages.  I do have the lumps though- and they SUCK.  the actual injection is fine though, the lumps are what hurt and i don't usually get them until about day 10 of injections.  this go-round they hurt much less and are smaller than my first cycle.  good luck, you will be fine!!! 

    Me (37) DH (39); PCOS changed to Unexplained, changed to DOR in 2012 (finally a correct diagnosis!); 
    Started TTC 2009 with RE after 6 months.  
    Clomid + Trigger x2; 
    IUI + Femara x1,
    IUI + Follistim x2;
    IVF #1 (MDL) February 2013- BFN.
    IVF #2 (antagonist) May 2013, First BFP of my life. 
    Identical twin miracle BOYS (!!) headed our way- due date is technically 2/4/14 but c section is scheduled for 1/7! 


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  • I posted on IFV about this today too.  Also I had the nurse draw circles :) 

    I have been on it and hopefully will be starting back on it on Wednesday.  First warm it.  The fastest way I found to do so is by rolling it in my heating pad.  I like laying down for the injection.  I lay down on the couch because it makes it easier for me to relax.  I put my hand on my hip bone to give him a marker (he goes just below hip bone in outer upper quadrant, it's more like low low back than butt).  I have DH countdown (3-2-1).  When he gets to 1, I squeeze my hand in a fist tightly (digging nails into palm, this makes me focus more on the palm pain than the needle stick).  He pulls back, then injects slowly.  Afterwards, he massages hard for a few minutes.  If it is before the transfer, I will use a heating pad after ( I was told not to use heating pad after transfer because it may increase your body temperature).  It also helps to move around after.  I like someone's suggestion to walk up and down the stairs.  I was definitely sore the next day but as time goes on, you get used to it and the soreness dulls.  I have also given myself the PIO and delestrogen last cycle during beta hell when DH was out of town.  It's not as hard as it seems.  I really felt proud of myself and it gave me some positive feelings when everything was going hell.  By this point, I had been on it for at least 2.5 weeks.  You could see where all the marks where so the spot was easy to find.  I laid on my hip/side to be able to turn a little bit to see it and just stuck it.  Pulling back is the hardest part to injecting yourself I found. You could definitely do the injects if you have to!!  I think that I prefer it to the suppositories because I know that I am getting the right amount and it's not messy.  Good luck!!  

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    Married June 2011 Dx: anovulatory due to prolactinoma (1.5cmx 1.5cm in 2006)
    April 2012: MRI- questionable cyst 8mg by 12mm in pituitary ; referred to RE by Ob-gyn after amenorrhea x 4+ months, provera ineffective, low estrogen level
    cycle 1: May 2012, clomid 50mg; cycle cancelled, thin lining, no response
    cycle 2: June 2012, femara 5mg; cycle cancelled, no response
    cycle 3: July 2012, femara 7.5mg; cycle cancelled (largest folli on Cd12 & cd 16: 11, lining 4)
    Repeat MRI July 25,2012- Cyst unchanged, likely old infarction.
    Aug. 8: met with RE, move to injectables if HSG and SA normal
    Aug. 23: HSG all clear; DH- perfect
    Switched to a new RE in early Sept. IVF here we come
    Genetic testing reveals: Fragile X- Intermediate risk/grey zone.
    IVF#1: ER 11/30: 14 retrieved, 10 mature, 7 fertilized. E2 prior to trigger 5200. Decision made to freeze 6 embryos and transfer later due to OHSS.
    IVF#1.2/FET #1: estrogen injects start 1/18, FET delayed to try to thicken lining. lining 5.4mm. FET- 2/18- transferred one 3AA expanded blast. BFP 5dp5dt. Beta #1- 2/27 9dp5dt- 102.27 beta #2 3/1: 147 :(, beta #3 3/4: 268 told to stop meds and let nature take its course. requested 4th beta (3/6); Beta hell for 2 months.

    FET # 2: endometrial scratch 5/6, added estrace vaginally and ASA to delestrogen and PIO. June 10- transferred one 4AA hatched embryo, BFP 4dp6dt, Beta 1 (9dp6dt) 187, Beta 2 (11dp6dt): 412; Beta 3 (15dp6dt ): 4452. U/S #1- one beautiful embryo with a heartbeat of 133 at 7 weeks.  8 weeks: heartbeat 156. EDD 2/26/2014: born 2-3-14 induced due to Pre-E and HELLP at 36w5d.

    12/1: met with RE to discuss trying for #2


  • Hope all is going well with the injections so far. I am answering because am deathly afraid of needles and the PIO is hard for me (and there is no end in sight)... My MD called in a RX for a topical cream called Fougera - it's a lidocaine/prilocane cream - and I put it on an hour before the injection - cannot feel the needle at all. Sorry I am such a wuss - but if the sites get too sore, this med is a miracle. :-)

     

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